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The map label for this gene is glmU

Identifier: 114797715

GI number: 114797715

Start: 716484

End: 717869

Strand: Direct

Name: glmU

Synonym: HNE_0705

Alternate gene names: 114797715

Gene position: 716484-717869 (Clockwise)

Preceding gene: 114797576

Following gene: 114798972

Centisome position: 19.34

GC content: 65.73

Gene sequence:

>1386_bases
TTGACCGACACCCGCAAACAGCGCGCCGCCGTCATCCTTGCCGCCGGCAAGGGAACCCGCATGAAGTCGCCCCTGCCCAA
GGTGATGCATGCCGTGGGCGGCCGCCCGATGATGGACTGGTCGATCGCGCTCGCCCGTCAGGTCGGCGCGGAGCGTATCG
TGGCCGTCGTGCATCCCTCGCAGGACGTGCTGATCGCCCATCTCGGCAAGCACCATCCAGATGTGGCGATTGCCTATCAG
GACCCACCCCAGGGCACCGGCCATGCCGTGCGCTGCGCAGAGGAGGCCCTGCGCGGGTTCGAGGGCGACCTTGCCGTGCT
CTATGGCGACAGCCCGCTGGTGCCGGCCGCGACAATCGAAGACCTGTTCGGGACACTTTCGGACAAAACCGGTCTCGGCG
TACTCGGTTTCGAAGCCGAAGACCCCGGCCTCTATGGCCGCCTGATCACCGGTGAGGATGGCAGCCTGGAGGCGATCGTC
GAAGCGCGCGAGGCCACCCCGTTCCAACTCAGGGTGCGCCTGTGCAACTCAGGCGTCATGGCAGGCCGCGCGGCAGACAT
GTTCCGCCTTCTCGCGAAGGTCACCAACTCCAACGCCAAGGGCGAGTATTACCTGACCGACCTTGTCGGCCTCGCCCGCG
CCGAAGGCATCCGCTGCGCGGTCGCGGTCTCCGGCGAAGACGATCTGATCGGCTGCGATTCCAAGGCAGACCTTGCCGAG
GCTGAAGCGATCTTCCAGCAAAAGCGCCGCCGCGCGCTGATGGAGGCGGGTGTCACGATGGTGGCCCCGGAAACCGTGTT
TCTGTCCCATGATACGCAGATCGGCGCTGATGCCGTGATCGAACCGAATGTCGTGTTCGGTCCCGGCGTGAAGGTGGCTG
GCGGCGCGCAGATCCGCGCGTTCAGCCATCTGGAAGGCGCCGTGGTGGGCGAGGGTTGCAGTGTTGGTCCCTACGCCCGT
CTGCGTCCCGGCACGGTGCTGGCAGCAAACGTTCACATCGGCAACTTTGTCGAGACCAAGAACACCGCCATGGGCGAAGG
CGCCAAGGCGAACCACCTCGCTTATCTCGGCGATGGCACCATCGGCGCGGGCGCCAATATCGGCGCGGGCACGATCTTCT
GCAATTATGATGGCTTCCTCAAACATCAGACCGATGTGGGCGAGGGGGCGTTCGTCGGCTCCAACTCGGCCCTCGTCGCG
CCGGTGAGAATCGGCGATGGCGCCTATATCGGCTCGGGCAGCGTGATCACCAAGGATGTGCCAGACGACGCCCTCGCCGT
CGGGCGCGGCCAGCAGATCACCCGCGAGGGCTGGGCCAGGAACTACCGGGCAAAGAAGGCCGCAGAAAAGGCCGCCCGCA
CCACAGACCAGAACAAGAAGGGCTGA

Upstream 100 bases:

>100_bases
AACCTGCCGTTTTCAGCCATCTGGAACCCTCCTTCGCCCTCGCCAAGATGCGGGGTTTCGTCTAGGCGATGGGGCAGAGG
AAAGCGAGAGGGAGCCCGCA

Downstream 100 bases:

>100_bases
TTGCCGGACATGGCTAGCGACACCGAAAAGCAGAATGCGGCCGCCGCCGCGATGGACTTTGTTGAAGAGGGCATGACGAT
TGGCCTCGGCACCGGCTCAA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTDTRKQRAAVILAAGKGTRMKSPLPKVMHAVGGRPMMDWSIALARQVGAERIVAVVHPSQDVLIAHLGKHHPDVAIAYQ
DPPQGTGHAVRCAEEALRGFEGDLAVLYGDSPLVPAATIEDLFGTLSDKTGLGVLGFEAEDPGLYGRLITGEDGSLEAIV
EAREATPFQLRVRLCNSGVMAGRAADMFRLLAKVTNSNAKGEYYLTDLVGLARAEGIRCAVAVSGEDDLIGCDSKADLAE
AEAIFQQKRRRALMEAGVTMVAPETVFLSHDTQIGADAVIEPNVVFGPGVKVAGGAQIRAFSHLEGAVVGEGCSVGPYAR
LRPGTVLAANVHIGNFVETKNTAMGEGAKANHLAYLGDGTIGAGANIGAGTIFCNYDGFLKHQTDVGEGAFVGSNSALVA
PVRIGDGAYIGSGSVITKDVPDDALAVGRGQQITREGWARNYRAKKAAEKAARTTDQNKKG

Sequences:

>Translated_461_residues
MTDTRKQRAAVILAAGKGTRMKSPLPKVMHAVGGRPMMDWSIALARQVGAERIVAVVHPSQDVLIAHLGKHHPDVAIAYQ
DPPQGTGHAVRCAEEALRGFEGDLAVLYGDSPLVPAATIEDLFGTLSDKTGLGVLGFEAEDPGLYGRLITGEDGSLEAIV
EAREATPFQLRVRLCNSGVMAGRAADMFRLLAKVTNSNAKGEYYLTDLVGLARAEGIRCAVAVSGEDDLIGCDSKADLAE
AEAIFQQKRRRALMEAGVTMVAPETVFLSHDTQIGADAVIEPNVVFGPGVKVAGGAQIRAFSHLEGAVVGEGCSVGPYAR
LRPGTVLAANVHIGNFVETKNTAMGEGAKANHLAYLGDGTIGAGANIGAGTIFCNYDGFLKHQTDVGEGAFVGSNSALVA
PVRIGDGAYIGSGSVITKDVPDDALAVGRGQQITREGWARNYRAKKAAEKAARTTDQNKKG
>Mature_460_residues
TDTRKQRAAVILAAGKGTRMKSPLPKVMHAVGGRPMMDWSIALARQVGAERIVAVVHPSQDVLIAHLGKHHPDVAIAYQD
PPQGTGHAVRCAEEALRGFEGDLAVLYGDSPLVPAATIEDLFGTLSDKTGLGVLGFEAEDPGLYGRLITGEDGSLEAIVE
AREATPFQLRVRLCNSGVMAGRAADMFRLLAKVTNSNAKGEYYLTDLVGLARAEGIRCAVAVSGEDDLIGCDSKADLAEA
EAIFQQKRRRALMEAGVTMVAPETVFLSHDTQIGADAVIEPNVVFGPGVKVAGGAQIRAFSHLEGAVVGEGCSVGPYARL
RPGTVLAANVHIGNFVETKNTAMGEGAKANHLAYLGDGTIGAGANIGAGTIFCNYDGFLKHQTDVGEGAFVGSNSALVAP
VRIGDGAYIGSGSVITKDVPDDALAVGRGQQITREGWARNYRAKKAAEKAARTTDQNKKG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=456, Percent_Identity=39.9122807017544, Blast_Score=307, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_HYPNA (Q0C4B0)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759433.1
- ProteinModelPortal:   Q0C4B0
- SMR:   Q0C4B0
- STRING:   Q0C4B0
- GeneID:   4289230
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0705
- NMPDR:   fig|228405.5.peg.690
- TIGR:   HNE_0705
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   MERTCLA
- PhylomeDB:   Q0C4B0
- ProtClustDB:   PRK14353
- BioCyc:   HNEP81032:HNE_0705-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48223; Mature: 48092

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 352-352 BINDING 80-80 BINDING 146-146 BINDING 161-161 BINDING 176-176 BINDING 376-376 BINDING 394-394 BINDING 429-429

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTRKQRAAVILAAGKGTRMKSPLPKVMHAVGGRPMMDWSIALARQVGAERIVAVVHPS
CCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCC
QDVLIAHLGKHHPDVAIAYQDPPQGTGHAVRCAEEALRGFEGDLAVLYGDSPLVPAATIE
CCCHHEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHH
DLFGTLSDKTGLGVLGFEAEDPGLYGRLITGEDGSLEAIVEAREATPFQLRVRLCNSGVM
HHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCC
AGRAADMFRLLAKVTNSNAKGEYYLTDLVGLARAEGIRCAVAVSGEDDLIGCDSKADLAE
CCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCHHHH
AEAIFQQKRRRALMEAGVTMVAPETVFLSHDTQIGADAVIEPNVVFGPGVKVAGGAQIRA
HHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCCEEECCCEEECCCEEEECCCEEEE
FSHLEGAVVGEGCSVGPYARLRPGTVLAANVHIGNFVETKNTAMGEGAKANHLAYLGDGT
ECCCCCEEEECCCCCCCCCEECCCEEEEEEEEECCEEECCCCCCCCCCCCCEEEEECCCC
IGAGANIGAGTIFCNYDGFLKHQTDVGEGAFVGSNSALVAPVRIGDGAYIGSGSVITKDV
CCCCCCCCCCEEEECCCCCEEECCCCCCCEEECCCCEEEEEEEECCCEEECCCCEEEECC
PDDALAVGRGQQITREGWARNYRAKKAAEKAARTTDQNKKG
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDTRKQRAAVILAAGKGTRMKSPLPKVMHAVGGRPMMDWSIALARQVGAERIVAVVHPS
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCC
QDVLIAHLGKHHPDVAIAYQDPPQGTGHAVRCAEEALRGFEGDLAVLYGDSPLVPAATIE
CCCHHEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHH
DLFGTLSDKTGLGVLGFEAEDPGLYGRLITGEDGSLEAIVEAREATPFQLRVRLCNSGVM
HHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCC
AGRAADMFRLLAKVTNSNAKGEYYLTDLVGLARAEGIRCAVAVSGEDDLIGCDSKADLAE
CCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCHHHH
AEAIFQQKRRRALMEAGVTMVAPETVFLSHDTQIGADAVIEPNVVFGPGVKVAGGAQIRA
HHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCCEEECCCEEECCCEEEECCCEEEE
FSHLEGAVVGEGCSVGPYARLRPGTVLAANVHIGNFVETKNTAMGEGAKANHLAYLGDGT
ECCCCCEEEECCCCCCCCCEECCCEEEEEEEEECCEEECCCCCCCCCCCCCEEEEECCCC
IGAGANIGAGTIFCNYDGFLKHQTDVGEGAFVGSNSALVAPVRIGDGAYIGSGSVITKDV
CCCCCCCCCCEEEECCCCCEEECCCCCCCEEECCCCEEEEEEEECCCEEECCCCEEEECC
PDDALAVGRGQQITREGWARNYRAKKAAEKAARTTDQNKKG
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA