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The map label for this gene is caiD [C]

Identifier: 114799512

GI number: 114799512

Start: 1189511

End: 1190275

Strand: Reverse

Name: caiD [C]

Synonym: HNE_1182

Alternate gene names: 114799512

Gene position: 1190275-1189511 (Counterclockwise)

Preceding gene: 114799756

Following gene: 114797528

Centisome position: 32.13

GC content: 64.71

Gene sequence:

>765_bases
ATGCCCGTCGAATACGTCAAAAAAGGCCACGTCGCGATCATCACGATGAACCGCCCCGAAGCCCGCAACGCCATCAACGG
CGAAATGGCCGCCACCATGGAAGCTGCGCTCGACCAGATGGAATCAGATCCGGAAGTCTGGGTCGGCATCCTCACCGCCG
TCGGCAAAGCGTTCTGCGCTGGCGCAGACCTGAAAGAAATCTCCGCCGGCAATGGCGGCGCCCTCTCCACCAAGAAGGGT
GGCTTCGCCGGCATCGCCAAGCGCGAGCGCACCAAGCCTCTCATCGCCGCCATCACAGGCTCGGCGCTGGCCGGCGGCAC
AGAGATCGCGCTTTCCTGCGACATGATCGTGGCGGCCGACGACACCAATTTCGGCCTGCCGGAAGTCAAGCGCTCGCTCG
TCGCCGGCGCCGGCGGCCTCTTCCGCCTGCCCCGCCAGATCGGCAAAGCCGTCGCCCTGGAAGCCATCCTCACGGGTGAC
CCGCTCTCCTCGCAGCGCGCTTACGAGCTCGGCATGGTCAACAAGGTCGTCCCGGAAGCCGACGTGATGGCCGAAGCCGA
AAAGCTCGCCGGCCGCATCACCGCCAACGCCCCCCTCGCCGTCGCCGCCAGCCGCGCCGTCGCGATCAGCGCGACAGCCA
AAACCGACGAAGAACTCTGGAAAGACTCCGGCGTCGCCTTCGCCAGCATCATCAACACCGAAGACTACAAAGAAGGCCCC
AAAGCCTTCATCGAAAAACGCGCGCCTGTCTGGAAGGGTAAGTAA

Upstream 100 bases:

>100_bases
TCTCTCGCCCCTTGCCCCAACGTCGCGCAAGAGGGGTTCTTGCGCGACGTTGCGGAAACCCTCTTAGCTGAGTGCCACTC
AGTTAAGGGAGAGACCCACA

Downstream 100 bases:

>100_bases
CTCCGCCTAAAGCCCCCGCTCCCTTGGGAGAGGGGGGTGGGGGTGAGGGCGCGCAACAGCGCCTCTGAGTTCAACATCCC
GGAAAGAAACAAGCCAACAA

Product: enoyl-CoA hydratase/isomerase family protein

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MPVEYVKKGHVAIITMNRPEARNAINGEMAATMEAALDQMESDPEVWVGILTAVGKAFCAGADLKEISAGNGGALSTKKG
GFAGIAKRERTKPLIAAITGSALAGGTEIALSCDMIVAADDTNFGLPEVKRSLVAGAGGLFRLPRQIGKAVALEAILTGD
PLSSQRAYELGMVNKVVPEADVMAEAEKLAGRITANAPLAVAASRAVAISATAKTDEELWKDSGVAFASIINTEDYKEGP
KAFIEKRAPVWKGK

Sequences:

>Translated_254_residues
MPVEYVKKGHVAIITMNRPEARNAINGEMAATMEAALDQMESDPEVWVGILTAVGKAFCAGADLKEISAGNGGALSTKKG
GFAGIAKRERTKPLIAAITGSALAGGTEIALSCDMIVAADDTNFGLPEVKRSLVAGAGGLFRLPRQIGKAVALEAILTGD
PLSSQRAYELGMVNKVVPEADVMAEAEKLAGRITANAPLAVAASRAVAISATAKTDEELWKDSGVAFASIINTEDYKEGP
KAFIEKRAPVWKGK
>Mature_253_residues
PVEYVKKGHVAIITMNRPEARNAINGEMAATMEAALDQMESDPEVWVGILTAVGKAFCAGADLKEISAGNGGALSTKKGG
FAGIAKRERTKPLIAAITGSALAGGTEIALSCDMIVAADDTNFGLPEVKRSLVAGAGGLFRLPRQIGKAVALEAILTGDP
LSSQRAYELGMVNKVVPEADVMAEAEKLAGRITANAPLAVAASRAVAISATAKTDEELWKDSGVAFASIINTEDYKEGPK
AFIEKRAPVWKGK

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=248, Percent_Identity=36.6935483870968, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI31542718, Length=250, Percent_Identity=31.6, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI150378541, Length=247, Percent_Identity=34.8178137651822, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI20127408, Length=182, Percent_Identity=32.967032967033, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI70995211, Length=255, Percent_Identity=27.0588235294118, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI68989263, Length=197, Percent_Identity=31.9796954314721, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI37594469, Length=196, Percent_Identity=33.1632653061224, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI37594471, Length=196, Percent_Identity=33.1632653061224, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI221142681, Length=258, Percent_Identity=38.3720930232558, Blast_Score=168, Evalue=3e-43,
Organism=Escherichia coli, GI1787659, Length=255, Percent_Identity=34.1176470588235, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=31.8007662835249, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1788597, Length=246, Percent_Identity=31.7073170731707, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082183, Length=260, Percent_Identity=30.3846153846154, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1788682, Length=195, Percent_Identity=37.4358974358974, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790281, Length=200, Percent_Identity=30, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=252, Percent_Identity=39.2857142857143, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17554946, Length=250, Percent_Identity=37.6, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17540714, Length=209, Percent_Identity=37.799043062201, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17560910, Length=244, Percent_Identity=30.7377049180328, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144276, Length=181, Percent_Identity=34.8066298342541, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17558304, Length=178, Percent_Identity=32.5842696629214, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17508951, Length=181, Percent_Identity=34.8066298342541, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17508953, Length=181, Percent_Identity=34.8066298342541, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17534483, Length=208, Percent_Identity=29.8076923076923, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535521, Length=193, Percent_Identity=29.5336787564767, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=220, Percent_Identity=26.8181818181818, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540306, Length=228, Percent_Identity=27.1929824561404, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25141363, Length=210, Percent_Identity=28.0952380952381, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=201, Percent_Identity=25.3731343283582, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129971, Length=251, Percent_Identity=38.2470119521912, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24653477, Length=251, Percent_Identity=38.2470119521912, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24653139, Length=253, Percent_Identity=35.5731225296443, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21357171, Length=248, Percent_Identity=31.8548387096774, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24650670, Length=248, Percent_Identity=33.4677419354839, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19922422, Length=247, Percent_Identity=26.3157894736842, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19920382, Length=263, Percent_Identity=24.3346007604563, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24583077, Length=175, Percent_Identity=35.4285714285714, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583079, Length=175, Percent_Identity=35.4285714285714, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921000, Length=175, Percent_Identity=35.4285714285714, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24654903, Length=180, Percent_Identity=26.1111111111111, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 26439; Mature: 26307

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVEYVKKGHVAIITMNRPEARNAINGEMAATMEAALDQMESDPEVWVGILTAVGKAFCA
CCCCCCCCCCEEEEEECCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GADLKEISAGNGGALSTKKGGFAGIAKRERTKPLIAAITGSALAGGTEIALSCDMIVAAD
CCCHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCHHCCCCEEEEEEEEEEEEC
DTNFGLPEVKRSLVAGAGGLFRLPRQIGKAVALEAILTGDPLSSQRAYELGMVNKVVPEA
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCH
DVMAEAEKLAGRITANAPLAVAASRAVAISATAKTDEELWKDSGVAFASIINTEDYKEGP
HHHHHHHHHHCEECCCCCEEEECCCEEEEEECCCCHHHHHHCCCCEEEEECCCCCCCCCH
KAFIEKRAPVWKGK
HHHHHHCCCCCCCC
>Mature Secondary Structure 
PVEYVKKGHVAIITMNRPEARNAINGEMAATMEAALDQMESDPEVWVGILTAVGKAFCA
CCCCCCCCCEEEEEECCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GADLKEISAGNGGALSTKKGGFAGIAKRERTKPLIAAITGSALAGGTEIALSCDMIVAAD
CCCHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCHHCCCCEEEEEEEEEEEEC
DTNFGLPEVKRSLVAGAGGLFRLPRQIGKAVALEAILTGDPLSSQRAYELGMVNKVVPEA
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCH
DVMAEAEKLAGRITANAPLAVAASRAVAISATAKTDEELWKDSGVAFASIINTEDYKEGP
HHHHHHHHHHCEECCCCCEEEECCCEEEEEECCCCHHHHHHCCCCEEEEECCCCCCCCCH
KAFIEKRAPVWKGK
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA