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The map label for this gene is can [H]

Identifier: 114798000

GI number: 114798000

Start: 1597249

End: 1597887

Strand: Direct

Name: can [H]

Synonym: HNE_1567

Alternate gene names: 114798000

Gene position: 1597249-1597887 (Clockwise)

Preceding gene: 114798885

Following gene: 114799679

Centisome position: 43.11

GC content: 56.49

Gene sequence:

>639_bases
ATGATCGGAACACTGCTTAACAACAATATGAACTGGGCGAGCGCGAGAGTTCGGGCAGACCCTGGATTCTTCCGCCGGCT
CTCTGCACAGCAGGCGCCGGAATATCTCTGGATCGGGTGCAGCGATAGCCGTGTACCTGCCAACGAAATTGTCGGGCTCG
ACCCGGGCGAACTCTTCGTCCACCGAAACATCGCGAATCTGGCGCCGCCGCGCGACATCAATTTTCTTGCTGTCCTTCAG
TATTCCGTCGAAGTTCTGAGAGTGCGCCATATCATCGTTTGCGGGCATTATGGGTGTGGCGGTGTCCGGGCTGCCCTCGA
TACCGAACGTCGGGGCCTGATCGACCACTGGCTTCAGCCAGTTTCTGATCTTGCGCACAGACACGCCGGTCACCTCGATA
AGATTTCTGATTTTGATACCAGGGTGAATGTCGCCTGTGAGCACAATGTCCGGGCGCAGGTCGAATATCTCGGTCGCAAT
CCGTTTGTGACGGATGCCTGGCGGCGTGGTCAGAAGATAGCAGTCCATGGATGGATTTATTCCATCCGGGACGGTCTGCT
GCGCGATCTGGACCTCACAATCGAACGTCCCAAGGATGTTGACCGTCTTTCAGCGAAGGCCTGGTTTCCGGATGGATAG

Upstream 100 bases:

>100_bases
TTCCGATTGCGCGGCATCGCCTGACTGTGGAAGACTTGGATAATCTTGCGCGCAGACTCGCTGCGCGCCGTGGCCTCAAC
GATCCGTTTGCGGATGCCTC

Downstream 100 bases:

>100_bases
AGTCGGAGTCGCCATTCTCGCAGGCGGGCAGGGAACACGGATGGGCGGCAGGAAGCCGGAACGGCATTTTCGAGGTCGCC
GGTTGATTGATCCCGTGCTT

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase 2 [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MIGTLLNNNMNWASARVRADPGFFRRLSAQQAPEYLWIGCSDSRVPANEIVGLDPGELFVHRNIANLAPPRDINFLAVLQ
YSVEVLRVRHIIVCGHYGCGGVRAALDTERRGLIDHWLQPVSDLAHRHAGHLDKISDFDTRVNVACEHNVRAQVEYLGRN
PFVTDAWRRGQKIAVHGWIYSIRDGLLRDLDLTIERPKDVDRLSAKAWFPDG

Sequences:

>Translated_212_residues
MIGTLLNNNMNWASARVRADPGFFRRLSAQQAPEYLWIGCSDSRVPANEIVGLDPGELFVHRNIANLAPPRDINFLAVLQ
YSVEVLRVRHIIVCGHYGCGGVRAALDTERRGLIDHWLQPVSDLAHRHAGHLDKISDFDTRVNVACEHNVRAQVEYLGRN
PFVTDAWRRGQKIAVHGWIYSIRDGLLRDLDLTIERPKDVDRLSAKAWFPDG
>Mature_212_residues
MIGTLLNNNMNWASARVRADPGFFRRLSAQQAPEYLWIGCSDSRVPANEIVGLDPGELFVHRNIANLAPPRDINFLAVLQ
YSVEVLRVRHIIVCGHYGCGGVRAALDTERRGLIDHWLQPVSDLAHRHAGHLDKISDFDTRVNVACEHNVRAQVEYLGRN
PFVTDAWRRGQKIAVHGWIYSIRDGLLRDLDLTIERPKDVDRLSAKAWFPDG

Specific function: Unknown

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786318, Length=201, Percent_Identity=50.7462686567164, Blast_Score=222, Evalue=1e-59,
Organism=Escherichia coli, GI1786534, Length=176, Percent_Identity=34.6590909090909, Blast_Score=101, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324292, Length=195, Percent_Identity=30.7692307692308, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 24009; Mature: 24009

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGTLLNNNMNWASARVRADPGFFRRLSAQQAPEYLWIGCSDSRVPANEIVGLDPGELFV
CCCCEECCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCHHHEECCCCCCEEE
HRNIANLAPPRDINFLAVLQYSVEVLRVRHIIVCGHYGCGGVRAALDTERRGLIDHWLQP
ECCHHHCCCCCCCCEEHHHHHHHHHHHHEEEEEECCCCCCCHHHHHCCHHCHHHHHHHHH
VSDLAHRHAGHLDKISDFDTRVNVACEHNVRAQVEYLGRNPFVTDAWRRGQKIAVHGWIY
HHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHCCCEEEEEHHHH
SIRDGLLRDLDLTIERPKDVDRLSAKAWFPDG
HHHHHHHHCCCEEEECCCCHHHHCCCCCCCCC
>Mature Secondary Structure
MIGTLLNNNMNWASARVRADPGFFRRLSAQQAPEYLWIGCSDSRVPANEIVGLDPGELFV
CCCCEECCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCHHHEECCCCCCEEE
HRNIANLAPPRDINFLAVLQYSVEVLRVRHIIVCGHYGCGGVRAALDTERRGLIDHWLQP
ECCHHHCCCCCCCCEEHHHHHHHHHHHHEEEEEECCCCCCCHHHHHCCHHCHHHHHHHHH
VSDLAHRHAGHLDKISDFDTRVNVACEHNVRAQVEYLGRNPFVTDAWRRGQKIAVHGWIY
HHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHCCCEEEEEHHHH
SIRDGLLRDLDLTIERPKDVDRLSAKAWFPDG
HHHHHHHHCCCEEEECCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8202364; 9278503; 10493123 [H]