Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 114799637

GI number: 114799637

Start: 1780289

End: 1781758

Strand: Direct

Name: zwf [H]

Synonym: HNE_1738

Alternate gene names: 114799637

Gene position: 1780289-1781758 (Clockwise)

Preceding gene: 114799867

Following gene: 114798389

Centisome position: 48.05

GC content: 58.57

Gene sequence:

>1470_bases
GTGGCAAAGTTCGTTCCTGTTGAAGCCTTCGACATCGTCATCTTTGGCGGCACGGGCGATCTGTCCCGCCGCAAGCTGCT
TCCTGCGCTCTATCACCGCTGGGTGGATGGCCAGATTCCGGAAAACTCGACGATCGTCGGAACGGCTCGCTCCGAGCTGG
ATGCGCAGGCTTATCGGGACCTTGCGCGGGAAGCTTGCGAGAAAGCCTCAGGCAAATCGTGGGACGCTGACGCTTGGGAG
AAGTTTGCTCAGATCCTCCATTATGTCGCGATCGATGCGACCGATCCGGAAGGGGATTGGGAGGGGCTCAAGGCCAGGCT
GAAGGCAGAAGATGGCCGTCCACGGATATTCTATCTGGCAACGTCGCCTCACCTTTATGTCGATATCTCCCGCGCGCTGG
GAAAGGTCGGCCTTGTGGACGGCATGTGCAGGGTCGTGCTGGAAAAGCCCATCGGTACGGACCTTGCATCCGCGCAGGCG
ATCAATGACGGCGTCGGCGAGGTGTTCACCGAACGGCAGGTATTCCGTATTGACCACTATCTGGGCAAGGAAACCGTCCA
GAACCTGATGGTTTTGCGCTTTGCCAATATCCTGTTCGAACCGCTCTGGTCGCAGAATTATATCGATCACGTTCAGATCA
CTGTCGCTGAAGATCTCGGCCTTGAAGGGCGGGCCGACTATTACGACCGGTCCGGCGCGCTGCGCGACATGGTCCAGAAC
CACCTGTTGCAGCTCCTGTGCCTCACGGCGATGGAGCCCCCCAACGACATGGATGACGACGATATACGCACAGAAAAGAT
CAAGGTTCTGAAGGCCCTGCGGCCGGTATCGTCTCAGGATGCAAAGCGGCTGACCGTGCGCGGGCAATACGCGGCAGGCA
TGCATGCGGGCAAACCGGCTAAAGGCTATGTCGAGGAGCTCTCCGAAACCGGGGGCAGCAAGACCGAAACATTTGTGGCC
ATCAAGGCAGAGATCAACAACTGGCGCTGGACGGGCGTGCCATTCTATCTGCGCACCGGAAAACGCATGTCGTCGCGCCA
TTCCGACATCGTGATCCAGTTCAAGCAGGCGCCCCACAATCTGTTCGGTGAGCAATCGGGAAATGTAAACCAGCTTGTAA
TCCGTCTGCAGCCGGATGAAGCGGTTCGCCTGTATGTTCAGATCAAGGAACCCGGCCCTGGTGGCCTGCGCGTCAAATCG
CTCCCACTCAACCTTTCCTATGCGGAAAGTTTCACCCTACGCTATCCCGACGCCTATGAGCGGCTGTTGATGGATGTCGT
TCGCGGAAACCTTTCCCTGTTCATGCGCCGGGACGAGGTTGAGGCCGCCTGGCGCTGGGTTGATGGCCTGATCGATGCGT
GGGACACCAGCGGCTATCAGCCTGAAGCCTATCCGGCGGGTACGGATGGCCCGATGTCGGCCGCGATGCTGATGGACCGT
GACAATCGTAGTTGGTGGAAAGAAAGCTGA

Upstream 100 bases:

>100_bases
ACTCCGACTGACCAACGTTGTCATTTTGATCCAAAGCGACTTATAAGACCTGGAACGGCTTCGGGTATCCCGAAGCCCCC
TCAGAAAGGAAGCGCCCACG

Downstream 100 bases:

>100_bases
AGCCATGGAATCCAGACTGATCGTTCTTGATGACCGGGAGGCTGCGTCTGTCCTCGCGGCGGAGCTCGCCTCTCTTCACC
TGTCCCGCGCAATTGCGAAA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MAKFVPVEAFDIVIFGGTGDLSRRKLLPALYHRWVDGQIPENSTIVGTARSELDAQAYRDLAREACEKASGKSWDADAWE
KFAQILHYVAIDATDPEGDWEGLKARLKAEDGRPRIFYLATSPHLYVDISRALGKVGLVDGMCRVVLEKPIGTDLASAQA
INDGVGEVFTERQVFRIDHYLGKETVQNLMVLRFANILFEPLWSQNYIDHVQITVAEDLGLEGRADYYDRSGALRDMVQN
HLLQLLCLTAMEPPNDMDDDDIRTEKIKVLKALRPVSSQDAKRLTVRGQYAAGMHAGKPAKGYVEELSETGGSKTETFVA
IKAEINNWRWTGVPFYLRTGKRMSSRHSDIVIQFKQAPHNLFGEQSGNVNQLVIRLQPDEAVRLYVQIKEPGPGGLRVKS
LPLNLSYAESFTLRYPDAYERLLMDVVRGNLSLFMRRDEVEAAWRWVDGLIDAWDTSGYQPEAYPAGTDGPMSAAMLMDR
DNRSWWKES

Sequences:

>Translated_489_residues
MAKFVPVEAFDIVIFGGTGDLSRRKLLPALYHRWVDGQIPENSTIVGTARSELDAQAYRDLAREACEKASGKSWDADAWE
KFAQILHYVAIDATDPEGDWEGLKARLKAEDGRPRIFYLATSPHLYVDISRALGKVGLVDGMCRVVLEKPIGTDLASAQA
INDGVGEVFTERQVFRIDHYLGKETVQNLMVLRFANILFEPLWSQNYIDHVQITVAEDLGLEGRADYYDRSGALRDMVQN
HLLQLLCLTAMEPPNDMDDDDIRTEKIKVLKALRPVSSQDAKRLTVRGQYAAGMHAGKPAKGYVEELSETGGSKTETFVA
IKAEINNWRWTGVPFYLRTGKRMSSRHSDIVIQFKQAPHNLFGEQSGNVNQLVIRLQPDEAVRLYVQIKEPGPGGLRVKS
LPLNLSYAESFTLRYPDAYERLLMDVVRGNLSLFMRRDEVEAAWRWVDGLIDAWDTSGYQPEAYPAGTDGPMSAAMLMDR
DNRSWWKES
>Mature_488_residues
AKFVPVEAFDIVIFGGTGDLSRRKLLPALYHRWVDGQIPENSTIVGTARSELDAQAYRDLAREACEKASGKSWDADAWEK
FAQILHYVAIDATDPEGDWEGLKARLKAEDGRPRIFYLATSPHLYVDISRALGKVGLVDGMCRVVLEKPIGTDLASAQAI
NDGVGEVFTERQVFRIDHYLGKETVQNLMVLRFANILFEPLWSQNYIDHVQITVAEDLGLEGRADYYDRSGALRDMVQNH
LLQLLCLTAMEPPNDMDDDDIRTEKIKVLKALRPVSSQDAKRLTVRGQYAAGMHAGKPAKGYVEELSETGGSKTETFVAI
KAEINNWRWTGVPFYLRTGKRMSSRHSDIVIQFKQAPHNLFGEQSGNVNQLVIRLQPDEAVRLYVQIKEPGPGGLRVKSL
PLNLSYAESFTLRYPDAYERLLMDVVRGNLSLFMRRDEVEAAWRWVDGLIDAWDTSGYQPEAYPAGTDGPMSAAMLMDRD
NRSWWKES

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=475, Percent_Identity=37.6842105263158, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI109389365, Length=475, Percent_Identity=37.6842105263158, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI52145310, Length=509, Percent_Identity=29.2730844793713, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=48.0572597137014, Blast_Score=451, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17538218, Length=480, Percent_Identity=37.0833333333333, Blast_Score=314, Evalue=8e-86,
Organism=Saccharomyces cerevisiae, GI6324088, Length=481, Percent_Identity=36.1746361746362, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=36.5145228215768, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=36.5145228215768, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI221513548, Length=479, Percent_Identity=30.6889352818372, Blast_Score=223, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55105; Mature: 54974

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFVPVEAFDIVIFGGTGDLSRRKLLPALYHRWVDGQIPENSTIVGTARSELDAQAYRD
CCCEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHH
LAREACEKASGKSWDADAWEKFAQILHYVAIDATDPEGDWEGLKARLKAEDGRPRIFYLA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHEEEECCCCCCEEEEEE
TSPHLYVDISRALGKVGLVDGMCRVVLEKPIGTDLASAQAINDGVGEVFTERQVFRIDHY
CCCEEEEEHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LGKETVQNLMVLRFANILFEPLWSQNYIDHVQITVAEDLGLEGRADYYDRSGALRDMVQN
HCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHCCCHHHHHHHH
HLLQLLCLTAMEPPNDMDDDDIRTEKIKVLKALRPVSSQDAKRLTVRGQYAAGMHAGKPA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHCCCCCCCCC
KGYVEELSETGGSKTETFVAIKAEINNWRWTGVPFYLRTGKRMSSRHSDIVIQFKQAPHN
HHHHHHHHHCCCCCCEEEEEEEEECCCEEECCCCEEEECCCHHCCCCCCEEEEEECCCCH
LFGEQSGNVNQLVIRLQPDEAVRLYVQIKEPGPGGLRVKSLPLNLSYAESFTLRYPDAYE
HCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCEEEEEECCEEEECCEEEEECCHHHH
RLLMDVVRGNLSLFMRRDEVEAAWRWVDGLIDAWDTSGYQPEAYPAGTDGPMSAAMLMDR
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEC
DNRSWWKES
CCCCCCCCC
>Mature Secondary Structure 
AKFVPVEAFDIVIFGGTGDLSRRKLLPALYHRWVDGQIPENSTIVGTARSELDAQAYRD
CCEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHH
LAREACEKASGKSWDADAWEKFAQILHYVAIDATDPEGDWEGLKARLKAEDGRPRIFYLA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHEEEECCCCCCEEEEEE
TSPHLYVDISRALGKVGLVDGMCRVVLEKPIGTDLASAQAINDGVGEVFTERQVFRIDHY
CCCEEEEEHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LGKETVQNLMVLRFANILFEPLWSQNYIDHVQITVAEDLGLEGRADYYDRSGALRDMVQN
HCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHCCCHHHHHHHH
HLLQLLCLTAMEPPNDMDDDDIRTEKIKVLKALRPVSSQDAKRLTVRGQYAAGMHAGKPA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHCCCCCCCCC
KGYVEELSETGGSKTETFVAIKAEINNWRWTGVPFYLRTGKRMSSRHSDIVIQFKQAPHN
HHHHHHHHHCCCCCCEEEEEEEEECCCEEECCCCEEEECCCHHCCCCCCEEEEEECCCCH
LFGEQSGNVNQLVIRLQPDEAVRLYVQIKEPGPGGLRVKSLPLNLSYAESFTLRYPDAYE
HCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCEEEEEECCEEEECCEEEEECCHHHH
RLLMDVVRGNLSLFMRRDEVEAAWRWVDGLIDAWDTSGYQPEAYPAGTDGPMSAAMLMDR
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEC
DNRSWWKES
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]