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The map label for this gene is lon [H]

Identifier: 114797553

GI number: 114797553

Start: 991154

End: 993574

Strand: Direct

Name: lon [H]

Synonym: HNE_0977

Alternate gene names: 114797553

Gene position: 991154-993574 (Clockwise)

Preceding gene: 114799120

Following gene: 114800345

Centisome position: 26.75

GC content: 62.33

Gene sequence:

>2421_bases
ATGCCAAAGACAAAAACAGTGCCGGTGTTGCCGCTTCGGGACATCGTTGTTTTTCCTGACATGGTCGCCCCCCTCTTTGT
GGGCCGCGACAAGTCCGTCCGGGCGCTCGAGATGATCGACGAGTCCGACAATGAGATCATGCTGGTGGCCCAGAAGGATG
CGGCCGTCGACAACCCTGTGACCAGTGACCTGCATGCGACGGGCACGCTGGCGACCATCCTGCAACTCTTGAAGCTGCCC
GATGGCACCGTGAAGGTGCTGGTCGAGGGCCGCTCGCGCGCGCGCCTGGTGGCGCTGCATGACCGGGCCGAGTATTTCGA
GGCTGAGGTTGAGGCCATTCCGGAAGCCGATGCGTCGGGCGCTGATGTGCAGGCGCTGATGCGCGCCGTGCAGGAGCAGT
TCGAGAACTATGTGAAGCTTAACCGCAAGATCCCGCCTGAGGCGGTGACCACGATCAGCCAGCTGACTGATCCGGGCCGG
CTTGCCGATCAGGTGGCGTCAAACCTCTCTGTGAAGCTTTCCGACAAGCAGGAATTGCTGGAGATGCCGGAGGTTAAAGA
CCGGCTGGAGAAGGTCTTCTCGCTGATGGAAGGCGAGATGGGCATGCTGCAGATGGAGCGGAAGATCAAAAACCGCGTCA
AGCGGCAGATGGAGAAGACCCAGCGCGAATATTATCTCAACGAGCAGATGAAGGCGATCCAGCGCGAGCTGGGCGATTCT
GGCGGCGAGGGCGGCGAGCGCGATGAGCTGGCCGAGCTTGACCAGAAGATTGCCGACACGCCGCTGAGCCAGGAAGCGCG
CACCAAGGCCGAAGCCGAGATGAAGAAGCTGCGTCAGATGTCGCCGATGTCGGCGGAATCGACGGTTGTGCGGAACTATC
TCGACTGGATTCTGTCGCTGCCCTGGGGCAAGCGGAAGGACATCGAAACTGACCTTCTCAAAGCCGAGAAGCAGCTCGAT
GACGACCATTACGGCCTCGACAAGGTGAAAGAGCGTATTCTCGAATACCTCGCCGTGCAGAAGCGGACCGGGCGCCTCAA
AGGCCCGATCCTCTGTCTCGTCGGGCCTCCGGGCGTGGGTAAGACCTCGCTGGGCCGCTCGATTGCCGAAGCCACGGGAC
GCGACTTTGTGCGTGTGTCGCTGGGCGGCGTGCGCGATGAGAGCGAGATCCGCGGTCACCGCCGGACCTATATCGGCTCG
ATGCCGGGCCGGGTGATCCAGAGCCTGAAGAAGACCAAGAGCGGCAACCCGCTGTTCCTGCTCGACGAGATCGACAAGAT
GGGCATGGACCATCGCGGCGATCCGGCTTCGGCGCTGCTCGAAGTGCTCGACCCTGAGCAGAACTCGACGTTCAACGACC
ATTATCTGGAGGTCGACTATGACCTCTCCGACGTGATGTTCGTGACGACGGCGAACTCGCTCAACATGCCTCAGCCGCTG
CTGGACCGGATGGAGATCATCCGTATCGCGGGCTACACCGAAGAAGAGAAGCTGGAGATCACCAAGCGCCACCTCATTCC
GCAGGTGCGCGAGGATCATGGTCTCAGGGATGACGAATGGATCGTGACCGACGAGGCCATCCGCGACCTGATCCGCTACT
ATTCGCGTGAAGCGGGCGTGCGGAGCCTGAAGCGTGAAGTTTCGCGCCTTGCCCGCAAGGCTGTGCGTGAGATTGCAACG
GGCGAGCATACGAGCCTGACCATCGATTCGGACAATCTCGCCAAATATGCGGGCGTCCGGAAGCATCGCTACGGCCTTGC
CGACGAAACCGATCAGGTGGGCGCTGTCACCGGCCTTGCCTGGACGGAAGTGGGCGGCGACCTGCTGACCATCGAGGCGG
TGAAAATGCCCGGCCGGGGCGCGATGAAGGTGACGGGTAACCTGCGCGATGTGATGAAGGAGTCGATTTCGGCGGCCAGC
TCGCTCGTGCGGGCCCGCTCTGTGGACCTCGGCATCAAGCCGACCGTGTTCAACACGACCGACATCCACGTGCACGTGCC
AGATGGCGCAACGCCCAAGGATGGCCCGTCTGCGGGCGCGGCCATGACCACGGCCATCGTTTCGCTGCTGACCGGCATTC
CGGTGAACCGCGAAGTGGCGATGACAGGCGAGATATCCTTGCGTGGACGGGTGCTGCCGATTGGCGGCCTCAAGGAGAAA
CTGCTCGCGGCCCTGCGCGGCGGCATCAAGACGGTGCTGATCCCGAAGGAAAACGAGAAGGACCTCGATGAGATCCCCGA
TAACGTCAAAACCGGCATGAAGATCATTCCGGTGTCGGACATCCAGGAAGTGCTGAAACTGGCGCTGACCGGGCCTCTGA
CGGCGATCGAATGGTCTGAAGCCGATGAGGCGCGCCTGCAGGCGAGCCTGGGCGGCGGACCGGCCCCGGCAACGGACGGC
GATGCGGTGCGCACGCACTGA

