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The map label for this gene is cysA [H]

Identifier: 114799026

GI number: 114799026

Start: 1232467

End: 1233588

Strand: Reverse

Name: cysA [H]

Synonym: HNE_1212

Alternate gene names: 114799026

Gene position: 1233588-1232467 (Counterclockwise)

Preceding gene: 114797773

Following gene: 114797592

Centisome position: 33.3

GC content: 67.2

Gene sequence:

>1122_bases
TTGGCTGACGAACTCTCCCCCATCTCGCGCCTGCTGCACCGGCGGGGTGAAAGCCTGCAAAAAGGTGATCCGGTCGCCCT
GCCCATCGTGGCGTCGACGACGTTTCATCTGCCGGGCGACCCGCAGGCGAGCCATGTGTATGGCCGCTATGGCAACCCGA
CGGTGGAGGAAGTGGAGGCCGAGATCGGCCTGCTGGAAGGGGCCGAGGCGGTGCTGTTTCCGTCCGGCATGGCGGCGATT
GCGGCGGTGTTTTACGCCCATCTGAAACCGGGTGACCGGGTGCTGGTGCATGCGGACGGCTATTACAATGCCCGCGCGCT
GCTGGAGGCGTATTTTGCGCCGCTGGGCGTGGATATTGCCACCTGCCCGACGGCGGACATGGCGGAAGCCGATCTGACAG
GCGTGAAGCTGGTGCTGGCGGAGACGCCGTCCAATCCGGGGCTGGAGGTGTGCGACCTCGCCAAGCTGGCGCGCAATGCG
AAGGATGCAGGCGCGCTGCTGGCGGTGGACAACACCACGGCCACACCGCTGTGCCAGCGACCGCTGGACCTGGGGGCCGA
CTTTGCCATCATGGCCGATACAAAGGCGATGGCGGGGCATTCGGACATTCTGGCCGGACATGTGGCGAGCCGTGACCCGG
CGCTGATGGCGCCGGTGAAGACCTGGCGGCGACTGGGCGGGGCGATCTGCAGCCCGTTTGATGCCTATCTGCTGCACCGG
GGGCTCGCCACGCTGGAGCTGCGCGTGGCGCGGGCGAATGCCAATGCGCTGGCGGTTGCCAATGCGCTGGCGGGCATCGA
GGGGGTGGCGGGCCTGCGCTATCCGGGGCTGGCGACGGACCCCGCGCATGACATCGCACGCAAGCAAATGAGCGGGTACG
GACCAATTGTGAGCTTTTGCCTGCCGAGCCGGGAGCTGGCTGAAGCGTTCATCGCGCGCCACCCCCTGCTGACGCCGTCC
ACGAGCTTTGGCGGTGTGCATTCGGCGGCCGAATGCCGGGTGCGCTGGGGGGATCATGTGGCGCCGGGGTTCATCCGCAT
GGCGTGCGGGATAGAGCCTGTGGCTGACCTGACCGGCGCAACGATCCGGACGCTGGATTCCCTTAACCTTCGCGGTGCTT
AG

Upstream 100 bases:

>100_bases
CAGGTGAAGTGTCTTGCGAGCCTGCGCGAGGAGTGGCAGCGGCTGGACGAGAACACACGCGGCGCAATTGCGCGCCTCAT
TGGCCCCGGAGCAGACATAC

Downstream 100 bases:

>100_bases
GGGTTAGCCAGAGGCTGGCAGGGCCGTTATGATGGCCGCAGATTCGAGTTGTTGCGGGGTCCGGCGATGCGCCGTTTTGG
TATAGTTGTTCTCTTGCTCC

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: Gamma-cystathionase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MADELSPISRLLHRRGESLQKGDPVALPIVASTTFHLPGDPQASHVYGRYGNPTVEEVEAEIGLLEGAEAVLFPSGMAAI
AAVFYAHLKPGDRVLVHADGYYNARALLEAYFAPLGVDIATCPTADMAEADLTGVKLVLAETPSNPGLEVCDLAKLARNA
KDAGALLAVDNTTATPLCQRPLDLGADFAIMADTKAMAGHSDILAGHVASRDPALMAPVKTWRRLGGAICSPFDAYLLHR
GLATLELRVARANANALAVANALAGIEGVAGLRYPGLATDPAHDIARKQMSGYGPIVSFCLPSRELAEAFIARHPLLTPS
TSFGGVHSAAECRVRWGDHVAPGFIRMACGIEPVADLTGATIRTLDSLNLRGA

Sequences:

>Translated_373_residues
MADELSPISRLLHRRGESLQKGDPVALPIVASTTFHLPGDPQASHVYGRYGNPTVEEVEAEIGLLEGAEAVLFPSGMAAI
AAVFYAHLKPGDRVLVHADGYYNARALLEAYFAPLGVDIATCPTADMAEADLTGVKLVLAETPSNPGLEVCDLAKLARNA
KDAGALLAVDNTTATPLCQRPLDLGADFAIMADTKAMAGHSDILAGHVASRDPALMAPVKTWRRLGGAICSPFDAYLLHR
GLATLELRVARANANALAVANALAGIEGVAGLRYPGLATDPAHDIARKQMSGYGPIVSFCLPSRELAEAFIARHPLLTPS
TSFGGVHSAAECRVRWGDHVAPGFIRMACGIEPVADLTGATIRTLDSLNLRGA
>Mature_372_residues
ADELSPISRLLHRRGESLQKGDPVALPIVASTTFHLPGDPQASHVYGRYGNPTVEEVEAEIGLLEGAEAVLFPSGMAAIA
AVFYAHLKPGDRVLVHADGYYNARALLEAYFAPLGVDIATCPTADMAEADLTGVKLVLAETPSNPGLEVCDLAKLARNAK
DAGALLAVDNTTATPLCQRPLDLGADFAIMADTKAMAGHSDILAGHVASRDPALMAPVKTWRRLGGAICSPFDAYLLHRG
LATLELRVARANANALAVANALAGIEGVAGLRYPGLATDPAHDIARKQMSGYGPIVSFCLPSRELAEAFIARHPLLTPST
SFGGVHSAAECRVRWGDHVAPGFIRMACGIEPVADLTGATIRTLDSLNLRGA

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=315, Percent_Identity=35.8730158730159, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI299473759, Length=312, Percent_Identity=33.0128205128205, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI25453487, Length=311, Percent_Identity=30.8681672025724, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1790375, Length=352, Percent_Identity=36.9318181818182, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1789383, Length=330, Percent_Identity=28.7878787878788, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71980708, Length=388, Percent_Identity=32.2164948453608, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17538055, Length=354, Percent_Identity=33.6158192090396, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17560056, Length=354, Percent_Identity=33.8983050847458, Blast_Score=165, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319307, Length=366, Percent_Identity=33.3333333333333, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321904, Length=352, Percent_Identity=27.5568181818182, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6321254, Length=371, Percent_Identity=27.4932614555256, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6321170, Length=296, Percent_Identity=28.3783783783784, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922554, Length=352, Percent_Identity=32.9545454545455, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1 [H]

Molecular weight: Translated: 39120; Mature: 38989

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADELSPISRLLHRRGESLQKGDPVALPIVASTTFHLPGDPQASHVYGRYGNPTVEEVEA
CCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCEECCCCCCHHHHHHH
EIGLLEGAEAVLFPSGMAAIAAVFYAHLKPGDRVLVHADGYYNARALLEAYFAPLGVDIA
HHHHHCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEE
TCPTADMAEADLTGVKLVLAETPSNPGLEVCDLAKLARNAKDAGALLAVDNTTATPLCQR
CCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHC
PLDLGADFAIMADTKAMAGHSDILAGHVASRDPALMAPVKTWRRLGGAICSPFDAYLLHR
CHHCCCCEEEEECCHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCHHCCHHHHHHHHC
GLATLELRVARANANALAVANALAGIEGVAGLRYPGLATDPAHDIARKQMSGYGPIVSFC
CCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHH
LPSRELAEAFIARHPLLTPSTSFGGVHSAAECRVRWGDHVAPGFIRMACGIEPVADLTGA
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEECCCCCCCHHHHHHCCCCHHHHHCCC
TIRTLDSLNLRGA
HHHHHHCCCCCCC
>Mature Secondary Structure 
ADELSPISRLLHRRGESLQKGDPVALPIVASTTFHLPGDPQASHVYGRYGNPTVEEVEA
CCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCEECCCCCCHHHHHHH
EIGLLEGAEAVLFPSGMAAIAAVFYAHLKPGDRVLVHADGYYNARALLEAYFAPLGVDIA
HHHHHCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEE
TCPTADMAEADLTGVKLVLAETPSNPGLEVCDLAKLARNAKDAGALLAVDNTTATPLCQR
CCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHC
PLDLGADFAIMADTKAMAGHSDILAGHVASRDPALMAPVKTWRRLGGAICSPFDAYLLHR
CHHCCCCEEEEECCHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCHHCCHHHHHHHHC
GLATLELRVARANANALAVANALAGIEGVAGLRYPGLATDPAHDIARKQMSGYGPIVSFC
CCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHH
LPSRELAEAFIARHPLLTPSTSFGGVHSAAECRVRWGDHVAPGFIRMACGIEPVADLTGA
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEECCCCCCCHHHHHHCCCCHHHHHCCC
TIRTLDSLNLRGA
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953; 8550407 [H]