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The map label for this gene is bioF [H]

Identifier: 114797693

GI number: 114797693

Start: 1622095

End: 1623288

Strand: Reverse

Name: bioF [H]

Synonym: HNE_1590

Alternate gene names: 114797693

Gene position: 1623288-1622095 (Counterclockwise)

Preceding gene: 114798454

Following gene: 114799914

Centisome position: 43.81

GC content: 59.21

Gene sequence:

>1194_bases
ATGTTCGATAGTGACATCAAGAAGTCCGACATTTTCGAGAAATTCGAAAAGGTAGGCCAGCGCGCCGAGGCGGTCATTTC
CCTCGGCAAGCTGCCTTTCGGGATGACATTTGACGAGATCCTGTCGCCCACCCGCGCCCTCGTCGACGGGCGGGAAGTCA
TCCTCGCGGGAACCAACAACTATCTCGGTCTGACATTTTCCGAAGCGGTGAAATCCGCCGCAGTCGATGCCGTTATCCGG
CAGGGCACCGCCACAACCGGAAGCCGTCTGGCGAACGGTACGTTTCGGGAGCATGTCGAGCTTGAGGAAGACCTCAAGGC
ATTTTTCGGCGCACAATCGGCTATCGTTTTCACGACCGGTTATCAGGCCAACCTCGCTGCGATCAGCACGCTGGCAGGAC
GAGGCGATCATTTGCTCATCGACGCAGATAGCCATGCCTGCATCTATGACGGATGCCGGCTGAGCGACGCCGAAACCATC
CGTTTCCGGCATAACAGCCCTGAAGATCTGGCCAAACGGCTGGCGCGCCTTCCCGATGAAGGTGCGCGACTGGTTGTCGT
CGAAGGGCTGTACTCGATGCTCGGCGATGTGGCGCCGATTGATGAGTTTGTGGCTGTCGCCCATGAACATGGCGCGTATC
TATATGTCGATGAGGCCCATTCGGTCGGTTGCTATGGTGATCGGGGCCGCGGGCTGGCGCAGGCATTGGGTGTGCTCGAT
AAGGTAGACTTTCTATCAGGCACATTTTCGAAAAGCTTCGCGTCGATCGGGGGTTTCTGCGTGTCGCGTCACCCCGGCCT
TGAGCTGATGCGGCTTGTGAGCCGGCCGTATCTTTTCACTGCTTCAGGGTCGCCCTCGAACGTCGCGGCTGCCCGCGCGG
CTATGGGCGAGATGATGAAGGGGCCTGATCTGAGCCGACAGCTTATGGCGCGGGCGCATCAGCTGCACGCCGGCCTGGTC
GAAGCCGGATTTGTGCCAGCATCCCCACCCGGCCCCATCATTGCTATTCCGCGCCCGGATGAATTGACCGCCGTGAAGGA
GTGGAACCAACTACTTGAAGCAGGTATCTATGTGAACCTTGCGGTTCCCCCCGCAACTCCGCACGCGAAATCGCTTCTGC
GGCTCAGCGTGTCGGCCGCACACTCCGAAGCGGAAATCGCGTCAATCATCGCCGCATTCCGCACACTGATATAA

Upstream 100 bases:

>100_bases
ATGGAGCTGGAAGACCTTTACAATATTTCCCTGCCTGTCGAAGCTGCTTCCGATATTGATACCGTCAAAGACCTTGTTGC
AAAAATAGGACAGCTCGCAA

Downstream 100 bases:

>100_bases
GCGCAAATTCGCGCTGCTTTTCAGCGGAACGCGCCGGCACGGTATAGCCGCCAGGCAAGAGAGGGCGCGTGCAACAAAGG
CCGCCTGCGCTCGGCCTCGG

Product: putative serine C-palmitoyltransferase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFDSDIKKSDIFEKFEKVGQRAEAVISLGKLPFGMTFDEILSPTRALVDGREVILAGTNNYLGLTFSEAVKSAAVDAVIR
QGTATTGSRLANGTFREHVELEEDLKAFFGAQSAIVFTTGYQANLAAISTLAGRGDHLLIDADSHACIYDGCRLSDAETI
RFRHNSPEDLAKRLARLPDEGARLVVVEGLYSMLGDVAPIDEFVAVAHEHGAYLYVDEAHSVGCYGDRGRGLAQALGVLD
KVDFLSGTFSKSFASIGGFCVSRHPGLELMRLVSRPYLFTASGSPSNVAAARAAMGEMMKGPDLSRQLMARAHQLHAGLV
EAGFVPASPPGPIIAIPRPDELTAVKEWNQLLEAGIYVNLAVPPATPHAKSLLRLSVSAAHSEAEIASIIAAFRTLI

Sequences:

>Translated_397_residues
MFDSDIKKSDIFEKFEKVGQRAEAVISLGKLPFGMTFDEILSPTRALVDGREVILAGTNNYLGLTFSEAVKSAAVDAVIR
QGTATTGSRLANGTFREHVELEEDLKAFFGAQSAIVFTTGYQANLAAISTLAGRGDHLLIDADSHACIYDGCRLSDAETI
RFRHNSPEDLAKRLARLPDEGARLVVVEGLYSMLGDVAPIDEFVAVAHEHGAYLYVDEAHSVGCYGDRGRGLAQALGVLD
KVDFLSGTFSKSFASIGGFCVSRHPGLELMRLVSRPYLFTASGSPSNVAAARAAMGEMMKGPDLSRQLMARAHQLHAGLV
EAGFVPASPPGPIIAIPRPDELTAVKEWNQLLEAGIYVNLAVPPATPHAKSLLRLSVSAAHSEAEIASIIAAFRTLI
>Mature_397_residues
MFDSDIKKSDIFEKFEKVGQRAEAVISLGKLPFGMTFDEILSPTRALVDGREVILAGTNNYLGLTFSEAVKSAAVDAVIR
QGTATTGSRLANGTFREHVELEEDLKAFFGAQSAIVFTTGYQANLAAISTLAGRGDHLLIDADSHACIYDGCRLSDAETI
RFRHNSPEDLAKRLARLPDEGARLVVVEGLYSMLGDVAPIDEFVAVAHEHGAYLYVDEAHSVGCYGDRGRGLAQALGVLD
KVDFLSGTFSKSFASIGGFCVSRHPGLELMRLVSRPYLFTASGSPSNVAAARAAMGEMMKGPDLSRQLMARAHQLHAGLV
EAGFVPASPPGPIIAIPRPDELTAVKEWNQLLEAGIYVNLAVPPATPHAKSLLRLSVSAAHSEAEIASIIAAFRTLI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977440, Length=384, Percent_Identity=32.03125, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI83977442, Length=384, Percent_Identity=32.03125, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI83977444, Length=384, Percent_Identity=32.03125, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI7657118, Length=336, Percent_Identity=32.4404761904762, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI284448556, Length=336, Percent_Identity=32.4404761904762, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=31.4207650273224, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4502025, Length=384, Percent_Identity=30.46875, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI40316939, Length=384, Percent_Identity=30.46875, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI5454084, Length=286, Percent_Identity=31.8181818181818, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4758668, Length=353, Percent_Identity=31.4447592067989, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI1790046, Length=350, Percent_Identity=34, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=30.0859598853868, Blast_Score=138, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI71994529, Length=349, Percent_Identity=32.9512893982808, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI32566772, Length=363, Percent_Identity=31.404958677686, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17560914, Length=363, Percent_Identity=27.2727272727273, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17560912, Length=363, Percent_Identity=27.2727272727273, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71982617, Length=266, Percent_Identity=27.4436090225564, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982625, Length=266, Percent_Identity=27.4436090225564, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320438, Length=366, Percent_Identity=27.0491803278689, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6320267, Length=352, Percent_Identity=28.4090909090909, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323954, Length=272, Percent_Identity=25.7352941176471, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24662918, Length=353, Percent_Identity=29.4617563739377, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17137420, Length=395, Percent_Identity=29.1139240506329, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24653280, Length=287, Percent_Identity=31.7073170731707, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24653276, Length=287, Percent_Identity=31.7073170731707, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24653278, Length=287, Percent_Identity=31.7073170731707, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI17136286, Length=378, Percent_Identity=30.952380952381, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42452; Mature: 42452

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDSDIKKSDIFEKFEKVGQRAEAVISLGKLPFGMTFDEILSPTRALVDGREVILAGTNN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHHCCCEEEEEECCC
YLGLTFSEAVKSAAVDAVIRQGTATTGSRLANGTFREHVELEEDLKAFFGAQSAIVFTTG
CEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECC
YQANLAAISTLAGRGDHLLIDADSHACIYDGCRLSDAETIRFRHNSPEDLAKRLARLPDE
CCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCCC
GARLVVVEGLYSMLGDVAPIDEFVAVAHEHGAYLYVDEAHSVGCYGDRGRGLAQALGVLD
CCEEEEHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
KVDFLSGTFSKSFASIGGFCVSRHPGLELMRLVSRPYLFTASGSPSNVAAARAAMGEMMK
HHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHC
GPDLSRQLMARAHQLHAGLVEAGFVPASPPGPIIAIPRPDELTAVKEWNQLLEAGIYVNL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCEEEEE
AVPPATPHAKSLLRLSVSAAHSEAEIASIIAAFRTLI
ECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFDSDIKKSDIFEKFEKVGQRAEAVISLGKLPFGMTFDEILSPTRALVDGREVILAGTNN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHHCCCEEEEEECCC
YLGLTFSEAVKSAAVDAVIRQGTATTGSRLANGTFREHVELEEDLKAFFGAQSAIVFTTG
CEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECC
YQANLAAISTLAGRGDHLLIDADSHACIYDGCRLSDAETIRFRHNSPEDLAKRLARLPDE
CCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCCC
GARLVVVEGLYSMLGDVAPIDEFVAVAHEHGAYLYVDEAHSVGCYGDRGRGLAQALGVLD
CCEEEEHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
KVDFLSGTFSKSFASIGGFCVSRHPGLELMRLVSRPYLFTASGSPSNVAAARAAMGEMMK
HHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHC
GPDLSRQLMARAHQLHAGLVEAGFVPASPPGPIIAIPRPDELTAVKEWNQLLEAGIYVNL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCEEEEE
AVPPATPHAKSLLRLSVSAAHSEAEIASIIAAFRTLI
ECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]