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The map label for this gene is lspA1 [H]

Identifier: 114798762

GI number: 114798762

Start: 869897

End: 870433

Strand: Direct

Name: lspA1 [H]

Synonym: HNE_0850

Alternate gene names: 114798762

Gene position: 869897-870433 (Clockwise)

Preceding gene: 114797776

Following gene: 114799408

Centisome position: 23.48

GC content: 61.27

Gene sequence:

>537_bases
ATGAAATTCTCGCCGCAGACAGCCTGGCCCTTCGCGGTGATTCCGCTCGTCGTCCTGTTCGATCAGGTGACGAAATGGCT
GATCCTGGCGGAAACGCGCCTGAATGGCCTTGCCTGCCTCTCTGATGGGCGCCTGTGCGGCCGGATCGAGGTTCCAGGGC
CCGTAGACCTCTCAATGGTGTGGAACCGGGGCATGAGCTATGGCCTGTTTCAGGCCGATGGGCTGATGCGCTGGGTGCTG
GCGGGGGTCATGGCGGCCATCGCCATCGGCTTTTTCCTCTGGCTTCTTCGCGCAGAAGGGCGTTTCCTGCGGCTCTCGCT
CGCCCTCGTGGTTGGCGGCGCCATCGGAAACCTGATCGACCGGGTGCGCTTTGGCGCTGTGGTCGACTTTGTAGACGTCA
ACGAGCTGACCTTCGGCTACTTCCCCTGGGTCTTCAACGTGGCCGACGCCGCCATCACAATCGGCGCGCTGCTCTTGTTT
GTAGACCAGTTCTTACTTTCGCGCCCGAAACAGGCTAACAGCCTGAAGCAAGGTTAA

Upstream 100 bases:

>100_bases
GCGGGGTAGGGCGCCGTAAAGCCTCCTCTCCACGGGAGAGGAGGCCTTCCCCTGCACAGAAGTGCTTGATCCCTCCGCCA
GCGTCTGCAATCTCACCCCC

Downstream 100 bases:

>100_bases
TCCACTCCAGTTCAAGCGGATCTCGTACAGTCACATGAAAAAGACCCTCCCGCTCCTCGCTGCCGGCCTCGCTCTTGGCG
TAACGGCTGCCTGTTCGGCC

Product: signal peptidase II

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MKFSPQTAWPFAVIPLVVLFDQVTKWLILAETRLNGLACLSDGRLCGRIEVPGPVDLSMVWNRGMSYGLFQADGLMRWVL
AGVMAAIAIGFFLWLLRAEGRFLRLSLALVVGGAIGNLIDRVRFGAVVDFVDVNELTFGYFPWVFNVADAAITIGALLLF
VDQFLLSRPKQANSLKQG

Sequences:

>Translated_178_residues
MKFSPQTAWPFAVIPLVVLFDQVTKWLILAETRLNGLACLSDGRLCGRIEVPGPVDLSMVWNRGMSYGLFQADGLMRWVL
AGVMAAIAIGFFLWLLRAEGRFLRLSLALVVGGAIGNLIDRVRFGAVVDFVDVNELTFGYFPWVFNVADAAITIGALLLF
VDQFLLSRPKQANSLKQG
>Mature_178_residues
MKFSPQTAWPFAVIPLVVLFDQVTKWLILAETRLNGLACLSDGRLCGRIEVPGPVDLSMVWNRGMSYGLFQADGLMRWVL
AGVMAAIAIGFFLWLLRAEGRFLRLSLALVVGGAIGNLIDRVRFGAVVDFVDVNELTFGYFPWVFNVADAAITIGALLLF
VDQFLLSRPKQANSLKQG

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=123, Percent_Identity=34.1463414634146, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 19622; Mature: 19622

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFSPQTAWPFAVIPLVVLFDQVTKWLILAETRLNGLACLSDGRLCGRIEVPGPVDLSMV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCHHHHH
WNRGMSYGLFQADGLMRWVLAGVMAAIAIGFFLWLLRAEGRFLRLSLALVVGGAIGNLID
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
RVRFGAVVDFVDVNELTFGYFPWVFNVADAAITIGALLLFVDQFLLSRPKQANSLKQG
HHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKFSPQTAWPFAVIPLVVLFDQVTKWLILAETRLNGLACLSDGRLCGRIEVPGPVDLSMV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCHHHHH
WNRGMSYGLFQADGLMRWVLAGVMAAIAIGFFLWLLRAEGRFLRLSLALVVGGAIGNLID
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
RVRFGAVVDFVDVNELTFGYFPWVFNVADAAITIGALLLFVDQFLLSRPKQANSLKQG
HHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA