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The map label for this gene is msrA2 [H]

Identifier: 114797543

GI number: 114797543

Start: 3613303

End: 3613953

Strand: Direct

Name: msrA2 [H]

Synonym: HNE_3479

Alternate gene names: 114797543

Gene position: 3613303-3613953 (Clockwise)

Preceding gene: 114799390

Following gene: 114799552

Centisome position: 97.52

GC content: 60.52

Gene sequence:

>651_bases
ATGCTCTTCATGAAGAAAAACCTCGACCTGCCGACCGCCGAAACCGCCCTGAAAGGCCGCAGCATTGCGATTCCGACGGC
AGACACCCACTTCGTATTTGGCCGGCCGCTGAATGCGCCCCCACCCGAAGGGATTGAGACGGCGATCTTTGGCCTCGGCT
GTTTTTGGGGCGCCGAGCGCATTTTCTGGAAAACGCCCGGCGTCTGGCTCACCCGCGTTGGCTATGCTGGCGGCATCACG
CCCAACCCCACCTATGAAGAAGTCTGCTCCGGCCGCACTGGCCATACCGAGATTGTGGAGGTCCAGTTCGACCCCAAAGA
GGTCAGCTTTGCGGCCCTGGTCAAACTCTTCCTCGAAAGCCATGACCCGACCCAGGGCATGCGTCAGGGCAATGACATCG
GCACCCAATACCGCTCCGCGATCTATTTCCGCTCCCCTGAGCAAGAAGCCACTGCAAGGCAGATGATCACCGAGTATGAA
AAGGCGCTCGCCGCCTCCGGCCACCGGGAAAAGGTCACCAGCGAAGTCAAACCGCTCGATACGCTGTATCTGGCCGAAGA
TTACCACCAGCAATATCTGGCGAAGAACCCCAACGGCTATTGCGGCATCGGCGGCACAGGCGTCAGCTGCCCCCTGCCCC
AGACCGCTTAG

Upstream 100 bases:

>100_bases
GAAGCGAGCGAGATACCGGATGACCCGCCGCCCCGCAAGCGTGTGATTGCCATAAAACTCATCAATCCCCATATCCTGGG
TCAGAGAAGGAACCCCGCCC

Downstream 100 bases:

>100_bases
GGGCGGCCTGAAGTATCAGGAGCCGAAGTTAAGCGAAAACCGCTTGCGGGACTCAATCATCGACTGCGCCTTGAACAGGG
CGTCGGATGCGGATTGGGCC

Product: methionine-S-sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1 [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MLFMKKNLDLPTAETALKGRSIAIPTADTHFVFGRPLNAPPPEGIETAIFGLGCFWGAERIFWKTPGVWLTRVGYAGGIT
PNPTYEEVCSGRTGHTEIVEVQFDPKEVSFAALVKLFLESHDPTQGMRQGNDIGTQYRSAIYFRSPEQEATARQMITEYE
KALAASGHREKVTSEVKPLDTLYLAEDYHQQYLAKNPNGYCGIGGTGVSCPLPQTA

Sequences:

>Translated_216_residues
MLFMKKNLDLPTAETALKGRSIAIPTADTHFVFGRPLNAPPPEGIETAIFGLGCFWGAERIFWKTPGVWLTRVGYAGGIT
PNPTYEEVCSGRTGHTEIVEVQFDPKEVSFAALVKLFLESHDPTQGMRQGNDIGTQYRSAIYFRSPEQEATARQMITEYE
KALAASGHREKVTSEVKPLDTLYLAEDYHQQYLAKNPNGYCGIGGTGVSCPLPQTA
>Mature_216_residues
MLFMKKNLDLPTAETALKGRSIAIPTADTHFVFGRPLNAPPPEGIETAIFGLGCFWGAERIFWKTPGVWLTRVGYAGGIT
PNPTYEEVCSGRTGHTEIVEVQFDPKEVSFAALVKLFLESHDPTQGMRQGNDIGTQYRSAIYFRSPEQEATARQMITEYE
KALAASGHREKVTSEVKPLDTLYLAEDYHQQYLAKNPNGYCGIGGTGVSCPLPQTA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=204, Percent_Identity=54.9019607843137, Blast_Score=234, Evalue=5e-62,
Organism=Homo sapiens, GI208609995, Length=183, Percent_Identity=57.9234972677596, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI208609993, Length=204, Percent_Identity=41.1764705882353, Blast_Score=150, Evalue=6e-37,
Organism=Escherichia coli, GI1790665, Length=196, Percent_Identity=52.0408163265306, Blast_Score=211, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=39.8648648648649, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=34.1317365269461, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24664627, Length=162, Percent_Identity=37.037037037037, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24664631, Length=162, Percent_Identity=36.4197530864198, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=37.5886524822695, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23775; Mature: 23775

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFMKKNLDLPTAETALKGRSIAIPTADTHFVFGRPLNAPPPEGIETAIFGLGCFWGAER
CEEECCCCCCCCHHHHHCCCEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCE
IFWKTPGVWLTRVGYAGGITPNPTYEEVCSGRTGHTEIVEVQFDPKEVSFAALVKLFLES
EEEECCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHC
HDPTQGMRQGNDIGTQYRSAIYFRSPEQEATARQMITEYEKALAASGHREKVTSEVKPLD
CCCHHHHHCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCH
TLYLAEDYHQQYLAKNPNGYCGIGGTGVSCPLPQTA
HHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MLFMKKNLDLPTAETALKGRSIAIPTADTHFVFGRPLNAPPPEGIETAIFGLGCFWGAER
CEEECCCCCCCCHHHHHCCCEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCE
IFWKTPGVWLTRVGYAGGITPNPTYEEVCSGRTGHTEIVEVQFDPKEVSFAALVKLFLES
EEEECCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHC
HDPTQGMRQGNDIGTQYRSAIYFRSPEQEATARQMITEYEKALAASGHREKVTSEVKPLD
CCCHHHHHCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCH
TLYLAEDYHQQYLAKNPNGYCGIGGTGVSCPLPQTA
HHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]