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The map label for this gene is nuoE [H]

Identifier: 114797708

GI number: 114797708

Start: 1789039

End: 1789812

Strand: Direct

Name: nuoE [H]

Synonym: HNE_1748

Alternate gene names: 114797708

Gene position: 1789039-1789812 (Clockwise)

Preceding gene: 114798704

Following gene: 114799778

Centisome position: 48.29

GC content: 59.82

Gene sequence:

>774_bases
ATGGCATTGCGCCGGTTTGATCTCGAGGCGGGGGGCGACAGCTTCTCGTTCAAGTCCGAGACGGAAGAGAAGATCACATT
CTGGCGGGCAAAATACCCGGCAGACAAGCAGCGTTCGGCTGTCATCCCGATGCTGTGGCTGGCGCAGAAAGACAATAATG
GCTGGCTATCCGAGCCTGCCATGCGCGAAGTCGCAGACCGTCTGGAAATGCCCTATATGCGGGTCTACGAGGTCGCGACT
TTCTACACGATGTTCCGCCTGCAGCCGGTCGGTAAATTCCACGTCCAGCTCTGCGGTACTACGCCTTGCCAGCTTCGCGG
CGCCGAAAACCTCAAGGAAGTCTGCACCCGCGAGATCGGCAAGCAGATGTATGTGACCGACGATAAACGTCTGTCCTGGG
AAGAAGTCGAGTGCCTGGGCGCTTGCGTGAATGCGCCGATGGTTCAGATCAATGACGACTATTACGAAGACCTCACGCCG
GACTCGCTGGCCCAGATCATCGGCCGTCTGAAGAATGGCGTGGAAGTTACGCCCGGCCCGCAGATCGACCGCGTGAACAG
CGCGCCCGAAGGGGGCAACGCAACACTGACTGAACCTGCCCTGTTCGATGGCAGCCGCAATTCCGTCAGTACGCTTCCAA
ACCTTCCGGAGCCCCCGGCGCCCGAGCCGGCGCCCAAGCCAGAAGCGACGGCAGAAGCTACCGGCCAGCCAGAAAAATCT
GCGCCGACGAATACCGATCGCGAAGAGCCCTCCAGCAAGGACATCAAGGAATAG

Upstream 100 bases:

>100_bases
TGCGGACCCTGAAGGGAATGCCTGGGAAGTGGCTCACAATCCGTTCTGGCCAATTGACGAAGCGGGCCGCGTCAGCATCC
CGCTTGCGAAGGAGCAGTAG

Downstream 100 bases:

>100_bases
GCCATGTTGCAGGACAAGGACCGCATTTTCACAAACCTTTACGGCCTTCATTCGCCGGACCTCGAAGCTGCGAAGAAGCG
CGGCGCGTGGCATCTGACAC

Product: NADH-quinone oxidoreductase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E 1; NDH-1 subunit E 1 [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MALRRFDLEAGGDSFSFKSETEEKITFWRAKYPADKQRSAVIPMLWLAQKDNNGWLSEPAMREVADRLEMPYMRVYEVAT
FYTMFRLQPVGKFHVQLCGTTPCQLRGAENLKEVCTREIGKQMYVTDDKRLSWEEVECLGACVNAPMVQINDDYYEDLTP
DSLAQIIGRLKNGVEVTPGPQIDRVNSAPEGGNATLTEPALFDGSRNSVSTLPNLPEPPAPEPAPKPEATAEATGQPEKS
APTNTDREEPSSKDIKE

Sequences:

>Translated_257_residues
MALRRFDLEAGGDSFSFKSETEEKITFWRAKYPADKQRSAVIPMLWLAQKDNNGWLSEPAMREVADRLEMPYMRVYEVAT
FYTMFRLQPVGKFHVQLCGTTPCQLRGAENLKEVCTREIGKQMYVTDDKRLSWEEVECLGACVNAPMVQINDDYYEDLTP
DSLAQIIGRLKNGVEVTPGPQIDRVNSAPEGGNATLTEPALFDGSRNSVSTLPNLPEPPAPEPAPKPEATAEATGQPEKS
APTNTDREEPSSKDIKE
>Mature_256_residues
ALRRFDLEAGGDSFSFKSETEEKITFWRAKYPADKQRSAVIPMLWLAQKDNNGWLSEPAMREVADRLEMPYMRVYEVATF
YTMFRLQPVGKFHVQLCGTTPCQLRGAENLKEVCTREIGKQMYVTDDKRLSWEEVECLGACVNAPMVQINDDYYEDLTPD
SLAQIIGRLKNGVEVTPGPQIDRVNSAPEGGNATLTEPALFDGSRNSVSTLPNLPEPPAPEPAPKPEATAEATGQPEKSA
PTNTDREEPSSKDIKE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=186, Percent_Identity=50.5376344086022, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1788621, Length=160, Percent_Identity=28.75, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17561328, Length=185, Percent_Identity=50.2702702702703, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI18859877, Length=185, Percent_Identity=48.1081081081081, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI21355353, Length=183, Percent_Identity=38.7978142076503, Blast_Score=140, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 28675; Mature: 28544

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRRFDLEAGGDSFSFKSETEEKITFWRAKYPADKQRSAVIPMLWLAQKDNNGWLSEPA
CCCEECCCCCCCCCCCCCCCCHHHHEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCHH
MREVADRLEMPYMRVYEVATFYTMFRLQPVGKFHVQLCGTTPCQLRGAENLKEVCTREIG
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHC
KQMYVTDDKRLSWEEVECLGACVNAPMVQINDDYYEDLTPDSLAQIIGRLKNGVEVTPGP
CEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCHHHCCCHHHHHHHHHHHHCCCEECCCC
QIDRVNSAPEGGNATLTEPALFDGSRNSVSTLPNLPEPPAPEPAPKPEATAEATGQPEKS
CCCCCCCCCCCCCCEECCCHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APTNTDREEPSSKDIKE
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALRRFDLEAGGDSFSFKSETEEKITFWRAKYPADKQRSAVIPMLWLAQKDNNGWLSEPA
CCEECCCCCCCCCCCCCCCCHHHHEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCHH
MREVADRLEMPYMRVYEVATFYTMFRLQPVGKFHVQLCGTTPCQLRGAENLKEVCTREIG
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHC
KQMYVTDDKRLSWEEVECLGACVNAPMVQINDDYYEDLTPDSLAQIIGRLKNGVEVTPGP
CEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCHHHCCCHHHHHHHHHHHHCCCEECCCC
QIDRVNSAPEGGNATLTEPALFDGSRNSVSTLPNLPEPPAPEPAPKPEATAEATGQPEKS
CCCCCCCCCCCCCCEECCCHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APTNTDREEPSSKDIKE
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]