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The map label for this gene is hisD [H]

Identifier: 114797246

GI number: 114797246

Start: 1380402

End: 1381700

Strand: Direct

Name: hisD [H]

Synonym: HNE_1346

Alternate gene names: 114797246

Gene position: 1380402-1381700 (Clockwise)

Preceding gene: 114797987

Following gene: 114800489

Centisome position: 37.26

GC content: 68.44

Gene sequence:

>1299_bases
ATGGCCCGTCATCTCGATGCATCTCAGCCCGGTTTCGAGGAGGCATTGCGCCATTTCCTCGATGAAGACCGCGGGCAGGG
CGAGGATGTCGCGGGGATCGTCTCGGCCATCATCGCCGATGTGCGCCAGCGCGGCGGGGCAGCCGTGGCCGACTACACCG
CGAAATTCGACCGGCTGCAGCTCGACCCCTCAACGCTCCAGTCAGACAATGTCGACCTCGACCTGATCGCCGCGCAATGC
CCGCAGGACCTGCGCGACGCCATCGACTTCGCGCACGACCGCATCGCCGCCTATCACAGCGCGCAGCGCCCGGCAGACCA
CCGCTTCACCGATGATGCGGGCGTCGAGCTTGGCTGGCGCTGGACGGCGCTGGATTCGGTCGGCGTGTATGTGCCCGGCG
GGCGGGCGAGCTACCCGTCTTCGGTGCTGATGAACATCGTGCCTGCGCGCATTGCGGGGGTTGAGCGCATCGTCATGGTC
GCCCCGGCGCCCGATGGCGAGCTCGCCCCGGCCGTCGCCTATGCGGCACGCAAAGCGGGCGCGACCGAGTTTTTCCCCAT
CGGCGGGGCGCAGGCGGTGGCCGCGCTGGCCTATGGCGCCGGGCCGGTTGTAGCTGTGGACAAGATCGTCGGGCCGGGCA
ACGCCTTCGTGGCCGAGGCCAAGCGCCAGGTATTCGGCCGCGTCGGCATCGACACCATCGCGGGCCCGTCCGAAATCCTC
GTAATCGCCGACAATACCGCCAATCCGGACTGGGTGGCCGCCGACCTGCTGAGCCAGGCCGAGCATGACCCCTCCAGCCA
GTCGATCCTCATCACGCTGGACGCCGCTCTTGGCAAAGCTGTTGAGAAGGCTGTGGATAACCAGTTGAATTCCCTCGCCA
CCGGCGCCCGCGCCCGCGAATCCTGGACCGCCCATGGCGCCATCATCACCGCGCCGGATCTGGCGACCGCCGCCCGCGCG
GCCAACATCATCGCGGCCGAACATGTCGAGCTCTGCATCGCAGATCCCGATGGCATGCTGCCGATGATCAAGCATGCCGG
CGCCGTGTTCCTGGGCCACCACACGCCTGAGGCGCTGGGCGACTATGTGACGGGCTCCAACCACGTCCTGCCGACCAGCC
GCGCCGCGCGCTTTTCCTCCGGCCTCGGACTGTATGATTTCCTCAAGCGGATGAGCATCCAGCGCGCCGGCCCCAAAGGC
CTCGCCGCGCTGGCGCCCGCCGCCCTGCGCCTGGCGGAGGCCGAACGCCTCCCGGCGCATGGCCGGTCCGTCTCCATACG
AACAAATCAGGGCGGCTGA

Upstream 100 bases:

>100_bases
TAGGGCTACGCTGCCCCAAAACACCCAGCCGCCGTCTTGCCAGCACTGGCCGCACGGTCCATGTAGCGGGGCTGGAAATA
CCCCGTTGGAAAGCGCCCGC

Downstream 100 bases:

>100_bases
TCCCATGGGCGCCAACCGGCTCGTCGCCGTACACATCGACGAGGAAACGCTCGGTGCCTCCGGACCGGACGCCGAGCATG
AGCGCCGCGTCGCCATCTTC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MARHLDASQPGFEEALRHFLDEDRGQGEDVAGIVSAIIADVRQRGGAAVADYTAKFDRLQLDPSTLQSDNVDLDLIAAQC
PQDLRDAIDFAHDRIAAYHSAQRPADHRFTDDAGVELGWRWTALDSVGVYVPGGRASYPSSVLMNIVPARIAGVERIVMV
APAPDGELAPAVAYAARKAGATEFFPIGGAQAVAALAYGAGPVVAVDKIVGPGNAFVAEAKRQVFGRVGIDTIAGPSEIL
VIADNTANPDWVAADLLSQAEHDPSSQSILITLDAALGKAVEKAVDNQLNSLATGARARESWTAHGAIITAPDLATAARA
ANIIAAEHVELCIADPDGMLPMIKHAGAVFLGHHTPEALGDYVTGSNHVLPTSRAARFSSGLGLYDFLKRMSIQRAGPKG
LAALAPAALRLAEAERLPAHGRSVSIRTNQGG

Sequences:

>Translated_432_residues
MARHLDASQPGFEEALRHFLDEDRGQGEDVAGIVSAIIADVRQRGGAAVADYTAKFDRLQLDPSTLQSDNVDLDLIAAQC
PQDLRDAIDFAHDRIAAYHSAQRPADHRFTDDAGVELGWRWTALDSVGVYVPGGRASYPSSVLMNIVPARIAGVERIVMV
APAPDGELAPAVAYAARKAGATEFFPIGGAQAVAALAYGAGPVVAVDKIVGPGNAFVAEAKRQVFGRVGIDTIAGPSEIL
VIADNTANPDWVAADLLSQAEHDPSSQSILITLDAALGKAVEKAVDNQLNSLATGARARESWTAHGAIITAPDLATAARA
ANIIAAEHVELCIADPDGMLPMIKHAGAVFLGHHTPEALGDYVTGSNHVLPTSRAARFSSGLGLYDFLKRMSIQRAGPKG
LAALAPAALRLAEAERLPAHGRSVSIRTNQGG
>Mature_431_residues
ARHLDASQPGFEEALRHFLDEDRGQGEDVAGIVSAIIADVRQRGGAAVADYTAKFDRLQLDPSTLQSDNVDLDLIAAQCP
QDLRDAIDFAHDRIAAYHSAQRPADHRFTDDAGVELGWRWTALDSVGVYVPGGRASYPSSVLMNIVPARIAGVERIVMVA
PAPDGELAPAVAYAARKAGATEFFPIGGAQAVAALAYGAGPVVAVDKIVGPGNAFVAEAKRQVFGRVGIDTIAGPSEILV
IADNTANPDWVAADLLSQAEHDPSSQSILITLDAALGKAVEKAVDNQLNSLATGARARESWTAHGAIITAPDLATAARAA
NIIAAEHVELCIADPDGMLPMIKHAGAVFLGHHTPEALGDYVTGSNHVLPTSRAARFSSGLGLYDFLKRMSIQRAGPKGL
AALAPAALRLAEAERLPAHGRSVSIRTNQGG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=409, Percent_Identity=42.5427872860636, Blast_Score=288, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=442, Percent_Identity=36.6515837104072, Blast_Score=253, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45203; Mature: 45072

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARHLDASQPGFEEALRHFLDEDRGQGEDVAGIVSAIIADVRQRGGAAVADYTAKFDRLQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHEE
LDPSTLQSDNVDLDLIAAQCPQDLRDAIDFAHDRIAAYHSAQRPADHRFTDDAGVELGWR
CCHHHCCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECEE
WTALDSVGVYVPGGRASYPSSVLMNIVPARIAGVERIVMVAPAPDGELAPAVAYAARKAG
EEEECCCCEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCC
ATEFFPIGGAQAVAALAYGAGPVVAVDKIVGPGNAFVAEAKRQVFGRVGIDTIAGPSEIL
CCEEEECCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHHCCCCCEEE
VIADNTANPDWVAADLLSQAEHDPSSQSILITLDAALGKAVEKAVDNQLNSLATGARARE
EEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHH
SWTAHGAIITAPDLATAARAANIIAAEHVELCIADPDGMLPMIKHAGAVFLGHHTPEALG
CCCCCCEEEECCCHHHHHHHHHHHEECCEEEEEECCCCCHHHHHHCCEEEEECCCHHHHH
DYVTGSNHVLPTSRAARFSSGLGLYDFLKRMSIQRAGPKGLAALAPAALRLAEAERLPAH
HHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
GRSVSIRTNQGG
CCEEEEEECCCC
>Mature Secondary Structure 
ARHLDASQPGFEEALRHFLDEDRGQGEDVAGIVSAIIADVRQRGGAAVADYTAKFDRLQ
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHEE
LDPSTLQSDNVDLDLIAAQCPQDLRDAIDFAHDRIAAYHSAQRPADHRFTDDAGVELGWR
CCHHHCCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECEE
WTALDSVGVYVPGGRASYPSSVLMNIVPARIAGVERIVMVAPAPDGELAPAVAYAARKAG
EEEECCCCEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCC
ATEFFPIGGAQAVAALAYGAGPVVAVDKIVGPGNAFVAEAKRQVFGRVGIDTIAGPSEIL
CCEEEECCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHHCCCCCEEE
VIADNTANPDWVAADLLSQAEHDPSSQSILITLDAALGKAVEKAVDNQLNSLATGARARE
EEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHH
SWTAHGAIITAPDLATAARAANIIAAEHVELCIADPDGMLPMIKHAGAVFLGHHTPEALG
CCCCCCEEEECCCHHHHHHHHHHHEECCEEEEEECCCCCHHHHHHCCEEEEECCCHHHHH
DYVTGSNHVLPTSRAARFSSGLGLYDFLKRMSIQRAGPKGLAALAPAALRLAEAERLPAH
HHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
GRSVSIRTNQGG
CCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA