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The map label for this gene is lldD [H]

Identifier: 114797165

GI number: 114797165

Start: 1208622

End: 1209788

Strand: Reverse

Name: lldD [H]

Synonym: HNE_1192

Alternate gene names: 114797165

Gene position: 1209788-1208622 (Counterclockwise)

Preceding gene: 114799683

Following gene: 114799756

Centisome position: 32.65

GC content: 63.75

Gene sequence:

>1167_bases
ATGCCAACCCTGACCCTTGCTCCCGCCTGCGCCTCTGACTACCGCCTGAGGGCCGAGAAGCGCCTCCCGCGCTTCCTCTT
CGACTATCTGGACGGCGGCGCTTACGCCGAACTGACGCTCAGACGGAATGTGGCGGACCTTGAAGCGATTGAACTTCGCC
AACGCATTCTGCGCGATGTTTCGGCGCTGACCACCGAAAAATCCTTTCTTGGCAACACGTTGACCATGCCGCTGGCCCTG
TCACCCGTCGGTCTGTCCGGAATGATGGCACGCCGCGGCGAGGCGAGTGCCGCAAAGGTGGCGGGCGAGTTCGGCATTCC
TTATTGTCTTTCCACGCTGTCGATCTGCTCGGTCGAGGAGGTTGCTGCCGCAACCCAGGGGCCGCTCTGGTTTCAGCTCT
ACATGATCCGGGATCGCGGTTCGGTGGCCGATCTGATCGCGCGCGCGAAGGCCGCTGGCGCCTCGGCGCTGGTTCTGACC
GTTGACCTCCCGGTGGTCGGCACCCGGTACAGGGATGTGCGCAATACCATGAGCGGCGGCGGCGGCGCCTGGGCCAGGCT
GCGCCGCGGCCTTCTCTCCTACATGATGCATCCCGGATGGAGTATGGATGTCGGCCTGCGTGGCGGGCCGCATATTCTCG
CCAATGTCGCGCCTTATGTGCCAGATGCTGCCACCCCGGCAGATTTCTCCGCATGGGCCAATGCCTCGCTCGACCCCTCC
GTCAGCTGGAAAGATATTGAATGGATCAAGGCCCAATGGGGCGGGCCGCTCATCATCAAGGGAATTCTGGACCGCGAGGA
CGCGCTTGAAGCGGTCAACTGCGGCGCTGATGGCATCGTGGTGTCCAACCATGGTGGCCGCCAGCTTGACGGCGTTGCTT
CGTCCATCCGGGCGCTGCCCCCGATTGCCGAGGCTGTTTCCGGGAAAACCCTGATCCTCATGGATGGCGGCATTCGTTCC
GGGCAGGACATCCTCAAGGCGCTTTCCAGCGGCGCCGACCTTGCCATGATGGGCCGCCCATGGGTTTACGCGCTCGCAGG
CGGCGGCGAAAAAGGCCTCGCCCACCTTCTGGCGGCCATGAAAGGCGAGTTGACCGTTTCCATGGCGTTGACCGGAATCA
CCCAAGTGACGGAAGCGGCGCCCGGTCTGCTATCGCCCACGGATTGA

Upstream 100 bases:

>100_bases
GTAATTTTAGAAATATGAGTCAGAACGCTCAGAAAATGCGAGCAATTTTGATTCAGAATAGCTTTGCCAAGCCCTGCCCT
GCTCCCTTACAACGGCGCGC

Downstream 100 bases:

>100_bases
ACGCGGCGCCTCAAGCCCTTGCCGGCTTGAGCAATGGCTCACTTGGCCGGGGGTAGAGTGGCAAGGAACTCTGCCAAGCG
GGCACGATACGCGTCCCCGG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MPTLTLAPACASDYRLRAEKRLPRFLFDYLDGGAYAELTLRRNVADLEAIELRQRILRDVSALTTEKSFLGNTLTMPLAL
SPVGLSGMMARRGEASAAKVAGEFGIPYCLSTLSICSVEEVAAATQGPLWFQLYMIRDRGSVADLIARAKAAGASALVLT
VDLPVVGTRYRDVRNTMSGGGGAWARLRRGLLSYMMHPGWSMDVGLRGGPHILANVAPYVPDAATPADFSAWANASLDPS
VSWKDIEWIKAQWGGPLIIKGILDREDALEAVNCGADGIVVSNHGGRQLDGVASSIRALPPIAEAVSGKTLILMDGGIRS
GQDILKALSSGADLAMMGRPWVYALAGGGEKGLAHLLAAMKGELTVSMALTGITQVTEAAPGLLSPTD

Sequences:

>Translated_388_residues
MPTLTLAPACASDYRLRAEKRLPRFLFDYLDGGAYAELTLRRNVADLEAIELRQRILRDVSALTTEKSFLGNTLTMPLAL
SPVGLSGMMARRGEASAAKVAGEFGIPYCLSTLSICSVEEVAAATQGPLWFQLYMIRDRGSVADLIARAKAAGASALVLT
VDLPVVGTRYRDVRNTMSGGGGAWARLRRGLLSYMMHPGWSMDVGLRGGPHILANVAPYVPDAATPADFSAWANASLDPS
VSWKDIEWIKAQWGGPLIIKGILDREDALEAVNCGADGIVVSNHGGRQLDGVASSIRALPPIAEAVSGKTLILMDGGIRS
GQDILKALSSGADLAMMGRPWVYALAGGGEKGLAHLLAAMKGELTVSMALTGITQVTEAAPGLLSPTD
>Mature_387_residues
PTLTLAPACASDYRLRAEKRLPRFLFDYLDGGAYAELTLRRNVADLEAIELRQRILRDVSALTTEKSFLGNTLTMPLALS
PVGLSGMMARRGEASAAKVAGEFGIPYCLSTLSICSVEEVAAATQGPLWFQLYMIRDRGSVADLIARAKAAGASALVLTV
DLPVVGTRYRDVRNTMSGGGGAWARLRRGLLSYMMHPGWSMDVGLRGGPHILANVAPYVPDAATPADFSAWANASLDPSV
SWKDIEWIKAQWGGPLIIKGILDREDALEAVNCGADGIVVSNHGGRQLDGVASSIRALPPIAEAVSGKTLILMDGGIRSG
QDILKALSSGADLAMMGRPWVYALAGGGEKGLAHLLAAMKGELTVSMALTGITQVTEAAPGLLSPTD

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=382, Percent_Identity=37.434554973822, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI7705393, Length=382, Percent_Identity=37.434554973822, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI11068137, Length=370, Percent_Identity=36.2162162162162, Blast_Score=231, Evalue=1e-60,
Organism=Escherichia coli, GI1790033, Length=370, Percent_Identity=54.0540540540541, Blast_Score=403, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI193208036, Length=371, Percent_Identity=33.4231805929919, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=289, Percent_Identity=32.5259515570934, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323587, Length=383, Percent_Identity=31.0704960835509, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI78707188, Length=369, Percent_Identity=36.5853658536585, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI281363140, Length=369, Percent_Identity=36.5853658536585, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI78707190, Length=369, Percent_Identity=36.5853658536585, Blast_Score=218, Evalue=6e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 40945; Mature: 40814

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLTLAPACASDYRLRAEKRLPRFLFDYLDGGAYAELTLRRNVADLEAIELRQRILRDV
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
SALTTEKSFLGNTLTMPLALSPVGLSGMMARRGEASAAKVAGEFGIPYCLSTLSICSVEE
HHHHHHHHHHCCCEECCEEECCCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCHHH
VAAATQGPLWFQLYMIRDRGSVADLIARAKAAGASALVLTVDLPVVGTRYRDVRNTMSGG
HHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHCCCC
GGAWARLRRGLLSYMMHPGWSMDVGLRGGPHILANVAPYVPDAATPADFSAWANASLDPS
CHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHCCCCCCCC
VSWKDIEWIKAQWGGPLIIKGILDREDALEAVNCGADGIVVSNHGGRQLDGVASSIRALP
CCCCHHHHHHHCCCCCEEEEEHHCHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCC
PIAEAVSGKTLILMDGGIRSGQDILKALSSGADLAMMGRPWVYALAGGGEKGLAHLLAAM
CHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCEEEEEECCCHHHHHHHHHHH
KGELTVSMALTGITQVTEAAPGLLSPTD
CCCEEEEHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PTLTLAPACASDYRLRAEKRLPRFLFDYLDGGAYAELTLRRNVADLEAIELRQRILRDV
CCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
SALTTEKSFLGNTLTMPLALSPVGLSGMMARRGEASAAKVAGEFGIPYCLSTLSICSVEE
HHHHHHHHHHCCCEECCEEECCCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCHHH
VAAATQGPLWFQLYMIRDRGSVADLIARAKAAGASALVLTVDLPVVGTRYRDVRNTMSGG
HHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHCCCC
GGAWARLRRGLLSYMMHPGWSMDVGLRGGPHILANVAPYVPDAATPADFSAWANASLDPS
CHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHCCCCCCCC
VSWKDIEWIKAQWGGPLIIKGILDREDALEAVNCGADGIVVSNHGGRQLDGVASSIRALP
CCCCHHHHHHHCCCCCEEEEEHHCHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCC
PIAEAVSGKTLILMDGGIRSGQDILKALSSGADLAMMGRPWVYALAGGGEKGLAHLLAAM
CHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCEEEEEECCCHHHHHHHHHHH
KGELTVSMALTGITQVTEAAPGLLSPTD
CCCEEEEHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA