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The map label for this gene is trx [C]

Identifier: 114798336

GI number: 114798336

Start: 1945641

End: 1945961

Strand: Reverse

Name: trx [C]

Synonym: HNE_1882

Alternate gene names: 114798336

Gene position: 1945961-1945641 (Counterclockwise)

Preceding gene: 114799862

Following gene: 114800346

Centisome position: 52.52

GC content: 56.7

Gene sequence:

>321_bases
ATGGCAGCGATCAATGTAAATGAAGACGATTTCGACGGCGTCGTCACCGAGTCGGAAACACCCGTCGTCGTCGATTTCTG
GGCCGAATGGTGTGGCCCCTGTAAGCAGATGTCACCGCATCTGGAGGCCGTTTCCGAGGAAATGACCGGCAAGGTGAAGA
TCGTCAAAGTAAACGTTGACGACTATCCACTGGTCGGCGCCCGTTATGGCGTGCGCGGCCTGCCAACGTTGCTGATGTTC
AAAGGCGGCAAGGTCACGGCGACGCGCAATGGCGCCATGAACCGGCAAGCCCTCACGGATTGGATCAAACAGAGCCTTTA
A

Upstream 100 bases:

>100_bases
TTAGCTGTGCTCACAAGTGCGCGCGGGATGGTTTGACTTGCCCAAAGAGTCCCTATGTACCCAACTGTAAATCTTGAATG
ACGGCAAAGGAGCCGCAACC

Downstream 100 bases:

>100_bases
GGCTCTGTTTTTCCATATCTTTCAGGCCGTTTCGCTGGTCAGCGAGATAAATACATCTTCAAGATCCGGCGCTTCGGTCG
AGAGATCGGAAATGCTGATA

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MAAINVNEDDFDGVVTESETPVVVDFWAEWCGPCKQMSPHLEAVSEEMTGKVKIVKVNVDDYPLVGARYGVRGLPTLLMF
KGGKVTATRNGAMNRQALTDWIKQSL

Sequences:

>Translated_106_residues
MAAINVNEDDFDGVVTESETPVVVDFWAEWCGPCKQMSPHLEAVSEEMTGKVKIVKVNVDDYPLVGARYGVRGLPTLLMF
KGGKVTATRNGAMNRQALTDWIKQSL
>Mature_105_residues
AAINVNEDDFDGVVTESETPVVVDFWAEWCGPCKQMSPHLEAVSEEMTGKVKIVKVNVDDYPLVGARYGVRGLPTLLMFK
GGKVTATRNGAMNRQALTDWIKQSL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=42.1052631578947, Blast_Score=81, Evalue=2e-16,
Organism=Homo sapiens, GI5031973, Length=96, Percent_Identity=36.4583333333333, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI42794771, Length=100, Percent_Identity=35, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI224493972, Length=100, Percent_Identity=35, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI5803121, Length=100, Percent_Identity=28, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=42.7184466019417, Blast_Score=110, Evalue=2e-26,
Organism=Escherichia coli, GI1788936, Length=103, Percent_Identity=39.8058252427184, Blast_Score=97, Evalue=3e-22,
Organism=Escherichia coli, GI87081747, Length=82, Percent_Identity=31.7073170731707, Blast_Score=68, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=37.7551020408163, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17556044, Length=83, Percent_Identity=32.5301204819277, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=83, Percent_Identity=37.3493975903614, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=83, Percent_Identity=37.3493975903614, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=101, Percent_Identity=31.6831683168317, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=83, Percent_Identity=37.3493975903614, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=98, Percent_Identity=32.6530612244898, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=104, Percent_Identity=29.8076923076923, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71998175, Length=94, Percent_Identity=39.3617021276596, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=104, Percent_Identity=29.8076923076923, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=106, Percent_Identity=35.8490566037736, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=104, Percent_Identity=29.8076923076923, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=83, Percent_Identity=40.9638554216867, Blast_Score=68, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=97, Percent_Identity=35.0515463917526, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=97, Percent_Identity=35.0515463917526, Blast_Score=62, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=36.0824742268041, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=38.75, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21358065, Length=94, Percent_Identity=34.0425531914894, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17530795, Length=92, Percent_Identity=29.3478260869565, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17648013, Length=98, Percent_Identity=37.7551020408163, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583090, Length=98, Percent_Identity=37.7551020408163, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921434, Length=85, Percent_Identity=36.4705882352941, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11674; Mature: 11542

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAINVNEDDFDGVVTESETPVVVDFWAEWCGPCKQMSPHLEAVSEEMTGKVKIVKVNVD
CEEECCCCCCCCCEEECCCCCEEEEEHHHHCCCHHCCCHHHHHHHHHCCCCEEEEEECCC
DYPLVGARYGVRGLPTLLMFKGGKVTATRNGAMNRQALTDWIKQSL
CCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AAINVNEDDFDGVVTESETPVVVDFWAEWCGPCKQMSPHLEAVSEEMTGKVKIVKVNVD
EEECCCCCCCCCEEECCCCCEEEEEHHHHCCCHHCCCHHHHHHHHHCCCCEEEEEECCC
DYPLVGARYGVRGLPTLLMFKGGKVTATRNGAMNRQALTDWIKQSL
CCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]