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The map label for this gene is gcvPA

Identifier: 114797821

GI number: 114797821

Start: 2883746

End: 2885089

Strand: Direct

Name: gcvPA

Synonym: HNE_2721

Alternate gene names: 114797821

Gene position: 2883746-2885089 (Clockwise)

Preceding gene: 114799251

Following gene: 114800538

Centisome position: 77.83

GC content: 65.25

Gene sequence:

>1344_bases
ATGCGCTATCTGCCGCTCACGCCTGAGGACCGCGCCAACATGCTGGCGACCATCGGCGCGAAATCCGTCGATGATTTTTA
CACAGACGTTCCAGACGCCGCCCGCCTGAAGGGCAAGATTGCCGGCCTGCCCGACCATCAGGGCGAACTGGCCGTCGAGC
GGCACCTGACGAAGCTCGCGGCGAAGAACCGCTCGGCCTCCTCCGGGCCGTTCTTCGTCGGCGCGGGCGCCTACAAGCAT
CATGTGCCCGCCACGGTGGACATGATTATCCAGCGTTCGGAATTCCTGACGACCTACACGCCCTACCAGCCCGAAATCGC
ACAGGGCACGTTGCAGACGCTGTTTGAATTCCAGACACAGGTGGCCAGCCTCACCGCAATGGATGTGGCCAACGCCTCGA
TGTATGACGGCTCCACCTCCTGCGCCGAGGCCGCCGTGATGGCCGCCCGCGTCACCCGCCGCAAGAAGATCATCCTCTCG
GGCGGCCTGCACCCGCATTATGCCGCTGCTACCCGCCTGCTGGCCGAGGCGCAGGGCCTGACGGTGGTTCAGCTGCCCGT
CGCCATTGATGGCGAGGGAGAGCTGGCAAAGGCCGTGGACGGAGAAACTGCCTGCGTCATCGGCCAGAGCCCGAACGTCT
TCGGCACGGTGACCGATCTCTCTGCCGTGGCGGACGCCGCCCATGGCAAAGGCGCGCTGCTCGTCTCGGTGTTCACCGAA
GCCGTCAGCCTCGGCCTCGTCACCCCGCCCGGCGAAATGGGCGCAGACATCGCTGCGGGCGAAGGCCAGTCGATTGGCAA
TGGCCTCAATTTCGGCGGGCCATATGTGGGTCTCTTCTCCTGCCGCGAAAAGCTCGTGCGCCAGATGCCCGGCCGCCTCT
GCGGCGAAACGGTGGACGCCGATGGCAAGCGCGGTTTCGTGCTGACGCTCTCGACCCGCGAGCAGCATATCCGCCGCGAC
AAGGCGACTTCCAACATCTGCACAAACTCCGGCCTCTGCGCCCTCGCCTTCACGTCCCACATGACGCTGCTGGGCGGGAA
GGGTCTGAAACAGCTCGCTGAGCTCAACCATGAAGCGGCCATTGAACTCGCCGATGCGCTCGGCGCCGTGAAAGGCGTCG
AAATCCTCACCCCGCGCTTCTTCAACGAGTTCGCCATCCGCACACCGATGGACGCCGAAGCCGTCCTCGCGATGCTGGAC
GAAGCCGGCGTGGTCGGCGGCGTGCGCGCCTCGCGCCTCTTCCCCGGCGACCATCTGGGCGACGTGATCCTCGTCGCGGC
GACCGAATGCACGACGGCAGATGATATTGCTGCCTACACCGACGCTCTGAAGGAGATCATCTGA

Upstream 100 bases:

>100_bases
GATGCCTGGTTCGTCCGCGTCAAGATTTCGGACACTGCCGAGCTTGAAGGCCTGATGGATCTGGCCGCCTACACTGAATA
TTGCGAAGGGCTCTGATTAC

Downstream 100 bases:

>100_bases
TGTCCATGAACTCCACCGGCCGCCCCACGGCGCCCACCTCCGTCTCCGCCGCCGCCATCGAGACCATTTCCGGCTCGCGC
GGGCTTCTTCAGCATGAAGA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MRYLPLTPEDRANMLATIGAKSVDDFYTDVPDAARLKGKIAGLPDHQGELAVERHLTKLAAKNRSASSGPFFVGAGAYKH
HVPATVDMIIQRSEFLTTYTPYQPEIAQGTLQTLFEFQTQVASLTAMDVANASMYDGSTSCAEAAVMAARVTRRKKIILS
GGLHPHYAAATRLLAEAQGLTVVQLPVAIDGEGELAKAVDGETACVIGQSPNVFGTVTDLSAVADAAHGKGALLVSVFTE
AVSLGLVTPPGEMGADIAAGEGQSIGNGLNFGGPYVGLFSCREKLVRQMPGRLCGETVDADGKRGFVLTLSTREQHIRRD
KATSNICTNSGLCALAFTSHMTLLGGKGLKQLAELNHEAAIELADALGAVKGVEILTPRFFNEFAIRTPMDAEAVLAMLD
EAGVVGGVRASRLFPGDHLGDVILVAATECTTADDIAAYTDALKEII

Sequences:

