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The map label for this gene is bigR [H]

Identifier: 114332474

GI number: 114332474

Start: 2655969

End: 2656394

Strand: Reverse

Name: bigR [H]

Synonym: Neut_2527

Alternate gene names: 114332474

Gene position: 2656394-2655969 (Counterclockwise)

Preceding gene: 114332475

Following gene: 114332473

Centisome position: 99.82

GC content: 46.01

Gene sequence:

>426_bases
ATGATAGATTCATACCTGCAACAGGCTCTGTCGGCCATGGTGGAAAAAAAGGCTGCTGCAATCAAAGCCTGTTCCATGCT
GAAAATTCTAGCTAATGAAGACCGGCTGATGATCCTGTGTCAGTTGATACAGGGAAAGAAGAATGTCGGCGAACTGGAGC
AATTATTGGGTATCCGGCAACCTACCTTGTCGCAGCAACTTACTGTGCTGCGAGAGGAAAGGCTTGTCTCCACGGAACGC
CAGGGAAAATATATTTATTACAGTCTTGCCAGCCGGGAAGCAGTGCAAATCATTAGCACACTGTTTGATTTATACTGCGG
AAATGAAAATTACCCAATTTCAGATGACACAAATGGTTGCGACGAATCATGTCGTTCCACCAGCAATGTTCACGCTGACA
AACGGCATCCGCAAGAGCAGGATTAA

Upstream 100 bases:

>100_bases
TGGCTATGTTGCTGGGTATGATCATTTTTGATCGACTGGAAAAATACCGTCAGGCTGTTTCAAAACCAAATGATCGACAA
CAAAAAAATATTGGCAGAGA

Downstream 100 bases:

>100_bases
GCTCTTGGAATTCAACTCTGGAGCAGTCTCTGGAGCAGTTACACTACATACCGATACGAAGCCGCTATCAAATCGACAGT
AATAAAAAACAAAAGTAAGG

Product: transcriptional regulator, HxlR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MIDSYLQQALSAMVEKKAAAIKACSMLKILANEDRLMILCQLIQGKKNVGELEQLLGIRQPTLSQQLTVLREERLVSTER
QGKYIYYSLASREAVQIISTLFDLYCGNENYPISDDTNGCDESCRSTSNVHADKRHPQEQD

Sequences:

>Translated_141_residues
MIDSYLQQALSAMVEKKAAAIKACSMLKILANEDRLMILCQLIQGKKNVGELEQLLGIRQPTLSQQLTVLREERLVSTER
QGKYIYYSLASREAVQIISTLFDLYCGNENYPISDDTNGCDESCRSTSNVHADKRHPQEQD
>Mature_141_residues
MIDSYLQQALSAMVEKKAAAIKACSMLKILANEDRLMILCQLIQGKKNVGELEQLLGIRQPTLSQQLTVLREERLVSTER
QGKYIYYSLASREAVQIISTLFDLYCGNENYPISDDTNGCDESCRSTSNVHADKRHPQEQD

Specific function: Represses an operon that comprises at least itself and blh. Binds to a palindromic AT-rich sequence spanning the -10 region of the blh promoter and blocks transcription of the operon [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 15943; Mature: 15943

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSYLQQALSAMVEKKAAAIKACSMLKILANEDRLMILCQLIQGKKNVGELEQLLGIRQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
PTLSQQLTVLREERLVSTERQGKYIYYSLASREAVQIISTLFDLYCGNENYPISDDTNGC
CHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
DESCRSTSNVHADKRHPQEQD
HHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIDSYLQQALSAMVEKKAAAIKACSMLKILANEDRLMILCQLIQGKKNVGELEQLLGIRQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
PTLSQQLTVLREERLVSTERQGKYIYYSLASREAVQIISTLFDLYCGNENYPISDDTNGC
CHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
DESCRSTSNVHADKRHPQEQD
HHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]