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The map label for this gene is pip [H]

Identifier: 114798234

GI number: 114798234

Start: 3087157

End: 3088173

Strand: Direct

Name: pip [H]

Synonym: HNE_2930

Alternate gene names: 114798234

Gene position: 3087157-3088173 (Clockwise)

Preceding gene: 114799845

Following gene: 114799380

Centisome position: 83.32

GC content: 61.16

Gene sequence:

>1017_bases
TTGTGGCTGACCATAAGTGAAGAGCGCATGAACAGACGCCAGTCCCGCCGTATATTGTATCACCGGCATGAACCTCATGC
ATCCGGACGCCTTCGTGTCTCGGATATACATGAAATCTACTGGGAAGAGTCCGGGAATCCGAAAGGTATCCCCGTGGTTG
CGTTACATGGCGGCCCCGGCGGCGGGTCCAGCCCGGAAATGCGCCGGTTCTTTGACCCCGACCGTTACCGGATCTTCCTG
TTTGACCAGCGCGGATGTGGCCGCTCGACGCCCCATTCGGAGCTTCGCGAGAACACGACCTGGGATCTGGTGGCGGATAT
TGAGGCACTGCGCAAACATGCCGGGGTTTCAAACTGGCTGGTTTTCGGCGGTTCCTGGGGCTCGACGCTGGCACTCGCCT
ATGCGGTGACCCATACGTCGAAGGTGCTCGGCCTCGTCCTGCGCGGGATATTCCTGGTCAGCAAGGCGGAGATCGACTGG
TTCTACCAGTCCGGCGCCAGCCGCCTGTTTCCCGACGCCTTTGATCAGTATCTGGCTCCCATCCCGGAAGCAGAGCGCGG
AGACCTGCTTCAGGCCTTCCACCGGCGCCTGACGGGCGACGATCCCAAAGCCCGCATCGAGGCGGCCCGCGCCTGGTCGC
AATGGGAAGGCCATACCCTGTCGATCAAAGGGCCGATGACCACGCCGCCGCGGTTCAACGAGGATGATTTCGTCGACGCG
TTCGCGCGAATCGAATGCCATTATTTCGTCAATGGCGGGTTTTTCGAGACGGATAACTGGCTGCTGACGCAGGCCAAAGC
CAAGCTGGGCAAGGTGCCCGGTGTGATCGTCCACGGACGGTATGATGTGGTGACGCCGCTTTCGACCGCCTGGGAACTGA
CCAAAGCCTGGCCAGCGGCGCATCTGCATGTTGTGCCCGATGCCGGCCACTCCTCCATGGAGCCCGGCATCATCGACCGT
CTTGTTCAGGCGACCGATGATTTTGCGGACAAGCTGGGCTCGCGCTTCAGGGTTTAG

Upstream 100 bases:

>100_bases
CAAGAACGCTACGCATCAATTGCCACCCGTCAGCAGCCAACTTCCCCAAGTGTCATTAACACTATGGGTGTGGATAAGAG
AAGTCCAGTCACGCTAGGCA

Downstream 100 bases:

>100_bases
GAGCGCAGAGATTTGGGGGGCGGGAATTGGCCCGTTGCGCCCCCTGGGAAAAGCGCCTGATCTCTTCAAACTCAAACCAC
GGGGTGCTGGGTGGCTGACT

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MWLTISEERMNRRQSRRILYHRHEPHASGRLRVSDIHEIYWEESGNPKGIPVVALHGGPGGGSSPEMRRFFDPDRYRIFL
FDQRGCGRSTPHSELRENTTWDLVADIEALRKHAGVSNWLVFGGSWGSTLALAYAVTHTSKVLGLVLRGIFLVSKAEIDW
FYQSGASRLFPDAFDQYLAPIPEAERGDLLQAFHRRLTGDDPKARIEAARAWSQWEGHTLSIKGPMTTPPRFNEDDFVDA
FARIECHYFVNGGFFETDNWLLTQAKAKLGKVPGVIVHGRYDVVTPLSTAWELTKAWPAAHLHVVPDAGHSSMEPGIIDR
LVQATDDFADKLGSRFRV

Sequences:

>Translated_338_residues
MWLTISEERMNRRQSRRILYHRHEPHASGRLRVSDIHEIYWEESGNPKGIPVVALHGGPGGGSSPEMRRFFDPDRYRIFL
FDQRGCGRSTPHSELRENTTWDLVADIEALRKHAGVSNWLVFGGSWGSTLALAYAVTHTSKVLGLVLRGIFLVSKAEIDW
FYQSGASRLFPDAFDQYLAPIPEAERGDLLQAFHRRLTGDDPKARIEAARAWSQWEGHTLSIKGPMTTPPRFNEDDFVDA
FARIECHYFVNGGFFETDNWLLTQAKAKLGKVPGVIVHGRYDVVTPLSTAWELTKAWPAAHLHVVPDAGHSSMEPGIIDR
LVQATDDFADKLGSRFRV
>Mature_338_residues
MWLTISEERMNRRQSRRILYHRHEPHASGRLRVSDIHEIYWEESGNPKGIPVVALHGGPGGGSSPEMRRFFDPDRYRIFL
FDQRGCGRSTPHSELRENTTWDLVADIEALRKHAGVSNWLVFGGSWGSTLALAYAVTHTSKVLGLVLRGIFLVSKAEIDW
FYQSGASRLFPDAFDQYLAPIPEAERGDLLQAFHRRLTGDDPKARIEAARAWSQWEGHTLSIKGPMTTPPRFNEDDFVDA
FARIECHYFVNGGFFETDNWLLTQAKAKLGKVPGVIVHGRYDVVTPLSTAWELTKAWPAAHLHVVPDAGHSSMEPGIIDR
LVQATDDFADKLGSRFRV

Specific function: May be involved in proline metabolism and sensitivity to ascamycin. Has ascamycin dealanylating activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 38188; Mature: 38188

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00087 SOD_CU_ZN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWLTISEERMNRRQSRRILYHRHEPHASGRLRVSDIHEIYWEESGNPKGIPVVALHGGPG
CEEEECHHHHHHHHHHCEEEECCCCCCCCCEEHHHHHHHHHCCCCCCCCCEEEEEECCCC
GGSSPEMRRFFDPDRYRIFLFDQRGCGRSTPHSELRENTTWDLVADIEALRKHAGVSNWL
CCCCCHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEE
VFGGSWGSTLALAYAVTHTSKVLGLVLRGIFLVSKAEIDWFYQSGASRLFPDAFDQYLAP
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
IPEAERGDLLQAFHRRLTGDDPKARIEAARAWSQWEGHTLSIKGPMTTPPRFNEDDFVDA
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHH
FARIECHYFVNGGFFETDNWLLTQAKAKLGKVPGVIVHGRYDVVTPLSTAWELTKAWPAA
HHEEEEEEEECCCEEECCCEEEEHHHHHHCCCCCEEEECCCEECCCCHHHHHHHHCCCCC
HLHVVPDAGHSSMEPGIIDRLVQATDDFADKLGSRFRV
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MWLTISEERMNRRQSRRILYHRHEPHASGRLRVSDIHEIYWEESGNPKGIPVVALHGGPG
CEEEECHHHHHHHHHHCEEEECCCCCCCCCEEHHHHHHHHHCCCCCCCCCEEEEEECCCC
GGSSPEMRRFFDPDRYRIFLFDQRGCGRSTPHSELRENTTWDLVADIEALRKHAGVSNWL
CCCCCHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEE
VFGGSWGSTLALAYAVTHTSKVLGLVLRGIFLVSKAEIDWFYQSGASRLFPDAFDQYLAP
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
IPEAERGDLLQAFHRRLTGDDPKARIEAARAWSQWEGHTLSIKGPMTTPPRFNEDDFVDA
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHH
FARIECHYFVNGGFFETDNWLLTQAKAKLGKVPGVIVHGRYDVVTPLSTAWELTKAWPAA
HHEEEEEEEECCCEEECCCEEEEHHHHHHCCCCCEEEECCCEECCCCHHHHHHHHCCCCC
HLHVVPDAGHSSMEPGIIDRLVQATDDFADKLGSRFRV
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8885412; 8870654 [H]