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The map label for this gene is moeA1 [H]

Identifier: 114798744

GI number: 114798744

Start: 1577437

End: 1578621

Strand: Direct

Name: moeA1 [H]

Synonym: HNE_1553

Alternate gene names: 114798744

Gene position: 1577437-1578621 (Clockwise)

Preceding gene: 114799818

Following gene: 114797389

Centisome position: 42.58

GC content: 64.22

Gene sequence:

>1185_bases
ATGATTTCCTTCAATGAGGCACTCTCCCGCGTGATCGGCGTCGCGCTGCCATTGGGTTCTGAAAGCGTGTCCTTCGAAGC
CGCATCGGGTCGAGTGCTTTCCGAAGGGGTCACGGCGCGGTTTGCCATGCCGCGTACTGATGTCTCGGCCATGGATGGAT
ATGCCGTGCGTGAGGCCGATCTCAAGGATATTCCATTCAGCCTGATCATTGCCGGGGAGGCGGCTGCCGGCACGCTGCCA
GGCCAGCGGTTGCCGGAGCGCACGGCATTTCGCATCTTTACAGGCGCGCCGGTTCCCGACGGCGCAAACCGCGTGATCGT
TCAGGAAAACGCCGAACGCGCGGGCGATCGGGTCACCTTTCTTCGCCCACATGGACCTGGCCGCAATATTCGGGCCGCAG
GATCGGATTTCGCAGCGGGTGACCTGCTTGTGCCTGCCGGGATTCGCCTTGACTGGCGGGCTCTGACCACCGCTGCGGCC
GCAGACCAGGGCAGGATCTCTGTCTGGCGCCAACCGTGTGTGGTGATCCTGGCCACGGGTGATGAGTTGGCGGCGCCGGG
GCAGGCAATGGAAAGGCCCGGCGCCATCCCGGAAAGCGTCTCGCCTGGCATCGCCGCATTCGTTACCGCACATGGTGGCC
GTCTGTTGCGGTCCGAGCGCCTGCCGGATGTGCCCGAACTGCTTGGTGCGGCGGCTGCGCGCGCGCTGCAGGAGGCTGAT
CTGATCATCATGATTGGGGGCGCGTCAGTCGGTGACCGTGATTACTCGCGTTCGGTGTTTGGCGAAGCGCCTGATTATGT
TTTCCCAAAAGTAGCCATCAAGCCCGGCAAGCCCGTCTGGCTGGCGCGGATTGGTACCCGCCTCGTTCTTGGCCTTCCGG
GCAATCCAACGTCTGCCCTGGTCACCGCCCGGCTGCTGCTGGCGCCCCTCCTGACCGGGATGAGTGGCGGCGATGCGGCC
ACTGCCGTCGTGTTCGAGCAGGGCTGTTGCGCTGATCCTCTTCCTGCTTGCGGTGACCGGGAAACCTTCCTCCGGGCCCG
GATGACAGAACGCGGGCTTGTTCTGGCAGACTCGCAGGATTCAGGGAGCCAGCGGTCACTTGCGGCGTCAGATGCACTGA
TACGCCGTTTGCCTGGCGCACCGGCTGAACCGGCGGGCGCACCTGTTTCCTATATCCGCTTCTGA

Upstream 100 bases:

>100_bases
TGCTTAAAGCTGTCGACAAGGGTATTATCATTGAAGCGATCCGCCTTGAAGAGAAGAGCGGCGGCAAGTCCGGCGACTGG
CGGGCAGAGACCGAAGTGCC

Downstream 100 bases:

>100_bases
GACTTCAGGCTCATCCGACAGGAGACATAGATGACTGAAAACGAAAAAATCATCCGGGAATTCATAGCCGCCTGGTCGCG
TCTGGGCGTCGATGAAATTG

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MISFNEALSRVIGVALPLGSESVSFEAASGRVLSEGVTARFAMPRTDVSAMDGYAVREADLKDIPFSLIIAGEAAAGTLP
GQRLPERTAFRIFTGAPVPDGANRVIVQENAERAGDRVTFLRPHGPGRNIRAAGSDFAAGDLLVPAGIRLDWRALTTAAA
ADQGRISVWRQPCVVILATGDELAAPGQAMERPGAIPESVSPGIAAFVTAHGGRLLRSERLPDVPELLGAAAARALQEAD
LIIMIGGASVGDRDYSRSVFGEAPDYVFPKVAIKPGKPVWLARIGTRLVLGLPGNPTSALVTARLLLAPLLTGMSGGDAA
TAVVFEQGCCADPLPACGDRETFLRARMTERGLVLADSQDSGSQRSLAASDALIRRLPGAPAEPAGAPVSYIRF

Sequences:

>Translated_394_residues
MISFNEALSRVIGVALPLGSESVSFEAASGRVLSEGVTARFAMPRTDVSAMDGYAVREADLKDIPFSLIIAGEAAAGTLP
GQRLPERTAFRIFTGAPVPDGANRVIVQENAERAGDRVTFLRPHGPGRNIRAAGSDFAAGDLLVPAGIRLDWRALTTAAA
ADQGRISVWRQPCVVILATGDELAAPGQAMERPGAIPESVSPGIAAFVTAHGGRLLRSERLPDVPELLGAAAARALQEAD
LIIMIGGASVGDRDYSRSVFGEAPDYVFPKVAIKPGKPVWLARIGTRLVLGLPGNPTSALVTARLLLAPLLTGMSGGDAA
TAVVFEQGCCADPLPACGDRETFLRARMTERGLVLADSQDSGSQRSLAASDALIRRLPGAPAEPAGAPVSYIRF
>Mature_394_residues
MISFNEALSRVIGVALPLGSESVSFEAASGRVLSEGVTARFAMPRTDVSAMDGYAVREADLKDIPFSLIIAGEAAAGTLP
GQRLPERTAFRIFTGAPVPDGANRVIVQENAERAGDRVTFLRPHGPGRNIRAAGSDFAAGDLLVPAGIRLDWRALTTAAA
ADQGRISVWRQPCVVILATGDELAAPGQAMERPGAIPESVSPGIAAFVTAHGGRLLRSERLPDVPELLGAAAARALQEAD
LIIMIGGASVGDRDYSRSVFGEAPDYVFPKVAIKPGKPVWLARIGTRLVLGLPGNPTSALVTARLLLAPLLTGMSGGDAA
TAVVFEQGCCADPLPACGDRETFLRARMTERGLVLADSQDSGSQRSLAASDALIRRLPGAPAEPAGAPVSYIRF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=330, Percent_Identity=31.8181818181818, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI10880983, Length=330, Percent_Identity=31.8181818181818, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1787049, Length=321, Percent_Identity=36.1370716510903, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25147659, Length=363, Percent_Identity=29.2011019283747, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=327, Percent_Identity=26.2996941896024, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136978, Length=415, Percent_Identity=27.710843373494, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24638841, Length=415, Percent_Identity=27.710843373494, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41046; Mature: 41046

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFNEALSRVIGVALPLGSESVSFEAASGRVLSEGVTARFAMPRTDVSAMDGYAVREAD
CCCHHHHHHHHHHEECCCCCCCCEEECCCCEEECCCCEEEEECCCCCHHHCCCCEEECCC
LKDIPFSLIIAGEAAAGTLPGQRLPERTAFRIFTGAPVPDGANRVIVQENAERAGDRVTF
CCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCHHHCCCEEEE
LRPHGPGRNIRAAGSDFAAGDLLVPAGIRLDWRALTTAAAADQGRISVWRQPCVVILATG
ECCCCCCCCCEECCCCCCCCCEEECCCCEEEHHHHHHHHHCCCCCCEEECCCEEEEEECC
DELAAPGQAMERPGAIPESVSPGIAAFVTAHGGRLLRSERLPDVPELLGAAAARALQEAD
CCCCCCCHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHCC
LIIMIGGASVGDRDYSRSVFGEAPDYVFPKVAIKPGKPVWLARIGTRLVLGLPGNPTSAL
EEEEECCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCEEEEECCCEEEEECCCCCHHHH
VTARLLLAPLLTGMSGGDAATAVVFEQGCCADPLPACGDRETFLRARMTERGLVLADSQD
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCC
SGSQRSLAASDALIRRLPGAPAEPAGAPVSYIRF
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure
MISFNEALSRVIGVALPLGSESVSFEAASGRVLSEGVTARFAMPRTDVSAMDGYAVREAD
CCCHHHHHHHHHHEECCCCCCCCEEECCCCEEECCCCEEEEECCCCCHHHCCCCEEECCC
LKDIPFSLIIAGEAAAGTLPGQRLPERTAFRIFTGAPVPDGANRVIVQENAERAGDRVTF
CCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCHHHCCCEEEE
LRPHGPGRNIRAAGSDFAAGDLLVPAGIRLDWRALTTAAAADQGRISVWRQPCVVILATG
ECCCCCCCCCEECCCCCCCCCEEECCCCEEEHHHHHHHHHCCCCCCEEECCCEEEEEECC
DELAAPGQAMERPGAIPESVSPGIAAFVTAHGGRLLRSERLPDVPELLGAAAARALQEAD
CCCCCCCHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHCC
LIIMIGGASVGDRDYSRSVFGEAPDYVFPKVAIKPGKPVWLARIGTRLVLGLPGNPTSAL
EEEEECCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCEEEEECCCEEEEECCCCCHHHH
VTARLLLAPLLTGMSGGDAATAVVFEQGCCADPLPACGDRETFLRARMTERGLVLADSQD
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCC
SGSQRSLAASDALIRRLPGAPAEPAGAPVSYIRF
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]