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The map label for this gene is nuoH

Identifier: 114799074

GI number: 114799074

Start: 1793651

End: 1794745

Strand: Direct

Name: nuoH

Synonym: HNE_1752

Alternate gene names: 114799074

Gene position: 1793651-1794745 (Clockwise)

Preceding gene: 114798223

Following gene: 114798298

Centisome position: 48.41

GC content: 57.08

Gene sequence:

>1095_bases
ATGAGCAACGCGATCGAGTCTCTTGGCAGCCTCTGGGGCCCGCTGCTGGTGCTGGGCCAGATAGGCCTGTTCACCCTGGT
GCTCTTGTTGTCGATTGCCTTCCTTCTGCTGCTGGACCGCAAGGTCTGGGCAGGGGTGATGATGCGCAAAGGGCCAAACG
TTGTCGGCCCCTTTGGTCTGCTTCAGTCCTTTGCCGACTTTGGAAAATTCCTTCTGAAGGAAATCGTCATTCCGGCGGGC
GCCAACAAGGCGGTGTTCATTCTCGCGCCGATCCTGACCTGTACGCTGGCTTTCGTGACATGGGCGGCCATTCCGGTGGC
GCCAGGCACGGCAACCGGGACAAGTTGGGTCATCGCCAACCTGAATGTTGGCGTCCTCTACCTGTTCGCCATCTCTTCCC
TGGGTGTCTATGGCATCATCATGGGCGGCTGGGCCTCAAACTCGAAATACCCGTTCCTGGGCGCCCTACGTTCGGCGGCA
CAGATGGTCTCCTATGAGGTATCCATCGGCTTCGTGATCGTCACGGTGATCCTGCTGGTAGGGTCGATGAACCTGACCAC
CATCGTGAACAACCAGGACGGCGGCATCCAGAACTGGCACGTGTTCAGCTTTCAGTATTTCCCGCTGATTGTCGTCATGG
TGCCGATGTTCGTGATTTTCTTTATCTCGGCGTTGGCAGAAACCAACCGGCCACCTTTCGATCTGCCTGAAGCGGAGTCC
GAACTCGTGGCGGGCTATCAGGTCGAATATGGTTCGACGCCGTATCTCCTCTTTATGCTCGGGGAATATCTCAACATTGT
GCTCATGTGCGCGATGATGACGATCCTTTTCCTGGGGGGATGGCATGGCCCGATCTCGCTAGGACCGGAATTGACGGCAA
ATCTGCCGCCGTTGCTTCTCAGTCTTTCCGGGCTAGCCTGGTTCATGGGCAAGGTGCTGTTCTGCTTCTTCCTGTTCGCA
CTGGTGAAGGCCATCGTGCCGCGCTACCGCTATGATCAACTGATGCGTCTAGGCTGGAAAATCTTCCTGCCGACATCGCT
GGCGGCGGTCATCATCGTGGCAGGTTATGTGACATTCGTGGGAGGTCTCTCATGA

Upstream 100 bases:

>100_bases
CCTCACCAACCCCATTGCACGGGCATCCAAGACAATGGCCGAGTGTTCTGCGCTGGCAAGCCGCCTAGACACTCCGGTAG
CGGCAGAGTAGGGCGGCGCC

Downstream 100 bases:

>100_bases
GCCTTGCGCAGACACTTCGCGGCGCGCTGCTGACAGATTTCATGGGCGCAGCCTGGATTGCGGTGCGGGAAATGTTCCGG
CGCAAGGCGACCGTGAATTA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSNAIESLGSLWGPLLVLGQIGLFTLVLLLSIAFLLLLDRKVWAGVMMRKGPNVVGPFGLLQSFADFGKFLLKEIVIPAG
ANKAVFILAPILTCTLAFVTWAAIPVAPGTATGTSWVIANLNVGVLYLFAISSLGVYGIIMGGWASNSKYPFLGALRSAA
QMVSYEVSIGFVIVTVILLVGSMNLTTIVNNQDGGIQNWHVFSFQYFPLIVVMVPMFVIFFISALAETNRPPFDLPEAES
ELVAGYQVEYGSTPYLLFMLGEYLNIVLMCAMMTILFLGGWHGPISLGPELTANLPPLLLSLSGLAWFMGKVLFCFFLFA
LVKAIVPRYRYDQLMRLGWKIFLPTSLAAVIIVAGYVTFVGGLS

Sequences:

>Translated_364_residues
MSNAIESLGSLWGPLLVLGQIGLFTLVLLLSIAFLLLLDRKVWAGVMMRKGPNVVGPFGLLQSFADFGKFLLKEIVIPAG
ANKAVFILAPILTCTLAFVTWAAIPVAPGTATGTSWVIANLNVGVLYLFAISSLGVYGIIMGGWASNSKYPFLGALRSAA
QMVSYEVSIGFVIVTVILLVGSMNLTTIVNNQDGGIQNWHVFSFQYFPLIVVMVPMFVIFFISALAETNRPPFDLPEAES
ELVAGYQVEYGSTPYLLFMLGEYLNIVLMCAMMTILFLGGWHGPISLGPELTANLPPLLLSLSGLAWFMGKVLFCFFLFA
LVKAIVPRYRYDQLMRLGWKIFLPTSLAAVIIVAGYVTFVGGLS
>Mature_363_residues
SNAIESLGSLWGPLLVLGQIGLFTLVLLLSIAFLLLLDRKVWAGVMMRKGPNVVGPFGLLQSFADFGKFLLKEIVIPAGA
NKAVFILAPILTCTLAFVTWAAIPVAPGTATGTSWVIANLNVGVLYLFAISSLGVYGIIMGGWASNSKYPFLGALRSAAQ
MVSYEVSIGFVIVTVILLVGSMNLTTIVNNQDGGIQNWHVFSFQYFPLIVVMVPMFVIFFISALAETNRPPFDLPEAESE
LVAGYQVEYGSTPYLLFMLGEYLNIVLMCAMMTILFLGGWHGPISLGPELTANLPPLLLSLSGLAWFMGKVLFCFFLFAL
VKAIVPRYRYDQLMRLGWKIFLPTSLAAVIIVAGYVTFVGGLS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=318, Percent_Identity=41.8238993710692, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1788618, Length=332, Percent_Identity=39.1566265060241, Blast_Score=227, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_HYPNA (Q0C1D7)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760456.1
- STRING:   Q0C1D7
- GeneID:   4287728
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1752
- NMPDR:   fig|228405.5.peg.1687
- TIGR:   HNE_1752
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q0C1D7
- ProtClustDB:   PRK06076
- BioCyc:   HNEP81032:HNE_1752-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39506; Mature: 39375

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2; PS00389 ATPASE_DELTA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13ac6748)-; HASH(0x13de2980)-; HASH(0x13deb4a4)-; HASH(0x13deb714)-; HASH(0x13bf537c)-; HASH(0x131b9600)-; HASH(0x139ac884)-; HASH(0x13dc964c)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAIESLGSLWGPLLVLGQIGLFTLVLLLSIAFLLLLDRKVWAGVMMRKGPNVVGPFGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LQSFADFGKFLLKEIVIPAGANKAVFILAPILTCTLAFVTWAAIPVAPGTATGTSWVIAN
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
LNVGVLYLFAISSLGVYGIIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVILLV
CCHHHHHHHHHHHCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSMNLTTIVNNQDGGIQNWHVFSFQYFPLIVVMVPMFVIFFISALAETNRPPFDLPEAES
CCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
ELVAGYQVEYGSTPYLLFMLGEYLNIVLMCAMMTILFLGGWHGPISLGPELTANLPPLLL
HHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
SLSGLAWFMGKVLFCFFLFALVKAIVPRYRYDQLMRLGWKIFLPTSLAAVIIVAGYVTFV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHH
GGLS
CCCH
>Mature Secondary Structure 
SNAIESLGSLWGPLLVLGQIGLFTLVLLLSIAFLLLLDRKVWAGVMMRKGPNVVGPFGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LQSFADFGKFLLKEIVIPAGANKAVFILAPILTCTLAFVTWAAIPVAPGTATGTSWVIAN
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
LNVGVLYLFAISSLGVYGIIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVILLV
CCHHHHHHHHHHHCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSMNLTTIVNNQDGGIQNWHVFSFQYFPLIVVMVPMFVIFFISALAETNRPPFDLPEAES
CCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
ELVAGYQVEYGSTPYLLFMLGEYLNIVLMCAMMTILFLGGWHGPISLGPELTANLPPLLL
HHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
SLSGLAWFMGKVLFCFFLFALVKAIVPRYRYDQLMRLGWKIFLPTSLAAVIIVAGYVTFV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHH
GGLS
CCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA