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The map label for this gene is nrdZ [H]

Identifier: 114797863

GI number: 114797863

Start: 1579171

End: 1581366

Strand: Direct

Name: nrdZ [H]

Synonym: HNE_1555

Alternate gene names: 114797863

Gene position: 1579171-1581366 (Clockwise)

Preceding gene: 114797389

Following gene: 114798679

Centisome position: 42.62

GC content: 60.84

Gene sequence:

>2196_bases
ATGCCTTTCGACACGCCGCTTGCAGCCGAAATCTGGGAAAAGAAATACCGCTTCCGCTCCGACGAGGGTGAGGATGTTGA
CCTCGCCGCAACGCTTTCTCGTGTTGCCAATGCTGTTGCCAAAGCGGAGAACCCCGCAAACCGGAAGGTCTGGCGCGCGC
GGTTCCGCGATGCGCTCACGGACTTCCGATTTATCCCCGCAGGACGGATCCTCGCCGGTGCCGGGACGGCGCGCAATGTC
ACCCTGTTCAACTGTTTTGTGATGGGGACTCTCCCTGACAACCTGCCAGGAATCTTCGAACATCTTCGTGAAGCGGCTGT
TACCCTGCAGCAGGGCGGCGGGGTAGGGATGGATTTCTCCACCATCCGCCCGTCTGGTGCTCCGGTCATGGGCGTCGGCG
CGCAGGCGTCCGGTCCGCTCTCCTTCATGGACACATGGGATGCAATGTGCCGGACCATCATGTCGGCGGGCCAGCGGCGC
GGCGCGATGATGGGCTGCCTGCGCATTGATCATCCCGATATCGAGGCCTTCATCGACGCCAAGCGCGATGGCGCGCGGTT
TCGCAACTTCAACCTTTCGGTCCTTGTGACCGATGAATTCATGGCGGCGCTGGAGGCGGGCAGGGACTGGACGCTCAGCT
TCAATGGCCAGCCCTATCGCTCATTGCCTGCGTCAGGTCTCTGGGACCGGCTCATGCAGGCGACCTATGACGCCGCAGAG
CCCGGCGTGATCTTTGTCGACCGGGTGAATGCGCTCAACAATCTCGCAGACATTGAGACGATCAGCGCCTCAAATCCCTG
CGGCGAGCAGATGCTGCCGCCCTATGGCGCGTGTCTTCTGGGCTCGATCAATCTGGCGCGGCTTGTTTCCTCTCCCTTTG
AGGCAGATGCGAAAATCGAGCTGACCGAGCTTGAAACGCTGACAGAAACCGCCATCCGCTTTCTTGACAATGTTATCGAC
ATCTCGCGCTACCCCCTTGAGCAGCAGGGAGAGGAGGCCCGCGCCAAACGCAGGCTCGGACTGGGCGTCACGGGGCTTGC
TGACGCCTTGATCTTCTGCGGCGCTGCCTATGGTTCGGACAAGGCCGTCGCTCTGTCGGAGCGCTGGATGGGGGCAATCA
AGCGTGCCGCCTATCGCGCGTCAGCCCATCTCGCGGCGGAGAAGGGACCTTACCCGCTTTTTGACAAGGCCATTCTGGAT
CGCCCGAACCTTCTGGGCCTCGATCCTGACACGCGTGCCCTGATCTCCGAGCATGGCCTGCGCAATGGCTGCCTCACATC
GATAGCGCCTACTGGCACAACCTCTCTGCTTGCCGACAACGTTTCCTCCGGAGTGGAACCCGTTTTTGCCTTTTCCTATT
CGCGAAAAGTGCGTCAGGCGGACGGCACCAGTGTCGAAGAACCCGTCACCGACTATGCGCTTCGTGTCTGGCACAGGCTG
CACGGCGACGCGGCGCCACCGGCAGACGTATTCGTCAGTGCACAGACCCTGACCCCTCAGGATCATCTTCGCATGCAGGC
AAGCGCGCAGCGTTTTGTGGACAGTTCCATTTCGAAGACCGTCAACTGTCCGGCCGATATCAGCTTCGATGCGTTCAAGG
ATGTCTATCGCGAAGGCTATCGGCTCGGCTGCAAGGGACTGACGACCTACCGGCCCAATGCCATCACAGGATCTGTCCTT
TCGGTCGCTGAAACGCCTGTCCAGGCGGACGTTCCGGAGACGCCGCTCGCGCCGCGCGCACGCAAACTGGAAGGGGCGAC
CTACAAACTCAAATGGCCGCAAAGCGCGCATGCTGTCTATGTTACCATTAATGATGCAGACACCGGTCATGGACCCCGGC
CATTCGAGATCTTCGTCAACTCCAAGAACATGGACCATTATGCCTGGACCCTTGCCCTGACACGGATGATTTCGGCTGTG
TTCCGCCGGGGGGGCGATGTCAGTTTCGTCGCCGACGAGCTTCAGGCTGTGTTTGATCCGCAGGGCGGCGCGTTCATGGA
CGGGCGGTACGTGCCTTCTCTGCCCGCCGCGATCGGACGCGTTGTGGCCGAACATCTCGGCATGACGGGTGCGGGCAGTG
CCGAGACTGGCAACCGCAAGGATGCAGCCTGTTGCCCGAAATGTGGTCAGAAAGCACTGATCCGTAAGGAAGGCTGTGAC
ACCTGTCTCGAGTGCGGCCATTCGAAATGCGGGTAA

