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The map label for this gene is lpxD

Identifier: 114798725

GI number: 114798725

Start: 1822484

End: 1823500

Strand: Direct

Name: lpxD

Synonym: HNE_1778

Alternate gene names: 114798725

Gene position: 1822484-1823500 (Clockwise)

Preceding gene: 114798539

Following gene: 114799420

Centisome position: 49.19

GC content: 58.21

Gene sequence:

>1017_bases
GTGACGGTCGACAGTCGATTCTACGCGCCATTGGGGGCATTGACGCTGGAAGAGATTGCTGGCCGGACTGGGAGCAACCT
TGCGGGTAAGCCCAATCAGGTGATTTCTGGAATAGCGTCGGCGGCCAATGCGAAGGCCGCCGAGATCGCCTTCATCGAAG
GTGATGGAAAACGCCAACCTACTATCAGTCCCAGCCTGGCGGCAGTGTTTGTCGCGGCTGAAATGAAGCATTTCATTCCC
GAGGGCGTGGGCGTGCTGGAAACTGCGTTCCCAAGAAATGCCCACAGCGCAATCGCTTCATCACTTTTTAGGCCCCGGCA
CTTGATGGGAGCGGGACACGAGCTCGTCTCAGCGCTGGCGCAAATCCACGCCAATGCGATCGTTCAGCCGGGAGCTGTTA
TTGGCCCTGGGGCGGCGGTTGGCGAGGGCGCGGTCATCGGCGCAAACGCAGTGATTGGTCCAGGCGTTCAGATTGGCCGA
AATACATCCATCGGCGCAAACGCCTCGATTCATTGCGCCTTGGTCGGTGATCAGGTTACAATCTTGGCGGGTGCCAGAAT
TGGTGAAACCGGTTTCGGTGTGCTGGTCGGGCCTCAAGGCGCTGAAGATTCTCCCCATTTTGGCCGCGTCATCATCCAGG
ATCATGTAACGATTGGCGCAAACAGCTGCATCGACCGGGGCGTTTTCGAAGATACGATCATCGGCGAGCGGACGAAGATC
GATAATCTCTGCCAGATCGCCCACAATGTTGTCTTGGGCAGGGGCGTTATCGTTGCCGCCTTCGGCGGTATCTCTGGTTC
GGTCCGGGTTGGAGATGGATCTATGCTTGGCGGCAGGGTTGGCATCGCCGATCATGTCAAGGTTGGCGACCGCGTGAGCC
TTGCCGCGTCTGCCGGGCTTTTCAGGGATGTGGACAGTGGGGAAACCTGGGGCGGTACACCCGCAAAGCCGATAAGGCAG
TGGATGCGGGAAGTCGCATGGTTGCAAAAACAGGCCAACCCCAAGAAAAGCAATTGA

Upstream 100 bases:

>100_bases
TTCGGTCATTCAAAAACTCGACGCCAAGACGACAGCTATTGCGGTTACCCGTCAGAAGCTGCCAGCGGCGCCCCAAGGCG
GCAACTAACGGGGCATCACA

Downstream 100 bases:

>100_bases
CGGGCAATTACCTGTCTCGAAATGAGGAAAGGCCTCTCGATGAGCGTTGAGGTGCACTCCACGGCCGTCGTTGAAAGCGG
TGCCATTCTCCATGATGGCG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTVDSRFYAPLGALTLEEIAGRTGSNLAGKPNQVISGIASAANAKAAEIAFIEGDGKRQPTISPSLAAVFVAAEMKHFIP
EGVGVLETAFPRNAHSAIASSLFRPRHLMGAGHELVSALAQIHANAIVQPGAVIGPGAAVGEGAVIGANAVIGPGVQIGR
NTSIGANASIHCALVGDQVTILAGARIGETGFGVLVGPQGAEDSPHFGRVIIQDHVTIGANSCIDRGVFEDTIIGERTKI
DNLCQIAHNVVLGRGVIVAAFGGISGSVRVGDGSMLGGRVGIADHVKVGDRVSLAASAGLFRDVDSGETWGGTPAKPIRQ
WMREVAWLQKQANPKKSN

Sequences:

>Translated_338_residues
MTVDSRFYAPLGALTLEEIAGRTGSNLAGKPNQVISGIASAANAKAAEIAFIEGDGKRQPTISPSLAAVFVAAEMKHFIP
EGVGVLETAFPRNAHSAIASSLFRPRHLMGAGHELVSALAQIHANAIVQPGAVIGPGAAVGEGAVIGANAVIGPGVQIGR
NTSIGANASIHCALVGDQVTILAGARIGETGFGVLVGPQGAEDSPHFGRVIIQDHVTIGANSCIDRGVFEDTIIGERTKI
DNLCQIAHNVVLGRGVIVAAFGGISGSVRVGDGSMLGGRVGIADHVKVGDRVSLAASAGLFRDVDSGETWGGTPAKPIRQ
WMREVAWLQKQANPKKSN
>Mature_337_residues
TVDSRFYAPLGALTLEEIAGRTGSNLAGKPNQVISGIASAANAKAAEIAFIEGDGKRQPTISPSLAAVFVAAEMKHFIPE
GVGVLETAFPRNAHSAIASSLFRPRHLMGAGHELVSALAQIHANAIVQPGAVIGPGAAVGEGAVIGANAVIGPGVQIGRN
TSIGANASIHCALVGDQVTILAGARIGETGFGVLVGPQGAEDSPHFGRVIIQDHVTIGANSCIDRGVFEDTIIGERTKID
NLCQIAHNVVLGRGVIVAAFGGISGSVRVGDGSMLGGRVGIADHVKVGDRVSLAASAGLFRDVDSGETWGGTPAKPIRQW
MREVAWLQKQANPKKSN

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=319, Percent_Identity=30.7210031347962, Blast_Score=131, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_HYPNA (Q0C1B1)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760482.1
- ProteinModelPortal:   Q0C1B1
- SMR:   Q0C1B1
- STRING:   Q0C1B1
- GeneID:   4289288
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1778
- NMPDR:   fig|228405.5.peg.1712
- TIGR:   HNE_1778
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   TIGANSC
- PhylomeDB:   Q0C1B1
- BioCyc:   HNEP81032:HNE_1778-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 34582; Mature: 34451

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDSRFYAPLGALTLEEIAGRTGSNLAGKPNQVISGIASAANAKAAEIAFIEGDGKRQP
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
TISPSLAAVFVAAEMKHFIPEGVGVLETAFPRNAHSAIASSLFRPRHLMGAGHELVSALA
CCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHCCCHHHHCCCHHHHHHHH
QIHANAIVQPGAVIGPGAAVGEGAVIGANAVIGPGVQIGRNTSIGANASIHCALVGDQVT
HHHHHHEECCCCEECCCCCCCCCEEEECCCEECCCCEECCCCCCCCCCEEEEEEECCEEE
ILAGARIGETGFGVLVGPQGAEDSPHFGRVIIQDHVTIGANSCIDRGVFEDTIIGERTKI
EEECCEECCCCCEEEECCCCCCCCCCCCEEEEEECEEECCHHHHHCCCHHHHHCCCHHHH
DNLCQIAHNVVLGRGVIVAAFGGISGSVRVGDGSMLGGRVGIADHVKVGDRVSLAASAGL
HHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCEECCCCCCCCCCCCCCCEEHHHHCCH
FRDVDSGETWGGTPAKPIRQWMREVAWLQKQANPKKSN
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TVDSRFYAPLGALTLEEIAGRTGSNLAGKPNQVISGIASAANAKAAEIAFIEGDGKRQP
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
TISPSLAAVFVAAEMKHFIPEGVGVLETAFPRNAHSAIASSLFRPRHLMGAGHELVSALA
CCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHCCCHHHHCCCHHHHHHHH
QIHANAIVQPGAVIGPGAAVGEGAVIGANAVIGPGVQIGRNTSIGANASIHCALVGDQVT
HHHHHHEECCCCEECCCCCCCCCEEEECCCEECCCCEECCCCCCCCCCEEEEEEECCEEE
ILAGARIGETGFGVLVGPQGAEDSPHFGRVIIQDHVTIGANSCIDRGVFEDTIIGERTKI
EEECCEECCCCCEEEECCCCCCCCCCCCEEEEEECEEECCHHHHHCCCHHHHHCCCHHHH
DNLCQIAHNVVLGRGVIVAAFGGISGSVRVGDGSMLGGRVGIADHVKVGDRVSLAASAGL
HHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCEECCCCCCCCCCCCCCCEEHHHHCCH
FRDVDSGETWGGTPAKPIRQWMREVAWLQKQANPKKSN
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA