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The map label for this gene is iscS [H]

Identifier: 114797524

GI number: 114797524

Start: 2777912

End: 2779114

Strand: Reverse

Name: iscS [H]

Synonym: HNE_2620

Alternate gene names: 114797524

Gene position: 2779114-2777912 (Counterclockwise)

Preceding gene: 114798565

Following gene: 114797351

Centisome position: 75.01

GC content: 67.17

Gene sequence:

>1203_bases
ATGCAAATTTTTCTGCAGGGTGCGGGATTGATCGAAAGGCTCTATATTAGAGAGGTCATGATTTATGCTGATTACAACGC
CACCGCCCCGCTGCGGCCAGAGGCCAGGGCGGCCATGCTGGCGGCCTATGAGCTGGGGCCGGTGAACCCCTCCTCCGTCC
ACAAGGCCGGGCGGGCTGCGCGCGCCGTCGTCGAAAAGGCCCGTGCCGAGGTCGGCGCCGCCATCGGCAGCCGCGCCGAA
GACATCGTCTTCACCAGCGGGGGCACCGAATCCCTCGCCCTCGCCATCCAGGGCGCTGTGGCCGGGCTCGACGGGGCGGC
GACGCTTATTGTGTCCGCCATCGAGCATGAAGCCGCCAGCAAGGCTGCCGCCCATGCCGGCGTACCGGTCGAGACCGCCT
ACATCCTTCCCACCGGCCAGGTGGACCTGGACGATCTCCGCGTCCGCCTCGCGGCATGGGACCGGGGCCTCAAAGGCACC
CCCATTCTCGTGCTGATGCTGGCCAACAACGAAACCGGCATCCTCCAGCCCGTGGCTGAGGCTGCCGCGCTGATACGCGA
GGCCGGCGGGCTGACCGTGTGTGACGCGGTTCAGGGCCTCGGCAAGGTGGCGGTGAATGTCGCGCTGCTGGGCGTCGATT
ACCTTGCGCTTTCCGCCCACAAGGTCGGCGGCCCGCAGGGCACCGGCGCGCTGTGGCACCGGGCGGGCGCGCCGCTGAAA
GCCGTGCTTTATGGCGGCGGGCAGGAACGGGGCCTGCGCTCGGGCACCGAGAATGTCGCCGGGATTGCCGGGTTTGGCGC
GGCGATGTCCCAAGCTGTCCTGGATTTGTCCCGATATGTCTCGCTGGGAACCCACCGTGACGCGATGGAGGCCCGCCTGA
AGGCCGAAGGCGGCGTCATTGTCATAGGCGAGGGCAGCCCCCGTCTCGCCGGGGTCTCAAACTTCGCCCGCGCCGGTTTC
CGCGCCGAAACCCAGGTGATGGCCCTTGATCTGGCGGGGGTTTGCATCTCGGCAGGCTCGGCCTGCTCGTCGGGCAAGGT
GAAAAGATCCCTTGTGCTGATGGCCATGGGCGCAGATGACGCCCTTGCGGAATCGGCGATCCGCACCAGCTTTGGCTGGA
ACAGCCGCCCGGAAGATTTCCGCCACGTCGCCGACGCCTGGCTGGAGGCTGCCCGGAGAACTGTGTTGAAGGAATCCGTA
TGA

Upstream 100 bases:

>100_bases
TTCAATTCGGCCCTGGGGGCCCGGAATGATGATCTCGGCCATCGGTAACCTCGGCTTTTTTCCACAGAAGGGCGCGTAGA
TAGGCCAAGTCGGTCCTCAA

Downstream 100 bases:

>100_bases
TGGACTGCTGCGGCGGAATGGATGAGCACGAGGATGACTGCACCGAAGTGAAGGTGAAGGACAGCATCGATGCCAGAACG
GTCGAGGCGGCAAAGCGCCT

Product: class-V pyridoxal-phosphate-dependent aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MQIFLQGAGLIERLYIREVMIYADYNATAPLRPEARAAMLAAYELGPVNPSSVHKAGRAARAVVEKARAEVGAAIGSRAE
DIVFTSGGTESLALAIQGAVAGLDGAATLIVSAIEHEAASKAAAHAGVPVETAYILPTGQVDLDDLRVRLAAWDRGLKGT
PILVLMLANNETGILQPVAEAAALIREAGGLTVCDAVQGLGKVAVNVALLGVDYLALSAHKVGGPQGTGALWHRAGAPLK
AVLYGGGQERGLRSGTENVAGIAGFGAAMSQAVLDLSRYVSLGTHRDAMEARLKAEGGVIVIGEGSPRLAGVSNFARAGF
RAETQVMALDLAGVCISAGSACSSGKVKRSLVLMAMGADDALAESAIRTSFGWNSRPEDFRHVADAWLEAARRTVLKESV

Sequences:

>Translated_400_residues
MQIFLQGAGLIERLYIREVMIYADYNATAPLRPEARAAMLAAYELGPVNPSSVHKAGRAARAVVEKARAEVGAAIGSRAE
DIVFTSGGTESLALAIQGAVAGLDGAATLIVSAIEHEAASKAAAHAGVPVETAYILPTGQVDLDDLRVRLAAWDRGLKGT
PILVLMLANNETGILQPVAEAAALIREAGGLTVCDAVQGLGKVAVNVALLGVDYLALSAHKVGGPQGTGALWHRAGAPLK
AVLYGGGQERGLRSGTENVAGIAGFGAAMSQAVLDLSRYVSLGTHRDAMEARLKAEGGVIVIGEGSPRLAGVSNFARAGF
RAETQVMALDLAGVCISAGSACSSGKVKRSLVLMAMGADDALAESAIRTSFGWNSRPEDFRHVADAWLEAARRTVLKESV
>Mature_400_residues
MQIFLQGAGLIERLYIREVMIYADYNATAPLRPEARAAMLAAYELGPVNPSSVHKAGRAARAVVEKARAEVGAAIGSRAE
DIVFTSGGTESLALAIQGAVAGLDGAATLIVSAIEHEAASKAAAHAGVPVETAYILPTGQVDLDDLRVRLAAWDRGLKGT
PILVLMLANNETGILQPVAEAAALIREAGGLTVCDAVQGLGKVAVNVALLGVDYLALSAHKVGGPQGTGALWHRAGAPLK
AVLYGGGQERGLRSGTENVAGIAGFGAAMSQAVLDLSRYVSLGTHRDAMEARLKAEGGVIVIGEGSPRLAGVSNFARAGF
RAETQVMALDLAGVCISAGSACSSGKVKRSLVLMAMGADDALAESAIRTSFGWNSRPEDFRHVADAWLEAARRTVLKESV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI156713448, Length=405, Percent_Identity=35.3086419753086, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI32307132, Length=383, Percent_Identity=31.0704960835509, Blast_Score=168, Evalue=8e-42,
Organism=Escherichia coli, GI48994898, Length=396, Percent_Identity=33.0808080808081, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1787970, Length=240, Percent_Identity=25.8333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789175, Length=279, Percent_Identity=30.1075268817204, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25143064, Length=384, Percent_Identity=33.3333333333333, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17533177, Length=335, Percent_Identity=31.044776119403, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319831, Length=378, Percent_Identity=34.1269841269841, Blast_Score=175, Evalue=9e-45,
Organism=Drosophila melanogaster, GI20129463, Length=386, Percent_Identity=33.6787564766839, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41238; Mature: 41238

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIFLQGAGLIERLYIREVMIYADYNATAPLRPEARAAMLAAYELGPVNPSSVHKAGRAA
CEEEEECCHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
RAVVEKARAEVGAAIGSRAEDIVFTSGGTESLALAIQGAVAGLDGAATLIVSAIEHEAAS
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHH
KAAAHAGVPVETAYILPTGQVDLDDLRVRLAAWDRGLKGTPILVLMLANNETGILQPVAE
HHHHHCCCCEEEEEEEECCCCCHHHHHEEEEHHCCCCCCCCEEEEEEECCCCCCHHHHHH
AAALIREAGGLTVCDAVQGLGKVAVNVALLGVDYLALSAHKVGGPQGTGALWHRAGAPLK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEE
AVLYGGGQERGLRSGTENVAGIAGFGAAMSQAVLDLSRYVSLGTHRDAMEARLKAEGGVI
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEE
VIGEGSPRLAGVSNFARAGFRAETQVMALDLAGVCISAGSACSSGKVKRSLVLMAMGADD
EECCCCCCCCCHHHHHHCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCEEEEEEEEECCCH
ALAESAIRTSFGWNSRPEDFRHVADAWLEAARRTVLKESV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQIFLQGAGLIERLYIREVMIYADYNATAPLRPEARAAMLAAYELGPVNPSSVHKAGRAA
CEEEEECCHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
RAVVEKARAEVGAAIGSRAEDIVFTSGGTESLALAIQGAVAGLDGAATLIVSAIEHEAAS
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHH
KAAAHAGVPVETAYILPTGQVDLDDLRVRLAAWDRGLKGTPILVLMLANNETGILQPVAE
HHHHHCCCCEEEEEEEECCCCCHHHHHEEEEHHCCCCCCCCEEEEEEECCCCCCHHHHHH
AAALIREAGGLTVCDAVQGLGKVAVNVALLGVDYLALSAHKVGGPQGTGALWHRAGAPLK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEE
AVLYGGGQERGLRSGTENVAGIAGFGAAMSQAVLDLSRYVSLGTHRDAMEARLKAEGGVI
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEE
VIGEGSPRLAGVSNFARAGFRAETQVMALDLAGVCISAGSACSSGKVKRSLVLMAMGADD
EECCCCCCCCCHHHHHHCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCEEEEEEEEECCCH
ALAESAIRTSFGWNSRPEDFRHVADAWLEAARRTVLKESV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA