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The map label for this gene is betA [H]

Identifier: 114797128

GI number: 114797128

Start: 2826826

End: 2828463

Strand: Reverse

Name: betA [H]

Synonym: HNE_2666

Alternate gene names: 114797128

Gene position: 2828463-2826826 (Counterclockwise)

Preceding gene: 114798682

Following gene: 114799282

Centisome position: 76.34

GC content: 61.78

Gene sequence:

>1638_bases
ATGGAAGCCTATGATTATGTGATTGTCGGCGCGGGCAGCGCTGGATGTGTTCTGGCCAACCGGCTTTCGGCCGATCCTTC
GGTCAAGGTCTGCCTGATCGAGGCGGGTAAGAAAGACACCTCCCTTATGGTAAAGATGCCTGCGGGCGTCGGCGGCCTGA
TCAAACAGGCAAACGATCACAATTGGGGCTTCTTCACCGAGCCCCAGCAGCATATGGAAAACCGGCGCCTCTACTGGCCG
CGCGGCAAGGGCTGGGGCGGCTCCTCCTCCATCAACGGCATGGTGTATATTCGCGGCCATGCGGGCGACTATGACCAGTG
GGGCCAGATGGGCCTCAAGGGCTGGAGCTTTGCCGACGTGCTGCCGTATTTCCGCAAGTCGGAAAACTATGAGGGCGGGG
CGAACGAGTTTCACGGCGCGCAGGGCCCGCTGAATGTGACCGAGAGCCCGCTTTCCGGGCCGGTCTATCAGGCGTTCATC
AATGCCGGCAAGGAAGCAGGTTATCCGGTCACGGATGATTTCAATGGGGCAGAGCAGGAAGGCTTTGGCCGCTATCAGCG
CACGATCTTCAAGGGCGGACGCTGGAGCGCCTCTTTTGCCTATCTGCGCCCCATCGAAACCCAGCGCCCCAATCTCAAGA
TCGTCTCGACGGGCGTGGTAACCCGTGTGCTGATCGAAAAGGGTAAGGCGGTTGGCGTTGAAGTGGTGGAAGGCAAAGGC
CGCATTGCCCGCCAGATCCGCGCAGACCGTGAGGTGATCCTTTCGGCGGGCGCCGTACAGTCGCCGCAGATCCTGCAGCT
TTCGGGCGTGGGTGATCCAGAAGAACTGAAGCGCCACGGCATCGAGACGAAGGTGAAGTCCACCGGCGTGGGCCGCAATC
TTCAGGACCATCTGGACGTGACGGTGATCCATGACATGCCGTTGCCGCTGTCGGCCTATTCGTTGCAGAAGGGCCTGAAG
AAGCTCGCCGTGGGCATGCAGTATCTTTATAACCAGACCGGCGCGGGCGCGGACAACTTCCTTCAGGCAGGCGCGTTCCT
GTCGTCGCGCAGCGGGCTGTCGATGCCGGACATCCAGCTTCACCTCGTCAATGCGATCATGATGGATCACGGCAATACCG
GCCCGGAGAAAGATGGGTATACGGTACATGCCTGCCAGCTGCGTCCGGAGAGCCGGGGCACCGTCATGCTGGCGTCAGCT
GATCCGTTTGCCCATCCGGCGATTGATCCGAACTATCTGGCCACGGAAGAAGACCGCCGCGTGATGCGCGAGTCCGTGAA
GATGGTGCGCGATGTGTGCCGCCAGAACGCGCTGAAAGCCTATACGGGCGGCGAAATTCTGCCGGGCGCCTCGGTGAAGA
CCGATGCGGAGATCGATGCGTTCATCCGTGAGAAGGGCGAGACGATCTATCACCCGGTCGGCAGCGTTTCGATGGGGCCG
AATGAAACCAGCCCGCTGGACGGCGAACTGCGCGTGCGCGGCGTGGACGGCCTGCGGGTGGTGGACGCCTCTGTGATGCC
AACGCTGATTGGTGGCAACACCAATGCGCCGACGATCATGGTGGCAGAGAAAGCCGCTGACATGATCCTGGGCCGGGCGG
CAATGGCACGGGAAGAGGTTGCGCTGGCGCGGGCGTGA

Upstream 100 bases:

>100_bases
TCATGAATGTTGACAATTGGTTGCTCAAGCCCGTGAACCAGTTAGCAATGACCTGGTTAAAAGCCGGGCTGAAAGAATGA
GCCGGCGGGAGGAACTACCT

Downstream 100 bases:

>100_bases
TCTGCAGGCCACTTGACGCAATGTATCATAGAGTGATACGGAGTGTTCCGTGATACAGAGTACCAAGGGTAATCTGATTG
AGCAGGTGCTTGAAGGAAGG

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MEAYDYVIVGAGSAGCVLANRLSADPSVKVCLIEAGKKDTSLMVKMPAGVGGLIKQANDHNWGFFTEPQQHMENRRLYWP
RGKGWGGSSSINGMVYIRGHAGDYDQWGQMGLKGWSFADVLPYFRKSENYEGGANEFHGAQGPLNVTESPLSGPVYQAFI
NAGKEAGYPVTDDFNGAEQEGFGRYQRTIFKGGRWSASFAYLRPIETQRPNLKIVSTGVVTRVLIEKGKAVGVEVVEGKG
RIARQIRADREVILSAGAVQSPQILQLSGVGDPEELKRHGIETKVKSTGVGRNLQDHLDVTVIHDMPLPLSAYSLQKGLK
KLAVGMQYLYNQTGAGADNFLQAGAFLSSRSGLSMPDIQLHLVNAIMMDHGNTGPEKDGYTVHACQLRPESRGTVMLASA
DPFAHPAIDPNYLATEEDRRVMRESVKMVRDVCRQNALKAYTGGEILPGASVKTDAEIDAFIREKGETIYHPVGSVSMGP
NETSPLDGELRVRGVDGLRVVDASVMPTLIGGNTNAPTIMVAEKAADMILGRAAMAREEVALARA

Sequences:

>Translated_545_residues
MEAYDYVIVGAGSAGCVLANRLSADPSVKVCLIEAGKKDTSLMVKMPAGVGGLIKQANDHNWGFFTEPQQHMENRRLYWP
RGKGWGGSSSINGMVYIRGHAGDYDQWGQMGLKGWSFADVLPYFRKSENYEGGANEFHGAQGPLNVTESPLSGPVYQAFI
NAGKEAGYPVTDDFNGAEQEGFGRYQRTIFKGGRWSASFAYLRPIETQRPNLKIVSTGVVTRVLIEKGKAVGVEVVEGKG
RIARQIRADREVILSAGAVQSPQILQLSGVGDPEELKRHGIETKVKSTGVGRNLQDHLDVTVIHDMPLPLSAYSLQKGLK
KLAVGMQYLYNQTGAGADNFLQAGAFLSSRSGLSMPDIQLHLVNAIMMDHGNTGPEKDGYTVHACQLRPESRGTVMLASA
DPFAHPAIDPNYLATEEDRRVMRESVKMVRDVCRQNALKAYTGGEILPGASVKTDAEIDAFIREKGETIYHPVGSVSMGP
NETSPLDGELRVRGVDGLRVVDASVMPTLIGGNTNAPTIMVAEKAADMILGRAAMAREEVALARA
>Mature_545_residues
MEAYDYVIVGAGSAGCVLANRLSADPSVKVCLIEAGKKDTSLMVKMPAGVGGLIKQANDHNWGFFTEPQQHMENRRLYWP
RGKGWGGSSSINGMVYIRGHAGDYDQWGQMGLKGWSFADVLPYFRKSENYEGGANEFHGAQGPLNVTESPLSGPVYQAFI
NAGKEAGYPVTDDFNGAEQEGFGRYQRTIFKGGRWSASFAYLRPIETQRPNLKIVSTGVVTRVLIEKGKAVGVEVVEGKG
RIARQIRADREVILSAGAVQSPQILQLSGVGDPEELKRHGIETKVKSTGVGRNLQDHLDVTVIHDMPLPLSAYSLQKGLK
KLAVGMQYLYNQTGAGADNFLQAGAFLSSRSGLSMPDIQLHLVNAIMMDHGNTGPEKDGYTVHACQLRPESRGTVMLASA
DPFAHPAIDPNYLATEEDRRVMRESVKMVRDVCRQNALKAYTGGEILPGASVKTDAEIDAFIREKGETIYHPVGSVSMGP
NETSPLDGELRVRGVDGLRVVDASVMPTLIGGNTNAPTIMVAEKAADMILGRAAMAREEVALARA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=554, Percent_Identity=45.8483754512635, Blast_Score=504, Evalue=1e-142,
Organism=Escherichia coli, GI1786503, Length=539, Percent_Identity=44.7124304267161, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17532301, Length=546, Percent_Identity=40.6593406593407, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24642042, Length=571, Percent_Identity=39.5796847635727, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24642048, Length=572, Percent_Identity=37.7622377622378, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24642059, Length=573, Percent_Identity=37.696335078534, Blast_Score=331, Evalue=9e-91,
Organism=Drosophila melanogaster, GI24642055, Length=578, Percent_Identity=35.9861591695502, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI45551458, Length=570, Percent_Identity=37.1929824561403, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI45549471, Length=570, Percent_Identity=37.1929824561403, Blast_Score=324, Evalue=8e-89,
Organism=Drosophila melanogaster, GI24650267, Length=575, Percent_Identity=37.2173913043478, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24642039, Length=568, Percent_Identity=35.387323943662, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI18859995, Length=568, Percent_Identity=35.387323943662, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI17137792, Length=561, Percent_Identity=36.3636363636364, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24642037, Length=583, Percent_Identity=35.1629502572899, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24642035, Length=577, Percent_Identity=34.1421143847487, Blast_Score=270, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24642051, Length=573, Percent_Identity=31.7626527050611, Blast_Score=262, Evalue=6e-70,
Organism=Drosophila melanogaster, GI18859993, Length=565, Percent_Identity=30.4424778761062, Blast_Score=242, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24645930, Length=577, Percent_Identity=29.4627383015598, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24642057, Length=577, Percent_Identity=27.9029462738302, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 58937; Mature: 58937

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAYDYVIVGAGSAGCVLANRLSADPSVKVCLIEAGKKDTSLMVKMPAGVGGLIKQANDH
CCCEEEEEEECCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHCCCCC
NWGFFTEPQQHMENRRLYWPRGKGWGGSSSINGMVYIRGHAGDYDQWGQMGLKGWSFADV
CCCCCCCHHHHHCCCCEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCHHHH
LPYFRKSENYEGGANEFHGAQGPLNVTESPLSGPVYQAFINAGKEAGYPVTDDFNGAEQE
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHH
GFGRYQRTIFKGGRWSASFAYLRPIETQRPNLKIVSTGVVTRVLIEKGKAVGVEVVEGKG
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEECHHHHHHHHHCCCEEEEEEECCCC
RIARQIRADREVILSAGAVQSPQILQLSGVGDPEELKRHGIETKVKSTGVGRNLQDHLDV
HHHHHHHHCHHHEEECCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHCCCCCCHHHHCCE
TVIHDMPLPLSAYSLQKGLKKLAVGMQYLYNQTGAGADNFLQAGAFLSSRSGLSMPDIQL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHH
HLVNAIMMDHGNTGPEKDGYTVHACQLRPESRGTVMLASADPFAHPAIDPNYLATEEDRR
HEEHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
VMRESVKMVRDVCRQNALKAYTGGEILPGASVKTDAEIDAFIREKGETIYHPVGSVSMGP
HHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCC
NETSPLDGELRVRGVDGLRVVDASVMPTLIGGNTNAPTIMVAEKAADMILGRAAMAREEV
CCCCCCCCCEEEEECCCEEEECCCCCCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
ALARA
HHHCC
>Mature Secondary Structure
MEAYDYVIVGAGSAGCVLANRLSADPSVKVCLIEAGKKDTSLMVKMPAGVGGLIKQANDH
CCCEEEEEEECCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHCCCCC
NWGFFTEPQQHMENRRLYWPRGKGWGGSSSINGMVYIRGHAGDYDQWGQMGLKGWSFADV
CCCCCCCHHHHHCCCCEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCHHHH
LPYFRKSENYEGGANEFHGAQGPLNVTESPLSGPVYQAFINAGKEAGYPVTDDFNGAEQE
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHH
GFGRYQRTIFKGGRWSASFAYLRPIETQRPNLKIVSTGVVTRVLIEKGKAVGVEVVEGKG
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEECHHHHHHHHHCCCEEEEEEECCCC
RIARQIRADREVILSAGAVQSPQILQLSGVGDPEELKRHGIETKVKSTGVGRNLQDHLDV
HHHHHHHHCHHHEEECCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHCCCCCCHHHHCCE
TVIHDMPLPLSAYSLQKGLKKLAVGMQYLYNQTGAGADNFLQAGAFLSSRSGLSMPDIQL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHH
HLVNAIMMDHGNTGPEKDGYTVHACQLRPESRGTVMLASADPFAHPAIDPNYLATEEDRR
HEEHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
VMRESVKMVRDVCRQNALKAYTGGEILPGASVKTDAEIDAFIREKGETIYHPVGSVSMGP
HHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCC
NETSPLDGELRVRGVDGLRVVDASVMPTLIGGNTNAPTIMVAEKAADMILGRAAMAREEV
CCCCCCCCCEEEEECCCEEEECCCCCCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
ALARA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA