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The map label for this gene is pdxH

Identifier: 114798246

GI number: 114798246

Start: 846461

End: 847120

Strand: Direct

Name: pdxH

Synonym: HNE_0824

Alternate gene names: 114798246

Gene position: 846461-847120 (Clockwise)

Preceding gene: 114799703

Following gene: 114799860

Centisome position: 22.85

GC content: 66.36

Gene sequence:

>660_bases
ATGACGTCTTCTGTAATTCCGCCCAGCCCGAGCGCGGCTGACTATGCCGCCGAGGGCGACCGCCCGCTGGTGCCGGAGAC
CGATAACCCGATCGGCCTGTTCCAGGACTGGATGGCGCAGGCGCGCGCGAGCGAGCCCAATGATTCCAACGCCATGTCGC
TGGCAACGGTCGATGCCGACGGGCGCCCGGATGTACGGATCGTTCTGCTCAAGGGCGTCGATTCGGAAGGGTTTACCTTC
TTCACCAATCTGGAGAGCGTGAAGGGCGTGCAGCTTGCCGCAAATCCCGTCGCAGCGCTTTGTTTTCACTGGAAAAGCCA
GCGCCGGCAGGTGCGGGTTCGTGGCGGGGTGGCGCCGGTAAGCGCGGCCGAGGCCGACGCGTATTTTGCCAGCCGCGCGG
CCCAGAGCCGGATCAGCGCGATTGCGTCGGACCAGTCCCGCCCGCTGGCCGACCGGGCGATCTTCGAGCAGCGGGTGGCC
GAGATTTCGTCGGTCTATGGCGACGATAACGACATTCCGCGCCCGCCGCACTGGGGCGGGTTTCGCCTTGTGCCCACCGA
GATCGAGTTCTGGCAGGACCAGGCCTTCCGGATGCACGACCGGCTGCGCTTCTACCGCAAGGCCGATGGCGGCTGGGCGA
CGGTCCGGCTTTACCCGTAA

Upstream 100 bases:

>100_bases
ATGTGTTATGCGACATGTGACAGGCTATCCTCTCGCGGCTGCGGGCCTCGTCCTATATGAAAAACGAAGCCTTACAAACC
GCGAAAAGGTGGGCCGTCCC

Downstream 100 bases:

>100_bases
CCGCCGCCCTTGGCCTTCAGATGATCTCAGCCCCGGTGCGCTCCAGGATCATGTGGGGGGCCCCGTCGCTGGTGCGGGCC
TGCGAAATGCCGGACGCGGA

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTSSVIPPSPSAADYAAEGDRPLVPETDNPIGLFQDWMAQARASEPNDSNAMSLATVDADGRPDVRIVLLKGVDSEGFTF
FTNLESVKGVQLAANPVAALCFHWKSQRRQVRVRGGVAPVSAAEADAYFASRAAQSRISAIASDQSRPLADRAIFEQRVA
EISSVYGDDNDIPRPPHWGGFRLVPTEIEFWQDQAFRMHDRLRFYRKADGGWATVRLYP

Sequences:

>Translated_219_residues
MTSSVIPPSPSAADYAAEGDRPLVPETDNPIGLFQDWMAQARASEPNDSNAMSLATVDADGRPDVRIVLLKGVDSEGFTF
FTNLESVKGVQLAANPVAALCFHWKSQRRQVRVRGGVAPVSAAEADAYFASRAAQSRISAIASDQSRPLADRAIFEQRVA
EISSVYGDDNDIPRPPHWGGFRLVPTEIEFWQDQAFRMHDRLRFYRKADGGWATVRLYP
>Mature_218_residues
TSSVIPPSPSAADYAAEGDRPLVPETDNPIGLFQDWMAQARASEPNDSNAMSLATVDADGRPDVRIVLLKGVDSEGFTFF
TNLESVKGVQLAANPVAALCFHWKSQRRQVRVRGGVAPVSAAEADAYFASRAAQSRISAIASDQSRPLADRAIFEQRVAE
ISSVYGDDNDIPRPPHWGGFRLVPTEIEFWQDQAFRMHDRLRFYRKADGGWATVRLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=193, Percent_Identity=42.4870466321244, Blast_Score=161, Evalue=4e-40,
Organism=Escherichia coli, GI1787926, Length=191, Percent_Identity=40.3141361256544, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17553712, Length=211, Percent_Identity=40.7582938388626, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319509, Length=198, Percent_Identity=38.8888888888889, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45551845, Length=209, Percent_Identity=39.2344497607655, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24644901, Length=209, Percent_Identity=39.2344497607655, Blast_Score=143, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24644903, Length=168, Percent_Identity=29.7619047619048, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_HYPNA (Q0C3Z2)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759551.1
- ProteinModelPortal:   Q0C3Z2
- SMR:   Q0C3Z2
- STRING:   Q0C3Z2
- GeneID:   4288939
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0824
- NMPDR:   fig|228405.5.peg.806
- TIGR:   HNE_0824
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- PhylomeDB:   Q0C3Z2
- BioCyc:   HNEP81032:HNE_0824-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24153; Mature: 24022

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 66-66 BINDING 69-69 BINDING 71-71 BINDING 88-88 BINDING 128-128 BINDING 132-132 BINDING 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSVIPPSPSAADYAAEGDRPLVPETDNPIGLFQDWMAQARASEPNDSNAMSLATVDAD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
GRPDVRIVLLKGVDSEGFTFFTNLESVKGVQLAANPVAALCFHWKSQRRQVRVRGGVAPV
CCCCEEEEEEECCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHEEEECCCCCCC
SAAEADAYFASRAAQSRISAIASDQSRPLADRAIFEQRVAEISSVYGDDNDIPRPPHWGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
FRLVPTEIEFWQDQAFRMHDRLRFYRKADGGWATVRLYP
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TSSVIPPSPSAADYAAEGDRPLVPETDNPIGLFQDWMAQARASEPNDSNAMSLATVDAD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
GRPDVRIVLLKGVDSEGFTFFTNLESVKGVQLAANPVAALCFHWKSQRRQVRVRGGVAPV
CCCCEEEEEEECCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHEEEECCCCCCC
SAAEADAYFASRAAQSRISAIASDQSRPLADRAIFEQRVAEISSVYGDDNDIPRPPHWGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
FRLVPTEIEFWQDQAFRMHDRLRFYRKADGGWATVRLYP
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA