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The map label for this gene is uvrD [H]

Identifier: 114798822

GI number: 114798822

Start: 3097054

End: 3099399

Strand: Reverse

Name: uvrD [H]

Synonym: HNE_2938

Alternate gene names: 114798822

Gene position: 3099399-3097054 (Counterclockwise)

Preceding gene: 114797131

Following gene: 114800181

Centisome position: 83.65

GC content: 63.64

Gene sequence:

>2346_bases
ATGTTCCTGATGAGTTCTAACCCGAATCGTCTCTCCATCAGCCAGATGGCATCTGCCCGCCCGCCCGTGCCCACGGGCGA
TGGCGCGGCCTATCTCAATGGCCTGAACCCGGAGCAGCGCGACGCCGTGCTGCACACCGAAGGCCCGCTGCTGGTGCTGG
CCGGTGCCGGTACGGGCAAGACGCGCGTGCTTACCTCGCGGCTCGCCCATATCGTTGCCACGCGCCTTGCCTATCCCTCG
CAGACGCTGACGGTGACCTTCACCAACAAGGCCGCCCGCGAAATGCGCGAGCGGGCCCAGGCATTGCTGGGGGACGCGGG
CGAGGGGCTGAGATGGCTCGGCACGTTCCACTCCATCTCGGCGCAGATCCTGCGTAAGCATGCCGAGCTCGTCGGCCTGA
AATCCAGCTTCACCATCCTCGATACCGACGACCAGATCCGCCTCTGCAAGCAGATCGTCCAGGCCGAAAACCTTGATCCC
AAGCGCTGGACCCCGCGTTATCTCGCCGGTCTCATCGATGGCTGGAAGAACCGCGCGCTGACGCCCTCAAAGGTGCCGCC
CGAAGAGGCCGAACTGTTCGGCAATGGAAAGGCGATCAAATGCTACGAGATCTATCAGGCGCGGTTGAGGGTGCTCAACG
CCTGCGACTTTGGCGATCTGCTGATCCACAACATCACGATCTTTCAGGAAAGCCCTGATATTCTTCGCGAATATCATGAC
CGCTTCCGCTACATTCTGGTCGATGAGTATCAGGATACCAACGTCGCTCAGTATCTCTGGCTGCGCCTCCTCGCGCAGGG
CTCGAAGAACCTCTGCTGCGTGGGCGATGACGACCAGTCGATCTATGGCTGGCGCGGCGCCGAGGTCGACAACATCCTGC
GCTTCGAGAAGGACTTTCCCGGCGCCAAGGTCGTTCGCCTGGAGCGTAACTACCGCTCCACCCGCCACATCCTGGCGGCC
GCTTCCAGCGTCATCGCGCACAATAAGGGCCGTCTCGGCAAGACGCTGTATGTCGGCAATGACAGCGCCGTAAACGAGGA
TACCGACGCACCGAAGGTAAAGGTGCGCGGCCTCTGGGACGGGGAGGCGGAAAGCCGCCTGATCGCCGACGACATCGAAA
GCTGGGTGCGCGGCGGCGGGCGCCATGATGGCTGCGCCGTGCTCGTGCGCGCCTCCTGGCAGATGCGGGCGTTTGAAGAA
CGCTTCATCCTTCTGGGCATTCCCTACCGCGTCATCGGCGGCCCGCGCTTCTTCGAGCGCGCCGAAATCCGCGATGCAAT
GGCCTATCTGCGCCTCATCCGCTCGCCTGATGATGACCTGGCATTTGAGCGCGTGGTGAACGAGCCCAAGCGCGGGGTGG
GGGATACCAGCCTCGCCAAACTGCAATCCTATGCCCGCCAGGACGGGCGCAGCCTGTTCACGCTCACCCCTATGGTGCTG
CAAACCGATGAGATCAAAGGCGGCGCCAAGCGCGGCCTGACGACGTTCATCGACCAGATCAACCTCTGGCGCGGCAAGCT
CGCCGGTGGGATGCCGCACACAGAACTCGCCGAGATGATCCTCGAAGAGTCCGGCTATACCGACATGCTGCAGAAGGACC
GCAGCCCTCAGGCGCAGACCCGGCTCGACAACCTCAAGGAACTCGTCCGCGCCATGGGCGAGTTCGACACGCTGGCCGGC
TTCCTGGAACATGTGGAGCTGGTGATGGACGCCTCGGCGGGCGGAAACGGCGAGGATCAGGTGCAGATTCTCACCCTCCA
CGCCGCCAAGGGCCTTGAATGGCCAGTGGTTTTCCTGCCCGGCTGGGAAGAGGAAGTGTTCCCCTCCCGCCGCAGCCTCG
ATGAAAGCGGCCTCAAGGGCCTCGAGGAAGAGCGCCGCCTCGCCTATGTCGGCATCACGCGCGCGCGGGAGCGGTGTTAC
ATCTCCTTCGTCGCCAACCGGCAAATTTACGGCCGCTGGCAGGCGGTGATGCCCAGCCGCTTCATTGACGAGCTGCCGCC
CGAACATGTCGATGCTGTCTCGGAGACAGGCTATTCCGGCCTGCCCGCCAGCGCCGACGCCTTTTCCGGTACGATCGAGG
ATCTGGGCGAGCGCTCTGATTATCAGAGCCCCGGCTGGAAGCGCCTCAAGGAAAATGCAGGCCGGCCCACAGGCGCCCCG
CCACGTGATGCTGCCGGGCTGACCGCCACCGCCTCGGGCACTTCCGGCTTTACCACCGGCGCCCGCGTCTTCCATGACAA
GTTTGGCTATGGCCGCGTCGCCTTCTCCGAGGGCAACAAGCTGACCGTCGATTTCGACAAGACCGGCCGCAAGAAAGTCA
TCGCCACCTTCGTGACGAAAGCCTGA

Upstream 100 bases:

>100_bases
CGCGAGGTATCTGGCGAAAATTCATGCCTCTCTAACGCGGCAAAACCGATTCGGTTCATAATGTGCAGTCAGACCTGCCT
ATTATGGCAGGCCCTGCTAT

Downstream 100 bases:

>100_bases
TTTCCGGCGTCCTGGAGATTTGCAGCGCCGGAAGGCGTTTGCCAGGCAACGGGGGGCAGGGGTGCCCGGCGACACAGTAT
GGCTGGGAGAGGGATAGCAA

Product: putative DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 781; Mature: 781

Protein sequence:

>781_residues
MFLMSSNPNRLSISQMASARPPVPTGDGAAYLNGLNPEQRDAVLHTEGPLLVLAGAGTGKTRVLTSRLAHIVATRLAYPS
QTLTVTFTNKAAREMRERAQALLGDAGEGLRWLGTFHSISAQILRKHAELVGLKSSFTILDTDDQIRLCKQIVQAENLDP
KRWTPRYLAGLIDGWKNRALTPSKVPPEEAELFGNGKAIKCYEIYQARLRVLNACDFGDLLIHNITIFQESPDILREYHD
RFRYILVDEYQDTNVAQYLWLRLLAQGSKNLCCVGDDDQSIYGWRGAEVDNILRFEKDFPGAKVVRLERNYRSTRHILAA
ASSVIAHNKGRLGKTLYVGNDSAVNEDTDAPKVKVRGLWDGEAESRLIADDIESWVRGGGRHDGCAVLVRASWQMRAFEE
RFILLGIPYRVIGGPRFFERAEIRDAMAYLRLIRSPDDDLAFERVVNEPKRGVGDTSLAKLQSYARQDGRSLFTLTPMVL
QTDEIKGGAKRGLTTFIDQINLWRGKLAGGMPHTELAEMILEESGYTDMLQKDRSPQAQTRLDNLKELVRAMGEFDTLAG
FLEHVELVMDASAGGNGEDQVQILTLHAAKGLEWPVVFLPGWEEEVFPSRRSLDESGLKGLEEERRLAYVGITRARERCY
ISFVANRQIYGRWQAVMPSRFIDELPPEHVDAVSETGYSGLPASADAFSGTIEDLGERSDYQSPGWKRLKENAGRPTGAP
PRDAAGLTATASGTSGFTTGARVFHDKFGYGRVAFSEGNKLTVDFDKTGRKKVIATFVTKA

Sequences:

>Translated_781_residues
MFLMSSNPNRLSISQMASARPPVPTGDGAAYLNGLNPEQRDAVLHTEGPLLVLAGAGTGKTRVLTSRLAHIVATRLAYPS
QTLTVTFTNKAAREMRERAQALLGDAGEGLRWLGTFHSISAQILRKHAELVGLKSSFTILDTDDQIRLCKQIVQAENLDP
KRWTPRYLAGLIDGWKNRALTPSKVPPEEAELFGNGKAIKCYEIYQARLRVLNACDFGDLLIHNITIFQESPDILREYHD
RFRYILVDEYQDTNVAQYLWLRLLAQGSKNLCCVGDDDQSIYGWRGAEVDNILRFEKDFPGAKVVRLERNYRSTRHILAA
ASSVIAHNKGRLGKTLYVGNDSAVNEDTDAPKVKVRGLWDGEAESRLIADDIESWVRGGGRHDGCAVLVRASWQMRAFEE
RFILLGIPYRVIGGPRFFERAEIRDAMAYLRLIRSPDDDLAFERVVNEPKRGVGDTSLAKLQSYARQDGRSLFTLTPMVL
QTDEIKGGAKRGLTTFIDQINLWRGKLAGGMPHTELAEMILEESGYTDMLQKDRSPQAQTRLDNLKELVRAMGEFDTLAG
FLEHVELVMDASAGGNGEDQVQILTLHAAKGLEWPVVFLPGWEEEVFPSRRSLDESGLKGLEEERRLAYVGITRARERCY
ISFVANRQIYGRWQAVMPSRFIDELPPEHVDAVSETGYSGLPASADAFSGTIEDLGERSDYQSPGWKRLKENAGRPTGAP
PRDAAGLTATASGTSGFTTGARVFHDKFGYGRVAFSEGNKLTVDFDKTGRKKVIATFVTKA
>Mature_781_residues
MFLMSSNPNRLSISQMASARPPVPTGDGAAYLNGLNPEQRDAVLHTEGPLLVLAGAGTGKTRVLTSRLAHIVATRLAYPS
QTLTVTFTNKAAREMRERAQALLGDAGEGLRWLGTFHSISAQILRKHAELVGLKSSFTILDTDDQIRLCKQIVQAENLDP
KRWTPRYLAGLIDGWKNRALTPSKVPPEEAELFGNGKAIKCYEIYQARLRVLNACDFGDLLIHNITIFQESPDILREYHD
RFRYILVDEYQDTNVAQYLWLRLLAQGSKNLCCVGDDDQSIYGWRGAEVDNILRFEKDFPGAKVVRLERNYRSTRHILAA
ASSVIAHNKGRLGKTLYVGNDSAVNEDTDAPKVKVRGLWDGEAESRLIADDIESWVRGGGRHDGCAVLVRASWQMRAFEE
RFILLGIPYRVIGGPRFFERAEIRDAMAYLRLIRSPDDDLAFERVVNEPKRGVGDTSLAKLQSYARQDGRSLFTLTPMVL
QTDEIKGGAKRGLTTFIDQINLWRGKLAGGMPHTELAEMILEESGYTDMLQKDRSPQAQTRLDNLKELVRAMGEFDTLAG
FLEHVELVMDASAGGNGEDQVQILTLHAAKGLEWPVVFLPGWEEEVFPSRRSLDESGLKGLEEERRLAYVGITRARERCY
ISFVANRQIYGRWQAVMPSRFIDELPPEHVDAVSETGYSGLPASADAFSGTIEDLGERSDYQSPGWKRLKENAGRPTGAP
PRDAAGLTATASGTSGFTTGARVFHDKFGYGRVAFSEGNKLTVDFDKTGRKKVIATFVTKA

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=767, Percent_Identity=39.2438070404172, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI48994965, Length=651, Percent_Identity=36.2519201228879, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1787196, Length=358, Percent_Identity=29.8882681564246, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=467, Percent_Identity=33.1905781584582, Blast_Score=183, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6324477, Length=690, Percent_Identity=21.8840579710145, Blast_Score=104, Evalue=4e-23,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 86904; Mature: 86904

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLMSSNPNRLSISQMASARPPVPTGDGAAYLNGLNPEQRDAVLHTEGPLLVLAGAGTGK
CEEECCCCCEEEHHHHHCCCCCCCCCCCCCEECCCCCHHHCEEEECCCCEEEEECCCCCC
TRVLTSRLAHIVATRLAYPSQTLTVTFTNKAAREMRERAQALLGDAGEGLRWLGTFHSIS
HHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AQILRKHAELVGLKSSFTILDTDDQIRLCKQIVQAENLDPKRWTPRYLAGLIDGWKNRAL
HHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
TPSKVPPEEAELFGNGKAIKCYEIYQARLRVLNACDFGDLLIHNITIFQESPDILREYHD
CCCCCCCHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHEEEEEEECCHHHHHHHHH
RFRYILVDEYQDTNVAQYLWLRLLAQGSKNLCCVGDDDQSIYGWRGAEVDNILRFEKDFP
CCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCC
GAKVVRLERNYRSTRHILAAASSVIAHNKGRLGKTLYVGNDSAVNEDTDAPKVKVRGLWD
CCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEEC
GEAESRLIADDIESWVRGGGRHDGCAVLVRASWQMRAFEERFILLGIPYRVIGGPRFFER
CCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHCCEEEEECCHHCCCCCHHHHH
AEIRDAMAYLRLIRSPDDDLAFERVVNEPKRGVGDTSLAKLQSYARQDGRSLFTLTPMVL
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECHHHE
QTDEIKGGAKRGLTTFIDQINLWRGKLAGGMPHTELAEMILEESGYTDMLQKDRSPQAQT
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCCHHHH
RLDNLKELVRAMGEFDTLAGFLEHVELVMDASAGGNGEDQVQILTLHAAKGLEWPVVFLP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCEEEEC
GWEEEVFPSRRSLDESGLKGLEEERRLAYVGITRARERCYISFVANRQIYGRWQAVMPSR
CCCHHHCCCCCCCCHHHHCCCHHHHHEEEEEHHHHCCEEEEEEEECCCHHHHHHHHCCHH
FIDELPPEHVDAVSETGYSGLPASADAFSGTIEDLGERSDYQSPGWKRLKENAGRPTGAP
HHHHCCHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHCCCCCCCCCHHHHHHCCCCCCCCC
PRDAAGLTATASGTSGFTTGARVFHDKFGYGRVAFSEGNKLTVDFDKTGRKKVIATFVTK
CCCCCCCEEECCCCCCCCCCHHHHHHCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHC
A
C
>Mature Secondary Structure
MFLMSSNPNRLSISQMASARPPVPTGDGAAYLNGLNPEQRDAVLHTEGPLLVLAGAGTGK
CEEECCCCCEEEHHHHHCCCCCCCCCCCCCEECCCCCHHHCEEEECCCCEEEEECCCCCC
TRVLTSRLAHIVATRLAYPSQTLTVTFTNKAAREMRERAQALLGDAGEGLRWLGTFHSIS
HHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AQILRKHAELVGLKSSFTILDTDDQIRLCKQIVQAENLDPKRWTPRYLAGLIDGWKNRAL
HHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
TPSKVPPEEAELFGNGKAIKCYEIYQARLRVLNACDFGDLLIHNITIFQESPDILREYHD
CCCCCCCHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHEEEEEEECCHHHHHHHHH
RFRYILVDEYQDTNVAQYLWLRLLAQGSKNLCCVGDDDQSIYGWRGAEVDNILRFEKDFP
CCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCC
GAKVVRLERNYRSTRHILAAASSVIAHNKGRLGKTLYVGNDSAVNEDTDAPKVKVRGLWD
CCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEEC
GEAESRLIADDIESWVRGGGRHDGCAVLVRASWQMRAFEERFILLGIPYRVIGGPRFFER
CCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHCCEEEEECCHHCCCCCHHHHH
AEIRDAMAYLRLIRSPDDDLAFERVVNEPKRGVGDTSLAKLQSYARQDGRSLFTLTPMVL
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECHHHE
QTDEIKGGAKRGLTTFIDQINLWRGKLAGGMPHTELAEMILEESGYTDMLQKDRSPQAQT
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCCHHHH
RLDNLKELVRAMGEFDTLAGFLEHVELVMDASAGGNGEDQVQILTLHAAKGLEWPVVFLP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCEEEEC
GWEEEVFPSRRSLDESGLKGLEEERRLAYVGITRARERCYISFVANRQIYGRWQAVMPSR
CCCHHHCCCCCCCCHHHHCCCHHHHHEEEEEHHHHCCEEEEEEEECCCHHHHHHHHCCHH
FIDELPPEHVDAVSETGYSGLPASADAFSGTIEDLGERSDYQSPGWKRLKENAGRPTGAP
HHHHCCHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHCCCCCCCCCHHHHHHCCCCCCCCC
PRDAAGLTATASGTSGFTTGARVFHDKFGYGRVAFSEGNKLTVDFDKTGRKKVIATFVTK
CCCCCCCEEECCCCCCCCCCHHHHHHCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA