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The map label for this gene is moeB [H]

Identifier: 114797177

GI number: 114797177

Start: 3571083

End: 3571823

Strand: Direct

Name: moeB [H]

Synonym: HNE_3431

Alternate gene names: 114797177

Gene position: 3571083-3571823 (Clockwise)

Preceding gene: 114798022

Following gene: 114800369

Centisome position: 96.38

GC content: 63.97

Gene sequence:

>741_bases
ATGAGCCTTTCACCTGAAGATCTCGACCGCCACCGCCGCCACATCCTGCTGAAGGAAATCGGCGGGCCGGGCGTTGCAAA
ACTGCGGGCGGCGTCGGTTTCCATCATCGGCGCCGGCGCCCTGGGCGGCCCCGCCGCGCTTTACCTTGCCGCAGCCGGCG
TGGGCGAATTGGAGCTCTGGGATGACGACCGGGTCGAACGCTCAAACCTGCAGCGGCAGATACAGTTTACAGAAGCCGAC
ACCGGCGCGGAAAAAGGTGCCCGTCTTGCGGCGCGGATCACGGCGCTTGATCCTTCGATCAAGGTCGCCATCAGGCACGC
GCGATTTGACGAAAGCGCCGCGCCTTCCGGAAACATCCTGATTGACGCGACCGATAATTTCGAAACCCGCTTCGCGCTCA
ACGCCTTCGCACACGCACACGCGCGCTATCTCGTCTCCGGCGCGGCGAGCGGTTGGAGTGGACAGGTCAGCGTGTTTGCT
TCCGGCCTCGTGCCCGAAGCGCCTTGCTATCGCTGCTGGATTTCAGAGATGCCACCTGCGGCCGAAGCGTGTGATGAAGT
GGGCGTCGTCGGCGCGCTGACCGGCATGACCGGCTCGGCGATGGCGCTGGAAGCGGTGAAACTGATCACCGGCGCGGGCG
ATCCGCTGATCGGGCGCATCCTCCTCATCGACGGGTTGAGAAACGAGATGCGCACCGTGCGTTTGCGCCGGGATTCTCAG
TGTCCTGTCTGTTCCATCTGA

Upstream 100 bases:

>100_bases
AGCCGCAGGCCGCGGCTCTGGCTTACACGCAGGCCCCGGCCTGGGTTTATATCCGTACACGGGAAAACCCCACCTCCTCA
ACGGCGCTACGGGCAACCCC

Downstream 100 bases:

>100_bases
ACAGAAGGTTTGACATGCGCGCCAGCGCGCGCGTTATTCGCGAAGCAGTTTTGTTGATCGGATTCTTCGCCTCAGATGTT
GTCCCGCTTTCTCGCTGTTA

Product: putative molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSLSPEDLDRHRRHILLKEIGGPGVAKLRAASVSIIGAGALGGPAALYLAAAGVGELELWDDDRVERSNLQRQIQFTEAD
TGAEKGARLAARITALDPSIKVAIRHARFDESAAPSGNILIDATDNFETRFALNAFAHAHARYLVSGAASGWSGQVSVFA
SGLVPEAPCYRCWISEMPPAAEACDEVGVVGALTGMTGSAMALEAVKLITGAGDPLIGRILLIDGLRNEMRTVRLRRDSQ
CPVCSI

Sequences:

>Translated_246_residues
MSLSPEDLDRHRRHILLKEIGGPGVAKLRAASVSIIGAGALGGPAALYLAAAGVGELELWDDDRVERSNLQRQIQFTEAD
TGAEKGARLAARITALDPSIKVAIRHARFDESAAPSGNILIDATDNFETRFALNAFAHAHARYLVSGAASGWSGQVSVFA
SGLVPEAPCYRCWISEMPPAAEACDEVGVVGALTGMTGSAMALEAVKLITGAGDPLIGRILLIDGLRNEMRTVRLRRDSQ
CPVCSI
>Mature_245_residues
SLSPEDLDRHRRHILLKEIGGPGVAKLRAASVSIIGAGALGGPAALYLAAAGVGELELWDDDRVERSNLQRQIQFTEADT
GAEKGARLAARITALDPSIKVAIRHARFDESAAPSGNILIDATDNFETRFALNAFAHAHARYLVSGAASGWSGQVSVFAS
GLVPEAPCYRCWISEMPPAAEACDEVGVVGALTGMTGSAMALEAVKLITGAGDPLIGRILLIDGLRNEMRTVRLRRDSQC
PVCSI

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=239, Percent_Identity=35.9832635983264, Blast_Score=114, Evalue=6e-26,
Organism=Escherichia coli, GI1787048, Length=246, Percent_Identity=36.5853658536585, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI87082356, Length=248, Percent_Identity=41.1290322580645, Blast_Score=147, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17540406, Length=249, Percent_Identity=36.9477911646586, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI193203301, Length=151, Percent_Identity=27.8145695364238, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=253, Percent_Identity=34.7826086956522, Blast_Score=138, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24582879, Length=253, Percent_Identity=39.5256916996047, Blast_Score=160, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 25986; Mature: 25855

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSPEDLDRHRRHILLKEIGGPGVAKLRAASVSIIGAGALGGPAALYLAAAGVGELELW
CCCCHHHHHHHHHHHHHHHCCCCCHHHEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEC
DDDRVERSNLQRQIQFTEADTGAEKGARLAARITALDPSIKVAIRHARFDESAAPSGNIL
CCCCHHHHHHHHEEEEECCCCCHHHCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCEE
IDATDNFETRFALNAFAHAHARYLVSGAASGWSGQVSVFASGLVPEAPCYRCWISEMPPA
EEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCH
AEACDEVGVVGALTGMTGSAMALEAVKLITGAGDPLIGRILLIDGLRNEMRTVRLRRDSQ
HHHHHHCCHHEEECCCCCCHHHHHHHHHHHCCCCHHHHHEEEEHHHHHHHHHHHCCCCCC
CPVCSI
CCCCCC
>Mature Secondary Structure 
SLSPEDLDRHRRHILLKEIGGPGVAKLRAASVSIIGAGALGGPAALYLAAAGVGELELW
CCCHHHHHHHHHHHHHHHCCCCCHHHEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEC
DDDRVERSNLQRQIQFTEADTGAEKGARLAARITALDPSIKVAIRHARFDESAAPSGNIL
CCCCHHHHHHHHEEEEECCCCCHHHCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCEE
IDATDNFETRFALNAFAHAHARYLVSGAASGWSGQVSVFASGLVPEAPCYRCWISEMPPA
EEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCH
AEACDEVGVVGALTGMTGSAMALEAVKLITGAGDPLIGRILLIDGLRNEMRTVRLRRDSQ
HHHHHHCCHHEEECCCCCCHHHHHHHHHHHCCCCHHHHHEEEEHHHHHHHHHHHCCCCCC
CPVCSI
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA