Click here to switch to the map view.

The map label for this gene is 114797614

Identifier: 114797614

GI number: 114797614

Start: 1404174

End: 1405550

Strand: Direct

Name: 114797614

Synonym: HNE_1374

Alternate gene names: NA

Gene position: 1404174-1405550 (Clockwise)

Preceding gene: 114799792

Following gene: 114798387

Centisome position: 37.9

GC content: 63.76

Gene sequence:

>1377_bases
ATGACTACGCCAACGAGCGACATCGACGAAGCCTCGCCGCGAATCTCCGGCAAGCACGAACTGGTCGAGTATCTGGAAGG
GGGCTCAAAGCCCGCCAGCGACTGGGCCATTGGCACCGAACACGAGAAGTTCGGCTTCATCTGGGACGGCCTCAAGCCGC
TTCCCTATGAGGGGCCGGCCTCGATTCTGGCGATGCTGGAGGGGTTGCGCGACCGGTTTGCCTGGGAGCCCATTCTTGAG
GGCGGCTATCTGATCGGCCTGAAGAAGGACGGCGCCAGCGTCAGCCTTGAGCCTGGCGGGCAGTTTGAGCTGTCCGGCGC
GCCGCTGAAATCCATCCATGAGACCTGCGTGGAAGTGGGCCGCCACCTGACCGAGGTGCGCGAGATTGCCGAGCCGCTGG
GCATCGGGTTCATCGGTCTGGGCGCCAGCCCGATCTGGAGCATGGCCGACACGCCGGTGATGCCCAAGGGCCGCTACAAG
ATCATGACCGCCTATATGGACAAGGTGGGGCGCCTTGGCCGGCAGATGATGTTCCGCACGTCTACCGTGCAGGCAAACCT
CGATTTCGGCTCGGAAGCCGACATGGTGCAGAAATTCCGCGTGTCGCTGGCGTTGCAGCCGCTGGGCACGGCGCTGTTTG
CCAACTCGCCCTTCCTGGAAGGCCGCCCGAACGGGTTCCTCTCCTATCGCTCGCATATCTGGACCGACCTTGACCCCGAC
CGGACGGGCATGTTGCCCTTCGTGTTCGAGGACGGGTTCGGCTTTGAGCGCTATGTCGATTACGCACTGGATGTGCCGAT
GTATTTCGTGCGCCGGGGCGGGAAATATCTTGACGCTTCGGGCCTGAGCTTCCGGGATTTCATGGAGGGCAAACTGCCCA
TCCTGCCGGGTGAGCGGCCGGCGATGGACGATTTTGTCGATCACCTCTCGACGATTTTCCCGGAAGTGCGCCTGAAGCGC
TTCCTGGAAATGCGCGGCTCTGATTCCGGGCCGTGGGACCGGCTGTGCGCGTTCTCGGCGTTCTGGACCGGGATTTTCTA
TTCCCAGTCTTCGCTGGATGCGGCTTGGGATCTGGTGAAGGGCTGGAGCGCGGCAGAGCGCGAAGCGATGCGCCAGTCAG
TGCGCACGCTGGGCCTCAGGACGCCGATCCCTGGCGGGCGGACGATGCAGGACCTTGCCAAGGACGTGCTGGCGATCAGC
CGGGCGGGCCTGAAGGGGCGCGTGATTTCGTCGGCGGGCGACGATGAGACGGGCTTCCTGACCGAAATGGACCAGATTGC
CACCTCCGGCGTCACACCGGCGGAGCGCCTGTTGCAGCGCTATTACGGGCCGTGGGACCGGGATGTGCGCAAGGTGTTTG
CCGAAGAGGCGTATTGA

Upstream 100 bases:

>100_bases
TAATGACGCGTCTGTTCAAGAATTTGCATTGCCCCGTTGGCGTTGCCCCATTTCGGCCTTATCTCCCCAGCCGGACAAAC
TGTTTCAGGAGCGCGCCGCG

Downstream 100 bases:

>100_bases
GGCTGGCGCGGGCATCTCGCCCTCGCTAGCGTGACGCCATGTGCGGACGATTTTTCCGGGAAGGCGTGACCTGGGGCGAG
TATTATACCTGGCTCAACAT

Product: glutamate--cysteine ligase

Products: NA

Alternate protein names: Glutamate/Cysteine Ligase; Gamma-Glutamylcysteine Synthetase; Glutamate/Cysteine Ligase Family Protein; Glutamate-Cysteine Ligase GshA; Glutamylcysteine Synthetase; Glutamate-Cysteine Ligase Family 2 Protein; Glutamate-Cysteine Ligase Protein; Glutathione Synthetase; Glutamate-Cysteine Ligase Gsha; Glutamate-Cysteine Ligase Protein; Glutamate-Cysteine Ligase Family Protein; Glutamate Cystein Ligase Protein; Glutamate-Cysteine Ligase GSHA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTTPTSDIDEASPRISGKHELVEYLEGGSKPASDWAIGTEHEKFGFIWDGLKPLPYEGPASILAMLEGLRDRFAWEPILE
GGYLIGLKKDGASVSLEPGGQFELSGAPLKSIHETCVEVGRHLTEVREIAEPLGIGFIGLGASPIWSMADTPVMPKGRYK
IMTAYMDKVGRLGRQMMFRTSTVQANLDFGSEADMVQKFRVSLALQPLGTALFANSPFLEGRPNGFLSYRSHIWTDLDPD
RTGMLPFVFEDGFGFERYVDYALDVPMYFVRRGGKYLDASGLSFRDFMEGKLPILPGERPAMDDFVDHLSTIFPEVRLKR
FLEMRGSDSGPWDRLCAFSAFWTGIFYSQSSLDAAWDLVKGWSAAEREAMRQSVRTLGLRTPIPGGRTMQDLAKDVLAIS
RAGLKGRVISSAGDDETGFLTEMDQIATSGVTPAERLLQRYYGPWDRDVRKVFAEEAY

Sequences:

>Translated_458_residues
MTTPTSDIDEASPRISGKHELVEYLEGGSKPASDWAIGTEHEKFGFIWDGLKPLPYEGPASILAMLEGLRDRFAWEPILE
GGYLIGLKKDGASVSLEPGGQFELSGAPLKSIHETCVEVGRHLTEVREIAEPLGIGFIGLGASPIWSMADTPVMPKGRYK
IMTAYMDKVGRLGRQMMFRTSTVQANLDFGSEADMVQKFRVSLALQPLGTALFANSPFLEGRPNGFLSYRSHIWTDLDPD
RTGMLPFVFEDGFGFERYVDYALDVPMYFVRRGGKYLDASGLSFRDFMEGKLPILPGERPAMDDFVDHLSTIFPEVRLKR
FLEMRGSDSGPWDRLCAFSAFWTGIFYSQSSLDAAWDLVKGWSAAEREAMRQSVRTLGLRTPIPGGRTMQDLAKDVLAIS
RAGLKGRVISSAGDDETGFLTEMDQIATSGVTPAERLLQRYYGPWDRDVRKVFAEEAY
>Mature_457_residues
TTPTSDIDEASPRISGKHELVEYLEGGSKPASDWAIGTEHEKFGFIWDGLKPLPYEGPASILAMLEGLRDRFAWEPILEG
GYLIGLKKDGASVSLEPGGQFELSGAPLKSIHETCVEVGRHLTEVREIAEPLGIGFIGLGASPIWSMADTPVMPKGRYKI
MTAYMDKVGRLGRQMMFRTSTVQANLDFGSEADMVQKFRVSLALQPLGTALFANSPFLEGRPNGFLSYRSHIWTDLDPDR
TGMLPFVFEDGFGFERYVDYALDVPMYFVRRGGKYLDASGLSFRDFMEGKLPILPGERPAMDDFVDHLSTIFPEVRLKRF
LEMRGSDSGPWDRLCAFSAFWTGIFYSQSSLDAAWDLVKGWSAAEREAMRQSVRTLGLRTPIPGGRTMQDLAKDVLAISR
AGLKGRVISSAGDDETGFLTEMDQIATSGVTPAERLLQRYYGPWDRDVRKVFAEEAY

Specific function: Unknown

COG id: COG3572

COG function: function code H; Gamma-glutamylcysteine synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 50943; Mature: 50811

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTSDIDEASPRISGKHELVEYLEGGSKPASDWAIGTEHEKFGFIWDGLKPLPYEGPA
CCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHH
SILAMLEGLRDRFAWEPILEGGYLIGLKKDGASVSLEPGGQFELSGAPLKSIHETCVEVG
HHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCEEEECCCCCEEECCCCHHHHHHHHHHHH
RHLTEVREIAEPLGIGFIGLGASPIWSMADTPVMPKGRYKIMTAYMDKVGRLGRQMMFRT
HHHHHHHHHHHHHCCCEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
STVQANLDFGSEADMVQKFRVSLALQPLGTALFANSPFLEGRPNGFLSYRSHIWTDLDPD
HHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC
RTGMLPFVFEDGFGFERYVDYALDVPMYFVRRGGKYLDASGLSFRDFMEGKLPILPGERP
CCCCCCEEEECCCCHHHHHHHHHCCHHHHHHCCCCEECCCCCCHHHHHCCCCCCCCCCCC
AMDDFVDHLSTIFPEVRLKRFLEMRGSDSGPWDRLCAFSAFWTGIFYSQSSLDAAWDLVK
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GWSAAEREAMRQSVRTLGLRTPIPGGRTMQDLAKDVLAISRAGLKGRVISSAGDDETGFL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHH
TEMDQIATSGVTPAERLLQRYYGPWDRDVRKVFAEEAY
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TTPTSDIDEASPRISGKHELVEYLEGGSKPASDWAIGTEHEKFGFIWDGLKPLPYEGPA
CCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHH
SILAMLEGLRDRFAWEPILEGGYLIGLKKDGASVSLEPGGQFELSGAPLKSIHETCVEVG
HHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCEEEECCCCCEEECCCCHHHHHHHHHHHH
RHLTEVREIAEPLGIGFIGLGASPIWSMADTPVMPKGRYKIMTAYMDKVGRLGRQMMFRT
HHHHHHHHHHHHHCCCEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
STVQANLDFGSEADMVQKFRVSLALQPLGTALFANSPFLEGRPNGFLSYRSHIWTDLDPD
HHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC
RTGMLPFVFEDGFGFERYVDYALDVPMYFVRRGGKYLDASGLSFRDFMEGKLPILPGERP
CCCCCCEEEECCCCHHHHHHHHHCCHHHHHHCCCCEECCCCCCHHHHHCCCCCCCCCCCC
AMDDFVDHLSTIFPEVRLKRFLEMRGSDSGPWDRLCAFSAFWTGIFYSQSSLDAAWDLVK
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GWSAAEREAMRQSVRTLGLRTPIPGGRTMQDLAKDVLAISRAGLKGRVISSAGDDETGFL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHH
TEMDQIATSGVTPAERLLQRYYGPWDRDVRKVFAEEAY
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA