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The map label for this gene is edd [H]

Identifier: 114797638

GI number: 114797638

Start: 1782476

End: 1784308

Strand: Direct

Name: edd [H]

Synonym: HNE_1740

Alternate gene names: 114797638

Gene position: 1782476-1784308 (Clockwise)

Preceding gene: 114798389

Following gene: 114800054

Centisome position: 48.11

GC content: 63.88

Gene sequence:

>1833_bases
ATGACCCCACTTCATCCGGTAATCGCAGACGTCACGCAGCGGATAGAGGCCCGCTCCAGAGACTCGCGCGCCGCCTATCT
CGAGATGATCCGGTCGCGCAGGCCCAAGACCTTCGCGCGCACACGGCTGCACGAAGGCAATATTGCCCATGCCTCCGCAG
GCTGCGCAGTCATCGAAAAGTCTCAGGTCCTCGGCGCAGGCTGGCCAGTCATCGGCATCATCACCTCCTACAACGACATG
CTCTCGGCCCATGCGCCGTTTGAGAATTTCCCGCAGATCATCCGTGAGGCGGCGCGCGAAGTGAACGCAGTCGCGCAGGT
GGCAGGCGGGGTGCCGGCGATGTGTGACGGCGTCACGCAAGGGCAGGAGGGCATGGAACTGTCGCTGTTCTCGCGCGACA
TCATCGCCATGGCATCGGCCATCGGCCTCTCGCACGATTCTTTTGACGCGGCGCTGCATCTGGGTGTCTGCGACAAGATC
GTGCCGGGGCTCGTGATCGCGGCCCTGCGCTTTGGTTGGCTCCCGTCGATCTTCGTCCCCGCCGGTCCGATGCCTTCCGG
CCTGCCCAATCCGGAGAAAGTCCGTATCCGGCAATTGTTCGCCGAAGGCAAAGTAGACCGCAGCGCTTTGTTGAAGGCCG
AGGCGGAAAGCTACCACTCGCAAGGCACCTGCACGTTTTACGGCACAGCAAACTCAAACCAGATGATGATGGAGGTGATG
GGCCTGCATCTTCCTGGCGCGGCCTTCACCAATCCCGGTACACCCCTGCGCGCCGCGCTCACCCGCGCCGCCACGCAGCG
CGCCGCCGCCATTACAGCGCAAGGGGATGACTACCGCCCCGCTGGCGAAATGATCGATGCCCGCTCCATCGTCAACGCCA
TCGTTGGCCTGATGGCCACGGGTGGCTCCACCAACCACGCTCTGCACATCCCCGCGATGGCCGCAGCTGCGGGGCTTGAT
GTAACGCTTGAGGATTTCGCAGACATCTCGCATGTCACCCCGCTGCTCGCGCGGATCTATCCCAATGGCGGCGCCGACGT
GAACCACTTCCACGCGGCGGGCGGGATGGGCTTTCTCGTGCGCGAACTGCTCGACGTTGGCCTTTTGCACGGTGATGCGC
CGGCTGTTTCAGGCACGATCGCTGATTATGGTCAGGAACCCTTCTTGAAGGATGGCGATCTGGCCTGGCGTCCTGCGCCG
GAAACGAGCGGAGACCTGGACGTGCTTCGCCCGGCAAGCGATCCGTTTTCGGCCGATGGCGGCCTTCGGCTGATGGATGG
CCCGCTTGGGCGGGGCGTTTCCAAGGTGTCCGCCGTCAAGCCGGAAAACCGCATCGTTGAGGCGCCAGCCATCGTGTTCG
ACACGCAGGAAGCTCTGCGGGAAGCGTTCGATGCGGGGCGTCTTGATCGGGATTTTGTTGCGGTGGTCCGCTTTCAGGGG
CCAGCGGCAAACGGAATGCCGGAATTGCATGGGCTGTCGCCCGTGCTCGGCGTGCTCCAGGACCGGGGCTTCAAGGTTGC
CCTCGTCACCGATGGGCGGATGTCCGGCGCCAGCGGGAAGATAACGGCTGCCATTCATGTGGCGCCCGAAGCGGCGCGGG
GCGGCCCGCTGGCGCGGGTTCAGGATGGCGACATCATTAGGGTGGACGGAGAATCAGGCCGGCTGGAGCTCAAAGTGGAT
CAATCAGAATTTGCGGGCAGGGCGCCGGCTGAATTCCGCCCCAACCGGCCCGCAATGGGGCTCGGTCGTGAAATGTTCGA
TCTTTTCAGGCAGTTCGCCAGCACAGCCGATTCCGGCGCCAGCCCTTTCCGCTTCCTCGGTCAGGAAACCTGA

Upstream 100 bases:

>100_bases
CTCTCGAACAATCTCTCAAGGGCGATGAAAAACAGTTCCCGGTGCGCCGCGCCATTGAGGGTCTGGGTAGACGTCTCTCC
ATCATCTGGGCACCCTGATC

Downstream 100 bases:

>100_bases
AGGATGGAAGGTTCCGTCCTGGTCGGAGATGTCGGCGGCACAAATGTGCGCTTTGCCCTCGCGGCGCGCCGGAACGGCGC
TCTGAGTATCGAGCATTTTC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTPLHPVIADVTQRIEARSRDSRAAYLEMIRSRRPKTFARTRLHEGNIAHASAGCAVIEKSQVLGAGWPVIGIITSYNDM
LSAHAPFENFPQIIREAAREVNAVAQVAGGVPAMCDGVTQGQEGMELSLFSRDIIAMASAIGLSHDSFDAALHLGVCDKI
VPGLVIAALRFGWLPSIFVPAGPMPSGLPNPEKVRIRQLFAEGKVDRSALLKAEAESYHSQGTCTFYGTANSNQMMMEVM
GLHLPGAAFTNPGTPLRAALTRAATQRAAAITAQGDDYRPAGEMIDARSIVNAIVGLMATGGSTNHALHIPAMAAAAGLD
VTLEDFADISHVTPLLARIYPNGGADVNHFHAAGGMGFLVRELLDVGLLHGDAPAVSGTIADYGQEPFLKDGDLAWRPAP
ETSGDLDVLRPASDPFSADGGLRLMDGPLGRGVSKVSAVKPENRIVEAPAIVFDTQEALREAFDAGRLDRDFVAVVRFQG
PAANGMPELHGLSPVLGVLQDRGFKVALVTDGRMSGASGKITAAIHVAPEAARGGPLARVQDGDIIRVDGESGRLELKVD
QSEFAGRAPAEFRPNRPAMGLGREMFDLFRQFASTADSGASPFRFLGQET

Sequences:

>Translated_610_residues
MTPLHPVIADVTQRIEARSRDSRAAYLEMIRSRRPKTFARTRLHEGNIAHASAGCAVIEKSQVLGAGWPVIGIITSYNDM
LSAHAPFENFPQIIREAAREVNAVAQVAGGVPAMCDGVTQGQEGMELSLFSRDIIAMASAIGLSHDSFDAALHLGVCDKI
VPGLVIAALRFGWLPSIFVPAGPMPSGLPNPEKVRIRQLFAEGKVDRSALLKAEAESYHSQGTCTFYGTANSNQMMMEVM
GLHLPGAAFTNPGTPLRAALTRAATQRAAAITAQGDDYRPAGEMIDARSIVNAIVGLMATGGSTNHALHIPAMAAAAGLD
VTLEDFADISHVTPLLARIYPNGGADVNHFHAAGGMGFLVRELLDVGLLHGDAPAVSGTIADYGQEPFLKDGDLAWRPAP
ETSGDLDVLRPASDPFSADGGLRLMDGPLGRGVSKVSAVKPENRIVEAPAIVFDTQEALREAFDAGRLDRDFVAVVRFQG
PAANGMPELHGLSPVLGVLQDRGFKVALVTDGRMSGASGKITAAIHVAPEAARGGPLARVQDGDIIRVDGESGRLELKVD
QSEFAGRAPAEFRPNRPAMGLGREMFDLFRQFASTADSGASPFRFLGQET
>Mature_609_residues
TPLHPVIADVTQRIEARSRDSRAAYLEMIRSRRPKTFARTRLHEGNIAHASAGCAVIEKSQVLGAGWPVIGIITSYNDML
SAHAPFENFPQIIREAAREVNAVAQVAGGVPAMCDGVTQGQEGMELSLFSRDIIAMASAIGLSHDSFDAALHLGVCDKIV
PGLVIAALRFGWLPSIFVPAGPMPSGLPNPEKVRIRQLFAEGKVDRSALLKAEAESYHSQGTCTFYGTANSNQMMMEVMG
LHLPGAAFTNPGTPLRAALTRAATQRAAAITAQGDDYRPAGEMIDARSIVNAIVGLMATGGSTNHALHIPAMAAAAGLDV
TLEDFADISHVTPLLARIYPNGGADVNHFHAAGGMGFLVRELLDVGLLHGDAPAVSGTIADYGQEPFLKDGDLAWRPAPE
TSGDLDVLRPASDPFSADGGLRLMDGPLGRGVSKVSAVKPENRIVEAPAIVFDTQEALREAFDAGRLDRDFVAVVRFQGP
AANGMPELHGLSPVLGVLQDRGFKVALVTDGRMSGASGKITAAIHVAPEAARGGPLARVQDGDIIRVDGESGRLELKVDQ
SEFAGRAPAEFRPNRPAMGLGREMFDLFRQFASTADSGASPFRFLGQET

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=57.7114427860697, Blast_Score=703, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=582, Percent_Identity=28.5223367697594, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI2367371, Length=491, Percent_Identity=30.142566191446, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1786464, Length=541, Percent_Identity=29.2051756007394, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322476, Length=489, Percent_Identity=29.8568507157464, Blast_Score=178, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64553; Mature: 64422

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLHPVIADVTQRIEARSRDSRAAYLEMIRSRRPKTFARTRLHEGNIAHASAGCAVIEK
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCEEEEC
SQVLGAGWPVIGIITSYNDMLSAHAPFENFPQIIREAAREVNAVAQVAGGVPAMCDGVTQ
CCCCCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
GQEGMELSLFSRDIIAMASAIGLSHDSFDAALHLGVCDKIVPGLVIAALRFGWLPSIFVP
CCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHCCCCCEEEC
AGPMPSGLPNPEKVRIRQLFAEGKVDRSALLKAEAESYHSQGTCTFYGTANSNQMMMEVM
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHH
GLHLPGAAFTNPGTPLRAALTRAATQRAAAITAQGDDYRPAGEMIDARSIVNAIVGLMAT
HCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GGSTNHALHIPAMAAAAGLDVTLEDFADISHVTPLLARIYPNGGADVNHFHAAGGMGFLV
CCCCCCEEECCHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHH
RELLDVGLLHGDAPAVSGTIADYGQEPFLKDGDLAWRPAPETSGDLDVLRPASDPFSADG
HHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
GLRLMDGPLGRGVSKVSAVKPENRIVEAPAIVFDTQEALREAFDAGRLDRDFVAVVRFQG
CCEEECCCCCCCHHHHHHCCCCCCEEECCEEEECCHHHHHHHHHCCCCCCCEEEEEEECC
PAANGMPELHGLSPVLGVLQDRGFKVALVTDGRMSGASGKITAAIHVAPEAARGGPLARV
CCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCEEEE
QDGDIIRVDGESGRLELKVDQSEFAGRAPAEFRPNRPAMGLGREMFDLFRQFASTADSGA
CCCCEEEEECCCCEEEEEECHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
SPFRFLGQET
CCHHHCCCCC
>Mature Secondary Structure 
TPLHPVIADVTQRIEARSRDSRAAYLEMIRSRRPKTFARTRLHEGNIAHASAGCAVIEK
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCEEEEC
SQVLGAGWPVIGIITSYNDMLSAHAPFENFPQIIREAAREVNAVAQVAGGVPAMCDGVTQ
CCCCCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
GQEGMELSLFSRDIIAMASAIGLSHDSFDAALHLGVCDKIVPGLVIAALRFGWLPSIFVP
CCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHCCCCCEEEC
AGPMPSGLPNPEKVRIRQLFAEGKVDRSALLKAEAESYHSQGTCTFYGTANSNQMMMEVM
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHH
GLHLPGAAFTNPGTPLRAALTRAATQRAAAITAQGDDYRPAGEMIDARSIVNAIVGLMAT
HCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GGSTNHALHIPAMAAAAGLDVTLEDFADISHVTPLLARIYPNGGADVNHFHAAGGMGFLV
CCCCCCEEECCHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHH
RELLDVGLLHGDAPAVSGTIADYGQEPFLKDGDLAWRPAPETSGDLDVLRPASDPFSADG
HHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
GLRLMDGPLGRGVSKVSAVKPENRIVEAPAIVFDTQEALREAFDAGRLDRDFVAVVRFQG
CCEEECCCCCCCHHHHHHCCCCCCEEECCEEEECCHHHHHHHHHCCCCCCCEEEEEEECC
PAANGMPELHGLSPVLGVLQDRGFKVALVTDGRMSGASGKITAAIHVAPEAARGGPLARV
CCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCEEEE
QDGDIIRVDGESGRLELKVDQSEFAGRAPAEFRPNRPAMGLGREMFDLFRQFASTADSGA
CCCCEEEEECCCCEEEEEECHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
SPFRFLGQET
CCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]