The gene/protein map for NC_003228 is currently unavailable.
Definition Hyphomonas neptunium ATCC 15444 chromosome, complete genome.
Accession NC_008358
Length 3,705,021

Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 114799710

GI number: 114799710

Start: 2301362

End: 2302186

Strand: Reverse

Name: fabG [C]

Synonym: HNE_2205

Alternate gene names: 114799710

Gene position: 2302186-2301362 (Counterclockwise)

Preceding gene: 114798191

Following gene: 114798933

Centisome position: 62.14

GC content: 64.85

Gene sequence:

>825_bases
ATGGAAAAAACAACCCGCCGCTCAGTTCTGGCCCTTGCCGCCGCGGCCCCGGCCGCGCTGGCGGGCGCTGCTGGCGCGCA
GACGGCGCCGCCCCGTCCCGGCAATGGCCGCGCCGCGCTTGTCACAGGGTCTTCCCGGGGCATTGGCGCCGCAACGGCCA
AGCGCCTGGCGCAGGATGGCTTTGCCGTAACGGTCAACTATCTCACCAACCGGGATCTGGCCGCGCAGGTTGTGCGCGAC
ATCGAAGCGGCGGGGGGGCGGGCGATTTTCCGCCAGGGCGATGTCGCCGACCCGGAAGCGGTCAAGGCGCTGTTCGATGC
CAATGAGGAAGCGTTTGGCGGTGTAGATGTGGTTATCAGCAATGCCGCCATCATGAACACGGCGCCATTTGCGCAGTTCA
CGGATGAAGCGTTCGACCGGATGATCGCTACCAACATCAAAGGCAGCTTCAATGTTCTGCGTGAGGCAGCGCGGCGCACG
CGGGATGGCGGGCGCATTGTCACGCTCGCGTCAACCTCGATCAAGGCAATGCGGGCGACACATGGCGGATATGCCGCCAC
CAAGGCAGCCCAGCAGATTTATGCCGGCTGCCTGTCGAAGGAACTCTCTGGCCGCCGCATCTCGGTCAACGCCCTGGCCC
CCGGGCCAACCAATACAGACCTGCTCGATGTGCCCCCGCCACTGCGCGCGCAGGCCGCGCAGATGACCCCTTACGGACGG
ATTGGTGAGCCAGAAGACATCGCCAATGCGATTGCCGCCCTGTGTTCGGGGGATGGGGAGTGGATCAATGGCCAGGTCGT
GTTTGCCAATGGCGGCTTCCTTTAA

Upstream 100 bases:

>100_bases
TGAGCGCGCTCTCTCTGCATCCTTTCATCAGGGATCAGATCACTTTTTTTTGGATGTGCCTTTCAGGCCGCTTTTCGTGC
AACATAAGGAGTCCTCCGCA

Downstream 100 bases:

>100_bases
GGCCGGGTCTGGCAAAGGCCGGGAATTCTGCAGAGTGTCCGTAACAGGAGAAAACCGATGAAATATAAAACCCTTGGAAA
TACCGGCCTCTTTGTCTCCG

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MEKTTRRSVLALAAAAPAALAGAAGAQTAPPRPGNGRAALVTGSSRGIGAATAKRLAQDGFAVTVNYLTNRDLAAQVVRD
IEAAGGRAIFRQGDVADPEAVKALFDANEEAFGGVDVVISNAAIMNTAPFAQFTDEAFDRMIATNIKGSFNVLREAARRT
RDGGRIVTLASTSIKAMRATHGGYAATKAAQQIYAGCLSKELSGRRISVNALAPGPTNTDLLDVPPPLRAQAAQMTPYGR
IGEPEDIANAIAALCSGDGEWINGQVVFANGGFL

Sequences:

>Translated_274_residues
MEKTTRRSVLALAAAAPAALAGAAGAQTAPPRPGNGRAALVTGSSRGIGAATAKRLAQDGFAVTVNYLTNRDLAAQVVRD
IEAAGGRAIFRQGDVADPEAVKALFDANEEAFGGVDVVISNAAIMNTAPFAQFTDEAFDRMIATNIKGSFNVLREAARRT
RDGGRIVTLASTSIKAMRATHGGYAATKAAQQIYAGCLSKELSGRRISVNALAPGPTNTDLLDVPPPLRAQAAQMTPYGR
IGEPEDIANAIAALCSGDGEWINGQVVFANGGFL
>Mature_274_residues
MEKTTRRSVLALAAAAPAALAGAAGAQTAPPRPGNGRAALVTGSSRGIGAATAKRLAQDGFAVTVNYLTNRDLAAQVVRD
IEAAGGRAIFRQGDVADPEAVKALFDANEEAFGGVDVVISNAAIMNTAPFAQFTDEAFDRMIATNIKGSFNVLREAARRT
RDGGRIVTLASTSIKAMRATHGGYAATKAAQQIYAGCLSKELSGRRISVNALAPGPTNTDLLDVPPPLRAQAAQMTPYGR
IGEPEDIANAIAALCSGDGEWINGQVVFANGGFL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=30.5220883534137, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI15277342, Length=249, Percent_Identity=31.7269076305221, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=28.1632653061224, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI7705925, Length=247, Percent_Identity=29.9595141700405, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4504505, Length=241, Percent_Identity=31.1203319502075, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=28.8065843621399, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=27.734375, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=29.296875, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI10190704, Length=242, Percent_Identity=28.099173553719, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4502601, Length=235, Percent_Identity=26.8085106382979, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI109715829, Length=249, Percent_Identity=30.1204819277108, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=32.7800829875519, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI2367175, Length=243, Percent_Identity=34.156378600823, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367365, Length=239, Percent_Identity=30.9623430962343, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790717, Length=244, Percent_Identity=28.6885245901639, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=32.6612903225806, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=30.3643724696356, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=31.8181818181818, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=27.8884462151394, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082160, Length=244, Percent_Identity=27.4590163934426, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=27.5590551181102, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786812, Length=255, Percent_Identity=30.1960784313725, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1789057, Length=254, Percent_Identity=28.3464566929134, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=243, Percent_Identity=28.8065843621399, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=29.4820717131474, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17536025, Length=259, Percent_Identity=29.3436293436293, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=29.0196078431373, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=241, Percent_Identity=28.2157676348548, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=27.0588235294118, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=240, Percent_Identity=28.75, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=27.5471698113208, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=256, Percent_Identity=28.125, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=196, Percent_Identity=31.6326530612245, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561272, Length=264, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=28.3524904214559, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=24.7011952191235, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=27.34375, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=189, Percent_Identity=29.1005291005291, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=27.3076923076923, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=138, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=29.277566539924, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=256, Percent_Identity=26.171875, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=26.6917293233083, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=26.9961977186312, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=281, Percent_Identity=25.9786476868327, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=259, Percent_Identity=26.6409266409266, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=209, Percent_Identity=30.1435406698565, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=30.7377049180328, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=29.0836653386454, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=29.5275590551181, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=29.0836653386454, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24644339, Length=247, Percent_Identity=25.9109311740891, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=28.6290322580645, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=29.1497975708502, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573296, Length=222, Percent_Identity=27.9279279279279, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24656154, Length=209, Percent_Identity=27.7511961722488, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922628, Length=209, Percent_Identity=27.7511961722488, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007236, Length=233, Percent_Identity=27.4678111587983, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648944, Length=200, Percent_Identity=28.5, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=25.6, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357673, Length=189, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641232, Length=228, Percent_Identity=27.6315789473684, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28268; Mature: 28268

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MEKTTRRSVLALAAAAPAALAGAAGAQTAPPRPGNGRAALVTGSSRGIGAATAKRLAQDG
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCC
FAVTVNYLTNRDLAAQVVRDIEAAGGRAIFRQGDVADPEAVKALFDANEEAFGGVDVVIS
CEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEE
NAAIMNTAPFAQFTDEAFDRMIATNIKGSFNVLREAARRTRDGGRIVTLASTSIKAMRAT
CCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHC
HGGYAATKAAQQIYAGCLSKELSGRRISVNALAPGPTNTDLLDVPPPLRAQAAQMTPYGR
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCHHHHHCCCCCCC
IGEPEDIANAIAALCSGDGEWINGQVVFANGGFL
CCCHHHHHHHHHHHHCCCCCEECCEEEEECCCCC
>Mature Secondary Structure
MEKTTRRSVLALAAAAPAALAGAAGAQTAPPRPGNGRAALVTGSSRGIGAATAKRLAQDG
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCC
FAVTVNYLTNRDLAAQVVRDIEAAGGRAIFRQGDVADPEAVKALFDANEEAFGGVDVVIS
CEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEE
NAAIMNTAPFAQFTDEAFDRMIATNIKGSFNVLREAARRTRDGGRIVTLASTSIKAMRAT
CCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHC
HGGYAATKAAQQIYAGCLSKELSGRRISVNALAPGPTNTDLLDVPPPLRAQAAQMTPYGR
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCHHHHHCCCCCCC
IGEPEDIANAIAALCSGDGEWINGQVVFANGGFL
CCCHHHHHHHHHHHHCCCCCEECCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]