Click here to switch to the map view.

The map label for this gene is hemF [H]

Identifier: 114798887

GI number: 114798887

Start: 342121

End: 343014

Strand: Reverse

Name: hemF [H]

Synonym: HNE_0349

Alternate gene names: 114798887

Gene position: 343014-342121 (Counterclockwise)

Preceding gene: 114799643

Following gene: 114799543

Centisome position: 9.26

GC content: 63.53

Gene sequence:

>894_bases
ATGACCGATACAGAGACTGCCGGCTTTACCGGCCGCAAGGCGCAGGCGAGCGCCTGGTTCCGCGCCCTTCAGGAAGAGAT
CATTGGCCGCTTCGAGGCGATCGAAGACGCGGCTGTGCCACCGCTCTATCGCGGCGAGGCCGGGCGATTCGATCTGAAGG
CGTGGCGCCGGGGCGATGGCAGCGAAGACCTGGGCGGGGGCCGGATGGGCCTGATGCGCGGCAAGGTGTTCGAGAAGGTG
GGCGTCCACTTCTCAGAGGTGCACGGCACGTTTTCCGAAGCGTTTGCGGCGCAGATACCCGGCGCGGACAAGTCCGGCGG
ACGGTTCTGGGCCAGTGGCATCTCCTTGATTGCGCATCCTTTGAACCCGCGCGTGCCCGCCGCGCACATGAACACGCGCA
TGCTGGTGACCAGTGAAGCCTGGTTTGGCGGGGGCGGCGACCTCACCCCCCTGCTCGCCTATCAGCGCGATCAGGACTTT
GTGGATACGGTGGATTTTCACGCCGCGATGAAGGCGGCCTGCGATACCCATCCCGGCGCCGATTACGCGCACATGAAAGA
GCATTGCGAGACCTATTTCCACCTGCCCCATCGCAGCGAGCCGCGGGGCACGGGCGGCATCTTCTATGACCGGTTCAATA
CCGGCGACTGGGAGGCCGATTTTGCCTTCACTCAGGAAGTGGGGCGGAAATTTGCCGATATATATCCGGGCCTTGTACGC
CGCCGGATGATCGAGCCGTGGAGTGAGGCCGAGCGCGAGGCGCAGCTGATCCAGCGGGGGCGGTATGTGGAATATAACCT
GCTCTATGACCGGGGCACGACCTTTGGCCTGAAGACCGGCGGAAACATCGAGAGCATTCTTTCTTCGATGCCGCCGGTGG
TGAAATGGCCCTGA

Upstream 100 bases:

>100_bases
CGCGTCCAGCCCCCAGTTGGATGAGGGCGTTACCGCGCAACCGCCCCTGTGACAACAGGGGACTTGCGAGGCAAATGCCC
ACAGGCAACAGTCGGGCATG

Downstream 100 bases:

>100_bases
AAGATCAGAGTTTTTCGCAGGAGCGGCGGAGCCAGGCGGCGTAGCCCTCCTCACTTACTTCACTTGCAGCAAGCTGAAGC
GTGAAGGCCAGGCGCTCTGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTDTETAGFTGRKAQASAWFRALQEEIIGRFEAIEDAAVPPLYRGEAGRFDLKAWRRGDGSEDLGGGRMGLMRGKVFEKV
GVHFSEVHGTFSEAFAAQIPGADKSGGRFWASGISLIAHPLNPRVPAAHMNTRMLVTSEAWFGGGGDLTPLLAYQRDQDF
VDTVDFHAAMKAACDTHPGADYAHMKEHCETYFHLPHRSEPRGTGGIFYDRFNTGDWEADFAFTQEVGRKFADIYPGLVR
RRMIEPWSEAEREAQLIQRGRYVEYNLLYDRGTTFGLKTGGNIESILSSMPPVVKWP

Sequences:

>Translated_297_residues
MTDTETAGFTGRKAQASAWFRALQEEIIGRFEAIEDAAVPPLYRGEAGRFDLKAWRRGDGSEDLGGGRMGLMRGKVFEKV
GVHFSEVHGTFSEAFAAQIPGADKSGGRFWASGISLIAHPLNPRVPAAHMNTRMLVTSEAWFGGGGDLTPLLAYQRDQDF
VDTVDFHAAMKAACDTHPGADYAHMKEHCETYFHLPHRSEPRGTGGIFYDRFNTGDWEADFAFTQEVGRKFADIYPGLVR
RRMIEPWSEAEREAQLIQRGRYVEYNLLYDRGTTFGLKTGGNIESILSSMPPVVKWP
>Mature_296_residues
TDTETAGFTGRKAQASAWFRALQEEIIGRFEAIEDAAVPPLYRGEAGRFDLKAWRRGDGSEDLGGGRMGLMRGKVFEKVG
VHFSEVHGTFSEAFAAQIPGADKSGGRFWASGISLIAHPLNPRVPAAHMNTRMLVTSEAWFGGGGDLTPLLAYQRDQDFV
DTVDFHAAMKAACDTHPGADYAHMKEHCETYFHLPHRSEPRGTGGIFYDRFNTGDWEADFAFTQEVGRKFADIYPGLVRR
RMIEPWSEAEREAQLIQRGRYVEYNLLYDRGTTFGLKTGGNIESILSSMPPVVKWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=260, Percent_Identity=41.9230769230769, Blast_Score=178, Evalue=6e-45,
Organism=Escherichia coli, GI1788777, Length=270, Percent_Identity=41.8518518518518, Blast_Score=201, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320249, Length=308, Percent_Identity=36.038961038961, Blast_Score=179, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17864388, Length=260, Percent_Identity=40.3846153846154, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 33117; Mature: 32985

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTETAGFTGRKAQASAWFRALQEEIIGRFEAIEDAAVPPLYRGEAGRFDLKAWRRGDG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
SEDLGGGRMGLMRGKVFEKVGVHFSEVHGTFSEAFAAQIPGADKSGGRFWASGISLIAHP
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCC
LNPRVPAAHMNTRMLVTSEAWFGGGGDLTPLLAYQRDQDFVDTVDFHAAMKAACDTHPGA
CCCCCCCHHCCCEEEEEECCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
DYAHMKEHCETYFHLPHRSEPRGTGGIFYDRFNTGDWEADFAFTQEVGRKFADIYPGLVR
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RRMIEPWSEAEREAQLIQRGRYVEYNLLYDRGTTFGLKTGGNIESILSSMPPVVKWP
HHHCCCHHHHHHHHHHHHCCCEEEEEEEEECCCEEEECCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDTETAGFTGRKAQASAWFRALQEEIIGRFEAIEDAAVPPLYRGEAGRFDLKAWRRGDG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
SEDLGGGRMGLMRGKVFEKVGVHFSEVHGTFSEAFAAQIPGADKSGGRFWASGISLIAHP
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCC
LNPRVPAAHMNTRMLVTSEAWFGGGGDLTPLLAYQRDQDFVDTVDFHAAMKAACDTHPGA
CCCCCCCHHCCCEEEEEECCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
DYAHMKEHCETYFHLPHRSEPRGTGGIFYDRFNTGDWEADFAFTQEVGRKFADIYPGLVR
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RRMIEPWSEAEREAQLIQRGRYVEYNLLYDRGTTFGLKTGGNIESILSSMPPVVKWP
HHHCCCHHHHHHHHHHHHCCCEEEEEEEEECCCEEEECCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA