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The map label for this gene is kefC [H]

Identifier: 114799732

GI number: 114799732

Start: 35891

End: 37696

Strand: Direct

Name: kefC [H]

Synonym: HNE_0044

Alternate gene names: 114799732

Gene position: 35891-37696 (Clockwise)

Preceding gene: 114798164

Following gene: 114797793

Centisome position: 0.97

GC content: 64.34

Gene sequence:

>1806_bases
ATGGCCGCAGAATCACACGCATCACATGCGGTAGACCTGGCCCCCGTGGTCATCCTTCTGGGATCAGCCGTTCTGGCCGT
GCCGCTGTTCAAGAAGATCGGTTTCGGCTCGGTGCTGGGCTATCTCGCCGCCGGCCTTGTCATCGGCCCGTTTGGCTTCC
GGGTCTTCACCGAGCCCACGGCCATTCTGCATGTCGCCGAACTGGGCGTCGTTATGTTTCTTTTCATTATCGGACTGGAA
ATGCAGCCCTCCCGGCTCTGGTCCATGCGCAAGGACATATTCGGCCTCGGCTTGGCCCAGGTCGGTATCTGCATACTGCT
CCTCTCCTGGGTGGGCGTTGCGCTGGGTTATTCCCCGCAAACCTCGCTGGTCGCGGGCACGGGCTTTGTCCTCACCTCCA
CCGCCATCGTCATGCAGATGCTTCAGGAGCGGGGCGACCTCGCCAAGCCGCGCGGCCAGAAGATGGTGTCGATCCTTCTG
TTTGAGGATCTCGCCATCGTGCCGTTGCTGGCGCTGGTCGCCTTCCTGGCGCCGGGGGGCGGGGAGGTTACCCTCATGGA
ACGCCTGCAGGGCGTTGCCATCGGGCTTGGCTGCATTCTCGGCCTCGTCCTGGCGGGCCGCTACCTGCTCAATCCCGTCT
TCCGTATTCTCGCCGCCGCCCGCGCGCGCGAAGTGATGACCGCCGCGTCCCTGCTGCTGGTGCTCGGTGCCGCCTGGTGG
ATGCAGCTTGGCGGGCTCTCCACGGCCATGGGCGCGTTCCTTGCGGGCGTGCTTCTGTCAGAATCGTCTTACCGGCATGA
GCTGGAAGCAGATATCGAGCCTTTCCGGGGCATCCTGCTCGGCCTCTTCTTCCTTGCGGTCGGCATGTCGCTCGATCTCA
ATGTCGTGCTGGGCAACTGGGAAATCATAGCGCTCAGCGTCATCGCCTTCACCCTCCTGAAGGCCGCCGGCGTCTACGGC
GTCGCGCGCGCCTTCAGGGCAAATCACCGCGAAGCGGTCGAGCGCACCGTGTTGATGACGCAAGGCGGCGAGTTTGCCTT
TGTGCTCTACGCAGCGGCCCTCGCAGTCGGCATCATCGACCCGGAAGGCAGCGCCATGCTGACTGCCATCATCATCGTGT
CGATGCTGATGACCCCGCTCTTTGTCCTGATCCATGACCGGCTGATGCCGGAGGTTGAGGTCGATGCCAGCGGCGTTGAA
ACACCCGCTGATGTGCGGGGCACCGCGCTCCTCATCGGCTTTGGCCGGTTTGGTCAGGTTGTCAGCCAGCCGCTGCTCGC
GCGGGGCTACACGATCACAACCATCGACAATGATCCCGAGATGATCCGTGTCGCCGGGCAGTTCGGCTTCAAGGTCTGGT
ATGGCGATGGCGCCCGGCTCGACATTCTCCATGCGGCAGGGGCCCATCATGCCTCGCTGGTGCTGGTCTGCGTCGATGAC
CAGGCCGCCGCCACCAAGATCGTGGAGCTTGTCCGCCACGAATTTCCAAACGCCCTCCTGCTCGCCCGCGCCTATGACCG
GGATCACGGCCTTGAGCTGGTGAAGGCCGGCGTCGATTATCCCGTCCGCGAAACCTTCGAATCCGCTCTCAAATTCGCCC
ATGCGGCCCTCGACAGGCTGGGCGAGCCCGAAGACGCGATCACCGACGCCCTCGATGAGGTCCGCCGCCGCGACGAGGAA
CGCTTCGCCCTCCAGCTGACGGGGGGCAGCTTTGCCGGCCGCGAACTGATGTTCGGCAATGGCGGCGGGGCTGTTCCACT
GAACGCGCGCAAGGCCGAACCCGATGCCGAGCCTGGCGGTGGGTGA

Upstream 100 bases:

>100_bases
AGCCTTCCTCAGCCACGGGCGGGTTCGGCAGACGCCCGGCGTTGCGATTGCTGCCAAACTTTCTAAAAGTGCAGGTTAGC
TAGATCGCAGGGGAATCCAG

Downstream 100 bases:

>100_bases
CGGACGGCCCGGCCCGCGCTAAACCCCGCCCATGTTCAAGGCCACAGCCATCACCCTCATACCGGAAGCCTGGCCGGGTC
CCCTCGGCGCCTCCATTCTG

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MAAESHASHAVDLAPVVILLGSAVLAVPLFKKIGFGSVLGYLAAGLVIGPFGFRVFTEPTAILHVAELGVVMFLFIIGLE
MQPSRLWSMRKDIFGLGLAQVGICILLLSWVGVALGYSPQTSLVAGTGFVLTSTAIVMQMLQERGDLAKPRGQKMVSILL
FEDLAIVPLLALVAFLAPGGGEVTLMERLQGVAIGLGCILGLVLAGRYLLNPVFRILAAARAREVMTAASLLLVLGAAWW
MQLGGLSTAMGAFLAGVLLSESSYRHELEADIEPFRGILLGLFFLAVGMSLDLNVVLGNWEIIALSVIAFTLLKAAGVYG
VARAFRANHREAVERTVLMTQGGEFAFVLYAAALAVGIIDPEGSAMLTAIIIVSMLMTPLFVLIHDRLMPEVEVDASGVE
TPADVRGTALLIGFGRFGQVVSQPLLARGYTITTIDNDPEMIRVAGQFGFKVWYGDGARLDILHAAGAHHASLVLVCVDD
QAAATKIVELVRHEFPNALLLARAYDRDHGLELVKAGVDYPVRETFESALKFAHAALDRLGEPEDAITDALDEVRRRDEE
RFALQLTGGSFAGRELMFGNGGGAVPLNARKAEPDAEPGGG

Sequences:

>Translated_601_residues
MAAESHASHAVDLAPVVILLGSAVLAVPLFKKIGFGSVLGYLAAGLVIGPFGFRVFTEPTAILHVAELGVVMFLFIIGLE
MQPSRLWSMRKDIFGLGLAQVGICILLLSWVGVALGYSPQTSLVAGTGFVLTSTAIVMQMLQERGDLAKPRGQKMVSILL
FEDLAIVPLLALVAFLAPGGGEVTLMERLQGVAIGLGCILGLVLAGRYLLNPVFRILAAARAREVMTAASLLLVLGAAWW
MQLGGLSTAMGAFLAGVLLSESSYRHELEADIEPFRGILLGLFFLAVGMSLDLNVVLGNWEIIALSVIAFTLLKAAGVYG
VARAFRANHREAVERTVLMTQGGEFAFVLYAAALAVGIIDPEGSAMLTAIIIVSMLMTPLFVLIHDRLMPEVEVDASGVE
TPADVRGTALLIGFGRFGQVVSQPLLARGYTITTIDNDPEMIRVAGQFGFKVWYGDGARLDILHAAGAHHASLVLVCVDD
QAAATKIVELVRHEFPNALLLARAYDRDHGLELVKAGVDYPVRETFESALKFAHAALDRLGEPEDAITDALDEVRRRDEE
RFALQLTGGSFAGRELMFGNGGGAVPLNARKAEPDAEPGGG
>Mature_600_residues
AAESHASHAVDLAPVVILLGSAVLAVPLFKKIGFGSVLGYLAAGLVIGPFGFRVFTEPTAILHVAELGVVMFLFIIGLEM
QPSRLWSMRKDIFGLGLAQVGICILLLSWVGVALGYSPQTSLVAGTGFVLTSTAIVMQMLQERGDLAKPRGQKMVSILLF
EDLAIVPLLALVAFLAPGGGEVTLMERLQGVAIGLGCILGLVLAGRYLLNPVFRILAAARAREVMTAASLLLVLGAAWWM
QLGGLSTAMGAFLAGVLLSESSYRHELEADIEPFRGILLGLFFLAVGMSLDLNVVLGNWEIIALSVIAFTLLKAAGVYGV
ARAFRANHREAVERTVLMTQGGEFAFVLYAAALAVGIIDPEGSAMLTAIIIVSMLMTPLFVLIHDRLMPEVEVDASGVET
PADVRGTALLIGFGRFGQVVSQPLLARGYTITTIDNDPEMIRVAGQFGFKVWYGDGARLDILHAAGAHHASLVLVCVDDQ
AAATKIVELVRHEFPNALLLARAYDRDHGLELVKAGVDYPVRETFESALKFAHAALDRLGEPEDAITDALDEVRRRDEER
FALQLTGGSFAGRELMFGNGGGAVPLNARKAEPDAEPGGG

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=367, Percent_Identity=24.7956403269755, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786232, Length=534, Percent_Identity=41.5730337078652, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1789749, Length=550, Percent_Identity=40.5454545454545, Blast_Score=374, Evalue=1e-104,
Organism=Escherichia coli, GI1786685, Length=524, Percent_Identity=27.4809160305344, Blast_Score=155, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 63961; Mature: 63830

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAESHASHAVDLAPVVILLGSAVLAVPLFKKIGFGSVLGYLAAGLVIGPFGFRVFTEPT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCCH
AILHVAELGVVMFLFIIGLEMQPSRLWSMRKDIFGLGLAQVGICILLLSWVGVALGYSPQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
TSLVAGTGFVLTSTAIVMQMLQERGDLAKPRGQKMVSILLFEDLAIVPLLALVAFLAPGG
CCEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GEVTLMERLQGVAIGLGCILGLVLAGRYLLNPVFRILAAARAREVMTAASLLLVLGAAWW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQLGGLSTAMGAFLAGVLLSESSYRHELEADIEPFRGILLGLFFLAVGMSLDLNVVLGNW
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCC
EIIALSVIAFTLLKAAGVYGVARAFRANHREAVERTVLMTQGGEFAFVLYAAALAVGIID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCC
PEGSAMLTAIIIVSMLMTPLFVLIHDRLMPEVEVDASGVETPADVRGTALLIGFGRFGQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCEEEEECCHHHHH
VSQPLLARGYTITTIDNDPEMIRVAGQFGFKVWYGDGARLDILHAAGAHHASLVLVCVDD
HCCHHHHCCCEEEEECCCCCEEEEEECCCEEEEECCCCEEEEEECCCCCCEEEEEEEECC
QAAATKIVELVRHEFPNALLLARAYDRDHGLELVKAGVDYPVRETFESALKFAHAALDRL
HHHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GEPEDAITDALDEVRRRDEERFALQLTGGSFAGRELMFGNGGGAVPLNARKAEPDAEPGG
CCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure 
AAESHASHAVDLAPVVILLGSAVLAVPLFKKIGFGSVLGYLAAGLVIGPFGFRVFTEPT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCCH
AILHVAELGVVMFLFIIGLEMQPSRLWSMRKDIFGLGLAQVGICILLLSWVGVALGYSPQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
TSLVAGTGFVLTSTAIVMQMLQERGDLAKPRGQKMVSILLFEDLAIVPLLALVAFLAPGG
CCEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GEVTLMERLQGVAIGLGCILGLVLAGRYLLNPVFRILAAARAREVMTAASLLLVLGAAWW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQLGGLSTAMGAFLAGVLLSESSYRHELEADIEPFRGILLGLFFLAVGMSLDLNVVLGNW
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCC
EIIALSVIAFTLLKAAGVYGVARAFRANHREAVERTVLMTQGGEFAFVLYAAALAVGIID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCC
PEGSAMLTAIIIVSMLMTPLFVLIHDRLMPEVEVDASGVETPADVRGTALLIGFGRFGQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCEEEEECCHHHHH
VSQPLLARGYTITTIDNDPEMIRVAGQFGFKVWYGDGARLDILHAAGAHHASLVLVCVDD
HCCHHHHCCCEEEEECCCCCEEEEEECCCEEEEECCCCEEEEEECCCCCCEEEEEEEECC
QAAATKIVELVRHEFPNALLLARAYDRDHGLELVKAGVDYPVRETFESALKFAHAALDRL
HHHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
GEPEDAITDALDEVRRRDEERFALQLTGGSFAGRELMFGNGGGAVPLNARKAEPDAEPGG
CCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]