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The map label for this gene is acrA [H]

Identifier: 114799352

GI number: 114799352

Start: 1912478

End: 1913707

Strand: Reverse

Name: acrA [H]

Synonym: HNE_1852

Alternate gene names: 114799352

Gene position: 1913707-1912478 (Counterclockwise)

Preceding gene: 114797418

Following gene: 114800359

Centisome position: 51.65

GC content: 63.5

Gene sequence:

>1230_bases
GTGCGCGGCTCCCGTATCACCCGCTTGTTCCGGACACGGCCAATGACCCACGAGACACCCTACGAAGCCGACACCAGCCG
CCGCCGCCCGACCGTTCTCAAGGCGCTGGTCTTCATCGTTCTAATGGGGCTGGTGATTGCTGGCCTTCTGGCCGCGGCGA
CGCTGCTGCGAAGCGAAGAGGGGCCGAAGATCGCAATCGCCGAGCCCGAACCGTTGGCCGTCAGCGTCATTCCGGTTGAG
TATCTGACGGAGCTGGACATAGACGAACTGTTTACGGGCATCGCCGAAGCGCGGCGCACCAGCCGGCTGGGGTTTCAGAC
CGGGGGACGGATCGAACGGATTGATGTTCGGGTAGGCGACCGTGTTAAGGCCGGCCAGACCATAGCCCGCCTCGACACGC
GCGGACTTGGCGCGCAGCTGGCTTCATCGCAGGCTGTTGTTGAAGAGGCGCGGTCCGCCCACCAGCTGGCCCTGGATACG
GCTGACCGCCAGCGCCAACTTCAGGCGCAGGGGCATATTTCGCAGCAGCGTGTCGATGAAGTTGTTTCGCAGGCCGCCAC
TGCCATGGCGCGCGTCGATGCCGCCAAAGCGCAGGCGGATACGATCCGTGTGCAAATAGATCTGGCAAGCATTACGGCGC
CGTATGACGGGATGATTGTTTCACGCTTTGCAGATGAAGGCGCAATTGCCGGCCCCGGACAAGCCATTCTTGAGCTGGTC
GAGGGCGGGGCGCTGGAGGCACGCATCGGTGTTTCTGCCCGCGTAGTTTCCGAACTGGTGCCCGGCGACATTTATACGCT
GGAAGCGGAGACCGGGCCGGTCGATGCGCCACTGAGAAGTGTTACCGGCGTTGTGGACCCCTCACAGAGAACCGTTGCGG
CGATTTTTGACATACCAGAGACGACAGGCGTGCCTGCCGGTTCGATTGTTCGCCTGAAGATGGAGCGGAAGCTTGAAGAA
AAGGGTTTCTGGGTGCCGCTCAAAGCCCTGGCGAGCGCCAATCGGGGCATGTGGACTGTTTATGCCGTGGTGGGCGAAGG
CGAAGACGAAAGCTGGCGCGCTCAGCCGAGGTTGGTGGAGATGGTGTATCCCGCGGGGGAGCGTGCTTTCGTTCGCGGAC
CGCTGGAAGCGGGCGACCGGATTATTGTGGACGGACTGCAGCGGGTTACTCCCGGCGCCAGGGTCGTGCCGCGAGAGGTG
CAGCGCGCCGAAGCGGCGAGCGGCGGCTGA

Upstream 100 bases:

>100_bases
TCCATCTGCCGGGTTTCCCCGTAAGCCTTCCAACACCACAGGGCGGCACGGACACGGCAGGGTTCATTCAGTTTCACGCC
GCGCTGCTGTTTCGCAGCCT

Downstream 100 bases:

>100_bases
CGGTACGGAGTGGGTGGGGTGAGCACGCTATTCTTCAGAAATACACGCCTGACGATCCTGGCGATCCTTGTGATCCTGCT
GGGGGGTGGCGGCGCCTTGA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRGSRITRLFRTRPMTHETPYEADTSRRRPTVLKALVFIVLMGLVIAGLLAAATLLRSEEGPKIAIAEPEPLAVSVIPVE
YLTELDIDELFTGIAEARRTSRLGFQTGGRIERIDVRVGDRVKAGQTIARLDTRGLGAQLASSQAVVEEARSAHQLALDT
ADRQRQLQAQGHISQQRVDEVVSQAATAMARVDAAKAQADTIRVQIDLASITAPYDGMIVSRFADEGAIAGPGQAILELV
EGGALEARIGVSARVVSELVPGDIYTLEAETGPVDAPLRSVTGVVDPSQRTVAAIFDIPETTGVPAGSIVRLKMERKLEE
KGFWVPLKALASANRGMWTVYAVVGEGEDESWRAQPRLVEMVYPAGERAFVRGPLEAGDRIIVDGLQRVTPGARVVPREV
QRAEAASGG

Sequences:

>Translated_409_residues
MRGSRITRLFRTRPMTHETPYEADTSRRRPTVLKALVFIVLMGLVIAGLLAAATLLRSEEGPKIAIAEPEPLAVSVIPVE
YLTELDIDELFTGIAEARRTSRLGFQTGGRIERIDVRVGDRVKAGQTIARLDTRGLGAQLASSQAVVEEARSAHQLALDT
ADRQRQLQAQGHISQQRVDEVVSQAATAMARVDAAKAQADTIRVQIDLASITAPYDGMIVSRFADEGAIAGPGQAILELV
EGGALEARIGVSARVVSELVPGDIYTLEAETGPVDAPLRSVTGVVDPSQRTVAAIFDIPETTGVPAGSIVRLKMERKLEE
KGFWVPLKALASANRGMWTVYAVVGEGEDESWRAQPRLVEMVYPAGERAFVRGPLEAGDRIIVDGLQRVTPGARVVPREV
QRAEAASGG
>Mature_409_residues
MRGSRITRLFRTRPMTHETPYEADTSRRRPTVLKALVFIVLMGLVIAGLLAAATLLRSEEGPKIAIAEPEPLAVSVIPVE
YLTELDIDELFTGIAEARRTSRLGFQTGGRIERIDVRVGDRVKAGQTIARLDTRGLGAQLASSQAVVEEARSAHQLALDT
ADRQRQLQAQGHISQQRVDEVVSQAATAMARVDAAKAQADTIRVQIDLASITAPYDGMIVSRFADEGAIAGPGQAILELV
EGGALEARIGVSARVVSELVPGDIYTLEAETGPVDAPLRSVTGVVDPSQRTVAAIFDIPETTGVPAGSIVRLKMERKLEE
KGFWVPLKALASANRGMWTVYAVVGEGEDESWRAQPRLVEMVYPAGERAFVRGPLEAGDRIIVDGLQRVTPGARVVPREV
QRAEAASGG

Specific function: AcrAB is a drug efflux protein with a broad substrate specificity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786668, Length=362, Percent_Identity=27.9005524861878, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789665, Length=390, Percent_Identity=25.1282051282051, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789929, Length=393, Percent_Identity=27.2264631043257, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081796, Length=257, Percent_Identity=27.6264591439689, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43962; Mature: 43962

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGSRITRLFRTRPMTHETPYEADTSRRRPTVLKALVFIVLMGLVIAGLLAAATLLRSEE
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPKIAIAEPEPLAVSVIPVEYLTELDIDELFTGIAEARRTSRLGFQTGGRIERIDVRVGD
CCEEEEECCCCCEEEEECHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECC
RVKAGQTIARLDTRGLGAQLASSQAVVEEARSAHQLALDTADRQRQLQAQGHISQQRVDE
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VVSQAATAMARVDAAKAQADTIRVQIDLASITAPYDGMIVSRFADEGAIAGPGQAILELV
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHH
EGGALEARIGVSARVVSELVPGDIYTLEAETGPVDAPLRSVTGVVDPSQRTVAAIFDIPE
CCCCEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHCCCCCCCCCEEEEEEECCC
TTGVPAGSIVRLKMERKLEEKGFWVPLKALASANRGMWTVYAVVGEGEDESWRAQPRLVE
CCCCCCCCEEEEHHHHHHHHCCCEEEHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCEEE
MVYPAGERAFVRGPLEAGDRIIVDGLQRVTPGARVVPREVQRAEAASGG
EECCCCCCEEEECCHHCCCEEEEHHHHHCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MRGSRITRLFRTRPMTHETPYEADTSRRRPTVLKALVFIVLMGLVIAGLLAAATLLRSEE
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPKIAIAEPEPLAVSVIPVEYLTELDIDELFTGIAEARRTSRLGFQTGGRIERIDVRVGD
CCEEEEECCCCCEEEEECHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECC
RVKAGQTIARLDTRGLGAQLASSQAVVEEARSAHQLALDTADRQRQLQAQGHISQQRVDE
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VVSQAATAMARVDAAKAQADTIRVQIDLASITAPYDGMIVSRFADEGAIAGPGQAILELV
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHH
EGGALEARIGVSARVVSELVPGDIYTLEAETGPVDAPLRSVTGVVDPSQRTVAAIFDIPE
CCCCEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHCCCCCCCCCEEEEEEECCC
TTGVPAGSIVRLKMERKLEEKGFWVPLKALASANRGMWTVYAVVGEGEDESWRAQPRLVE
CCCCCCCCEEEEHHHHHHHHCCCEEEHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCEEE
MVYPAGERAFVRGPLEAGDRIIVDGLQRVTPGARVVPREVQRAEAASGG
EECCCCCCEEEECCHHCCCEEEEHHHHHCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]