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The map label for this gene is clpX

Identifier: 114799276

GI number: 114799276

Start: 2159071

End: 2160333

Strand: Reverse

Name: clpX

Synonym: HNE_2086

Alternate gene names: 114799276

Gene position: 2160333-2159071 (Counterclockwise)

Preceding gene: 114800297

Following gene: 114797257

Centisome position: 58.31

GC content: 60.02

Gene sequence:

>1263_bases
ATGACCAAACCAAACGGCTCCGGCGATTCAAAGAACACGCTGTACTGTTCCTTCTGCGGGAAGAGCCAGCATGAGGTTAA
AAAGCTCATTGCCGGACCGACCGTGTTCATCTGCGATGAATGCGTCGAGCTCTGTATGGACATCATCCGCGAGGAAAACA
AAACCTCTGCGATCAAGTCCCGCGACGGCGTACCGACACCGCAGGAAATCTGCGATGTTCTCGACGATTACGTGATCGGA
CAGCGCTATGCCAAGCGCATCCTCTCCGTCGCCGTGCATAACCACTACAAGCGCCTTTCCCATGCGGGCAAAACCGATGG
GGTTGAGCTGTCGAAGTCCAACATTTTGCTCGTCGGCCCCACGGGCTGCGGCAAGACGCTGCTGGCCCAGACGCTGGCGC
GCATCCTGGATGTGCCCTTCACCATGGCCGATGCCACCACGCTGACCGAGGCCGGCTATGTCGGCGAGGACGTGGAAAAC
ATCGTCCTGAAACTGCTCCAGTCGGCCGATTACAACGTTGAGCGCGCCCAGCGCGGCATCGTCTATATCGATGAGATCGA
CAAGATTTCCCGCAAGTCGGACAACCCTTCGATCACACGCGACGTGTCGGGTGAGGGGGTCCAGCAGGCGCTCCTGAAGA
TCATGGAGGGCACCGTTGCTGCCGTTCCTCCGCAGGGCGGCCGCAAGCATCCTCAGCAGGAATTTCTGCAGGTCGATACG
ACCAATATCCTCTTCATCTGCGGCGGCGCATTTGCCGGGCTCGAAAAGATCATCGCTGCGCGCGGTGAGAACGCTTCGAT
CGGCTTTGGTGCCACCATCAAGAGCGGCGAAGAACGCGGCGTGGGCGACACGCTGCGCGAAGTCGAACCGGAAGATCTTC
AGAAGTTCGGCCTCATCCCGGAATTCATCGGCCGTCTGCCTGTCCTGGCAACGCTCGAAGATCTGGACGAGAAAGCCCTT
ATCCAGATCCTCACCCAGCCGAAGAACGCCCTGCTCAAGCAGTATCAGCGCCTCTTCGACATGGAGAGCGTGCAGCTGAC
ATTCACGCCTGAAGCGCTGGTGGCTGTTGCCCGCCGCGCCATCACGCGCAAGACCGGCGCCCGCGGCCTGCGGTCGATCA
TGGAATCGATCCTGCTCGACACGATGTTCGAGCTGCCAAACCTGCGCGGCGTGGAAGAAGTGGTCATCAACGCAGAAGTG
GTCGACGGCAATGCCGAGCCCCTCTACGTCCACGCCTCCAAGAGCCAGACCGAAGCGGGCTGA

Upstream 100 bases:

>100_bases
GCCCTTGCAGGGCAGGCGAACAGGTTTATTGTCTAGAAAAAGACCATGCTTGGCAGGGGCTTAAAGCCCACGTTAAGCCT
TGTATGGCAGTGAGGACCGC

Downstream 100 bases:

>100_bases
TCCGCGCGGCAGCGACACAATTCAAAAACGCCCGCCCGGAACGCCGAGGCGGGCGTTTTTCATTCCGGCAGATGCACCGT
CAGAACATCAATTTGCGGCG

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTKPNGSGDSKNTLYCSFCGKSQHEVKKLIAGPTVFICDECVELCMDIIREENKTSAIKSRDGVPTPQEICDVLDDYVIG
QRYAKRILSVAVHNHYKRLSHAGKTDGVELSKSNILLVGPTGCGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVEN
IVLKLLQSADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVAAVPPQGGRKHPQQEFLQVDT
TNILFICGGAFAGLEKIIAARGENASIGFGATIKSGEERGVGDTLREVEPEDLQKFGLIPEFIGRLPVLATLEDLDEKAL
IQILTQPKNALLKQYQRLFDMESVQLTFTPEALVAVARRAITRKTGARGLRSIMESILLDTMFELPNLRGVEEVVINAEV
VDGNAEPLYVHASKSQTEAG

Sequences:

>Translated_420_residues
MTKPNGSGDSKNTLYCSFCGKSQHEVKKLIAGPTVFICDECVELCMDIIREENKTSAIKSRDGVPTPQEICDVLDDYVIG
QRYAKRILSVAVHNHYKRLSHAGKTDGVELSKSNILLVGPTGCGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVEN
IVLKLLQSADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVAAVPPQGGRKHPQQEFLQVDT
TNILFICGGAFAGLEKIIAARGENASIGFGATIKSGEERGVGDTLREVEPEDLQKFGLIPEFIGRLPVLATLEDLDEKAL
IQILTQPKNALLKQYQRLFDMESVQLTFTPEALVAVARRAITRKTGARGLRSIMESILLDTMFELPNLRGVEEVVINAEV
VDGNAEPLYVHASKSQTEAG
>Mature_419_residues
TKPNGSGDSKNTLYCSFCGKSQHEVKKLIAGPTVFICDECVELCMDIIREENKTSAIKSRDGVPTPQEICDVLDDYVIGQ
RYAKRILSVAVHNHYKRLSHAGKTDGVELSKSNILLVGPTGCGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENI
VLKLLQSADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVAAVPPQGGRKHPQQEFLQVDTT
NILFICGGAFAGLEKIIAARGENASIGFGATIKSGEERGVGDTLREVEPEDLQKFGLIPEFIGRLPVLATLEDLDEKALI
QILTQPKNALLKQYQRLFDMESVQLTFTPEALVAVARRAITRKTGARGLRSIMESILLDTMFELPNLRGVEEVVINAEVV
DGNAEPLYVHASKSQTEAG

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=336, Percent_Identity=52.9761904761905, Blast_Score=330, Evalue=1e-90,
Organism=Escherichia coli, GI1786642, Length=420, Percent_Identity=69.7619047619048, Blast_Score=594, Evalue=1e-171,
Organism=Escherichia coli, GI1790366, Length=104, Percent_Identity=41.3461538461538, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982908, Length=321, Percent_Identity=47.0404984423676, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71982905, Length=321, Percent_Identity=47.0404984423676, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71988663, Length=390, Percent_Identity=37.6923076923077, Blast_Score=244, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI71988660, Length=247, Percent_Identity=40.4858299595142, Blast_Score=164, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6319704, Length=439, Percent_Identity=38.0410022779043, Blast_Score=263, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24648289, Length=321, Percent_Identity=49.8442367601246, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24648291, Length=321, Percent_Identity=49.8442367601246, Blast_Score=303, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_HYPNA (Q0C0G0)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760783.1
- ProteinModelPortal:   Q0C0G0
- STRING:   Q0C0G0
- GeneID:   4288591
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2086
- NMPDR:   fig|228405.5.peg.2010
- TIGR:   HNE_2086
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   Q0C0G0
- ProtClustDB:   PRK05342
- BioCyc:   HNEP81032:HNE_2086-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 45815; Mature: 45684

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPNGSGDSKNTLYCSFCGKSQHEVKKLIAGPTVFICDECVELCMDIIREENKTSAIKS
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHC
RDGVPTPQEICDVLDDYVIGQRYAKRILSVAVHNHYKRLSHAGKTDGVELSKSNILLVGP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEECC
TGCGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENIVLKLLQSADYNVERAQRGI
CCCCHHHHHHHHHHHHCCCCCHHCHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCCC
VYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVAAVPPQGGRKHPQQEFLQVDT
EEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHCC
TNILFICGGAFAGLEKIIAARGENASIGFGATIKSGEERGVGDTLREVEPEDLQKFGLIP
CCEEEEECCHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCHHHHHCCHHHHHHHCCCH
EFIGRLPVLATLEDLDEKALIQILTQPKNALLKQYQRLFDMESVQLTFTPEALVAVARRA
HHHCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHH
ITRKTGARGLRSIMESILLDTMFELPNLRGVEEVVINAEVVDGNAEPLYVHASKSQTEAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEECCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
TKPNGSGDSKNTLYCSFCGKSQHEVKKLIAGPTVFICDECVELCMDIIREENKTSAIKS
CCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHC
RDGVPTPQEICDVLDDYVIGQRYAKRILSVAVHNHYKRLSHAGKTDGVELSKSNILLVGP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEECC
TGCGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENIVLKLLQSADYNVERAQRGI
CCCCHHHHHHHHHHHHCCCCCHHCHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCCC
VYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVAAVPPQGGRKHPQQEFLQVDT
EEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHCC
TNILFICGGAFAGLEKIIAARGENASIGFGATIKSGEERGVGDTLREVEPEDLQKFGLIP
CCEEEEECCHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCHHHHHCCHHHHHHHCCCH
EFIGRLPVLATLEDLDEKALIQILTQPKNALLKQYQRLFDMESVQLTFTPEALVAVARRA
HHHCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHH
ITRKTGARGLRSIMESILLDTMFELPNLRGVEEVVINAEVVDGNAEPLYVHASKSQTEAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEECCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA