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The map label for this gene is aatC [H]

Identifier: 114798447

GI number: 114798447

Start: 2410768

End: 2411982

Strand: Reverse

Name: aatC [H]

Synonym: HNE_2311

Alternate gene names: 114798447

Gene position: 2411982-2410768 (Counterclockwise)

Preceding gene: 114797962

Following gene: 114797674

Centisome position: 65.1

GC content: 63.87

Gene sequence:

>1215_bases
ATGAACACCGACTTTCACAAGATCCGGCGCCTTCCGCCTTACGTGTTTGAACAGGTGAACCGCACAAAAGCGGCGCTGCG
CGCCAAAGGCGCTGACATTATCGACCTCGGCATGGGCAATCCTGACCTGCCGACGCCCAAGCATATCGTCGACAAGCTGG
TCGAGACGGCCCGCAAGCCGGACGTGAACGGCTATTCCGCCTCGCGCGGCATTCCCGGCCTGCGCCGGGCGCTGACCGAT
TATTACAAGCGCCGCTTTGATGTGGTGCTGGATAGGGACCGGGAGGTGATTGTCACGCTCGGCTCCAAGGAGGGGTTTGC
CAATCTCGCGCAGGCCATCTCTGCGCCGGGTGATGTGATCCTGGCGCCGGACCCGTCCTATCCGCTGCACCATTTCGGCT
TCATCATTGCCGGGGCCTCGATCCGCGGCGTGCCCGCGCATACGCCCGAGCAGTATCTCTCCAGCCTCGGCCGGGCGGTG
AAGTATTCCGTGCCGCCGCCGACCGCGATGGTGCTGTGCTTCCCGTCGAACCCGACGGCGGCTGTGTGCGATCTCGATTT
CTACAAAGAGGCCGTGAAGTTCGCCAAGAAGCACGACCTCTGGGTGCTGTCGGACCTTGCCTATAACGAGATCTATTTCG
AGGAGCCCACGCCCTCGATCCTGCAGGTGGACGGGGCGAAGGACATTGCGGTGGAGTTCACCACGATGTCGAAGACCTAT
TCCATGGCCGGATGGCGGATGGGCTTTGTGGCGGGCAATGAGAAGCTCGTCGGGGCGCTGGCGCGGGTGAAATCCTATCT
CGATTATGGCGCGTATACGCCGATCCAGGTGGCCGCTGTGGCCGCGCTCGACGGGCCGCAGGAATGCGTGGCGGAGACGC
GCGCGATCTATAAAGGCCGCCGCGACGTGCTGGTGGACAGCTTCACCCGCGCTGGATGGCCGGTGCCGAGCCCGAAGGCC
TCGATGTTTGCCTGGGCGCCGATCCCCGAACAGCTGCGCCATCTGGGCAGCCTGGAGTTTGCCCTGCAGCTGATCAACGA
GGCGCATGTGGCCGTCGCGCCGGGCGCTGGCTTTGGCGAGCATGGGGATGATTACGTCCGCATCGCGCTCGTGGAAAATG
AGCAGCGCATCCGTCAGGCGGGCCGTAACATCCGGAAGTTTCTGGCTGCGCGCGGCGTGAAGGAGATCAAGCCGGCGGTT
GCGGCTGCGGAGTAA

Upstream 100 bases:

>100_bases
GAAATGCCGCCGGAATCCGATTTCCTTACCCAAGCCGAAATCGCTGCCATCCGCAGCCAGTTCAATGTACCCCGCGTTAC
CCAGGACGAATGAGACCCAA

Downstream 100 bases:

>100_bases
TCCGTAGGGTGCATTGCGACCGTTGGCCTTAATGCACCCTACATTTCCCAATTCCCTGACCCGAAACGTCCTCGCTTTGC
GCCTTTATGGTCAGAGAGTG

Product: classes I and II aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNTDFHKIRRLPPYVFEQVNRTKAALRAKGADIIDLGMGNPDLPTPKHIVDKLVETARKPDVNGYSASRGIPGLRRALTD
YYKRRFDVVLDRDREVIVTLGSKEGFANLAQAISAPGDVILAPDPSYPLHHFGFIIAGASIRGVPAHTPEQYLSSLGRAV
KYSVPPPTAMVLCFPSNPTAAVCDLDFYKEAVKFAKKHDLWVLSDLAYNEIYFEEPTPSILQVDGAKDIAVEFTTMSKTY
SMAGWRMGFVAGNEKLVGALARVKSYLDYGAYTPIQVAAVAALDGPQECVAETRAIYKGRRDVLVDSFTRAGWPVPSPKA
SMFAWAPIPEQLRHLGSLEFALQLINEAHVAVAPGAGFGEHGDDYVRIALVENEQRIRQAGRNIRKFLAARGVKEIKPAV
AAAE

Sequences:

>Translated_404_residues
MNTDFHKIRRLPPYVFEQVNRTKAALRAKGADIIDLGMGNPDLPTPKHIVDKLVETARKPDVNGYSASRGIPGLRRALTD
YYKRRFDVVLDRDREVIVTLGSKEGFANLAQAISAPGDVILAPDPSYPLHHFGFIIAGASIRGVPAHTPEQYLSSLGRAV
KYSVPPPTAMVLCFPSNPTAAVCDLDFYKEAVKFAKKHDLWVLSDLAYNEIYFEEPTPSILQVDGAKDIAVEFTTMSKTY
SMAGWRMGFVAGNEKLVGALARVKSYLDYGAYTPIQVAAVAALDGPQECVAETRAIYKGRRDVLVDSFTRAGWPVPSPKA
SMFAWAPIPEQLRHLGSLEFALQLINEAHVAVAPGAGFGEHGDDYVRIALVENEQRIRQAGRNIRKFLAARGVKEIKPAV
AAAE
>Mature_404_residues
MNTDFHKIRRLPPYVFEQVNRTKAALRAKGADIIDLGMGNPDLPTPKHIVDKLVETARKPDVNGYSASRGIPGLRRALTD
YYKRRFDVVLDRDREVIVTLGSKEGFANLAQAISAPGDVILAPDPSYPLHHFGFIIAGASIRGVPAHTPEQYLSSLGRAV
KYSVPPPTAMVLCFPSNPTAAVCDLDFYKEAVKFAKKHDLWVLSDLAYNEIYFEEPTPSILQVDGAKDIAVEFTTMSKTY
SMAGWRMGFVAGNEKLVGALARVKSYLDYGAYTPIQVAAVAALDGPQECVAETRAIYKGRRDVLVDSFTRAGWPVPSPKA
SMFAWAPIPEQLRHLGSLEFALQLINEAHVAVAPGAGFGEHGDDYVRIALVENEQRIRQAGRNIRKFLAARGVKEIKPAV
AAAE

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=268, Percent_Identity=24.6268656716418, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI56713254, Length=268, Percent_Identity=24.6268656716418, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI95147551, Length=400, Percent_Identity=21.75, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI169881279, Length=400, Percent_Identity=21.75, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1788722, Length=390, Percent_Identity=54.1025641025641, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1786816, Length=377, Percent_Identity=22.5464190981432, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788627, Length=384, Percent_Identity=22.9166666666667, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994476, Length=270, Percent_Identity=24.0740740740741, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994472, Length=270, Percent_Identity=24.0740740740741, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17567369, Length=392, Percent_Identity=20.4081632653061, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17567663, Length=371, Percent_Identity=23.7196765498652, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=388, Percent_Identity=20.6185567010309, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18859735, Length=393, Percent_Identity=22.64631043257, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.- [C]

Molecular weight: Translated: 44305; Mature: 44305

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDFHKIRRLPPYVFEQVNRTKAALRAKGADIIDLGMGNPDLPTPKHIVDKLVETARKP
CCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCC
DVNGYSASRGIPGLRRALTDYYKRRFDVVLDRDREVIVTLGSKEGFANLAQAISAPGDVI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHCCCCCEE
LAPDPSYPLHHFGFIIAGASIRGVPAHTPEQYLSSLGRAVKYSVPPPTAMVLCFPSNPTA
ECCCCCCCHHHHHHHEECCCCCCCCCCCHHHHHHHHCHHEEECCCCCCEEEEEECCCCCE
AVCDLDFYKEAVKFAKKHDLWVLSDLAYNEIYFEEPTPSILQVDGAKDIAVEFTTMSKTY
EEECHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCEEEECCCCEEEEEEEEHHHHH
SMAGWRMGFVAGNEKLVGALARVKSYLDYGAYTPIQVAAVAALDGPQECVAETRAIYKGR
HHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
RDVLVDSFTRAGWPVPSPKASMFAWAPIPEQLRHLGSLEFALQLINEAHVAVAPGAGFGE
HHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHCHHHHHHHHHHCCCEEEECCCCCCC
HGDDYVRIALVENEQRIRQAGRNIRKFLAARGVKEIKPAVAAAE
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MNTDFHKIRRLPPYVFEQVNRTKAALRAKGADIIDLGMGNPDLPTPKHIVDKLVETARKP
CCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCC
DVNGYSASRGIPGLRRALTDYYKRRFDVVLDRDREVIVTLGSKEGFANLAQAISAPGDVI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHCCCCCEE
LAPDPSYPLHHFGFIIAGASIRGVPAHTPEQYLSSLGRAVKYSVPPPTAMVLCFPSNPTA
ECCCCCCCHHHHHHHEECCCCCCCCCCCHHHHHHHHCHHEEECCCCCCEEEEEECCCCCE
AVCDLDFYKEAVKFAKKHDLWVLSDLAYNEIYFEEPTPSILQVDGAKDIAVEFTTMSKTY
EEECHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCEEEECCCCEEEEEEEEHHHHH
SMAGWRMGFVAGNEKLVGALARVKSYLDYGAYTPIQVAAVAALDGPQECVAETRAIYKGR
HHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
RDVLVDSFTRAGWPVPSPKASMFAWAPIPEQLRHLGSLEFALQLINEAHVAVAPGAGFGE
HHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHCHHHHHHHHHHCCCEEEECCCCCCC
HGDDYVRIALVENEQRIRQAGRNIRKFLAARGVKEIKPAVAAAE
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430; 9734305 [H]