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The map label for this gene is gcp

Identifier: 114797789

GI number: 114797789

Start: 119883

End: 120980

Strand: Reverse

Name: gcp

Synonym: HNE_0136

Alternate gene names: 114797789

Gene position: 120980-119883 (Counterclockwise)

Preceding gene: 114798778

Following gene: 114797485

Centisome position: 3.27

GC content: 68.49

Gene sequence:

>1098_bases
ATGCGGGCGATGAGCAAGTCCCTGACGATCCTCGGTATCGAGACAAGCTGCGACGAGACCGCCGCCGCCGTGCTGCGCTA
TGAGGATGGCCGGGCAACGCTCCTGTCAGATGTGATCCGCACACAGCTGGCCGAGCACGCGCCCTATCTCGGCGTCGTGC
CGGAAATCGCCGCCCGCGCGCATGCCGAGCTGGCTGACCTGACCGTCGCGGCCGCCATGAATGCCTCGGGCCTCTCTTAT
GCTGAGCTTGACGGCGTCGCCGCTACAGCCGGCCCCGGCCTCATCGGCGGCGTGCTTGTCGGGTTGATGACCGGCAAGGC
CATCGCCCAGGCCGCCGGCAAGCCCTTCATCCCGGTCAACCATCTGGAAGGCCACGCGCTTTCCCCCCGCCTCAGTGAAG
ACTGCCCCTTTCCCTATCTCCTGCTGCTTGTCTCGGGCGGGCATTGCCAGTTCCTGGACGTGCGCGGCCTGGGCGACTAT
CGCCGCCTCGGCTCAACAATAGATGACGCGGTGGGCGAAGCCTTCGACAAGGTGGCCAAGCTCCTCGGCCTCGGCTTTCC
CGGCGGCCCGGCGGTGGAAGCCCTGGCGCGAAACGGCGACCCGAAGGCCCACGACTTTCCACGCCCGCTCCTGAACCGCC
CCGGTCTCGACATGAGCTTTGCCGGCCTCAAGACCGCCGTGGCCCGCGCGTCCGCAAACGCAAAGAGCGAAGCGGAAAAG
GCCGACATCTGCGCCAGCTTCCAGGCCGCGATCTGTGACGTGCTGGCGGAAAAGGCCCGCCGCGCGCTGGAAGGGTTTGA
CGCGGGGGCCGGCGACAAGCGCTTCGTGGTCGCCGGGGGCGTTGCCTCAAACAAGGCCATCCGGGCCGCGCTGGAGACGG
CCGCCACCGCGCAGGGCGCGCGCCTGATCGCCCCGCCCCTGCGCCACTGCACCGATAATGCCGCCATGATTGCTCTTGCC
GGGGCCGAACATCTTGCCGCTGGCCTGTGTGAAACAGATGGGCTCGCCTCATCGGCCCGGCCACGCTGGCCGCTCGACGA
AGCATCCGCAAAAGCAGACCCTGTCTTCGGTGCCGGCCGGCGCGGCGCGAAAGCCTGA

Upstream 100 bases:

>100_bases
TCTGGATCGACGCCGAATTCACCGGCCCGCCTGCACCAGAGACGGCCACGCCAGAGGCGCCCTGACTTAGCCGCTTCTAT
CCTGCCCCCGCCCCCGCTAT

Downstream 100 bases:

>100_bases
CGGGCTCACTTCAGGTCAAAAAAATACGGGCGCCTGTGTGAGAGGCGCCCGTTTCGCCAGGCTGCGGGTGGGAGGAAACC
CCGCATCTGCCTGACCTGGC

Product: O-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MRAMSKSLTILGIETSCDETAAAVLRYEDGRATLLSDVIRTQLAEHAPYLGVVPEIAARAHAELADLTVAAAMNASGLSY
AELDGVAATAGPGLIGGVLVGLMTGKAIAQAAGKPFIPVNHLEGHALSPRLSEDCPFPYLLLLVSGGHCQFLDVRGLGDY
RRLGSTIDDAVGEAFDKVAKLLGLGFPGGPAVEALARNGDPKAHDFPRPLLNRPGLDMSFAGLKTAVARASANAKSEAEK
ADICASFQAAICDVLAEKARRALEGFDAGAGDKRFVVAGGVASNKAIRAALETAATAQGARLIAPPLRHCTDNAAMIALA
GAEHLAAGLCETDGLASSARPRWPLDEASAKADPVFGAGRRGAKA

Sequences:

>Translated_365_residues
MRAMSKSLTILGIETSCDETAAAVLRYEDGRATLLSDVIRTQLAEHAPYLGVVPEIAARAHAELADLTVAAAMNASGLSY
AELDGVAATAGPGLIGGVLVGLMTGKAIAQAAGKPFIPVNHLEGHALSPRLSEDCPFPYLLLLVSGGHCQFLDVRGLGDY
RRLGSTIDDAVGEAFDKVAKLLGLGFPGGPAVEALARNGDPKAHDFPRPLLNRPGLDMSFAGLKTAVARASANAKSEAEK
ADICASFQAAICDVLAEKARRALEGFDAGAGDKRFVVAGGVASNKAIRAALETAATAQGARLIAPPLRHCTDNAAMIALA
GAEHLAAGLCETDGLASSARPRWPLDEASAKADPVFGAGRRGAKA
>Mature_365_residues
MRAMSKSLTILGIETSCDETAAAVLRYEDGRATLLSDVIRTQLAEHAPYLGVVPEIAARAHAELADLTVAAAMNASGLSY
AELDGVAATAGPGLIGGVLVGLMTGKAIAQAAGKPFIPVNHLEGHALSPRLSEDCPFPYLLLLVSGGHCQFLDVRGLGDY
RRLGSTIDDAVGEAFDKVAKLLGLGFPGGPAVEALARNGDPKAHDFPRPLLNRPGLDMSFAGLKTAVARASANAKSEAEK
ADICASFQAAICDVLAEKARRALEGFDAGAGDKRFVVAGGVASNKAIRAALETAATAQGARLIAPPLRHCTDNAAMIALA
GAEHLAAGLCETDGLASSARPRWPLDEASAKADPVFGAGRRGAKA

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=340, Percent_Identity=38.2352941176471, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI8923380, Length=325, Percent_Identity=33.5384615384615, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1789445, Length=346, Percent_Identity=47.6878612716763, Blast_Score=288, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17557464, Length=328, Percent_Identity=33.2317073170732, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71995670, Length=353, Percent_Identity=30.3116147308782, Blast_Score=127, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320099, Length=374, Percent_Identity=31.5508021390374, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322891, Length=375, Percent_Identity=22.6666666666667, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20129063, Length=342, Percent_Identity=36.2573099415205, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI21357207, Length=333, Percent_Identity=30.03003003003, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_HYPNA (Q0C5X3)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_758870.1
- ProteinModelPortal:   Q0C5X3
- SMR:   Q0C5X3
- STRING:   Q0C5X3
- MEROPS:   M22.001
- GeneID:   4289633
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0136
- NMPDR:   fig|228405.5.peg.134
- TIGR:   HNE_0136
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q0C5X3
- BioCyc:   HNEP81032:HNE_0136-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37448; Mature: 37448

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMSKSLTILGIETSCDETAAAVLRYEDGRATLLSDVIRTQLAEHAPYLGVVPEIAARA
CCCCCCCEEEEEECCCCCHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
HAELADLTVAAAMNASGLSYAELDGVAATAGPGLIGGVLVGLMTGKAIAQAAGKPFIPVN
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HLEGHALSPRLSEDCPFPYLLLLVSGGHCQFLDVRGLGDYRRLGSTIDDAVGEAFDKVAK
CCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHH
LLGLGFPGGPAVEALARNGDPKAHDFPRPLLNRPGLDMSFAGLKTAVARASANAKSEAEK
HHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
ADICASFQAAICDVLAEKARRALEGFDAGAGDKRFVVAGGVASNKAIRAALETAATAQGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCC
RLIAPPLRHCTDNAAMIALAGAEHLAAGLCETDGLASSARPRWPLDEASAKADPVFGAGR
EECCCHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCC
RGAKA
CCCCC
>Mature Secondary Structure
MRAMSKSLTILGIETSCDETAAAVLRYEDGRATLLSDVIRTQLAEHAPYLGVVPEIAARA
CCCCCCCEEEEEECCCCCHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
HAELADLTVAAAMNASGLSYAELDGVAATAGPGLIGGVLVGLMTGKAIAQAAGKPFIPVN
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HLEGHALSPRLSEDCPFPYLLLLVSGGHCQFLDVRGLGDYRRLGSTIDDAVGEAFDKVAK
CCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHH
LLGLGFPGGPAVEALARNGDPKAHDFPRPLLNRPGLDMSFAGLKTAVARASANAKSEAEK
HHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
ADICASFQAAICDVLAEKARRALEGFDAGAGDKRFVVAGGVASNKAIRAALETAATAQGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCC
RLIAPPLRHCTDNAAMIALAGAEHLAAGLCETDGLASSARPRWPLDEASAKADPVFGAGR
EECCCHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCC
RGAKA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA