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The map label for this gene is gmk

Identifier: 114798626

GI number: 114798626

Start: 2242093

End: 2242746

Strand: Reverse

Name: gmk

Synonym: HNE_2153

Alternate gene names: 114798626

Gene position: 2242746-2242093 (Counterclockwise)

Preceding gene: 114798477

Following gene: 114798261

Centisome position: 60.53

GC content: 61.01

Gene sequence:

>654_bases
ATGTCGAATAGCGGACATCCCAAAGACCGGGGCAATCGCCGGGGCCTGATGCTGGTGCTTTCCAGCCCCTCGGGCGCGGG
CAAGACCACGCTGTCCCGGATGCTGCTGGAAGAGTTCGGCGATGTGAAGCTTTCGATCTCCGCCACCACCCGGCCTCCGC
GCCCCAATGAGGTTCACGGCGAAGACTATTACTTCAAGACGCCCGATGAATTTCACAGGATGATCGAGCGGCGCGAATTC
CTCGAATGGGCGCATGTCTTCGACAAACATTACGGCACCCCGAAAGCCGACACGGTTGCCCGCCTCGAAGCGGGTGAAGA
CGTCCTGTTCGATGTGGACTGGCAGGGGGCCGACGCGCTGCACGATCAGATGCCCAATGATGTGGTCTCGGTGTTCATCC
TGCCGCCCAGCATTGAGGCATTGCAGGCGCGTCTTATGGGCCGTCCAGGGTCAACGCCGGAACTGGTTGCCCGCCGCATG
GAGGACGCCAAGCGCGAGATCATGCACTGGCGGCGCTATGACTATGTCATCGTCAATGATGATCTCAACGTCGCCTACCA
ACGCCTCAAGCGCATCCTGCTGGTCGAGCGGCTGAAGCGCCTGCGCCAGATTGATCTGGAAGATCACGTGCGCGCCCTGC
TGGGCGAAGCTTAA

Upstream 100 bases:

>100_bases
GAAGCCAACACCCTCTGCTCCAAATCCATCAGCCTCGATTTGACGAATGCGGGCCTTGGCCTCAAAGGGGTGATCGACCA
GTTCAAGGAGCAATCGGCCA

Downstream 100 bases:

>100_bases
GCCAGGCTTGTTGCCAGTTTGCGGAATTCCGCCTGTGTAAGCGTTTCGGCGCGCGCGGTCGGCTTGATGCCGCAATCTTC
CAGCCAGGCTTCGGCTTTCA

Product: putative guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MSNSGHPKDRGNRRGLMLVLSSPSGAGKTTLSRMLLEEFGDVKLSISATTRPPRPNEVHGEDYYFKTPDEFHRMIERREF
LEWAHVFDKHYGTPKADTVARLEAGEDVLFDVDWQGADALHDQMPNDVVSVFILPPSIEALQARLMGRPGSTPELVARRM
EDAKREIMHWRRYDYVIVNDDLNVAYQRLKRILLVERLKRLRQIDLEDHVRALLGEA

Sequences:

>Translated_217_residues
MSNSGHPKDRGNRRGLMLVLSSPSGAGKTTLSRMLLEEFGDVKLSISATTRPPRPNEVHGEDYYFKTPDEFHRMIERREF
LEWAHVFDKHYGTPKADTVARLEAGEDVLFDVDWQGADALHDQMPNDVVSVFILPPSIEALQARLMGRPGSTPELVARRM
EDAKREIMHWRRYDYVIVNDDLNVAYQRLKRILLVERLKRLRQIDLEDHVRALLGEA
>Mature_216_residues
SNSGHPKDRGNRRGLMLVLSSPSGAGKTTLSRMLLEEFGDVKLSISATTRPPRPNEVHGEDYYFKTPDEFHRMIERREFL
EWAHVFDKHYGTPKADTVARLEAGEDVLFDVDWQGADALHDQMPNDVVSVFILPPSIEALQARLMGRPGSTPELVARRME
DAKREIMHWRRYDYVIVNDDLNVAYQRLKRILLVERLKRLRQIDLEDHVRALLGEA

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=37.696335078534, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=37.696335078534, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=37.696335078534, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI38570142, Length=182, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=46.875, Blast_Score=173, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=35.3591160220994, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=35.3591160220994, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=28.9617486338798, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=188, Percent_Identity=28.7234042553192, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=39.344262295082, Blast_Score=139, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21356141, Length=190, Percent_Identity=33.6842105263158, Blast_Score=98, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_HYPNA (Q0C093)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760850.1
- ProteinModelPortal:   Q0C093
- SMR:   Q0C093
- STRING:   Q0C093
- GeneID:   4289885
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2153
- NMPDR:   fig|228405.5.peg.2074
- TIGR:   HNE_2153
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q0C093
- BioCyc:   HNEP81032:HNE_2153-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 25018; Mature: 24887

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSGHPKDRGNRRGLMLVLSSPSGAGKTTLSRMLLEEFGDVKLSISATTRPPRPNEVHG
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
EDYYFKTPDEFHRMIERREFLEWAHVFDKHYGTPKADTVARLEAGEDVLFDVDWQGADAL
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCCHHH
HDQMPNDVVSVFILPPSIEALQARLMGRPGSTPELVARRMEDAKREIMHWRRYDYVIVND
HHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEC
DLNVAYQRLKRILLVERLKRLRQIDLEDHVRALLGEA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SNSGHPKDRGNRRGLMLVLSSPSGAGKTTLSRMLLEEFGDVKLSISATTRPPRPNEVHG
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
EDYYFKTPDEFHRMIERREFLEWAHVFDKHYGTPKADTVARLEAGEDVLFDVDWQGADAL
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCCHHH
HDQMPNDVVSVFILPPSIEALQARLMGRPGSTPELVARRMEDAKREIMHWRRYDYVIVND
HHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEC
DLNVAYQRLKRILLVERLKRLRQIDLEDHVRALLGEA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA