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The map label for this gene is ilvX [H]

Identifier: 114797649

GI number: 114797649

Start: 2312775

End: 2314349

Strand: Reverse

Name: ilvX [H]

Synonym: HNE_2213

Alternate gene names: 114797649

Gene position: 2314349-2312775 (Counterclockwise)

Preceding gene: 114798316

Following gene: 114800415

Centisome position: 62.47

GC content: 65.71

Gene sequence:

>1575_bases
ATGAATACGGATAAACCTGAAAGCGGCGCCGAGCGTCTTGTCCATACGCTTATTGAGGGCGGGGTGGATGTCTGTTTTGC
CAATCCCGGAACCTCAGAGATGCACTTTGTCGGTGCGCTCGACCGGATCAGCGGCATGCGGTGCGTTCTGGGACTGTTTG
AGGGGATCGTGACGGGCGCGGCGGACGGGTATTACCGGGTTTCCGGCAAGCCGGCAGCAACCCTGCTGCACCTGGCGCCG
GGGCTCGCCAACGGGCTGGCCAACCTTCACAATGCCAAAAAAGCCCGCTCGGGCATCGTCAATATTGTCGGCGACCATGC
CACCTATCATGCGCCGCTGGCCTCGCCGCTTGCCGGGGATGTGGAGGCGGTGGCCCGCCCGATGTCCAACTGGGTGCGCA
CGACGTGTTCGGCAGATAGCCTTGCGGGGGATGCTGCAGAGGCCGTCGCGCTGGCGCGTCAGTCACCGGGCAAGATTGCG
ACGCTTATCCTGCCTGCGGATATTTCGTGGTGCGCGGCGGGTGAGGCTGCGCCGGTGCGCTCCGTGGCGCCGCGCCGCGC
GGTTCGCGCCGAATTTGTGGATGCTGCGGCCGAGGCGCTGCGTCGCGGTGGCAGCAATGCCATTCTGCTGCTGGGGGACG
GGGCGGTCAGAGGCAAAGCGCTGTCCTGGGCCGGTGCGATTGCGGCCGCGACCGGCTGCCGCCTGATGGCGGAGACGCAT
AATGCCTGCATGGAACGGGGCGCCGGGCGCGCGCCGTTTTCTCTTGTTCCGTATACGCAGCCGGTCGAGGCCGCCCTGAA
GGCTCTTGCCGGGACGCGCGATGTGGTTCTTGCCGGCGCGCGCGATCCGATCGCTTTTTTTGCCTATCCCGGAAAGCCGG
TGAAATTGCTGCCGGCTGACTGTAATGTCTGTGAACTGGCGAGTCCGGAAGAAGACATCGAGGCGGCTTTAGAAGCTGTT
GCCCGGGCGCTTGGTGTGCGGTCGGCCGCGGGCGAAGGCGTCGCGCCGCTGGCGCGCCCGGCAGTGCCCACCGGCCCGAT
CAGCCATGACGGCCTGGGAGAGGTGATTGCGGCGCTCCTGCCGGAGCAGTGTATCGTCATTGATGAGGCGGTGACCGCCG
GGCGGAGCTTTTACGCAAAGACCCGGACGACGGCGCCGCATGACTGGATCTCCAGCATGGGCGCGGCCATCGGGTTTGCG
CTTCCGGCAGCTGTCGGCGCCGCTATCGCTGCGCCTGGCCGCAAGGTGCTGGCCCTGTCAGGCGATGGGAGCGCGATGTA
CACGCCGCAAGCGCTTTGGAGCATGGCGCGTGAAGGGCTCGACGTGACGATCGTGATCTTTGCCAATCGCGCCTATCAGA
TTTTGCGGGGTGAGTTTTTCAATATGGGGTCGGGCGTACCCGGCGCCCGCGCCGAGGCGATGCTGACGATCGGGGATCCA
GCGCTCGATTGGCAATCCCTTGCAAAAGGGTGCGGCGTGGAGTGCGGGATCGCGCGTGATCTGGAAGAATTCGCGCGGGA
ACTCCGGCGGGGGTTCGCCTCGCAGGGACCGTATCTGGTTGAGGTGCGGATGTGA

Upstream 100 bases:

>100_bases
GTCCGGAGGCGTGATGCCCCGGACGGATCCGTCCGCGCCCCGGCCTGAAGCGGGCCCGGGCCGGCCCCGGCACAATGATG
CAGAAATATTCGGAGAGAGT

Downstream 100 bases:

>100_bases
GGCAGTCGCCAGCGCCCAGCCCCCTCAGGTGATGGTGCCCTGCGCGCGAGCTATCGAACCTGGTTCAACAGTTCCATCGC
GTTGTTGTCGCGCACCTGGG

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase large subunit; AHAS [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MNTDKPESGAERLVHTLIEGGVDVCFANPGTSEMHFVGALDRISGMRCVLGLFEGIVTGAADGYYRVSGKPAATLLHLAP
GLANGLANLHNAKKARSGIVNIVGDHATYHAPLASPLAGDVEAVARPMSNWVRTTCSADSLAGDAAEAVALARQSPGKIA
TLILPADISWCAAGEAAPVRSVAPRRAVRAEFVDAAAEALRRGGSNAILLLGDGAVRGKALSWAGAIAAATGCRLMAETH
NACMERGAGRAPFSLVPYTQPVEAALKALAGTRDVVLAGARDPIAFFAYPGKPVKLLPADCNVCELASPEEDIEAALEAV
ARALGVRSAAGEGVAPLARPAVPTGPISHDGLGEVIAALLPEQCIVIDEAVTAGRSFYAKTRTTAPHDWISSMGAAIGFA
LPAAVGAAIAAPGRKVLALSGDGSAMYTPQALWSMAREGLDVTIVIFANRAYQILRGEFFNMGSGVPGARAEAMLTIGDP
ALDWQSLAKGCGVECGIARDLEEFARELRRGFASQGPYLVEVRM

Sequences:

>Translated_524_residues
MNTDKPESGAERLVHTLIEGGVDVCFANPGTSEMHFVGALDRISGMRCVLGLFEGIVTGAADGYYRVSGKPAATLLHLAP
GLANGLANLHNAKKARSGIVNIVGDHATYHAPLASPLAGDVEAVARPMSNWVRTTCSADSLAGDAAEAVALARQSPGKIA
TLILPADISWCAAGEAAPVRSVAPRRAVRAEFVDAAAEALRRGGSNAILLLGDGAVRGKALSWAGAIAAATGCRLMAETH
NACMERGAGRAPFSLVPYTQPVEAALKALAGTRDVVLAGARDPIAFFAYPGKPVKLLPADCNVCELASPEEDIEAALEAV
ARALGVRSAAGEGVAPLARPAVPTGPISHDGLGEVIAALLPEQCIVIDEAVTAGRSFYAKTRTTAPHDWISSMGAAIGFA
LPAAVGAAIAAPGRKVLALSGDGSAMYTPQALWSMAREGLDVTIVIFANRAYQILRGEFFNMGSGVPGARAEAMLTIGDP
ALDWQSLAKGCGVECGIARDLEEFARELRRGFASQGPYLVEVRM
>Mature_524_residues
MNTDKPESGAERLVHTLIEGGVDVCFANPGTSEMHFVGALDRISGMRCVLGLFEGIVTGAADGYYRVSGKPAATLLHLAP
GLANGLANLHNAKKARSGIVNIVGDHATYHAPLASPLAGDVEAVARPMSNWVRTTCSADSLAGDAAEAVALARQSPGKIA
TLILPADISWCAAGEAAPVRSVAPRRAVRAEFVDAAAEALRRGGSNAILLLGDGAVRGKALSWAGAIAAATGCRLMAETH
NACMERGAGRAPFSLVPYTQPVEAALKALAGTRDVVLAGARDPIAFFAYPGKPVKLLPADCNVCELASPEEDIEAALEAV
ARALGVRSAAGEGVAPLARPAVPTGPISHDGLGEVIAALLPEQCIVIDEAVTAGRSFYAKTRTTAPHDWISSMGAAIGFA
LPAAVGAAIAAPGRKVLALSGDGSAMYTPQALWSMAREGLDVTIVIFANRAYQILRGEFFNMGSGVPGARAEAMLTIGDP
ALDWQSLAKGCGVECGIARDLEEFARELRRGFASQGPYLVEVRM

Specific function: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=565, Percent_Identity=24.4247787610619, Blast_Score=93, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 54072; Mature: 54072

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDKPESGAERLVHTLIEGGVDVCFANPGTSEMHFVGALDRISGMRCVLGLFEGIVTGA
CCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ADGYYRVSGKPAATLLHLAPGLANGLANLHNAKKARSGIVNIVGDHATYHAPLASPLAGD
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCCC
VEAVARPMSNWVRTTCSADSLAGDAAEAVALARQSPGKIATLILPADISWCAAGEAAPVR
HHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCHHCCCCCCCCH
SVAPRRAVRAEFVDAAAEALRRGGSNAILLLGDGAVRGKALSWAGAIAAATGCRLMAETH
HHCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHH
NACMERGAGRAPFSLVPYTQPVEAALKALAGTRDVVLAGARDPIAFFAYPGKPVKLLPAD
HHHHHCCCCCCCEEECCCCCHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCEEEECC
CNVCELASPEEDIEAALEAVARALGVRSAAGEGVAPLARPAVPTGPISHDGLGEVIAALL
CCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
PEQCIVIDEAVTAGRSFYAKTRTTAPHDWISSMGAAIGFALPAAVGAAIAAPGRKVLALS
CCCEEEEHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GDGSAMYTPQALWSMAREGLDVTIVIFANRAYQILRGEFFNMGSGVPGARAEAMLTIGDP
CCCCEEECHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
ALDWQSLAKGCGVECGIARDLEEFARELRRGFASQGPYLVEVRM
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MNTDKPESGAERLVHTLIEGGVDVCFANPGTSEMHFVGALDRISGMRCVLGLFEGIVTGA
CCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ADGYYRVSGKPAATLLHLAPGLANGLANLHNAKKARSGIVNIVGDHATYHAPLASPLAGD
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCCC
VEAVARPMSNWVRTTCSADSLAGDAAEAVALARQSPGKIATLILPADISWCAAGEAAPVR
HHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCHHCCCCCCCCH
SVAPRRAVRAEFVDAAAEALRRGGSNAILLLGDGAVRGKALSWAGAIAAATGCRLMAETH
HHCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHH
NACMERGAGRAPFSLVPYTQPVEAALKALAGTRDVVLAGARDPIAFFAYPGKPVKLLPAD
HHHHHCCCCCCCEEECCCCCHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCEEEECC
CNVCELASPEEDIEAALEAVARALGVRSAAGEGVAPLARPAVPTGPISHDGLGEVIAALL
CCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
PEQCIVIDEAVTAGRSFYAKTRTTAPHDWISSMGAAIGFALPAAVGAAIAAPGRKVLALS
CCCEEEEHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GDGSAMYTPQALWSMAREGLDVTIVIFANRAYQILRGEFFNMGSGVPGARAEAMLTIGDP
CCCCEEECHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
ALDWQSLAKGCGVECGIARDLEEFARELRRGFASQGPYLVEVRM
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]