Upstream 100 bases:

>100_bases
TTTCCACATTCCCACTGTCGCCCAATTAATGTCCTAGTGTGGCATGACAGGGTATAAGGGTTGCTGCTCAGCGGGACCCG
AATCAAAGGAGGCACTTCAG

Downstream 100 bases:

>100_bases
TCTGCCAGCGACGCTGAAACTTTTGGAAAAGCCCCCTCGATGAGGGGGCTTTTTTGTTTGGGGGGTGACAGCAGCAAACC
ACACTTGCCTTCCTGCCACT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MPKTKTVPVLPLRDIVVFPDMVAPLFVGRDKSVRALEMIDESDNEIMLVAQKDAAVDNPVTSDLHATGTLATILQLLKLP
DGTVKVLVEGRSRARLVALHDRAEYFEAEVEAIPEADASGADVQALMRAVQEQFENYVKLNRKIPPEAVTTISQLTDPGR
LADQVASNLSVKLSDKQELLEMPEVKDRLEKVFSLMEGEMGMLQMERKIKNRVKRQMEKTQREYYLNEQMKAIQRELGDS
GGEGGERDELAELDQKIADTPLSQEARTKAEAEMKKLRQMSPMSAESTVVRNYLDWILSLPWGKRKDIETDLLKAEKQLD
DDHYGLDKVKERILEYLAVQKRTGRLKGPILCLVGPPGVGKTSLGRSIAEATGRDFVRVSLGGVRDESEIRGHRRTYIGS
MPGRVIQSLKKTKSGNPLFLLDEIDKMGMDHRGDPASALLEVLDPEQNSTFNDHYLEVDYDLSDVMFVTTANSLNMPQPL
LDRMEIIRIAGYTEEEKLEITKRHLIPQVREDHGLRDDEWIVTDEAIRDLIRYYSREAGVRSLKREVSRLARKAVREIAT
GEHTSLTIDSDNLAKYAGVRKHRYGLADETDQVGAVTGLAWTEVGGDLLTIEAVKMPGRGAMKVTGNLRDVMKESISAAS
SLVRARSVDLGIKPTVFNTTDIHVHVPDGATPKDGPSAGAAMTTAIVSLLTGIPVNREVAMTGEISLRGRVLPIGGLKEK
LLAALRGGIKTVLIPKENEKDLDEIPDNVKTGMKIIPVSDIQEVLKLALTGPLTAIEWSEADEARLQASLGGGPAPATDG
DAVRTH

Sequences:

>Translated_806_residues
MPKTKTVPVLPLRDIVVFPDMVAPLFVGRDKSVRALEMIDESDNEIMLVAQKDAAVDNPVTSDLHATGTLATILQLLKLP
DGTVKVLVEGRSRARLVALHDRAEYFEAEVEAIPEADASGADVQALMRAVQEQFENYVKLNRKIPPEAVTTISQLTDPGR
LADQVASNLSVKLSDKQELLEMPEVKDRLEKVFSLMEGEMGMLQMERKIKNRVKRQMEKTQREYYLNEQMKAIQRELGDS
GGEGGERDELAELDQKIADTPLSQEARTKAEAEMKKLRQMSPMSAESTVVRNYLDWILSLPWGKRKDIETDLLKAEKQLD
DDHYGLDKVKERILEYLAVQKRTGRLKGPILCLVGPPGVGKTSLGRSIAEATGRDFVRVSLGGVRDESEIRGHRRTYIGS
MPGRVIQSLKKTKSGNPLFLLDEIDKMGMDHRGDPASALLEVLDPEQNSTFNDHYLEVDYDLSDVMFVTTANSLNMPQPL
LDRMEIIRIAGYTEEEKLEITKRHLIPQVREDHGLRDDEWIVTDEAIRDLIRYYSREAGVRSLKREVSRLARKAVREIAT
GEHTSLTIDSDNLAKYAGVRKHRYGLADETDQVGAVTGLAWTEVGGDLLTIEAVKMPGRGAMKVTGNLRDVMKESISAAS
SLVRARSVDLGIKPTVFNTTDIHVHVPDGATPKDGPSAGAAMTTAIVSLLTGIPVNREVAMTGEISLRGRVLPIGGLKEK
LLAALRGGIKTVLIPKENEKDLDEIPDNVKTGMKIIPVSDIQEVLKLALTGPLTAIEWSEADEARLQASLGGGPAPATDG
DAVRTH
>Mature_805_residues
PKTKTVPVLPLRDIVVFPDMVAPLFVGRDKSVRALEMIDESDNEIMLVAQKDAAVDNPVTSDLHATGTLATILQLLKLPD
GTVKVLVEGRSRARLVALHDRAEYFEAEVEAIPEADASGADVQALMRAVQEQFENYVKLNRKIPPEAVTTISQLTDPGRL
ADQVASNLSVKLSDKQELLEMPEVKDRLEKVFSLMEGEMGMLQMERKIKNRVKRQMEKTQREYYLNEQMKAIQRELGDSG
GEGGERDELAELDQKIADTPLSQEARTKAEAEMKKLRQMSPMSAESTVVRNYLDWILSLPWGKRKDIETDLLKAEKQLDD
DHYGLDKVKERILEYLAVQKRTGRLKGPILCLVGPPGVGKTSLGRSIAEATGRDFVRVSLGGVRDESEIRGHRRTYIGSM
PGRVIQSLKKTKSGNPLFLLDEIDKMGMDHRGDPASALLEVLDPEQNSTFNDHYLEVDYDLSDVMFVTTANSLNMPQPLL
DRMEIIRIAGYTEEEKLEITKRHLIPQVREDHGLRDDEWIVTDEAIRDLIRYYSREAGVRSLKREVSRLARKAVREIATG
EHTSLTIDSDNLAKYAGVRKHRYGLADETDQVGAVTGLAWTEVGGDLLTIEAVKMPGRGAMKVTGNLRDVMKESISAASS
LVRARSVDLGIKPTVFNTTDIHVHVPDGATPKDGPSAGAAMTTAIVSLLTGIPVNREVAMTGEISLRGRVLPIGGLKEKL
LAALRGGIKTVLIPKENEKDLDEIPDNVKTGMKIIPVSDIQEVLKLALTGPLTAIEWSEADEARLQASLGGGPAPATDGD
AVRTH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=684, Percent_Identity=39.9122807017544, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI31377667, Length=785, Percent_Identity=38.7261146496815, Blast_Score=511, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=61.7801047120419, Blast_Score=948, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=707, Percent_Identity=39.4625176803395, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17556486, Length=536, Percent_Identity=41.6044776119403, Blast_Score=430, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=702, Percent_Identity=40.02849002849, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI221513036, Length=627, Percent_Identity=42.7432216905901, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=627, Percent_Identity=42.7432216905901, Blast_Score=517, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89005; Mature: 88874

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTKTVPVLPLRDIVVFPDMVAPLFVGRDKSVRALEMIDESDNEIMLVAQKDAAVDNPV
CCCCCCCCCCCCHHHHHCHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCC
TSDLHATGTLATILQLLKLPDGTVKVLVEGRSRARLVALHDRAEYFEAEVEAIPEADASG
CCCHHCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCCCCCC
ADVQALMRAVQEQFENYVKLNRKIPPEAVTTISQLTDPGRLADQVASNLSVKLSDKQELL
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEECCHHHHH
EMPEVKDRLEKVFSLMEGEMGMLQMERKIKNRVKRQMEKTQREYYLNEQMKAIQRELGDS
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGEGGERDELAELDQKIADTPLSQEARTKAEAEMKKLRQMSPMSAESTVVRNYLDWILSL
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
PWGKRKDIETDLLKAEKQLDDDHYGLDKVKERILEYLAVQKRTGRLKGPILCLVGPPGVG
CCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
KTSLGRSIAEATGRDFVRVSLGGVRDESEIRGHRRTYIGSMPGRVIQSLKKTKSGNPLFL
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCHHHHHHCCCHHHHHHHHHHCCCCCCEEE
LDEIDKMGMDHRGDPASALLEVLDPEQNSTFNDHYLEVDYDLSDVMFVTTANSLNMPQPL
EECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEIIRIAGYTEEEKLEITKRHLIPQVREDHGLRDDEWIVTDEAIRDLIRYYSREAGV
HHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHH
RSLKREVSRLARKAVREIATGEHTSLTIDSDNLAKYAGVRKHRYGLADETDQVGAVTGLA
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCH
WTEVGGDLLTIEAVKMPGRGAMKVTGNLRDVMKESISAASSLVRARSVDLGIKPTVFNTT
HHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCE
DIHVHVPDGATPKDGPSAGAAMTTAIVSLLTGIPVNREVAMTGEISLRGRVLPIGGLKEK
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECEEECCEEEECCCHHHH
LLAALRGGIKTVLIPKENEKDLDEIPDNVKTGMKIIPVSDIQEVLKLALTGPLTAIEWSE
HHHHHHCCCEEEEECCCCCCCHHHCCHHHHCCCEEEEHHHHHHHHHHHHCCCCCEEECCC
ADEARLQASLGGGPAPATDGDAVRTH
CHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKTKTVPVLPLRDIVVFPDMVAPLFVGRDKSVRALEMIDESDNEIMLVAQKDAAVDNPV
CCCCCCCCCCCHHHHHCHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCC
TSDLHATGTLATILQLLKLPDGTVKVLVEGRSRARLVALHDRAEYFEAEVEAIPEADASG
CCCHHCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCCCCCC
ADVQALMRAVQEQFENYVKLNRKIPPEAVTTISQLTDPGRLADQVASNLSVKLSDKQELL
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEECCHHHHH
EMPEVKDRLEKVFSLMEGEMGMLQMERKIKNRVKRQMEKTQREYYLNEQMKAIQRELGDS
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGEGGERDELAELDQKIADTPLSQEARTKAEAEMKKLRQMSPMSAESTVVRNYLDWILSL
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
PWGKRKDIETDLLKAEKQLDDDHYGLDKVKERILEYLAVQKRTGRLKGPILCLVGPPGVG
CCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
KTSLGRSIAEATGRDFVRVSLGGVRDESEIRGHRRTYIGSMPGRVIQSLKKTKSGNPLFL
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCHHHHHHCCCHHHHHHHHHHCCCCCCEEE
LDEIDKMGMDHRGDPASALLEVLDPEQNSTFNDHYLEVDYDLSDVMFVTTANSLNMPQPL
EECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEIIRIAGYTEEEKLEITKRHLIPQVREDHGLRDDEWIVTDEAIRDLIRYYSREAGV
HHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHH
RSLKREVSRLARKAVREIATGEHTSLTIDSDNLAKYAGVRKHRYGLADETDQVGAVTGLA
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCH
WTEVGGDLLTIEAVKMPGRGAMKVTGNLRDVMKESISAASSLVRARSVDLGIKPTVFNTT
HHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCE
DIHVHVPDGATPKDGPSAGAAMTTAIVSLLTGIPVNREVAMTGEISLRGRVLPIGGLKEK
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECEEECCEEEECCCHHHH
LLAALRGGIKTVLIPKENEKDLDEIPDNVKTGMKIIPVSDIQEVLKLALTGPLTAIEWSE
HHHHHHCCCEEEEECCCCCCCHHHCCHHHHCCCEEEEHHHHHHHHHHHHCCCCCEEECCC
ADEARLQASLGGGPAPATDGDAVRTH
CHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8666236 [H]