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The map label for this gene is yccK [H]

Identifier: 114798510

GI number: 114798510

Start: 1891814

End: 1892827

Strand: Reverse

Name: yccK [H]

Synonym: HNE_1834

Alternate gene names: 114798510

Gene position: 1892827-1891814 (Counterclockwise)

Preceding gene: 114797684

Following gene: 114800107

Centisome position: 51.09

GC content: 60.95

Gene sequence:

>1014_bases
ATGAAGCGACGCATAGGGGACCGGATGGTCCACCCTGTTGGTTTGGGCTGCATGAACATCATGCATGCCTATGGTCCGCC
AGCGGATGAAGGCGAAGCGAAGGCGTTGCTTGTCCGGGCGCTGGATATTGGCTGCGATTTTCTCGACACGGCAACGATCT
ACGGTCTTGGCCGCAGCGAGGCGTTGATTGGCGAGGCTCTGGGTGCTCGCCGCAAAGAATACTTCCTCGCGAGCAAGTGT
GTGTTGGGGTTTCGGGACCGCGAGCGCGTTCTGGATGGGCGGCCGGAGGCAATCAAGGCGGCGTGTGAGGCCAGCCTGAA
GCGTCTGCAAACGGATGTGATTGATCTCTACTATCTTCACCGGCCGGATCACAAAGTTCCCATCGAGGAGTCTGCCGGGG
CAATGGCCGACCTCATCAAGGAGGGCAAGATCCGGTATTACGGCCTTTCCGAAATGGGCGAGGAGCAGCTGCGCCGGGCG
CATGCGGTGCATCCGGTAGCAGCTCTGCAATCGGAATACTCGCTATGGGTGCGCAATCCGGAGATTGCTGTTCTGGAAGC
CTGCCGGGAGCTGGGCGTTGCGCTGGTGGCGTTCTCACCGGTTGGGCGGGGGTTTCTGGCCGATCCGCCCGCTGATCCGG
CAAGCTTTCATGCGACGGATATGCGCCGGTCCATGTTCCCGAGGTTTTCGGACGAAAATTATGCGGGCAACCTTCCGCTT
CTGGACACTGCGCGGGTTGTGGCTGCTGAGGCCGGTTGCCGCGTGGCGCAGCTTGCCATCGCCTGGACGATGGCGATGGG
GGATCATGTTTTGCCCATTCCGGGGACGCGCAATATCGCGCATCTTGAAGAGAACCACGCGGCCGCAGGCGTTCGTCTGA
CAGCGGAGCAAGTCGCACGTCTGAATGCAGCTTTTTCACCGGAGCGTGCCGTTGGCCCGCGATACTCACCGGCCGGGCAG
GCGAGTGTAACAACGGAGATGTTTGACTTCGAGAAGCGCCAGCATGGCGGATAA

Upstream 100 bases:

>100_bases
ATCCAATTTCAGGACGAGCCGCTTCCACGCAATGCAAACGGCAAGATCCTGAAGGCAGAATTGCGCCAGCGCTTCAAGGC
GCGGGCATAAGGGTATGAGC

Downstream 100 bases:

>100_bases
GCCGCCAGTTGCGCTGGAAGATCGTGGGGAGGGCGGAGACGGGCGGCGCTATTCACCCTCGGCCGAGCGTAACCGGGAGG
CTATACGGGATGTGTTGCGG

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKRRIGDRMVHPVGLGCMNIMHAYGPPADEGEAKALLVRALDIGCDFLDTATIYGLGRSEALIGEALGARRKEYFLASKC
VLGFRDRERVLDGRPEAIKAACEASLKRLQTDVIDLYYLHRPDHKVPIEESAGAMADLIKEGKIRYYGLSEMGEEQLRRA
HAVHPVAALQSEYSLWVRNPEIAVLEACRELGVALVAFSPVGRGFLADPPADPASFHATDMRRSMFPRFSDENYAGNLPL
LDTARVVAAEAGCRVAQLAIAWTMAMGDHVLPIPGTRNIAHLEENHAAAGVRLTAEQVARLNAAFSPERAVGPRYSPAGQ
ASVTTEMFDFEKRQHGG

Sequences:

>Translated_337_residues
MKRRIGDRMVHPVGLGCMNIMHAYGPPADEGEAKALLVRALDIGCDFLDTATIYGLGRSEALIGEALGARRKEYFLASKC
VLGFRDRERVLDGRPEAIKAACEASLKRLQTDVIDLYYLHRPDHKVPIEESAGAMADLIKEGKIRYYGLSEMGEEQLRRA
HAVHPVAALQSEYSLWVRNPEIAVLEACRELGVALVAFSPVGRGFLADPPADPASFHATDMRRSMFPRFSDENYAGNLPL
LDTARVVAAEAGCRVAQLAIAWTMAMGDHVLPIPGTRNIAHLEENHAAAGVRLTAEQVARLNAAFSPERAVGPRYSPAGQ
ASVTTEMFDFEKRQHGG
>Mature_337_residues
MKRRIGDRMVHPVGLGCMNIMHAYGPPADEGEAKALLVRALDIGCDFLDTATIYGLGRSEALIGEALGARRKEYFLASKC
VLGFRDRERVLDGRPEAIKAACEASLKRLQTDVIDLYYLHRPDHKVPIEESAGAMADLIKEGKIRYYGLSEMGEEQLRRA
HAVHPVAALQSEYSLWVRNPEIAVLEACRELGVALVAFSPVGRGFLADPPADPASFHATDMRRSMFPRFSDENYAGNLPL
LDTARVVAAEAGCRVAQLAIAWTMAMGDHVLPIPGTRNIAHLEENHAAAGVRLTAEQVARLNAAFSPERAVGPRYSPAGQ
ASVTTEMFDFEKRQHGG

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI4504825, Length=299, Percent_Identity=27.7591973244147, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI27436969, Length=299, Percent_Identity=27.7591973244147, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI27436962, Length=319, Percent_Identity=26.3322884012539, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI27436964, Length=272, Percent_Identity=27.2058823529412, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI27436966, Length=319, Percent_Identity=26.3322884012539, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI223718702, Length=300, Percent_Identity=28, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI27436971, Length=272, Percent_Identity=27.9411764705882, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI41327764, Length=274, Percent_Identity=27.3722627737226, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI41152114, Length=300, Percent_Identity=26.3333333333333, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI223718708, Length=140, Percent_Identity=35, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI87081735, Length=325, Percent_Identity=32.9230769230769, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788070, Length=265, Percent_Identity=27.1698113207547, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788081, Length=306, Percent_Identity=28.7581699346405, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787674, Length=310, Percent_Identity=28.0645161290323, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789375, Length=310, Percent_Identity=25.4838709677419, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789199, Length=338, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994888, Length=277, Percent_Identity=30.3249097472924, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17564128, Length=219, Percent_Identity=26.9406392694064, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=337, Percent_Identity=27.5964391691395, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323998, Length=313, Percent_Identity=25.2396166134185, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319958, Length=336, Percent_Identity=25, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322615, Length=243, Percent_Identity=26.3374485596708, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325384, Length=229, Percent_Identity=29.2576419213974, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319951, Length=291, Percent_Identity=23.0240549828179, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24657054, Length=342, Percent_Identity=23.6842105263158, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45553081, Length=324, Percent_Identity=25.3086419753086, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45549126, Length=285, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640980, Length=285, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281366140, Length=294, Percent_Identity=25.5102040816327, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646155, Length=266, Percent_Identity=25.187969924812, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24646159, Length=217, Percent_Identity=25.3456221198157, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36846; Mature: 36846

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRIGDRMVHPVGLGCMNIMHAYGPPADEGEAKALLVRALDIGCDFLDTATIYGLGRSE
CCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHEECCCCH
ALIGEALGARRKEYFLASKCVLGFRDRERVLDGRPEAIKAACEASLKRLQTDVIDLYYLH
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEE
RPDHKVPIEESAGAMADLIKEGKIRYYGLSEMGEEQLRRAHAVHPVAALQSEYSLWVRNP
CCCCCCCCHHHCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHCCCEEEECCC
EIAVLEACRELGVALVAFSPVGRGFLADPPADPASFHATDMRRSMFPRFSDENYAGNLPL
CHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
LDTARVVAAEAGCRVAQLAIAWTMAMGDHVLPIPGTRNIAHLEENHAAAGVRLTAEQVAR
HHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCEEECHHHHHH
LNAAFSPERAVGPRYSPAGQASVTTEMFDFEKRQHGG
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRRIGDRMVHPVGLGCMNIMHAYGPPADEGEAKALLVRALDIGCDFLDTATIYGLGRSE
CCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHEECCCCH
ALIGEALGARRKEYFLASKCVLGFRDRERVLDGRPEAIKAACEASLKRLQTDVIDLYYLH
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEE
RPDHKVPIEESAGAMADLIKEGKIRYYGLSEMGEEQLRRAHAVHPVAALQSEYSLWVRNP
CCCCCCCCHHHCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHCCCEEEECCC
EIAVLEACRELGVALVAFSPVGRGFLADPPADPASFHATDMRRSMFPRFSDENYAGNLPL
CHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
LDTARVVAAEAGCRVAQLAIAWTMAMGDHVLPIPGTRNIAHLEENHAAAGVRLTAEQVAR
HHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCEEECHHHHHH
LNAAFSPERAVGPRYSPAGQASVTTEMFDFEKRQHGG
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]