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The map label for this gene is fabH

Identifier: 114798802

GI number: 114798802

Start: 1174473

End: 1175444

Strand: Direct

Name: fabH

Synonym: HNE_1162

Alternate gene names: 114798802

Gene position: 1174473-1175444 (Clockwise)

Preceding gene: 114797527

Following gene: 114798281

Centisome position: 31.7

GC content: 64.51

Gene sequence:

>972_bases
ATGGGAAGGCGCAGCTTTATCCGTGGAACCGGCAGCTACCTGCCTGAGCGCGTTCTGACGAATGACGAACTCTCGGAAAT
GGTTGAGACCACCGATGCGTGGATTCAGGAACGCACCGGCATCAAGAAGCGCCATGTGGCAGCCGATGGCGAGCTGACGT
CCGACATTGCCGTGCACGCAGCGCGGCGCGCGCTGGAGGCGGCGGGCATGCAGGCCAGCGAGATCGACCTGATCGTGCTG
GCGACGACGACGCCGGACCAGACCTTCCCGGCAACGGCGACGGCGGTTCAGGCAAAGCTCGGCACCGGGCCGGGCGCAGC
GTTTGATGTTCAGGCGGTGTGTTCGGGCTTCCTGTTCGCGCTGGCGACAGCTGACTCGCTGATGAAGCAGGGGCTGTTCC
ACAAGGCGCTGGTGATCGGCGCGGAGACGTTCACGCGCATCATCGACTGGTCGGACCGGGGCACCTGCGTGCTGTTTGGC
GATGGCGGCGGGGCGATCGTGCTGGAATGCGTGGAATGGGACGGGGCCGATGACGCCGGCGTCATCACCCACCATGTACG
CACGGACGGGACGAAATCGAACCTGCTCTATGTGGACGGGGGCGTCAGCTCCACCGGCACCATCGGCCATGTGCGGATGG
AAGGGAACAAGGTGTTCAAGCACGCGGTGACCAACATCTCCGCAGCCATCGAGGCGGTGTTGACGGAAACCGGGCTGACC
TCGGCGGACATCGACTGGTTCGTGCCCCACCAGGCCAACAAGCGTATCCTCGACGGGGTTGCCAAAAAGATGAGCATTCC
GGAGGAGAAGGTGGTCATCACGGTGAGCGAGCATGCCAACACCTCGGCAGCCTCGATCCCGCTGGCGCTGGACCATGTGG
TGCGCTCAGGCCGTGCAAAACCGGGCGATCTGATCCTCTCCGAGGCGATGGGCGGCGGCTTCTCCTGGGGTGCCAGCCTG
TTCCGGCTTTGA

Upstream 100 bases:

>100_bases
GTGATTACCGGACTGAGATTGCGGCCAATCTGGCGCGTGTCGGGTCCGGCGGTCTGGCAGCAGAGTAACGGCGCAAGGGC
GCCAGACGAGGATAGGTGGA

Downstream 100 bases:

>100_bases
GTCAGAAGAAATCTGACACAAATTTAGCTAACGCCCGCGCTAGGAATTCGTTAAGATTGCGGGTCTAGGCTTTTGAAAAG
AAACGGGCTGACAGAATGAG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MGRRSFIRGTGSYLPERVLTNDELSEMVETTDAWIQERTGIKKRHVAADGELTSDIAVHAARRALEAAGMQASEIDLIVL
ATTTPDQTFPATATAVQAKLGTGPGAAFDVQAVCSGFLFALATADSLMKQGLFHKALVIGAETFTRIIDWSDRGTCVLFG
DGGGAIVLECVEWDGADDAGVITHHVRTDGTKSNLLYVDGGVSSTGTIGHVRMEGNKVFKHAVTNISAAIEAVLTETGLT
SADIDWFVPHQANKRILDGVAKKMSIPEEKVVITVSEHANTSAASIPLALDHVVRSGRAKPGDLILSEAMGGGFSWGASL
FRL

Sequences:

>Translated_323_residues
MGRRSFIRGTGSYLPERVLTNDELSEMVETTDAWIQERTGIKKRHVAADGELTSDIAVHAARRALEAAGMQASEIDLIVL
ATTTPDQTFPATATAVQAKLGTGPGAAFDVQAVCSGFLFALATADSLMKQGLFHKALVIGAETFTRIIDWSDRGTCVLFG
DGGGAIVLECVEWDGADDAGVITHHVRTDGTKSNLLYVDGGVSSTGTIGHVRMEGNKVFKHAVTNISAAIEAVLTETGLT
SADIDWFVPHQANKRILDGVAKKMSIPEEKVVITVSEHANTSAASIPLALDHVVRSGRAKPGDLILSEAMGGGFSWGASL
FRL
>Mature_322_residues
GRRSFIRGTGSYLPERVLTNDELSEMVETTDAWIQERTGIKKRHVAADGELTSDIAVHAARRALEAAGMQASEIDLIVLA
TTTPDQTFPATATAVQAKLGTGPGAAFDVQAVCSGFLFALATADSLMKQGLFHKALVIGAETFTRIIDWSDRGTCVLFGD
GGGAIVLECVEWDGADDAGVITHHVRTDGTKSNLLYVDGGVSSTGTIGHVRMEGNKVFKHAVTNISAAIEAVLTETGLTS
ADIDWFVPHQANKRILDGVAKKMSIPEEKVVITVSEHANTSAASIPLALDHVVRSGRAKPGDLILSEAMGGGFSWGASLF
RL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=319, Percent_Identity=46.7084639498433, Blast_Score=291, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_HYPNA (Q0C312)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759881.1
- ProteinModelPortal:   Q0C312
- SMR:   Q0C312
- STRING:   Q0C312
- GeneID:   4289152
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1162
- NMPDR:   fig|228405.5.peg.1131
- TIGR:   HNE_1162
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q0C312
- BioCyc:   HNEP81032:HNE_1162-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34173; Mature: 34042

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 250-250 ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRRSFIRGTGSYLPERVLTNDELSEMVETTDAWIQERTGIKKRHVAADGELTSDIAVHA
CCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCHHHHHHHH
ARRALEAAGMQASEIDLIVLATTTPDQTFPATATAVQAKLGTGPGAAFDVQAVCSGFLFA
HHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHEECCCCCCCCEEHHHHHHHHHHH
LATADSLMKQGLFHKALVIGAETFTRIIDWSDRGTCVLFGDGGGAIVLECVEWDGADDAG
HHHHHHHHHHCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCEEEEEEEECCCCCCCC
VITHHVRTDGTKSNLLYVDGGVSSTGTIGHVRMEGNKVFKHAVTNISAAIEAVLTETGLT
EEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
SADIDWFVPHQANKRILDGVAKKMSIPEEKVVITVSEHANTSAASIPLALDHVVRSGRAK
CCCCEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHCCHHHHHHHHHCCCCC
PGDLILSEAMGGGFSWGASLFRL
CCCEEHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
GRRSFIRGTGSYLPERVLTNDELSEMVETTDAWIQERTGIKKRHVAADGELTSDIAVHA
CCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCHHHHHHHH
ARRALEAAGMQASEIDLIVLATTTPDQTFPATATAVQAKLGTGPGAAFDVQAVCSGFLFA
HHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHEECCCCCCCCEEHHHHHHHHHHH
LATADSLMKQGLFHKALVIGAETFTRIIDWSDRGTCVLFGDGGGAIVLECVEWDGADDAG
HHHHHHHHHHCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCEEEEEEEECCCCCCCC
VITHHVRTDGTKSNLLYVDGGVSSTGTIGHVRMEGNKVFKHAVTNISAAIEAVLTETGLT
EEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
SADIDWFVPHQANKRILDGVAKKMSIPEEKVVITVSEHANTSAASIPLALDHVVRSGRAK
CCCCEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHCCHHHHHHHHHCCCCC
PGDLILSEAMGGGFSWGASLFRL
CCCEEHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA