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The map label for this gene is hpt [H]

Identifier: 114798562

GI number: 114798562

Start: 3534658

End: 3535182

Strand: Reverse

Name: hpt [H]

Synonym: HNE_3388

Alternate gene names: 114798562

Gene position: 3535182-3534658 (Counterclockwise)

Preceding gene: 114799317

Following gene: 114797490

Centisome position: 95.42

GC content: 66.67

Gene sequence:

>525_bases
TTGCCCAAGATTGATGTGATCCTGTCTGAAGCCGACCTGATGGCGCGGGTGGACGAGCTGGCCGCGCGCCTCGCCCCGCG
CCTGCAAAGCGATGACTGGACGGCCGTCTCCATCCTGATCGGGGCGACGCCCTTCACCAGCGACCTGATGAAGGCGCTGG
CCCGCCGCCACATTCACCCCGTGCTGGATGTGATGTGGCTGGAGAGCTACCGCGACGCCCGCGAGAGTTCCGGCCGCGTC
GTGGTGCGGGCCGATATTGCGCGCAGCGTGGAGGGCAGGGGCATCCTCCTGGTCGATGATGTGTTCGATACCGGCCGCAC
GCTGGATTTCGCCAAGCACCATCTGCTGGCCAAGGGCGCGCGCGAGGTGATCACCGTAGCGTTGACCCAGAAGCCCTGGG
CCCCGCGCGGCGAGAATGGCGTCGATTTCTGCGCCTTCGACGCGCCGGGCCGCTTCCTCGTCGGCTACGGCATGGACGAC
AAGGGGCGTTACCGGGGGCTGCCCTATATCGGGGCATTGGATTAA

Upstream 100 bases:

>100_bases
CGGTGGAAGCCCCGGCAGACGCGGTGATCGCGCCCGCTCCGCCTTTGCCGCCTACGGATGAACTGATGGATGAAGGAGCG
CCCGGCCCCCAATGACCGCG

Downstream 100 bases:

>100_bases
ATTGCTCGGTGCTGCTCCCGGCCAGAAGGTCGGGGCGCCTGCCGCTTCGCCTTGCTCGTGGGGGCGTCAGGCCGTGAGCG
TTTCGTTTGCCATGTTCCGC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MPKIDVILSEADLMARVDELAARLAPRLQSDDWTAVSILIGATPFTSDLMKALARRHIHPVLDVMWLESYRDARESSGRV
VVRADIARSVEGRGILLVDDVFDTGRTLDFAKHHLLAKGAREVITVALTQKPWAPRGENGVDFCAFDAPGRFLVGYGMDD
KGRYRGLPYIGALD

Sequences:

>Translated_174_residues
MPKIDVILSEADLMARVDELAARLAPRLQSDDWTAVSILIGATPFTSDLMKALARRHIHPVLDVMWLESYRDARESSGRV
VVRADIARSVEGRGILLVDDVFDTGRTLDFAKHHLLAKGAREVITVALTQKPWAPRGENGVDFCAFDAPGRFLVGYGMDD
KGRYRGLPYIGALD
>Mature_173_residues
PKIDVILSEADLMARVDELAARLAPRLQSDDWTAVSILIGATPFTSDLMKALARRHIHPVLDVMWLESYRDARESSGRVV
VRADIARSVEGRGILLVDDVFDTGRTLDFAKHHLLAKGAREVITVALTQKPWAPRGENGVDFCAFDAPGRFLVGYGMDDK
GRYRGLPYIGALD

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI87081689, Length=172, Percent_Identity=30.2325581395349, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17510817, Length=172, Percent_Identity=27.3255813953488, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19247; Mature: 19116

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKIDVILSEADLMARVDELAARLAPRLQSDDWTAVSILIGATPFTSDLMKALARRHIHP
CCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHH
VLDVMWLESYRDARESSGRVVVRADIARSVEGRGILLVDDVFDTGRTLDFAKHHLLAKGA
HHHHHHHHHHHHHHHCCCCEEEEECCHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCH
REVITVALTQKPWAPRGENGVDFCAFDAPGRFLVGYGMDDKGRYRGLPYIGALD
HHEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKIDVILSEADLMARVDELAARLAPRLQSDDWTAVSILIGATPFTSDLMKALARRHIHP
CCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHH
VLDVMWLESYRDARESSGRVVVRADIARSVEGRGILLVDDVFDTGRTLDFAKHHLLAKGA
HHHHHHHHHHHHHHHCCCCEEEEECCHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCH
REVITVALTQKPWAPRGENGVDFCAFDAPGRFLVGYGMDDKGRYRGLPYIGALD
HHEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]