Upstream 100 bases:

>100_bases
ATTTTCATCCCGCTGTCAGATGCTGCGCACCTCGCGTTTTGCCGCACCGAATCGGAGAGCCTGACCGTCCTTCAGCGATC
AGATGAACAGGACAATCACC

Downstream 100 bases:

>100_bases
ATTTGAAAAGGGATATGCAGAATGGCGACCAGTGCTGAACAAATTCGTGCCTATAGGGGGCCGGCTCTGTTCAGCCTTGG
CCTGCGGCCCTTCTTTCTGT

Product: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 731; Mature: 730

Protein sequence:

>731_residues
MPFDTPLAAEIWEKKYRFRSDEGEDVDLAATLSRVANAVAKAENPANRKVWRARFRDALTDFRFIPAGRILAGAGTARNV
TLFNCFVMGTLPDNLPGIFEHLREAAVTLQQGGGVGMDFSTIRPSGAPVMGVGAQASGPLSFMDTWDAMCRTIMSAGQRR
GAMMGCLRIDHPDIEAFIDAKRDGARFRNFNLSVLVTDEFMAALEAGRDWTLSFNGQPYRSLPASGLWDRLMQATYDAAE
PGVIFVDRVNALNNLADIETISASNPCGEQMLPPYGACLLGSINLARLVSSPFEADAKIELTELETLTETAIRFLDNVID
ISRYPLEQQGEEARAKRRLGLGVTGLADALIFCGAAYGSDKAVALSERWMGAIKRAAYRASAHLAAEKGPYPLFDKAILD
RPNLLGLDPDTRALISEHGLRNGCLTSIAPTGTTSLLADNVSSGVEPVFAFSYSRKVRQADGTSVEEPVTDYALRVWHRL
HGDAAPPADVFVSAQTLTPQDHLRMQASAQRFVDSSISKTVNCPADISFDAFKDVYREGYRLGCKGLTTYRPNAITGSVL
SVAETPVQADVPETPLAPRARKLEGATYKLKWPQSAHAVYVTINDADTGHGPRPFEIFVNSKNMDHYAWTLALTRMISAV
FRRGGDVSFVADELQAVFDPQGGAFMDGRYVPSLPAAIGRVVAEHLGMTGAGSAETGNRKDAACCPKCGQKALIRKEGCD
TCLECGHSKCG

Sequences:

>Translated_731_residues
MPFDTPLAAEIWEKKYRFRSDEGEDVDLAATLSRVANAVAKAENPANRKVWRARFRDALTDFRFIPAGRILAGAGTARNV
TLFNCFVMGTLPDNLPGIFEHLREAAVTLQQGGGVGMDFSTIRPSGAPVMGVGAQASGPLSFMDTWDAMCRTIMSAGQRR
GAMMGCLRIDHPDIEAFIDAKRDGARFRNFNLSVLVTDEFMAALEAGRDWTLSFNGQPYRSLPASGLWDRLMQATYDAAE
PGVIFVDRVNALNNLADIETISASNPCGEQMLPPYGACLLGSINLARLVSSPFEADAKIELTELETLTETAIRFLDNVID
ISRYPLEQQGEEARAKRRLGLGVTGLADALIFCGAAYGSDKAVALSERWMGAIKRAAYRASAHLAAEKGPYPLFDKAILD
RPNLLGLDPDTRALISEHGLRNGCLTSIAPTGTTSLLADNVSSGVEPVFAFSYSRKVRQADGTSVEEPVTDYALRVWHRL
HGDAAPPADVFVSAQTLTPQDHLRMQASAQRFVDSSISKTVNCPADISFDAFKDVYREGYRLGCKGLTTYRPNAITGSVL
SVAETPVQADVPETPLAPRARKLEGATYKLKWPQSAHAVYVTINDADTGHGPRPFEIFVNSKNMDHYAWTLALTRMISAV
FRRGGDVSFVADELQAVFDPQGGAFMDGRYVPSLPAAIGRVVAEHLGMTGAGSAETGNRKDAACCPKCGQKALIRKEGCD
TCLECGHSKCG
>Mature_730_residues
PFDTPLAAEIWEKKYRFRSDEGEDVDLAATLSRVANAVAKAENPANRKVWRARFRDALTDFRFIPAGRILAGAGTARNVT
LFNCFVMGTLPDNLPGIFEHLREAAVTLQQGGGVGMDFSTIRPSGAPVMGVGAQASGPLSFMDTWDAMCRTIMSAGQRRG
AMMGCLRIDHPDIEAFIDAKRDGARFRNFNLSVLVTDEFMAALEAGRDWTLSFNGQPYRSLPASGLWDRLMQATYDAAEP
GVIFVDRVNALNNLADIETISASNPCGEQMLPPYGACLLGSINLARLVSSPFEADAKIELTELETLTETAIRFLDNVIDI
SRYPLEQQGEEARAKRRLGLGVTGLADALIFCGAAYGSDKAVALSERWMGAIKRAAYRASAHLAAEKGPYPLFDKAILDR
PNLLGLDPDTRALISEHGLRNGCLTSIAPTGTTSLLADNVSSGVEPVFAFSYSRKVRQADGTSVEEPVTDYALRVWHRLH
GDAAPPADVFVSAQTLTPQDHLRMQASAQRFVDSSISKTVNCPADISFDAFKDVYREGYRLGCKGLTTYRPNAITGSVLS
VAETPVQADVPETPLAPRARKLEGATYKLKWPQSAHAVYVTINDADTGHGPRPFEIFVNSKNMDHYAWTLALTRMISAVF
RRGGDVSFVADELQAVFDPQGGAFMDGRYVPSLPAAIGRVVAEHLGMTGAGSAETGNRKDAACCPKCGQKALIRKEGCDT
CLECGHSKCG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=550, Percent_Identity=26, Blast_Score=164, Evalue=3e-40,
Organism=Escherichia coli, GI2367133, Length=531, Percent_Identity=24.8587570621469, Blast_Score=110, Evalue=5e-25,
Organism=Escherichia coli, GI1789030, Length=537, Percent_Identity=24.3947858472998, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17555242, Length=573, Percent_Identity=25.4799301919721, Blast_Score=164, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320914, Length=442, Percent_Identity=27.6018099547511, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322123, Length=442, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17352481, Length=552, Percent_Identity=24.8188405797101, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 79168; Mature: 79036

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFDTPLAAEIWEKKYRFRSDEGEDVDLAATLSRVANAVAKAENPANRKVWRARFRDALT
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DFRFIPAGRILAGAGTARNVTLFNCFVMGTLPDNLPGIFEHLREAAVTLQQGGGVGMDFS
HCEECCCCCEEECCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
TIRPSGAPVMGVGAQASGPLSFMDTWDAMCRTIMSAGQRRGAMMGCLRIDHPDIEAFIDA
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCC
KRDGARFRNFNLSVLVTDEFMAALEAGRDWTLSFNGQPYRSLPASGLWDRLMQATYDAAE
CCCCCEEECCCEEEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCC
PGVIFVDRVNALNNLADIETISASNPCGEQMLPPYGACLLGSINLARLVSSPFEADAKIE
CCEEEEECHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCEEE
LTELETLTETAIRFLDNVIDISRYPLEQQGEEARAKRRLGLGVTGLADALIFCGAAYGSD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
KAVALSERWMGAIKRAAYRASAHLAAEKGPYPLFDKAILDRPNLLGLDPDTRALISEHGL
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEECCCCCHHHHHHHCCC
RNGCLTSIAPTGTTSLLADNVSSGVEPVFAFSYSRKVRQADGTSVEEPVTDYALRVWHRL
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
HGDAAPPADVFVSAQTLTPQDHLRMQASAQRFVDSSISKTVNCPADISFDAFKDVYREGY
CCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
RLGCKGLTTYRPNAITGSVLSVAETPVQADVPETPLAPRARKLEGATYKLKWPQSAHAVY
EECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCEEE
VTINDADTGHGPRPFEIFVNSKNMDHYAWTLALTRMISAVFRRGGDVSFVADELQAVFDP
EEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
QGGAFMDGRYVPSLPAAIGRVVAEHLGMTGAGSAETGNRKDAACCPKCGQKALIRKEGCD
CCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCH
TCLECGHSKCG
HHHHCCCCCCC
>Mature Secondary Structure 
PFDTPLAAEIWEKKYRFRSDEGEDVDLAATLSRVANAVAKAENPANRKVWRARFRDALT
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DFRFIPAGRILAGAGTARNVTLFNCFVMGTLPDNLPGIFEHLREAAVTLQQGGGVGMDFS
HCEECCCCCEEECCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
TIRPSGAPVMGVGAQASGPLSFMDTWDAMCRTIMSAGQRRGAMMGCLRIDHPDIEAFIDA
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCC
KRDGARFRNFNLSVLVTDEFMAALEAGRDWTLSFNGQPYRSLPASGLWDRLMQATYDAAE
CCCCCEEECCCEEEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCC
PGVIFVDRVNALNNLADIETISASNPCGEQMLPPYGACLLGSINLARLVSSPFEADAKIE
CCEEEEECHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCEEE
LTELETLTETAIRFLDNVIDISRYPLEQQGEEARAKRRLGLGVTGLADALIFCGAAYGSD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
KAVALSERWMGAIKRAAYRASAHLAAEKGPYPLFDKAILDRPNLLGLDPDTRALISEHGL
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEECCCCCHHHHHHHCCC
RNGCLTSIAPTGTTSLLADNVSSGVEPVFAFSYSRKVRQADGTSVEEPVTDYALRVWHRL
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
HGDAAPPADVFVSAQTLTPQDHLRMQASAQRFVDSSISKTVNCPADISFDAFKDVYREGY
CCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
RLGCKGLTTYRPNAITGSVLSVAETPVQADVPETPLAPRARKLEGATYKLKWPQSAHAVY
EECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCEEE
VTINDADTGHGPRPFEIFVNSKNMDHYAWTLALTRMISAVFRRGGDVSFVADELQAVFDP
EEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
QGGAFMDGRYVPSLPAAIGRVVAEHLGMTGAGSAETGNRKDAACCPKCGQKALIRKEGCD
CCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCH
TCLECGHSKCG
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]