>Translated_447_residues
MRYLPLTPEDRANMLATIGAKSVDDFYTDVPDAARLKGKIAGLPDHQGELAVERHLTKLAAKNRSASSGPFFVGAGAYKH
HVPATVDMIIQRSEFLTTYTPYQPEIAQGTLQTLFEFQTQVASLTAMDVANASMYDGSTSCAEAAVMAARVTRRKKIILS
GGLHPHYAAATRLLAEAQGLTVVQLPVAIDGEGELAKAVDGETACVIGQSPNVFGTVTDLSAVADAAHGKGALLVSVFTE
AVSLGLVTPPGEMGADIAAGEGQSIGNGLNFGGPYVGLFSCREKLVRQMPGRLCGETVDADGKRGFVLTLSTREQHIRRD
KATSNICTNSGLCALAFTSHMTLLGGKGLKQLAELNHEAAIELADALGAVKGVEILTPRFFNEFAIRTPMDAEAVLAMLD
EAGVVGGVRASRLFPGDHLGDVILVAATECTTADDIAAYTDALKEII
>Mature_447_residues
MRYLPLTPEDRANMLATIGAKSVDDFYTDVPDAARLKGKIAGLPDHQGELAVERHLTKLAAKNRSASSGPFFVGAGAYKH
HVPATVDMIIQRSEFLTTYTPYQPEIAQGTLQTLFEFQTQVASLTAMDVANASMYDGSTSCAEAAVMAARVTRRKKIILS
GGLHPHYAAATRLLAEAQGLTVVQLPVAIDGEGELAKAVDGETACVIGQSPNVFGTVTDLSAVADAAHGKGALLVSVFTE
AVSLGLVTPPGEMGADIAAGEGQSIGNGLNFGGPYVGLFSCREKLVRQMPGRLCGETVDADGKRGFVLTLSTREQHIRRD
KATSNICTNSGLCALAFTSHMTLLGGKGLKQLAELNHEAAIELADALGAVKGVEILTPRFFNEFAIRTPMDAEAVLAMLD
EAGVVGGVRASRLFPGDHLGDVILVAATECTTADDIAAYTDALKEII

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=391, Percent_Identity=37.3401534526854, Blast_Score=234, Evalue=9e-62,
Organism=Escherichia coli, GI1789269, Length=443, Percent_Identity=29.3453724604966, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17535605, Length=385, Percent_Identity=35.8441558441558, Blast_Score=207, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6323843, Length=401, Percent_Identity=32.4189526184539, Blast_Score=200, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24645648, Length=382, Percent_Identity=40.3141361256544, Blast_Score=249, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_HYPNA (Q0BYP2)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761401.1
- STRING:   Q0BYP2
- GeneID:   4288474
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2721
- NMPDR:   fig|228405.5.peg.2608
- TIGR:   HNE_2721
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   HNEP81032:HNE_2721-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 46985; Mature: 46985

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLPLTPEDRANMLATIGAKSVDDFYTDVPDAARLKGKIAGLPDHQGELAVERHLTKLA
CCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHH
AKNRSASSGPFFVGAGAYKHHVPATVDMIIQRSEFLTTYTPYQPEIAQGTLQTLFEFQTQ
HCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHH
VASLTAMDVANASMYDGSTSCAEAAVMAARVTRRKKIILSGGLHPHYAAATRLLAEAQGL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCC
TVVQLPVAIDGEGELAKAVDGETACVIGQSPNVFGTVTDLSAVADAAHGKGALLVSVFTE
EEEEEEEEECCCCCHHHHCCCCEEEEECCCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHH
AVSLGLVTPPGEMGADIAAGEGQSIGNGLNFGGPYVGLFSCREKLVRQMPGRLCGETVDA
HHHHCCCCCCCHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCC
DGKRGFVLTLSTREQHIRRDKATSNICTNSGLCALAFTSHMTLLGGKGLKQLAELNHEAA
CCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCHHHHHHHCCHHHH
IELADALGAVKGVEILTPRFFNEFAIRTPMDAEAVLAMLDEAGVVGGVRASRLFPGDHLG
HHHHHHHHHHCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCC
DVILVAATECTTADDIAAYTDALKEII
CEEEEEECCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRYLPLTPEDRANMLATIGAKSVDDFYTDVPDAARLKGKIAGLPDHQGELAVERHLTKLA
CCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHH
AKNRSASSGPFFVGAGAYKHHVPATVDMIIQRSEFLTTYTPYQPEIAQGTLQTLFEFQTQ
HCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHH
VASLTAMDVANASMYDGSTSCAEAAVMAARVTRRKKIILSGGLHPHYAAATRLLAEAQGL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCC
TVVQLPVAIDGEGELAKAVDGETACVIGQSPNVFGTVTDLSAVADAAHGKGALLVSVFTE
EEEEEEEEECCCCCHHHHCCCCEEEEECCCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHH
AVSLGLVTPPGEMGADIAAGEGQSIGNGLNFGGPYVGLFSCREKLVRQMPGRLCGETVDA
HHHHCCCCCCCHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCC
DGKRGFVLTLSTREQHIRRDKATSNICTNSGLCALAFTSHMTLLGGKGLKQLAELNHEAA
CCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCHHHHHHHCCHHHH
IELADALGAVKGVEILTPRFFNEFAIRTPMDAEAVLAMLDEAGVVGGVRASRLFPGDHLG
HHHHHHHHHHCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCC
DVILVAATECTTADDIAAYTDALKEII
CEEEEEECCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA