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The map label for this gene is msrA3 [H]

Identifier: 114798714

GI number: 114798714

Start: 3632144

End: 3632761

Strand: Reverse

Name: msrA3 [H]

Synonym: HNE_3496

Alternate gene names: 114798714

Gene position: 3632761-3632144 (Counterclockwise)

Preceding gene: 114799630

Following gene: 114799817

Centisome position: 98.05

GC content: 62.14

Gene sequence:

>618_bases
ATGCGCACTCTCCTTCTCGCGGCAGCTGCCGCCTGTCTTACAGCCTGTAGCAATGCCGCCCTCCCTCAGGCTGCCAGCGC
GGAGCCGGCTGCCCGCGCCCAGGCCGCCGAAAATGAAGCCATCGCCGTATTCGCGGGCGGGTGTTTCTGGTGCATCGAGG
CGGAGCTGGAAGAAGTGCCCGGCGTGCGCACGGTCGTCTCCGGATATACCGGCGGCACGACGCCAGACCCGACCTATGAG
CGCATGGGCGATCATGCCGAAGCGGTCGAAGTGATCTACGACCCAGCCGAAGTCACCTATGACCAGCTACTGGAAGTCTT
CTGGTCGAATATCGACCCGACCGATGAAGGCGGTCAATTCTATGACCGCGGCAGCCAGTATCGCACCGCCATCTATGTTC
TGGACGATGCCCAGGCCGCCGCCGCCCGCGCCTCGCTGGAGGCGAACGCCAAGCGCCTCAACCAGCCCATCGCCACGGCA
GTTATTCCCGCCACCGAATTCTATCCCGCCGAGGAATATCATCAGGACTATTACCTGAAAGAACCCGACCGCTACGAAGC
CTATAAGAAAGGCAGCCGCCGCGAAGAGACCCTCAAAGAGGTCTGGCAAACCGAATAG

Upstream 100 bases:

>100_bases
CTCTCTATTGTGAAAGGCGCCGGGCTGGACGTGGCCCCGGCGCCCCATACCTTTGACCTCGTAACCGCGCGGTACTTCCG
GCGGGCTAGAAAGGTCTCTT

Downstream 100 bases:

>100_bases
GGCAGGGCTGCCTCAGCAGTAGGTATTCCCAGGCCTGCAGGAGGAGGAATAGGCCGTGCCTATATTAGCGGTGGCCCGGC
GCGCTTCGTTCCAGTCGCGA

Product: methionine-S-sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MRTLLLAAAAACLTACSNAALPQAASAEPAARAQAAENEAIAVFAGGCFWCIEAELEEVPGVRTVVSGYTGGTTPDPTYE
RMGDHAEAVEVIYDPAEVTYDQLLEVFWSNIDPTDEGGQFYDRGSQYRTAIYVLDDAQAAAARASLEANAKRLNQPIATA
VIPATEFYPAEEYHQDYYLKEPDRYEAYKKGSRREETLKEVWQTE

Sequences:

>Translated_205_residues
MRTLLLAAAAACLTACSNAALPQAASAEPAARAQAAENEAIAVFAGGCFWCIEAELEEVPGVRTVVSGYTGGTTPDPTYE
RMGDHAEAVEVIYDPAEVTYDQLLEVFWSNIDPTDEGGQFYDRGSQYRTAIYVLDDAQAAAARASLEANAKRLNQPIATA
VIPATEFYPAEEYHQDYYLKEPDRYEAYKKGSRREETLKEVWQTE
>Mature_205_residues
MRTLLLAAAAACLTACSNAALPQAASAEPAARAQAAENEAIAVFAGGCFWCIEAELEEVPGVRTVVSGYTGGTTPDPTYE
RMGDHAEAVEVIYDPAEVTYDQLLEVFWSNIDPTDEGGQFYDRGSQYRTAIYVLDDAQAAAARASLEANAKRLNQPIATA
VIPATEFYPAEEYHQDYYLKEPDRYEAYKKGSRREETLKEVWQTE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=158, Percent_Identity=41.7721518987342, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=41.7721518987342, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=43.2432432432432, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1790665, Length=181, Percent_Identity=44.1988950276243, Blast_Score=137, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17533973, Length=140, Percent_Identity=35, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=31.4465408805031, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664627, Length=143, Percent_Identity=39.1608391608392, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI45553131, Length=135, Percent_Identity=39.2592592592593, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=37.7622377622378, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 22505; Mature: 22505

Theoretical pI: Translated: 4.10; Mature: 4.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLLLAAAAACLTACSNAALPQAASAEPAARAQAAENEAIAVFAGGCFWCIEAELEEVP
CHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEEEEEECHHHHCC
GVRTVVSGYTGGTTPDPTYERMGDHAEAVEVIYDPAEVTYDQLLEVFWSNIDPTDEGGQF
CHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHCCCHHHCHHHHHHHHHCCCCCCCCCCCH
YDRGSQYRTAIYVLDDAQAAAARASLEANAKRLNQPIATAVIPATEFYPAEEYHQDYYLK
HHCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHEECCHHCCCCHHHCCCCCCC
EPDRYEAYKKGSRREETLKEVWQTE
CCHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRTLLLAAAAACLTACSNAALPQAASAEPAARAQAAENEAIAVFAGGCFWCIEAELEEVP
CHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEEEEEECHHHHCC
GVRTVVSGYTGGTTPDPTYERMGDHAEAVEVIYDPAEVTYDQLLEVFWSNIDPTDEGGQF
CHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHCCCHHHCHHHHHHHHHCCCCCCCCCCCH
YDRGSQYRTAIYVLDDAQAAAARASLEANAKRLNQPIATAVIPATEFYPAEEYHQDYYLK
HHCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHEECCHHCCCCHHHCCCCCCC
EPDRYEAYKKGSRREETLKEVWQTE
CCHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA