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The map label for this gene is cysK [H]

Identifier: 114798354

GI number: 114798354

Start: 168947

End: 170020

Strand: Reverse

Name: cysK [H]

Synonym: HNE_0181

Alternate gene names: 114798354

Gene position: 170020-168947 (Counterclockwise)

Preceding gene: 114797420

Following gene: 114797635

Centisome position: 4.59

GC content: 60.8

Gene sequence:

>1074_bases
ATGCCTCAGCCCGCTTCCGCTATAACGCCGCCCGCCGTTTCGTCCCTCCCTTCGGCGCGCCAGTGCCAGGAGGCGCGGCT
GAAGGCGCTCTCTGCCCTCATCGGACGCACGCCGATGCTGTCCATTCGGTTACGCTTCAGGGGCCGGGAGCGTGTTATCC
ACGCAAAGGCGGAGCATTATAATCTGACGGGCTCGATCAAGGATCGCATGGCGCTTTCGATCCTTGCGTGCGCCTATCGT
TCGGGCGCCCTTCAGCCCGGAGACACGATTGCCGAAGCCACCAGCGGTAATGCCGGTATTGCCCTCACTGCGCTGGGCCG
CGCGCTTGGCCATCCGGTTGAGATTTTCATGCCAGACTGGATGAGCGGTGAACGCAAGAACCTTCTGCGCAGCCTTGGGG
CGAACCTGAACCTTCTATCGAGAGAGGCGGGCGGATTTCTGGGCGCCATCGCCGCGACCGAAACCCTTGCTGCCAGCAGG
AAGGATGTATTTCTGCCCTGCCAGTTTTCCAATGGCGACAATTCCGCCGCGCACGCCCAGACCACTGCACGTGAACTGAT
CAATCAGCTGGCCACGCTTGATGCCCGACCGGATGCCTTTGTAGCCGGTGTTGGAACAGGTGGCACCGTCATGGGTGTCG
GACGTGCGTTCAAATCGGCATTTCCGGACGTAAAGGTTCACCCCCTCGAGCCCCAGGAATCTCCCACTTTGTCGACCGGC
TACAAGGTGGGCCAACATCGCATCCAGGGGATATCCGATGACTTTATCCCGGCCCTCGTAAAGCTGGAACAAGTCGACGA
GGTTATTGCCGTTTCAGACGGGGACGCCATCCGGATGGCGCAAAGGCTCGCTCGTGAGCTCGGCCTGGGAGTTGGCATTT
CTTCAGGCGCCAACCTGATCGGCGCGCTGATTGCCGCAGAGAGGCTGGGAGACACAGCTTGCGTAGCGACGGTCTTCTGC
GACGATAACAAGAAGTATCTCTCCGGCGCACTGGCATGCGAAGAGCCGCATAAGGAGGGCCACCTCACGCCAGAGATTGA
GTTGCTGGACTTCGAGGCGACGATCTGCGGCTAG

Upstream 100 bases:

>100_bases
CCATAAATAGATATTTATTCCGAAAATTATACTCTTCCAATAGTACTTTTTGATAATTTTCTAAGATGAAACTGCGTAAA
TGGCGTGAGACATTACTCGT

Downstream 100 bases:

>100_bases
ACCAGCTTAGCGGCGGGCCGCGGCCACGCTGTGAGCCGCTTCTTCCTTCTCACGATCGGTAAAGCGCCGGGTGAACTGTG
CCACACGCGGCGCAATTTCC

Product: cysteine synthase/cystathionine beta-synthase family protein

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MPQPASAITPPAVSSLPSARQCQEARLKALSALIGRTPMLSIRLRFRGRERVIHAKAEHYNLTGSIKDRMALSILACAYR
SGALQPGDTIAEATSGNAGIALTALGRALGHPVEIFMPDWMSGERKNLLRSLGANLNLLSREAGGFLGAIAATETLAASR
KDVFLPCQFSNGDNSAAHAQTTARELINQLATLDARPDAFVAGVGTGGTVMGVGRAFKSAFPDVKVHPLEPQESPTLSTG
YKVGQHRIQGISDDFIPALVKLEQVDEVIAVSDGDAIRMAQRLARELGLGVGISSGANLIGALIAAERLGDTACVATVFC
DDNKKYLSGALACEEPHKEGHLTPEIELLDFEATICG

Sequences:

>Translated_357_residues
MPQPASAITPPAVSSLPSARQCQEARLKALSALIGRTPMLSIRLRFRGRERVIHAKAEHYNLTGSIKDRMALSILACAYR
SGALQPGDTIAEATSGNAGIALTALGRALGHPVEIFMPDWMSGERKNLLRSLGANLNLLSREAGGFLGAIAATETLAASR
KDVFLPCQFSNGDNSAAHAQTTARELINQLATLDARPDAFVAGVGTGGTVMGVGRAFKSAFPDVKVHPLEPQESPTLSTG
YKVGQHRIQGISDDFIPALVKLEQVDEVIAVSDGDAIRMAQRLARELGLGVGISSGANLIGALIAAERLGDTACVATVFC
DDNKKYLSGALACEEPHKEGHLTPEIELLDFEATICG
>Mature_356_residues
PQPASAITPPAVSSLPSARQCQEARLKALSALIGRTPMLSIRLRFRGRERVIHAKAEHYNLTGSIKDRMALSILACAYRS
GALQPGDTIAEATSGNAGIALTALGRALGHPVEIFMPDWMSGERKNLLRSLGANLNLLSREAGGFLGAIAATETLAASRK
DVFLPCQFSNGDNSAAHAQTTARELINQLATLDARPDAFVAGVGTGGTVMGVGRAFKSAFPDVKVHPLEPQESPTLSTGY
KVGQHRIQGISDDFIPALVKLEQVDEVIAVSDGDAIRMAQRLARELGLGVGISSGANLIGALIAAERLGDTACVATVFCD
DNKKYLSGALACEEPHKEGHLTPEIELLDFEATICG

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=320, Percent_Identity=31.875, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI295821200, Length=320, Percent_Identity=31.875, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557415, Length=320, Percent_Identity=31.875, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1788754, Length=310, Percent_Identity=39.3548387096774, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI2367138, Length=317, Percent_Identity=33.4384858044164, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI32566674, Length=276, Percent_Identity=39.8550724637681, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17562970, Length=276, Percent_Identity=39.8550724637681, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=37.171052631579, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI115535073, Length=279, Percent_Identity=42.2939068100358, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17561720, Length=276, Percent_Identity=40.2173913043478, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=228, Percent_Identity=35.9649122807018, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147552, Length=308, Percent_Identity=30.1948051948052, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17534315, Length=312, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321594, Length=354, Percent_Identity=27.9661016949153, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=32.4242424242424, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24643623, Length=304, Percent_Identity=32.2368421052632, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI20129101, Length=304, Percent_Identity=32.2368421052632, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 37630; Mature: 37499

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQPASAITPPAVSSLPSARQCQEARLKALSALIGRTPMLSIRLRFRGRERVIHAKAEHY
CCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCE
NLTGSIKDRMALSILACAYRSGALQPGDTIAEATSGNAGIALTALGRALGHPVEIFMPDW
ECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCEEEECCCC
MSGERKNLLRSLGANLNLLSREAGGFLGAIAATETLAASRKDVFLPCQFSNGDNSAAHAQ
CCCHHHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHH
TTARELINQLATLDARPDAFVAGVGTGGTVMGVGRAFKSAFPDVKVHPLEPQESPTLSTG
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
YKVGQHRIQGISDDFIPALVKLEQVDEVIAVSDGDAIRMAQRLARELGLGVGISSGANLI
HHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHH
GALIAAERLGDTACVATVFCDDNKKYLSGALACEEPHKEGHLTPEIELLDFEATICG
HHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure 
PQPASAITPPAVSSLPSARQCQEARLKALSALIGRTPMLSIRLRFRGRERVIHAKAEHY
CCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCE
NLTGSIKDRMALSILACAYRSGALQPGDTIAEATSGNAGIALTALGRALGHPVEIFMPDW
ECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCEEEECCCC
MSGERKNLLRSLGANLNLLSREAGGFLGAIAATETLAASRKDVFLPCQFSNGDNSAAHAQ
CCCHHHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHH
TTARELINQLATLDARPDAFVAGVGTGGTVMGVGRAFKSAFPDVKVHPLEPQESPTLSTG
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
YKVGQHRIQGISDDFIPALVKLEQVDEVIAVSDGDAIRMAQRLARELGLGVGISSGANLI
HHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHH
GALIAAERLGDTACVATVFCDDNKKYLSGALACEEPHKEGHLTPEIELLDFEATICG
HHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA