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The map label for this gene is blh [H]

Identifier: 114799100

GI number: 114799100

Start: 476262

End: 477125

Strand: Reverse

Name: blh [H]

Synonym: HNE_0483

Alternate gene names: 114799100

Gene position: 477125-476262 (Counterclockwise)

Preceding gene: 114800118

Following gene: 114798941

Centisome position: 12.88

GC content: 64.35

Gene sequence:

>864_bases
ATGCCCGAGATCAAACCGTTTTTTGACCCCGCAACAAACACGGTCACCTATCTCGTCTGGGACAAGGCCACCCGCGACGC
CGTCATCATAGACCCCGTGCTGGACTTCGACCCCGCGCCCGCCCGCCTTTCCACGGCATCGGCCGATAAGGTGCTCGCCG
CGGCAGAGGCTGAGGGCCTGAAAATCCGCTGGGCGCTCGACACCCACGCCCATGCCGATCACCTTTCGGCCGCTGACTAT
GTCCGCCAGAAAACCGGCGCCAAGGTCGGCATCGGCGCGCACATCACCGATGTTCAGAAAATCTTCCGCCCGATGTTCGG
CCCCACCTCCGACACGCCGGACGAAACCGTGTTCGACGCCCTCTTCAATGAAGGCGATGAATTCCCGCTCGGCAACGAAA
CAATCCGTGTACTGCACACACCCGGCCACACCGCTGCCTGCCTCACCTATCTGATCGGCGACGCCGCCTTCGTGGGCGAT
ACCGTCTTCATGCCCGACTATGGCACCGCGCGGGCAGACTTTCCCGGCGGCGACGCCCACGCGCTTTACCGCTCAATCCG
CAAGCTGCTCGCCCTGCCGCCCGAAACCCGCATCTTCACCGGCCATGACTATCTCCCCGAAGGCCGCGACAAGCATGCCT
GGGAATCCACCGTCGCCCAGCACCGCGCCGCCAACGTCCATGTCCATGACGGCGTCTCGGAAGAAGACTTCGTCACCATG
CGCACCACCCGCGACAAAACCCTTGGCGCTCCGCGCCTGATCCTCCCCTCCCTGCAGGTCAACATCCGCGCCGGCACCCT
TCCCCCACCAGAATCCGACGGCCAGACCTACCTCCGCCTCCCGGTAAACCGCCTCGGCAAATAG

Upstream 100 bases:

>100_bases
GGCGTGTCCAGCGTGAAATATATGATAACTTGCTAAATTAGCAATATCTCATATATTTGAAGCAGACCTGAGATTTGACG
ATTCCGCAGAGGAGATTCCC

Downstream 100 bases:

>100_bases
TGTATTGCCGCAAGGCCCCCCTCCGTCCGCTTCGCGTCCACCTCCCCCGCTTCGCAGGGGAGGATAACGGCTTGGTCCAA
TCCGGTAAGATGGGTAACAA

Product: metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPEIKPFFDPATNTVTYLVWDKATRDAVIIDPVLDFDPAPARLSTASADKVLAAAEAEGLKIRWALDTHAHADHLSAADY
VRQKTGAKVGIGAHITDVQKIFRPMFGPTSDTPDETVFDALFNEGDEFPLGNETIRVLHTPGHTAACLTYLIGDAAFVGD
TVFMPDYGTARADFPGGDAHALYRSIRKLLALPPETRIFTGHDYLPEGRDKHAWESTVAQHRAANVHVHDGVSEEDFVTM
RTTRDKTLGAPRLILPSLQVNIRAGTLPPPESDGQTYLRLPVNRLGK

Sequences:

>Translated_287_residues
MPEIKPFFDPATNTVTYLVWDKATRDAVIIDPVLDFDPAPARLSTASADKVLAAAEAEGLKIRWALDTHAHADHLSAADY
VRQKTGAKVGIGAHITDVQKIFRPMFGPTSDTPDETVFDALFNEGDEFPLGNETIRVLHTPGHTAACLTYLIGDAAFVGD
TVFMPDYGTARADFPGGDAHALYRSIRKLLALPPETRIFTGHDYLPEGRDKHAWESTVAQHRAANVHVHDGVSEEDFVTM
RTTRDKTLGAPRLILPSLQVNIRAGTLPPPESDGQTYLRLPVNRLGK
>Mature_286_residues
PEIKPFFDPATNTVTYLVWDKATRDAVIIDPVLDFDPAPARLSTASADKVLAAAEAEGLKIRWALDTHAHADHLSAADYV
RQKTGAKVGIGAHITDVQKIFRPMFGPTSDTPDETVFDALFNEGDEFPLGNETIRVLHTPGHTAACLTYLIGDAAFVGDT
VFMPDYGTARADFPGGDAHALYRSIRKLLALPPETRIFTGHDYLPEGRDKHAWESTVAQHRAANVHVHDGVSEEDFVTMR
TTRDKTLGAPRLILPSLQVNIRAGTLPPPESDGQTYLRLPVNRLGK

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=270, Percent_Identity=29.2592592592593, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI14150041, Length=258, Percent_Identity=26.7441860465116, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46361987, Length=198, Percent_Identity=28.2828282828283, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787158, Length=193, Percent_Identity=33.160621761658, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17538952, Length=267, Percent_Identity=25.4681647940075, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221330176, Length=283, Percent_Identity=30.3886925795053, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 31414; Mature: 31282

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEIKPFFDPATNTVTYLVWDKATRDAVIIDPVLDFDPAPARLSTASADKVLAAAEAEGL
CCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCEECCCCHHHEEEEECCCCE
KIRWALDTHAHADHLSAADYVRQKTGAKVGIGAHITDVQKIFRPMFGPTSDTPDETVFDA
EEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
LFNEGDEFPLGNETIRVLHTPGHTAACLTYLIGDAAFVGDTVFMPDYGTARADFPGGDAH
HHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHCCEEECCCCCCCCCCCCCCHHH
ALYRSIRKLLALPPETRIFTGHDYLPEGRDKHAWESTVAQHRAANVHVHDGVSEEDFVTM
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCEEEEECCCCCCCEEEE
RTTRDKTLGAPRLILPSLQVNIRAGTLPPPESDGQTYLRLPVNRLGK
EECCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCEEEEECHHHHCC
>Mature Secondary Structure 
PEIKPFFDPATNTVTYLVWDKATRDAVIIDPVLDFDPAPARLSTASADKVLAAAEAEGL
CCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCEECCCCHHHEEEEECCCCE
KIRWALDTHAHADHLSAADYVRQKTGAKVGIGAHITDVQKIFRPMFGPTSDTPDETVFDA
EEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
LFNEGDEFPLGNETIRVLHTPGHTAACLTYLIGDAAFVGDTVFMPDYGTARADFPGGDAH
HHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHCCEEECCCCCCCCCCCCCCHHH
ALYRSIRKLLALPPETRIFTGHDYLPEGRDKHAWESTVAQHRAANVHVHDGVSEEDFVTM
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCEEEEECCCCCCCEEEE
RTTRDKTLGAPRLILPSLQVNIRAGTLPPPESDGQTYLRLPVNRLGK
EECCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]