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The map label for this gene is fadA [H]

Identifier: 114798142

GI number: 114798142

Start: 2866498

End: 2867706

Strand: Direct

Name: fadA [H]

Synonym: HNE_2706

Alternate gene names: 114798142

Gene position: 2866498-2867706 (Clockwise)

Preceding gene: 114797578

Following gene: 114799738

Centisome position: 77.37

GC content: 63.03

Gene sequence:

>1209_bases
ATGCGTGAAGCCGTAATCGTTTCAACAGCCCGTACTGCCCTGACCAAAGCCGGTCGCGGCGCCCTCAATGACACCCATGG
CATCACCATGGCTGGCCACGCCATCAAGGGCGCGCTCGAGCGCGCCGGCGTTGAAGCCGCTGCGGTTGAAGACGTGTTCC
TCGGCTGCGCCGCGCCGGAAGGCGCTACCGGCCACAACGTTGCCCGTAACGCCGCGCTCGCCGCTGGCTGCCCGTCCAGC
ACGTCTGGCGCCACCATCAACCGCTTCTGTTCCTCGGGCCTGCAGGCCATCGCAAACGCCGCGCACACCGTGATCCATGA
AGGCGCAGCGGTCACCGTTGGCGGCGGCGTGGAGAGCATCAGCCTCGTTCAGGGTTCGGGCCAGTCCAACCGCTACAAGT
ATTTCGAGCCGGAACTGGCCAAGACCTGGCCGGCCATCTGGATGACGATGATCGAAACGGCCGAGATCGTTGCCGAGCGT
TACAATGTCAGCCGCGAACACCAGGACCAGTATTCTGCCGAGAGCCAGCGCCGCACGGCCGAGTTCCAGCAGAAAGGCTA
CATGGCACAGGAAATCGTGCCGATGAAAACCAAGATGCGCCTCGTCAACAAAGAGACCAAGGAAGAAACCTTCCAGGACG
TGATCGCTGACCGTGACGACTGTAACCGTCCCGGCACGACCTATGAGAGCCTGGCTGGCCTTCCGCCGGTGTTCTCCGGT
GGCCAGGTCATCAAGCAGGGCAAGTTCGTCACTGCCGGTAACGCCTCGCAGCTCTCCGATGGCGCCGCGGCTGTGGTCGT
CATGGAAGCCAAGGAAGCGGCAAAGCGCGGCCTGAAGCCGCTCGGCCGTTTTGCTGGTTTCAACGTTGCCGGTTGCGATC
CTGACGAAATGGGCATCGGCCCGGTCTTCGCAGTGCCGCGTCTGCTGGAGCGTCATGGCCTGAAGGTCGACGATATCGAC
CTCTGGGAACTGAACGAAGCGTTCGCCTCGCAGTGCCTCTACTCGCGCGATCGCCTCGGCATTGATCCTGAGAAGTACAA
CGTGAACGGCGGCTCGATCTCGATCGGCCACCCCTTCGGCATGACCGGCGCACGCTGCACCGGATCCATCCTGCTCGAAG
GTCAGCGCCGCGGCGCAAAATGGGGCGTTGTCACCATGTGTATCGGTGGCGGTATGGGCGCAGCCGGCCTGTTCGAAATC
TACAGCTGA

Upstream 100 bases:

>100_bases
TCTGAACTGCCCGTTTACGTCAACGGAAGGCTGGCCTTACGGAAATTCACTCACTAGGGTGCGCCGCACAAAGACGTAAG
CATCATCCAGGAGGAAGCCA

Downstream 100 bases:

>100_bases
GCCTGATTTCCGGTCTCCGCCGGAAGCCAGACAGACACGTATTGCGAGGGGCGGCTCATTCGGGCCGCCCTTTTGCTTAT
GGGTGGGTTCAGAATTGCTG

Product: acetyl-CoA acyltransferase/thiolase family protein

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MREAVIVSTARTALTKAGRGALNDTHGITMAGHAIKGALERAGVEAAAVEDVFLGCAAPEGATGHNVARNAALAAGCPSS
TSGATINRFCSSGLQAIANAAHTVIHEGAAVTVGGGVESISLVQGSGQSNRYKYFEPELAKTWPAIWMTMIETAEIVAER
YNVSREHQDQYSAESQRRTAEFQQKGYMAQEIVPMKTKMRLVNKETKEETFQDVIADRDDCNRPGTTYESLAGLPPVFSG
GQVIKQGKFVTAGNASQLSDGAAAVVVMEAKEAAKRGLKPLGRFAGFNVAGCDPDEMGIGPVFAVPRLLERHGLKVDDID
LWELNEAFASQCLYSRDRLGIDPEKYNVNGGSISIGHPFGMTGARCTGSILLEGQRRGAKWGVVTMCIGGGMGAAGLFEI
YS

Sequences:

>Translated_402_residues
MREAVIVSTARTALTKAGRGALNDTHGITMAGHAIKGALERAGVEAAAVEDVFLGCAAPEGATGHNVARNAALAAGCPSS
TSGATINRFCSSGLQAIANAAHTVIHEGAAVTVGGGVESISLVQGSGQSNRYKYFEPELAKTWPAIWMTMIETAEIVAER
YNVSREHQDQYSAESQRRTAEFQQKGYMAQEIVPMKTKMRLVNKETKEETFQDVIADRDDCNRPGTTYESLAGLPPVFSG
GQVIKQGKFVTAGNASQLSDGAAAVVVMEAKEAAKRGLKPLGRFAGFNVAGCDPDEMGIGPVFAVPRLLERHGLKVDDID
LWELNEAFASQCLYSRDRLGIDPEKYNVNGGSISIGHPFGMTGARCTGSILLEGQRRGAKWGVVTMCIGGGMGAAGLFEI
YS
>Mature_402_residues
MREAVIVSTARTALTKAGRGALNDTHGITMAGHAIKGALERAGVEAAAVEDVFLGCAAPEGATGHNVARNAALAAGCPSS
TSGATINRFCSSGLQAIANAAHTVIHEGAAVTVGGGVESISLVQGSGQSNRYKYFEPELAKTWPAIWMTMIETAEIVAER
YNVSREHQDQYSAESQRRTAEFQQKGYMAQEIVPMKTKMRLVNKETKEETFQDVIADRDDCNRPGTTYESLAGLPPVFSG
GQVIKQGKFVTAGNASQLSDGAAAVVVMEAKEAAKRGLKPLGRFAGFNVAGCDPDEMGIGPVFAVPRLLERHGLKVDDID
LWELNEAFASQCLYSRDRLGIDPEKYNVNGGSISIGHPFGMTGARCTGSILLEGQRRGAKWGVVTMCIGGGMGAAGLFEI
YS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=399, Percent_Identity=39.5989974937343, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI167614485, Length=408, Percent_Identity=35.7843137254902, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=35.75, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=33.2512315270936, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4504327, Length=444, Percent_Identity=31.0810810810811, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI194353979, Length=88, Percent_Identity=54.5454545454545, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1787663, Length=417, Percent_Identity=40.5275779376499, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=38.1188118811881, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1788554, Length=412, Percent_Identity=38.5922330097087, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI87082165, Length=409, Percent_Identity=37.1638141809291, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=28.9411764705882, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=403, Percent_Identity=38.7096774193548, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI25147385, Length=406, Percent_Identity=33.2512315270936, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17535921, Length=419, Percent_Identity=32.9355608591885, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=448, Percent_Identity=27.4553571428571, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=30.4239401496259, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=409, Percent_Identity=36.4303178484108, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=415, Percent_Identity=30.6024096385542, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24655093, Length=405, Percent_Identity=39.2592592592593, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17648125, Length=404, Percent_Identity=37.6237623762376, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=34.1584158415842, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17137578, Length=415, Percent_Identity=33.0120481927711, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42564; Mature: 42564

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVSTARTALTKAGRGALNDTHGITMAGHAIKGALERAGVEAAAVEDVFLGCAAPE
CCCEEEEEHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCCC
GATGHNVARNAALAAGCPSSTSGATINRFCSSGLQAIANAAHTVIHEGAAVTVGGGVESI
CCCCCHHHHHCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEE
SLVQGSGQSNRYKYFEPELAKTWPAIWMTMIETAEIVAERYNVSREHQDQYSAESQRRTA
EEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EFQQKGYMAQEIVPMKTKMRLVNKETKEETFQDVIADRDDCNRPGTTYESLAGLPPVFSG
HHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCC
GQVIKQGKFVTAGNASQLSDGAAAVVVMEAKEAAKRGLKPLGRFAGFNVAGCDPDEMGIG
CHHHCCCCEEECCCHHHCCCCCEEEEEEECHHHHHHCCHHHHHHCCCCCCCCCHHHCCCC
PVFAVPRLLERHGLKVDDIDLWELNEAFASQCLYSRDRLGIDPEKYNVNGGSISIGHPFG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEEECCCCC
MTGARCTGSILLEGQRRGAKWGVVTMCIGGGMGAAGLFEIYS
CCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHCCC
>Mature Secondary Structure
MREAVIVSTARTALTKAGRGALNDTHGITMAGHAIKGALERAGVEAAAVEDVFLGCAAPE
CCCEEEEEHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCCC
GATGHNVARNAALAAGCPSSTSGATINRFCSSGLQAIANAAHTVIHEGAAVTVGGGVESI
CCCCCHHHHHCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEE
SLVQGSGQSNRYKYFEPELAKTWPAIWMTMIETAEIVAERYNVSREHQDQYSAESQRRTA
EEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EFQQKGYMAQEIVPMKTKMRLVNKETKEETFQDVIADRDDCNRPGTTYESLAGLPPVFSG
HHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCC
GQVIKQGKFVTAGNASQLSDGAAAVVVMEAKEAAKRGLKPLGRFAGFNVAGCDPDEMGIG
CHHHCCCCEEECCCHHHCCCCCEEEEEEECHHHHHHCCHHHHHHCCCCCCCCCHHHCCCC
PVFAVPRLLERHGLKVDDIDLWELNEAFASQCLYSRDRLGIDPEKYNVNGGSISIGHPFG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEEECCCCC
MTGARCTGSILLEGQRRGAKWGVVTMCIGGGMGAAGLFEIYS
CCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]