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The map label for this gene is sugE [H]

Identifier: 114797945

GI number: 114797945

Start: 2769593

End: 2769907

Strand: Direct

Name: sugE [H]

Synonym: HNE_2609

Alternate gene names: 114797945

Gene position: 2769593-2769907 (Clockwise)

Preceding gene: 114797415

Following gene: 114798935

Centisome position: 74.75

GC content: 61.59

Gene sequence:

>315_bases
ATGCCTTGGGTCTTTCTTGTTATCGCCGGTCTTCTGGAAATCGTCTGGGCAACCTCGATGAAGCAATCGGCCGGGTTCAC
CCGCCTCGGCCCCAGCCTCATTACCCTCGCCGCCATGCCTGCCAGCTTCCTGCTGCTGGCGCTTGCCATGCGCAGCCTGC
CGCTGGGCACGTCTTACATGGTGTGGACGGGCATTGGCGCGGTGGGCGCGTTTATTGTGGGCATCCTGTGGATGGGCGAA
GCCATAACGCCTCTGCGCGTGCTGGCGGCGGCGCTGATTGCCGGCGGTATGATCCTGATGAAAATCGCTGAATAA

Upstream 100 bases:

>100_bases
TGAGCTCTGCCCCAAACCGCCTATCTAACCTGCACAGGCAGGAGGACGGCCTCCCCCATATCGGGAACGCTTCGGGACGG
CCCGTTTACGGGAGCCCCCC

Downstream 100 bases:

>100_bases
TTCCGCATTTAATCCGGTCCGCGAGCCCCCGAGAATTTAGGCATATCCAAGTGAGGTTGAGCGGGGCGACGAAATGCCCG
CTTTGCTTTGGATCAATTGG

Product: quaternary ammonium compound-resistance protein SugE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MPWVFLVIAGLLEIVWATSMKQSAGFTRLGPSLITLAAMPASFLLLALAMRSLPLGTSYMVWTGIGAVGAFIVGILWMGE
AITPLRVLAAALIAGGMILMKIAE

Sequences:

>Translated_104_residues
MPWVFLVIAGLLEIVWATSMKQSAGFTRLGPSLITLAAMPASFLLLALAMRSLPLGTSYMVWTGIGAVGAFIVGILWMGE
AITPLRVLAAALIAGGMILMKIAE
>Mature_103_residues
PWVFLVIAGLLEIVWATSMKQSAGFTRLGPSLITLAAMPASFLLLALAMRSLPLGTSYMVWTGIGAVGAFIVGILWMGEA
ITPLRVLAAALIAGGMILMKIAE

Specific function: Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. SugE (TC 2.A.7.1.4) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082378, Length=103, Percent_Identity=57.2815533980583, Blast_Score=111, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 10934; Mature: 10802

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.7 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWVFLVIAGLLEIVWATSMKQSAGFTRLGPSLITLAAMPASFLLLALAMRSLPLGTSYM
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VWTGIGAVGAFIVGILWMGEAITPLRVLAAALIAGGMILMKIAE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHEEECC
>Mature Secondary Structure 
PWVFLVIAGLLEIVWATSMKQSAGFTRLGPSLITLAAMPASFLLLALAMRSLPLGTSYM
CHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VWTGIGAVGAFIVGILWMGEAITPLRVLAAALIAGGMILMKIAE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]