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The map label for this gene is hom [H]

Identifier: 114797674

GI number: 114797674

Start: 2408970

End: 2410253

Strand: Reverse

Name: hom [H]

Synonym: HNE_2310

Alternate gene names: 114797674

Gene position: 2410253-2408970 (Counterclockwise)

Preceding gene: 114798447

Following gene: 114800431

Centisome position: 65.05

GC content: 65.58

Gene sequence:

>1284_bases
GTGGGGCCTTTGAGAATTGGAATTGCCGGCCTGGGCCATGTGGGCTGCGGGCTGATTGAACTGGTGCAGCGTCAGGATCG
CCTGCGGCTGCCGGGGCGTGTGGAGATTGCGGGCGTGAGCGCGCGCTCGCAGAGCCGCAACCGGCCGGTCAGCACCGATG
GCTATACCTGGTTTGACGACGCCGCGACGCTGGCCGAAGACCCGAATGTGGACGTGTTTGTCGAACTCGTCGGCGGATCT
GACGGCCCGGCCAAGTTTGCCGTGGAATCGGCCTTGCGCGCGGGCAAGCATGTGGTGACCGCCAACAAGGCGCTGATCGC
CAAGCATGGCAACATGCTGGCCGCGCTGGCGGCCGAGAAGCAGGTGGACCTGCTGTTTGAAGCGGCCGTGGCCGGGGGCA
TTCCGGTGGTGCGCGTGCTGCGCGACAGCCTGGCGGGCACCGAAGTGACCCGCGTTTCGGGCATTCTGAACGGCACCTGC
AATTTCATCACCTCCACCATGCTGGACACCGGGCGCTCCTATGAGGACGTTCTGGAGGAAGCCCAGAAGCGCGGCTATGC
CGAGGCCGATCCGACACTGGACGTTTCAGGCATGGACGCGGCCCATAAGGCGGCGATCCTCTCGGCGATTGCCTTCTCGG
CTGACCTTGATTTCTCGAAGGTTTCGGTGCGCGGCATCGAAGACATCGGCCTTCTGGACCTGCGCCTGGCAGACCGGTTG
GGCTTCCGGATCAAACTGATCGCTGAAGGCGTTCTCAAGGCGGAAGGCGTTGTCTGCCGGGTGGAGCCGATGGCGCTGAC
GGCGGGCCATGCGCTGGCGCGGATTGACGGGTCGCTGAACTCTGTGCGGGTTGAGGGCGATCCGCTGGGCGCTGTTGTGT
TGACGGGCCCCGGCGCAGGCTCTGGCCCGACCGCGAGCGCCGTGATGGGCGATGTGGCGAAGCTCTTCCGCCCGGCCATT
CGCAACGCCTTTGGGCGGGCTGACCACCATGTGGCCCAGCCTTTCATCAAAGGCGGCGAGGATGAGATTTCGCCCTTCTT
CCTGCGCGTGCGCCTGACAGACAAGCCGGGCACGCTGGCCGCGCTGACCGAAGCGCTGGCCGAAGAGGGCGTGTCGGTCG
ACAAGCTGCTGCAGGATTCGGCTGATGAAACGGGCGCCAGCCCGGTCGCGGTGGTGACCCATCGCTGCCCGCGCCGGCAG
ATCCTTTCAGCCATTGCCCGCATCGAGGCGCTTGGCGTAACCGTTGACGCGCCCAGACTGATCAGAATTGAGACGGCAAG
CTAA

Upstream 100 bases:

>100_bases
GCTTTGCTTAATGCACCCTGCGGGAGGCTTGCCCCTTCCAAGGTTGCGCCAAAAAGGCTAGGCAGCAGCCCGAACCGTAA
GAGATGAAAAGGGGCGCCTT

Downstream 100 bases:

>100_bases
TTGCTAGGGCCGTCCTGCTATAAGAATAATGACCCGTTTCGGAGAAAAACCTATGGATAACAGCGTTCTGACTTCCAGCC
TTGCAGATGCAATGGTTAAT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MGPLRIGIAGLGHVGCGLIELVQRQDRLRLPGRVEIAGVSARSQSRNRPVSTDGYTWFDDAATLAEDPNVDVFVELVGGS
DGPAKFAVESALRAGKHVVTANKALIAKHGNMLAALAAEKQVDLLFEAAVAGGIPVVRVLRDSLAGTEVTRVSGILNGTC
NFITSTMLDTGRSYEDVLEEAQKRGYAEADPTLDVSGMDAAHKAAILSAIAFSADLDFSKVSVRGIEDIGLLDLRLADRL
GFRIKLIAEGVLKAEGVVCRVEPMALTAGHALARIDGSLNSVRVEGDPLGAVVLTGPGAGSGPTASAVMGDVAKLFRPAI
RNAFGRADHHVAQPFIKGGEDEISPFFLRVRLTDKPGTLAALTEALAEEGVSVDKLLQDSADETGASPVAVVTHRCPRRQ
ILSAIARIEALGVTVDAPRLIRIETAS

Sequences:

>Translated_427_residues
MGPLRIGIAGLGHVGCGLIELVQRQDRLRLPGRVEIAGVSARSQSRNRPVSTDGYTWFDDAATLAEDPNVDVFVELVGGS
DGPAKFAVESALRAGKHVVTANKALIAKHGNMLAALAAEKQVDLLFEAAVAGGIPVVRVLRDSLAGTEVTRVSGILNGTC
NFITSTMLDTGRSYEDVLEEAQKRGYAEADPTLDVSGMDAAHKAAILSAIAFSADLDFSKVSVRGIEDIGLLDLRLADRL
GFRIKLIAEGVLKAEGVVCRVEPMALTAGHALARIDGSLNSVRVEGDPLGAVVLTGPGAGSGPTASAVMGDVAKLFRPAI
RNAFGRADHHVAQPFIKGGEDEISPFFLRVRLTDKPGTLAALTEALAEEGVSVDKLLQDSADETGASPVAVVTHRCPRRQ
ILSAIARIEALGVTVDAPRLIRIETAS
>Mature_426_residues
GPLRIGIAGLGHVGCGLIELVQRQDRLRLPGRVEIAGVSARSQSRNRPVSTDGYTWFDDAATLAEDPNVDVFVELVGGSD
GPAKFAVESALRAGKHVVTANKALIAKHGNMLAALAAEKQVDLLFEAAVAGGIPVVRVLRDSLAGTEVTRVSGILNGTCN
FITSTMLDTGRSYEDVLEEAQKRGYAEADPTLDVSGMDAAHKAAILSAIAFSADLDFSKVSVRGIEDIGLLDLRLADRLG
FRIKLIAEGVLKAEGVVCRVEPMALTAGHALARIDGSLNSVRVEGDPLGAVVLTGPGAGSGPTASAVMGDVAKLFRPAIR
NAFGRADHHVAQPFIKGGEDEISPFFLRVRLTDKPGTLAALTEALAEEGVSVDKLLQDSADETGASPVAVVTHRCPRRQI
LSAIARIEALGVTVDAPRLIRIETAS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=251, Percent_Identity=31.4741035856574, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790376, Length=361, Percent_Identity=26.8698060941828, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=123, Percent_Identity=32.520325203252, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44754; Mature: 44623

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPLRIGIAGLGHVGCGLIELVQRQDRLRLPGRVEIAGVSARSQSRNRPVSTDGYTWFDD
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCCCCCCEEECC
AATLAEDPNVDVFVELVGGSDGPAKFAVESALRAGKHVVTANKALIAKHGNMLAALAAEK
CHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCEEEEHHHHH
QVDLLFEAAVAGGIPVVRVLRDSLAGTEVTRVSGILNGTCNFITSTMLDTGRSYEDVLEE
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHH
AQKRGYAEADPTLDVSGMDAAHKAAILSAIAFSADLDFSKVSVRGIEDIGLLDLRLADRL
HHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEHHHHHHHC
GFRIKLIAEGVLKAEGVVCRVEPMALTAGHALARIDGSLNSVRVEGDPLGAVVLTGPGAG
CCEEEEEEHHHHHHCCEEEEEECEEEECCCHHEEECCCCCEEEECCCCCEEEEEECCCCC
SGPTASAVMGDVAKLFRPAIRNAFGRADHHVAQPFIKGGEDEISPFFLRVRLTDKPGTLA
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCCCHHH
ALTEALAEEGVSVDKLLQDSADETGASPVAVVTHRCPRRQILSAIARIEALGVTVDAPRL
HHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCEEECCCEE
IRIETAS
EEEEECC
>Mature Secondary Structure 
GPLRIGIAGLGHVGCGLIELVQRQDRLRLPGRVEIAGVSARSQSRNRPVSTDGYTWFDD
CCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCCCCCCEEECC
AATLAEDPNVDVFVELVGGSDGPAKFAVESALRAGKHVVTANKALIAKHGNMLAALAAEK
CHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCEEEEHHHHH
QVDLLFEAAVAGGIPVVRVLRDSLAGTEVTRVSGILNGTCNFITSTMLDTGRSYEDVLEE
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHH
AQKRGYAEADPTLDVSGMDAAHKAAILSAIAFSADLDFSKVSVRGIEDIGLLDLRLADRL
HHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEHHHHHHHC
GFRIKLIAEGVLKAEGVVCRVEPMALTAGHALARIDGSLNSVRVEGDPLGAVVLTGPGAG
CCEEEEEEHHHHHHCCEEEEEECEEEECCCHHEEECCCCCEEEECCCCCEEEEEECCCCC
SGPTASAVMGDVAKLFRPAIRNAFGRADHHVAQPFIKGGEDEISPFFLRVRLTDKPGTLA
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCCCHHH
ALTEALAEEGVSVDKLLQDSADETGASPVAVVTHRCPRRQILSAIARIEALGVTVDAPRL
HHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCEEECCCEE
IRIETAS
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]