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The map label for this gene is echA8 [H]

Identifier: 114798582

GI number: 114798582

Start: 971665

End: 972447

Strand: Direct

Name: echA8 [H]

Synonym: HNE_0957

Alternate gene names: 114798582

Gene position: 971665-972447 (Clockwise)

Preceding gene: 114799848

Following gene: 114799237

Centisome position: 26.23

GC content: 63.35

Gene sequence:

>783_bases
ATGTCCGAACCCATTGTCCTGACCGAACGCCACGGCGCCGTCTGCCTGGTTACGCTGAACCGGCCTGACGCCCTCAACGC
GCTCAACCGCGCCCTGCGCGCCGAGATCGTGCGCGTGTTCACCGAGCTGAAAGACGACCCCGAAATCCGCGCTGTCGTGC
TGACCGGCGCGGGCCGCGCCTTCAGCGCAGGGATCGACCTCAAGGAAGCGGGCCAGACCGGTTTTGCCCTCGGCGCCGAC
GAGGATTCCAAATCGATCAACATGCTCGCCGCCCTCGAAGCTTATCCCTGGCCCATCATCGGCGCGATCAATGGCTTTGC
CATTACCGGCGGCTTTGAGCTGGCGCTGATGTGCGACGTGCTGCTCGCCTCCGAGCATACCCGCTTTGCCGATACTCATG
CCCGCGTTGGCATCGTGCCGGGCTGGGGCCTCTCGCAGAAACTCTCCCGCCTCATCGGCATCAGCCGCGCCAAGGAACTC
TCCTTCACCGGCAACTTCATCGACGCGGAAACCTCCGAGAAATGGGGCCTCGTCAACCGCGTCTATCCGGCCGCCGATCT
CGTGCCGGCCGCGCTGCAGATGGCCACCGAAATGACCTCCACCAATCCTGACCTCCTGCGCAAATACAAGGCGCTGATCG
ACGATGGCTTCGGCATGAATTTCGCCGCCTCGATGAAGGAAGAGATCAAACGCTCGATCGACCATTCCAAATCGGTTTCG
GCTTCGGCTGTGGAAGAAGCCCGCAAGCAGGTGACCGCGCGCGGGCGGGACCAGCAGGGATAA

Upstream 100 bases:

>100_bases
CCACCCGCCGCAAGGCGTAGGCAAGCGACGCGGCGTCAGGCTTGGCGGGCTCACGCGCGCGGCTTAACACCACTGCTGAA
CATTTCCGGAGGAACGCCCC

Downstream 100 bases:

>100_bases
GTCTTGCCCAGAACCCCTCTCTCTTGGGAGAGGAGGCTTTAGGGCCTACCCCGCAAACGCGAACGTATCCATCCTCAGCA
CGCTGAACGTAACCGATGTG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSEPIVLTERHGAVCLVTLNRPDALNALNRALRAEIVRVFTELKDDPEIRAVVLTGAGRAFSAGIDLKEAGQTGFALGAD
EDSKSINMLAALEAYPWPIIGAINGFAITGGFELALMCDVLLASEHTRFADTHARVGIVPGWGLSQKLSRLIGISRAKEL
SFTGNFIDAETSEKWGLVNRVYPAADLVPAALQMATEMTSTNPDLLRKYKALIDDGFGMNFAASMKEEIKRSIDHSKSVS
ASAVEEARKQVTARGRDQQG

Sequences:

>Translated_260_residues
MSEPIVLTERHGAVCLVTLNRPDALNALNRALRAEIVRVFTELKDDPEIRAVVLTGAGRAFSAGIDLKEAGQTGFALGAD
EDSKSINMLAALEAYPWPIIGAINGFAITGGFELALMCDVLLASEHTRFADTHARVGIVPGWGLSQKLSRLIGISRAKEL
SFTGNFIDAETSEKWGLVNRVYPAADLVPAALQMATEMTSTNPDLLRKYKALIDDGFGMNFAASMKEEIKRSIDHSKSVS
ASAVEEARKQVTARGRDQQG
>Mature_259_residues
SEPIVLTERHGAVCLVTLNRPDALNALNRALRAEIVRVFTELKDDPEIRAVVLTGAGRAFSAGIDLKEAGQTGFALGADE
DSKSINMLAALEAYPWPIIGAINGFAITGGFELALMCDVLLASEHTRFADTHARVGIVPGWGLSQKLSRLIGISRAKELS
FTGNFIDAETSEKWGLVNRVYPAADLVPAALQMATEMTSTNPDLLRKYKALIDDGFGMNFAASMKEEIKRSIDHSKSVSA
SAVEEARKQVTARGRDQQG

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=231, Percent_Identity=35.9307359307359, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI70995211, Length=269, Percent_Identity=30.1115241635688, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI213417737, Length=232, Percent_Identity=23.2758620689655, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI31542718, Length=188, Percent_Identity=26.5957446808511, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI157694516, Length=232, Percent_Identity=23.2758620689655, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4502327, Length=227, Percent_Identity=29.0748898678414, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI20127408, Length=187, Percent_Identity=28.8770053475936, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI68989263, Length=195, Percent_Identity=31.2820512820513, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI150378541, Length=217, Percent_Identity=28.110599078341, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI25453481, Length=216, Percent_Identity=25.462962962963, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI51538573, Length=216, Percent_Identity=25.462962962963, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4757966, Length=216, Percent_Identity=25.462962962963, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI51538581, Length=216, Percent_Identity=25.462962962963, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4757968, Length=216, Percent_Identity=25, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI49355787, Length=216, Percent_Identity=25, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI157694520, Length=202, Percent_Identity=22.7722772277228, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI116235487, Length=217, Percent_Identity=23.963133640553, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787659, Length=228, Percent_Identity=37.280701754386, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI221142681, Length=204, Percent_Identity=37.7450980392157, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1788597, Length=219, Percent_Identity=31.9634703196347, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788682, Length=214, Percent_Identity=30.8411214953271, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787660, Length=203, Percent_Identity=33.0049261083744, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI87082183, Length=193, Percent_Identity=27.979274611399, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790281, Length=179, Percent_Identity=29.0502793296089, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=204, Percent_Identity=34.8039215686275, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=33.0708661417323, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17540714, Length=227, Percent_Identity=31.2775330396476, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17560910, Length=202, Percent_Identity=30.6930693069307, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17536985, Length=223, Percent_Identity=27.3542600896861, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17549921, Length=222, Percent_Identity=29.7297297297297, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=202, Percent_Identity=27.7227722772277, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=181, Percent_Identity=32.0441988950276, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI25144276, Length=190, Percent_Identity=32.6315789473684, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=190, Percent_Identity=32.6315789473684, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=190, Percent_Identity=32.6315789473684, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=211, Percent_Identity=27.9620853080569, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25141363, Length=208, Percent_Identity=25.4807692307692, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=175, Percent_Identity=29.7142857142857, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=217, Percent_Identity=35.4838709677419, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24653477, Length=217, Percent_Identity=35.4838709677419, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24653139, Length=236, Percent_Identity=34.7457627118644, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI19920382, Length=208, Percent_Identity=31.25, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24654903, Length=234, Percent_Identity=27.3504273504274, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21357171, Length=200, Percent_Identity=29, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922422, Length=186, Percent_Identity=28.494623655914, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24650670, Length=198, Percent_Identity=28.7878787878788, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28045; Mature: 27914

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPIVLTERHGAVCLVTLNRPDALNALNRALRAEIVRVFTELKDDPEIRAVVLTGAGRA
CCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCE
FSAGIDLKEAGQTGFALGADEDSKSINMLAALEAYPWPIIGAINGFAITGGFELALMCDV
EECCCCHHHCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEECCCCEEEECCHHHHHHHHH
LLASEHTRFADTHARVGIVPGWGLSQKLSRLIGISRAKELSFTGNFIDAETSEKWGLVNR
HHHCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHEEECCCEECCCCCCCCCCHHH
VYPAADLVPAALQMATEMTSTNPDLLRKYKALIDDGFGMNFAASMKEEIKRSIDHSKSVS
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
ASAVEEARKQVTARGRDQQG
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEPIVLTERHGAVCLVTLNRPDALNALNRALRAEIVRVFTELKDDPEIRAVVLTGAGRA
CCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCE
FSAGIDLKEAGQTGFALGADEDSKSINMLAALEAYPWPIIGAINGFAITGGFELALMCDV
EECCCCHHHCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEECCCCEEEECCHHHHHHHHH
LLASEHTRFADTHARVGIVPGWGLSQKLSRLIGISRAKELSFTGNFIDAETSEKWGLVNR
HHHCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHEEECCCEECCCCCCCCCCHHH
VYPAADLVPAALQMATEMTSTNPDLLRKYKALIDDGFGMNFAASMKEEIKRSIDHSKSVS
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
ASAVEEARKQVTARGRDQQG
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]