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The map label for this gene is moaA [H]

Identifier: 114797605

GI number: 114797605

Start: 1582786

End: 1583778

Strand: Direct

Name: moaA [H]

Synonym: HNE_1557

Alternate gene names: 114797605

Gene position: 1582786-1583778 (Clockwise)

Preceding gene: 114798679

Following gene: 114798304

Centisome position: 42.72

GC content: 60.52

Gene sequence:

>993_bases
ATGACACATCCCGGCGCAGTCGCGACGGATGCCTTCGGGCGCAGGTTCAGTTACCTGCGGCTGTCGGTTACAGAAGTCTG
CAATTTTCGATGTACCTACTGCTTGCCGGATGGATACCGAAAAACCGGTTCCATGGACTTTCTCGCCGCAGACGAGATTG
AACGGCTCGTGCGCGCCTTCACCGGGCTTGGCATCCGTAAGGTCCGGCTGACAGGCGGCGAACCGACTGTCCGGAAGGAT
CTGACGCAACTGATCGCCCGCATTTCAGCGACGCCGGGGGTTGAGAAAGTCGCCCTGACGACAAATGGCTGGAATCTGCC
TCGCCGTATCGATGAGTGGGTTGGGGCGGGGCTGACCAACCTCAATGTCAGCATAGACTCCCTCGACAGGGAGGCCTTTC
ATCGCATTACCGGCCATGATCGTCTAGCGGATGTGCTTGCTGGACTGGAGTGCGCGCTGGCCTTGCCTCTGAAGACCGTC
AAAGTGAATGCCGTGCTGTTGCGGGACGGGCTTGAGGAGGATTTTTCGAGCTGGACAGAGTTCGTCCGTGAGCGTCCCGT
CTCCGTCCGTTTCATCGAGCTGATGCGGACAGGGGATAACAAGACGTTCTTTGAGGCGCAGCATGTGAGCGGCCGGATCC
TGCGCCAGTGGCTGGAGGACAATGGCTGGACAGCAAAAGCACGCGGGGAAGATGACGGACCGGCGACCGAGTTCACGCAC
CCTGGTTATGCCGGCCGGATCGGTCTGATCGCGCCCTACGGGCCGGGCTTCTGCGATGGGTGCAACCGGCTCCGCGTCAC
AGCGCGGGGACAACTCCGGCTGTGCCTTTTCGGACAAGGCGGACGCGACCTTCGGGACCTGCTCGGCTCAGATGATAGCA
CCCAAGTTCTCAAGTCGCGGATTGTCGAGGCTCTGACCTTCAAACCTGCAGCGCACAATCTTCACACCGCCAATCCCGGC
GACATCAGAAATCTGGCTCAGACCGGAGGCTAG

Upstream 100 bases:

>100_bases
CCGTTCCGCCTAAAGCGCCGTTTCCCGGTGTCATGGCGGCCCGGCCGAGGGTGGCAGTTGGAAACCCTGCCGCCTCCCGT
GCTTGGAAAGGAGCCATGCG

Downstream 100 bases:

>100_bases
TCGCTCTTCGTGTCTAGCAGGCCCTGCTGTCGTTCGGTGAAGGCCTTGCCTTTCGTGTTGCAATCCTGCGCATAGTGGTT
GTCGATCAGTGGGGTTGGGC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTHPGAVATDAFGRRFSYLRLSVTEVCNFRCTYCLPDGYRKTGSMDFLAADEIERLVRAFTGLGIRKVRLTGGEPTVRKD
LTQLIARISATPGVEKVALTTNGWNLPRRIDEWVGAGLTNLNVSIDSLDREAFHRITGHDRLADVLAGLECALALPLKTV
KVNAVLLRDGLEEDFSSWTEFVRERPVSVRFIELMRTGDNKTFFEAQHVSGRILRQWLEDNGWTAKARGEDDGPATEFTH
PGYAGRIGLIAPYGPGFCDGCNRLRVTARGQLRLCLFGQGGRDLRDLLGSDDSTQVLKSRIVEALTFKPAAHNLHTANPG
DIRNLAQTGG

Sequences:

>Translated_330_residues
MTHPGAVATDAFGRRFSYLRLSVTEVCNFRCTYCLPDGYRKTGSMDFLAADEIERLVRAFTGLGIRKVRLTGGEPTVRKD
LTQLIARISATPGVEKVALTTNGWNLPRRIDEWVGAGLTNLNVSIDSLDREAFHRITGHDRLADVLAGLECALALPLKTV
KVNAVLLRDGLEEDFSSWTEFVRERPVSVRFIELMRTGDNKTFFEAQHVSGRILRQWLEDNGWTAKARGEDDGPATEFTH
PGYAGRIGLIAPYGPGFCDGCNRLRVTARGQLRLCLFGQGGRDLRDLLGSDDSTQVLKSRIVEALTFKPAAHNLHTANPG
DIRNLAQTGG
>Mature_329_residues
THPGAVATDAFGRRFSYLRLSVTEVCNFRCTYCLPDGYRKTGSMDFLAADEIERLVRAFTGLGIRKVRLTGGEPTVRKDL
TQLIARISATPGVEKVALTTNGWNLPRRIDEWVGAGLTNLNVSIDSLDREAFHRITGHDRLADVLAGLECALALPLKTVK
VNAVLLRDGLEEDFSSWTEFVRERPVSVRFIELMRTGDNKTFFEAQHVSGRILRQWLEDNGWTAKARGEDDGPATEFTHP
GYAGRIGLIAPYGPGFCDGCNRLRVTARGQLRLCLFGQGGRDLRDLLGSDDSTQVLKSRIVEALTFKPAAHNLHTANPGD
IRNLAQTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=317, Percent_Identity=39.1167192429022, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI22027536, Length=316, Percent_Identity=39.2405063291139, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI1786999, Length=324, Percent_Identity=50.6172839506173, Blast_Score=342, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17561210, Length=306, Percent_Identity=39.5424836601307, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32566331, Length=306, Percent_Identity=39.2156862745098, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566329, Length=306, Percent_Identity=39.2156862745098, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI28574490, Length=309, Percent_Identity=40.7766990291262, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI28574488, Length=309, Percent_Identity=40.7766990291262, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36413; Mature: 36282

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPGAVATDAFGRRFSYLRLSVTEVCNFRCTYCLPDGYRKTGSMDFLAADEIERLVRAF
CCCCCCCCHHHHHHHHHHHEEEHHHHHCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHH
TGLGIRKVRLTGGEPTVRKDLTQLIARISATPGVEKVALTTNGWNLPRRIDEWVGAGLTN
HCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCE
LNVSIDSLDREAFHRITGHDRLADVLAGLECALALPLKTVKVNAVLLRDGLEEDFSSWTE
EEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHH
FVRERPVSVRFIELMRTGDNKTFFEAQHVSGRILRQWLEDNGWTAKARGEDDGPATEFTH
HHHHCCCCEEEEEHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
PGYAGRIGLIAPYGPGFCDGCNRLRVTARGQLRLCLFGQGGRDLRDLLGSDDSTQVLKSR
CCCCCCEEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHCCCCHHHHHHHH
IVEALTFKPAAHNLHTANPGDIRNLAQTGG
HHHHHHCCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
THPGAVATDAFGRRFSYLRLSVTEVCNFRCTYCLPDGYRKTGSMDFLAADEIERLVRAF
CCCCCCCHHHHHHHHHHHEEEHHHHHCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHH
TGLGIRKVRLTGGEPTVRKDLTQLIARISATPGVEKVALTTNGWNLPRRIDEWVGAGLTN
HCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCE
LNVSIDSLDREAFHRITGHDRLADVLAGLECALALPLKTVKVNAVLLRDGLEEDFSSWTE
EEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHH
FVRERPVSVRFIELMRTGDNKTFFEAQHVSGRILRQWLEDNGWTAKARGEDDGPATEFTH
HHHHCCCCEEEEEHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
PGYAGRIGLIAPYGPGFCDGCNRLRVTARGQLRLCLFGQGGRDLRDLLGSDDSTQVLKSR
CCCCCCEEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHCCCCHHHHHHHH
IVEALTFKPAAHNLHTANPGDIRNLAQTGG
HHHHHHCCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA