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The map label for this gene is ctrA [H]

Identifier: 114797249

GI number: 114797249

Start: 959302

End: 960015

Strand: Direct

Name: ctrA [H]

Synonym: HNE_0944

Alternate gene names: 114797249

Gene position: 959302-960015 (Clockwise)

Preceding gene: 114799550

Following gene: 114800145

Centisome position: 25.89

GC content: 58.4

Gene sequence:

>714_bases
ATGCGCGTCCTGCTAATTGAAGATGACCGGGCGCTGGCCCGCTCAATCGAGCTGATGCTCAAAGCCGCTGGCTTCAACGT
CTACCTCACCGACCTCGGTGAAGACGGCGTTGATATCGGCAAAGTCTACGAGTTCGACATGATCCTCCTGGATCTGTCGC
TGCCGGACATCACCGGTTTTGAGGTGCTCAAACAGCTCCGCATGAGCCGTGTGAACACGCCTGTCATGATCCTCTCGGGC
AATCCGGACATCGAAGCGAAGGTGAAAACCCTTGGCTACGGCGCTGACGATTACCTCACCAAGCCGTTCAACAAGGACGA
GCTGATCGCCCGGATCACCGCCATTGTGCGCCGCTCCAAAGGCCATGCCGAGAGCGTGATCCGCACCGGCGACATCCTGG
TGAACCTGGACGCAAAAACCGTCGAAGTCGACGGCGAGCGTGTCCACCTCACCGGCAAGGAATACGCCATGTTCGAGCTG
CTTTCCCTGCGCAAGGGCACGACGCTCACCAAGGAAATGTTCCTCAACCACCTCTATGGTGGCCTCGACGAACCCGAGCT
GAAGATCATCGACGTCTTCATCTGTAAGCTGCGCAAAAAACTGCAGCAGGCCACGGGCGGCAATCACTATATCGAAACCG
TCTGGGGACGGGGCTATGTGCTGCGCGATCCGCGCCCATCCCAGAAATCCAGCGAGATCGAAGAAGCCGCCTGA

Upstream 100 bases:

>100_bases
TTCCAACGCTTTTTTAATACCTGTTAATAAAGGTGCGTTAGGATTCACAATGTTAACCAAAGCCGCTACGACTAACTTAA
GATGATTCGGGAGACGAGCG

Downstream 100 bases:

>100_bases
ATTATCTGAGAGTGAGCTTTCTGAGACCCGTCAAAAATTTACGCCCGGAGAGCCAGACTCTCCGGGCGTTTTTCATTGCG
GATTTGAAGCGCGCCTATTT

Product: DNA-binding response regulator CtrA

Products: NA

Alternate protein names: Response regulator SokA [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MRVLLIEDDRALARSIELMLKAAGFNVYLTDLGEDGVDIGKVYEFDMILLDLSLPDITGFEVLKQLRMSRVNTPVMILSG
NPDIEAKVKTLGYGADDYLTKPFNKDELIARITAIVRRSKGHAESVIRTGDILVNLDAKTVEVDGERVHLTGKEYAMFEL
LSLRKGTTLTKEMFLNHLYGGLDEPELKIIDVFICKLRKKLQQATGGNHYIETVWGRGYVLRDPRPSQKSSEIEEAA

Sequences:

>Translated_237_residues
MRVLLIEDDRALARSIELMLKAAGFNVYLTDLGEDGVDIGKVYEFDMILLDLSLPDITGFEVLKQLRMSRVNTPVMILSG
NPDIEAKVKTLGYGADDYLTKPFNKDELIARITAIVRRSKGHAESVIRTGDILVNLDAKTVEVDGERVHLTGKEYAMFEL
LSLRKGTTLTKEMFLNHLYGGLDEPELKIIDVFICKLRKKLQQATGGNHYIETVWGRGYVLRDPRPSQKSSEIEEAA
>Mature_237_residues
MRVLLIEDDRALARSIELMLKAAGFNVYLTDLGEDGVDIGKVYEFDMILLDLSLPDITGFEVLKQLRMSRVNTPVMILSG
NPDIEAKVKTLGYGADDYLTKPFNKDELIARITAIVRRSKGHAESVIRTGDILVNLDAKTVEVDGERVHLTGKEYAMFEL
LSLRKGTTLTKEMFLNHLYGGLDEPELKIIDVFICKLRKKLQQATGGNHYIETVWGRGYVLRDPRPSQKSSEIEEAA

Specific function: Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=34.375, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=34.3891402714932, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=32.8888888888889, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=33.4821428571429, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=31.5068493150685, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=32.0175438596491, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=29.9559471365639, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=30, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=31.0810810810811, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=29.7297297297297, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=28.6363636363636, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.0748898678414, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=25.6637168141593, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790437, Length=160, Percent_Identity=28.125, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=28.9719626168224, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790299, Length=144, Percent_Identity=28.4722222222222, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26630; Mature: 26630

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLIEDDRALARSIELMLKAAGFNVYLTDLGEDGVDIGKVYEFDMILLDLSLPDITGF
CEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCHH
EVLKQLRMSRVNTPVMILSGNPDIEAKVKTLGYGADDYLTKPFNKDELIARITAIVRRSK
HHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHCC
GHAESVIRTGDILVNLDAKTVEVDGERVHLTGKEYAMFELLSLRKGTTLTKEMFLNHLYG
CCHHHHEEECCEEEEECCEEEEECCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHC
GLDEPELKIIDVFICKLRKKLQQATGGNHYIETVWGRGYVLRDPRPSQKSSEIEEAA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCCCHHHHCC
>Mature Secondary Structure
MRVLLIEDDRALARSIELMLKAAGFNVYLTDLGEDGVDIGKVYEFDMILLDLSLPDITGF
CEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCHH
EVLKQLRMSRVNTPVMILSGNPDIEAKVKTLGYGADDYLTKPFNKDELIARITAIVRRSK
HHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHCC
GHAESVIRTGDILVNLDAKTVEVDGERVHLTGKEYAMFELLSLRKGTTLTKEMFLNHLYG
CCHHHHEEECCEEEEECCEEEEECCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHC
GLDEPELKIIDVFICKLRKKLQQATGGNHYIETVWGRGYVLRDPRPSQKSSEIEEAA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8548829 [H]