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The map label for this gene is phr [H]

Identifier: 114797406

GI number: 114797406

Start: 1843380

End: 1844837

Strand: Reverse

Name: phr [H]

Synonym: HNE_1798

Alternate gene names: 114797406

Gene position: 1844837-1843380 (Counterclockwise)

Preceding gene: 114798382

Following gene: 114798865

Centisome position: 49.79

GC content: 58.85

Gene sequence:

>1458_bases
ATGTCTTCTGCCTCGCCCGCAATTCTATGGTTCCGAGAAGATCTGCGCCTGACGGACAATCCTGCGCTCAACGCTGCGGT
CAATAGTGGGCGGCCCCTGATATGCGTCTATCTTCGGGAAACCGGAGCCGGGGCGCCGCGGGAAATGGGCGGGGCAAGCC
GTTGGTGGCTGAACAAGAGCCTCGCATCGCTTGGCGCTTCGCTGGAAGCCATTGGTGGCAAGCTCACACTCAGAACCGGG
CCTGCGGAGAAAATCATCCCCGCGCTCGTTGAAGAGACAGGCGCAGCGGCCGTTTTCTGGAATCGGCGATATGGCTTGCC
AGAACGGGAAACAGACGCAGCCATCAAGAAAACGCTGAAGGACAATGGCGTCGAGTGCCAGAGCTTCAACGGCCGCCTTC
TCATGGAGCCGTGGGACCTGAAGACCGGTAGCGGCGGTTGGTACAAGGTATTCACCCCCTTCTGGAGGGCGCTTCAGGCG
CAGTATAAGCCGCCCGCATTCATCCCCTCCCCCAAGAAGATTGCAGGGGCATCGGCTGAAACTGAAAACCTCAAGGACTG
GGGCCTTCATCCGGAGAAGCCGGACTGGTCCGGCGGCATTGCAGCAGCTTGGGAGCCCGGCGAAGTGGGCGCGCAAAAAC
GGCTCGACGCGTTTCTGGATGGCCCCGTCAGCGATTATGTGGGCACGCGCAATCTTCCCGGTGTGTCGACAGGCACCTCA
AGGCTATCACCACATCTGCGCTTTGGTGAAATAGGTCCGGCACAGATATGGCGCGCAGTCCGAGCGCGCCTCGAAGCGCA
ACAGGCAGACGAAGATTCTGCCCGTGTCTTCCTGTCAGAGATCGCGTGGCGGGAATTTTCTTACACGCTGCTTTATTACA
ATCCGGCGTTGGCTACCGAAAACTACAATAGCAATTTCAATCAGATGGCCTGGCGCAAGGACGATTCCGGATTCGCAGCA
TGGTCGCGCGGACAGACCGGATATCCCATTGTTGACGCTGGCATGCGCGAACTTTGGCATACCGGCTGGATGCACAACCG
TGTCAGGATGATTGTTGCATCGTTTCTGACCAAACACCTTCTCCTCCCTTGGCAGCAGGGTGAGCAATGGTTCTGGGATA
CGTTGGTGGATGCCGACCCGGCTGCCAATCCGGCGAGCTGGCAGTGGACGGCGGGTAGCGGCGCAGATGCTGCCCCTTAC
TTCCGGGTGTTCAATCCAATTTCACAGGGACAGAAATTTGATGAGGACGGCGCCTATGTGCGCCATTGGTGCCCGGAACT
TGCCGGATTGCCAGACAAGTACCTTCATGCGCCTTTCGAAGCCGATGCGCAGACCCTGAAACGTGCACGCGTCATGCTGG
GCACGGACTATCCCGAACCGATAATCGACCACCCTGTAGGCCGGCAGCGCGCACTGGATGCCTATAAGGCCATGAAAGAG
GAACAGACCGCCGAATGA

Upstream 100 bases:

>100_bases
ACCTTCGCGAGTGAAAGCGATGCGCGCTGAAGGGTGATCCAATTGCCGATTCAAGGCGTAAGATCAAAGTTACAAAGCGT
TTTCCAAAGCTGGTCTGTTC

Downstream 100 bases:

>100_bases
AAAAAATTGCGATCATTGGCGCAGGCATCTCCGGATTGGGCGCCGCGTGGGCACTTAAGGACACAGCGGATGTCACCCTG
TTCGAGCAGGATAAGCGCGC

Product: deoxyribodipyrimidine photolyase family protein

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSSASPAILWFREDLRLTDNPALNAAVNSGRPLICVYLRETGAGAPREMGGASRWWLNKSLASLGASLEAIGGKLTLRTG
PAEKIIPALVEETGAAAVFWNRRYGLPERETDAAIKKTLKDNGVECQSFNGRLLMEPWDLKTGSGGWYKVFTPFWRALQA
QYKPPAFIPSPKKIAGASAETENLKDWGLHPEKPDWSGGIAAAWEPGEVGAQKRLDAFLDGPVSDYVGTRNLPGVSTGTS
RLSPHLRFGEIGPAQIWRAVRARLEAQQADEDSARVFLSEIAWREFSYTLLYYNPALATENYNSNFNQMAWRKDDSGFAA
WSRGQTGYPIVDAGMRELWHTGWMHNRVRMIVASFLTKHLLLPWQQGEQWFWDTLVDADPAANPASWQWTAGSGADAAPY
FRVFNPISQGQKFDEDGAYVRHWCPELAGLPDKYLHAPFEADAQTLKRARVMLGTDYPEPIIDHPVGRQRALDAYKAMKE
EQTAE

Sequences:

>Translated_485_residues
MSSASPAILWFREDLRLTDNPALNAAVNSGRPLICVYLRETGAGAPREMGGASRWWLNKSLASLGASLEAIGGKLTLRTG
PAEKIIPALVEETGAAAVFWNRRYGLPERETDAAIKKTLKDNGVECQSFNGRLLMEPWDLKTGSGGWYKVFTPFWRALQA
QYKPPAFIPSPKKIAGASAETENLKDWGLHPEKPDWSGGIAAAWEPGEVGAQKRLDAFLDGPVSDYVGTRNLPGVSTGTS
RLSPHLRFGEIGPAQIWRAVRARLEAQQADEDSARVFLSEIAWREFSYTLLYYNPALATENYNSNFNQMAWRKDDSGFAA
WSRGQTGYPIVDAGMRELWHTGWMHNRVRMIVASFLTKHLLLPWQQGEQWFWDTLVDADPAANPASWQWTAGSGADAAPY
FRVFNPISQGQKFDEDGAYVRHWCPELAGLPDKYLHAPFEADAQTLKRARVMLGTDYPEPIIDHPVGRQRALDAYKAMKE
EQTAE
>Mature_484_residues
SSASPAILWFREDLRLTDNPALNAAVNSGRPLICVYLRETGAGAPREMGGASRWWLNKSLASLGASLEAIGGKLTLRTGP
AEKIIPALVEETGAAAVFWNRRYGLPERETDAAIKKTLKDNGVECQSFNGRLLMEPWDLKTGSGGWYKVFTPFWRALQAQ
YKPPAFIPSPKKIAGASAETENLKDWGLHPEKPDWSGGIAAAWEPGEVGAQKRLDAFLDGPVSDYVGTRNLPGVSTGTSR
LSPHLRFGEIGPAQIWRAVRARLEAQQADEDSARVFLSEIAWREFSYTLLYYNPALATENYNSNFNQMAWRKDDSGFAAW
SRGQTGYPIVDAGMRELWHTGWMHNRVRMIVASFLTKHLLLPWQQGEQWFWDTLVDADPAANPASWQWTAGSGADAAPYF
RVFNPISQGQKFDEDGAYVRHWCPELAGLPDKYLHAPFEADAQTLKRARVMLGTDYPEPIIDHPVGRQRALDAYKAMKEE
QTAE

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=498, Percent_Identity=29.3172690763052, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI4758072, Length=492, Percent_Identity=28.4552845528455, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI188536103, Length=450, Percent_Identity=28, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1786926, Length=481, Percent_Identity=35.966735966736, Blast_Score=285, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6324962, Length=515, Percent_Identity=28.5436893203883, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17137248, Length=518, Percent_Identity=26.8339768339768, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24585455, Length=518, Percent_Identity=26.8339768339768, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24648152, Length=513, Percent_Identity=25.3411306042885, Blast_Score=161, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR019947
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54058; Mature: 53927

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSASPAILWFREDLRLTDNPALNAAVNSGRPLICVYLRETGAGAPREMGGASRWWLNKS
CCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCCCHHCCCCHHHHHHHH
LASLGASLEAIGGKLTLRTGPAEKIIPALVEETGAAAVFWNRRYGLPERETDAAIKKTLK
HHHHCCCHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHH
DNGVECQSFNGRLLMEPWDLKTGSGGWYKVFTPFWRALQAQYKPPAFIPSPKKIAGASAE
HCCCEEECCCCEEEECCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCC
TENLKDWGLHPEKPDWSGGIAAAWEPGEVGAQKRLDAFLDGPVSDYVGTRNLPGVSTGTS
CCCHHHCCCCCCCCCCCCCEEEECCCHHCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCHH
RLSPHLRFGEIGPAQIWRAVRARLEAQQADEDSARVFLSEIAWREFSYTLLYYNPALATE
HCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEECCEECCC
NYNSNFNQMAWRKDDSGFAAWSRGQTGYPIVDAGMRELWHTGWMHNRVRMIVASFLTKHL
CCCCCCHHHCEECCCCCCEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LLPWQQGEQWFWDTLVDADPAANPASWQWTAGSGADAAPYFRVFNPISQGQKFDEDGAYV
CCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHCHHHCCCCCCCCCCHH
RHWCPELAGLPDKYLHAPFEADAQTLKRARVMLGTDYPEPIIDHPVGRQRALDAYKAMKE
HHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHH
EQTAE
HHCCC
>Mature Secondary Structure 
SSASPAILWFREDLRLTDNPALNAAVNSGRPLICVYLRETGAGAPREMGGASRWWLNKS
CCCCCEEEEEECCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCCCHHCCCCHHHHHHHH
LASLGASLEAIGGKLTLRTGPAEKIIPALVEETGAAAVFWNRRYGLPERETDAAIKKTLK
HHHHCCCHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHH
DNGVECQSFNGRLLMEPWDLKTGSGGWYKVFTPFWRALQAQYKPPAFIPSPKKIAGASAE
HCCCEEECCCCEEEECCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCC
TENLKDWGLHPEKPDWSGGIAAAWEPGEVGAQKRLDAFLDGPVSDYVGTRNLPGVSTGTS
CCCHHHCCCCCCCCCCCCCEEEECCCHHCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCHH
RLSPHLRFGEIGPAQIWRAVRARLEAQQADEDSARVFLSEIAWREFSYTLLYYNPALATE
HCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEECCEECCC
NYNSNFNQMAWRKDDSGFAAWSRGQTGYPIVDAGMRELWHTGWMHNRVRMIVASFLTKHL
CCCCCCHHHCEECCCCCCEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LLPWQQGEQWFWDTLVDADPAANPASWQWTAGSGADAAPYFRVFNPISQGQKFDEDGAYV
CCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHCHHHCCCCCCCCCCHH
RHWCPELAGLPDKYLHAPFEADAQTLKRARVMLGTDYPEPIIDHPVGRQRALDAYKAMKE
HHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHH
EQTAE
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2837735; 2110564; 9360600 [H]