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The map label for this gene is ethA [H]

Identifier: 114797572

GI number: 114797572

Start: 1297227

End: 1298729

Strand: Direct

Name: ethA [H]

Synonym: HNE_1269

Alternate gene names: 114797572

Gene position: 1297227-1298729 (Clockwise)

Preceding gene: 114800115

Following gene: 114799935

Centisome position: 35.01

GC content: 58.15

Gene sequence:

>1503_bases
ATGGCGGATACCGCAGCGGTCAAAGAACGCAAACCCAAGGCAAAGATCGAGCATTTCGATGTGCTGATCGCCGGGGCGGG
GATTTCCGGGGTTGGCGCGGCCTATCATATCAAGACGCAGACGCCGAAGAAGAAGTTCCTGGTGCTGGAAGCTTATGAGA
GCTTTGGTGGCACCTGGTACATGCACCGCTATCCAGGCATCCGGTCTGACTCTGATCTTTACACGTTCGGTTACCGGTTC
AAGCCATGGGTCGGCCCGCCGATTGCGAGCCGGGAAGAGATCCTGAAATATATGGGCGAAGTGATCGACGAAGCCGGTCT
CGCCGAGCATATCCGCTATCGCCACAAGATCCGCTCGGCGAGCTGGTCGAGCGCGAAGAAGAAGTGGACCGTGAAGGCGG
AAAACCTTGAGACCGGGGATGTGCTGACGTTCACGGCAAACTTCCTCTGGATGTGTCAGGGCTATTACAATCATGCGCAG
GGCTATACGCCCGAATGGGCCGGAATGGCTGATTTCAAAGGGCAGATCGTTCATCCGCAGACCTGGCCGGAAGACCTGGA
CCTGACAGGAAAGAAGGTGATCTGCATCGGCTCTGGCGCGACGGCGGCGACGGTTGTGCCGGCGATTGCGGGCAAGTGTG
AGCATGTGACGCTGCTGCAACGCTCGCCGACCTATTTCATCCCGGCACGGAATGAAAACGTTCTGGCCGATGAGCTGCGG
ATGCTGGGCGTGGATGATGCGTGGATTCACGAGATCGTGCGACGCAAGTATAATCACGATCAGGCGGAGTTCACCCGGCG
GTCTTTCGAGGAGTCTGACACTGTGCGCCAGGAGCTTCTGGACGGGGTGAAAGCGTGCCTGCCGGAAGATTTCGACATGA
GCCATTTCACGCCGAGCTATCGGCCATGGCGCCAGCGGATTGCGTTTGTTCCGGATGCGGACCTGTTTGAAGGCATTAAG
GCCGGACAGGCGAGCGTGGTGACCGATCATATCGACCGGTTCACTGAGAAAGGCATCCTGCTGAAATCCGGCAACGAGCT
GGAAGCCGATGTGATCATCACGGCGACGGGGTTTGATCTTTCCGTGCTGGGCGACATTCCTTTCGAGGTGGATGGTGAGC
CGGTCGACTGGTCGAAGACCATCACCTATCGCGGAATGATGTTTACCGGCGTGCCGAACCTTGCCTGGGTGTTTGGCTAT
TTCCGGGCGAGCTGGACCCTGCGGGTGGACATGATGGGCGACCTGATCTGCCGTCTTCTCAAGCATATGGACGAGAAGAA
GGTGAAGCAGGTGGAAGTGGCCCTGCGTCCGCAGGACCATAATATGGAAATCCTGCCCTGGATCGATGAGGCCAACTTCA
ATCCCGGCTATCTCGCCCGATCAATGCACCTGATGCCCAAGCGCGGCACCACGCGCGACTGGCAGCACACGCAGGACTAT
TGGCGCGAGAAAGACGAGTTCCCGCTGATCGACCTGGACGGAGAAGAATTCCGCTACAGCTGA

Upstream 100 bases:

>100_bases
CTAGGGCCGATTACGTATTCACCTGCCTTCCTCCCAGGGCAAAATTTGCAAGCAAGTTTGAGGGCTCCGCGACACGTGGA
CGGAGCCGATGGAGGAATGC

Downstream 100 bases:

>100_bases
GACGGCCCGCGCGCCTGCTCTTGCCGGGGATCGACAACCCCGGCATGAGTGGCGCCAATGACTGATACGAGCGCCCCTTC
CCAGACAGAGTCTGACGGTC

Product: monooxygenase flavin-binding family protein

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MADTAAVKERKPKAKIEHFDVLIAGAGISGVGAAYHIKTQTPKKKFLVLEAYESFGGTWYMHRYPGIRSDSDLYTFGYRF
KPWVGPPIASREEILKYMGEVIDEAGLAEHIRYRHKIRSASWSSAKKKWTVKAENLETGDVLTFTANFLWMCQGYYNHAQ
GYTPEWAGMADFKGQIVHPQTWPEDLDLTGKKVICIGSGATAATVVPAIAGKCEHVTLLQRSPTYFIPARNENVLADELR
MLGVDDAWIHEIVRRKYNHDQAEFTRRSFEESDTVRQELLDGVKACLPEDFDMSHFTPSYRPWRQRIAFVPDADLFEGIK
AGQASVVTDHIDRFTEKGILLKSGNELEADVIITATGFDLSVLGDIPFEVDGEPVDWSKTITYRGMMFTGVPNLAWVFGY
FRASWTLRVDMMGDLICRLLKHMDEKKVKQVEVALRPQDHNMEILPWIDEANFNPGYLARSMHLMPKRGTTRDWQHTQDY
WREKDEFPLIDLDGEEFRYS

Sequences:

>Translated_500_residues
MADTAAVKERKPKAKIEHFDVLIAGAGISGVGAAYHIKTQTPKKKFLVLEAYESFGGTWYMHRYPGIRSDSDLYTFGYRF
KPWVGPPIASREEILKYMGEVIDEAGLAEHIRYRHKIRSASWSSAKKKWTVKAENLETGDVLTFTANFLWMCQGYYNHAQ
GYTPEWAGMADFKGQIVHPQTWPEDLDLTGKKVICIGSGATAATVVPAIAGKCEHVTLLQRSPTYFIPARNENVLADELR
MLGVDDAWIHEIVRRKYNHDQAEFTRRSFEESDTVRQELLDGVKACLPEDFDMSHFTPSYRPWRQRIAFVPDADLFEGIK
AGQASVVTDHIDRFTEKGILLKSGNELEADVIITATGFDLSVLGDIPFEVDGEPVDWSKTITYRGMMFTGVPNLAWVFGY
FRASWTLRVDMMGDLICRLLKHMDEKKVKQVEVALRPQDHNMEILPWIDEANFNPGYLARSMHLMPKRGTTRDWQHTQDY
WREKDEFPLIDLDGEEFRYS
>Mature_499_residues
ADTAAVKERKPKAKIEHFDVLIAGAGISGVGAAYHIKTQTPKKKFLVLEAYESFGGTWYMHRYPGIRSDSDLYTFGYRFK
PWVGPPIASREEILKYMGEVIDEAGLAEHIRYRHKIRSASWSSAKKKWTVKAENLETGDVLTFTANFLWMCQGYYNHAQG
YTPEWAGMADFKGQIVHPQTWPEDLDLTGKKVICIGSGATAATVVPAIAGKCEHVTLLQRSPTYFIPARNENVLADELRM
LGVDDAWIHEIVRRKYNHDQAEFTRRSFEESDTVRQELLDGVKACLPEDFDMSHFTPSYRPWRQRIAFVPDADLFEGIKA
GQASVVTDHIDRFTEKGILLKSGNELEADVIITATGFDLSVLGDIPFEVDGEPVDWSKTITYRGMMFTGVPNLAWVFGYF
RASWTLRVDMMGDLICRLLKHMDEKKVKQVEVALRPQDHNMEILPWIDEANFNPGYLARSMHLMPKRGTTRDWQHTQDYW
REKDEFPLIDLDGEEFRYS

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57227; Mature: 57095

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTAAVKERKPKAKIEHFDVLIAGAGISGVGAAYHIKTQTPKKKFLVLEAYESFGGTWY
CCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCHHEEEEEEHHHCCCEEE
MHRYPGIRSDSDLYTFGYRFKPWVGPPIASREEILKYMGEVIDEAGLAEHIRYRHKIRSA
EECCCCCCCCCCEEEECEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
SWSSAKKKWTVKAENLETGDVLTFTANFLWMCQGYYNHAQGYTPEWAGMADFKGQIVHPQ
CCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHCCHHHHCCCCCCCCCCCCCCCCEEECCC
TWPEDLDLTGKKVICIGSGATAATVVPAIAGKCEHVTLLQRSPTYFIPARNENVLADELR
CCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCHHHHHH
MLGVDDAWIHEIVRRKYNHDQAEFTRRSFEESDTVRQELLDGVKACLPEDFDMSHFTPSY
HCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
RPWRQRIAFVPDADLFEGIKAGQASVVTDHIDRFTEKGILLKSGNELEADVIITATGFDL
CCHHHHEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCE
SVLGDIPFEVDGEPVDWSKTITYRGMMFTGVPNLAWVFGYFRASWTLRVDMMGDLICRLL
EEECCCCEEECCCCCCCCCEEEECCEEEECCCHHHHHHHHHHCEEEEEEHHHHHHHHHHH
KHMDEKKVKQVEVALRPQDHNMEILPWIDEANFNPGYLARSMHLMPKRGTTRDWQHTQDY
HHCCHHHHHEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHEEECCCCCCCCCCHHHHHH
WREKDEFPLIDLDGEEFRYS
HCCCCCCCEEECCCHHCCCC
>Mature Secondary Structure 
ADTAAVKERKPKAKIEHFDVLIAGAGISGVGAAYHIKTQTPKKKFLVLEAYESFGGTWY
CCCHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCHHEEEEEEHHHCCCEEE
MHRYPGIRSDSDLYTFGYRFKPWVGPPIASREEILKYMGEVIDEAGLAEHIRYRHKIRSA
EECCCCCCCCCCEEEECEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
SWSSAKKKWTVKAENLETGDVLTFTANFLWMCQGYYNHAQGYTPEWAGMADFKGQIVHPQ
CCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHCCHHHHCCCCCCCCCCCCCCCCEEECCC
TWPEDLDLTGKKVICIGSGATAATVVPAIAGKCEHVTLLQRSPTYFIPARNENVLADELR
CCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCHHHHHH
MLGVDDAWIHEIVRRKYNHDQAEFTRRSFEESDTVRQELLDGVKACLPEDFDMSHFTPSY
HCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
RPWRQRIAFVPDADLFEGIKAGQASVVTDHIDRFTEKGILLKSGNELEADVIITATGFDL
CCHHHHEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCE
SVLGDIPFEVDGEPVDWSKTITYRGMMFTGVPNLAWVFGYFRASWTLRVDMMGDLICRLL
EEECCCCEEECCCCCCCCCEEEECCEEEECCCHHHHHHHHHHCEEEEEEHHHHHHHHHHH
KHMDEKKVKQVEVALRPQDHNMEILPWIDEANFNPGYLARSMHLMPKRGTTRDWQHTQDY
HHCCHHHHHEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHEEECCCCCCCCCCHHHHHH
WREKDEFPLIDLDGEEFRYS
HCCCCCCCEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]